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Invisiblehowsyournaggerdoin
Happy


Registered: 02/04/16
Posts: 1,600
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: impaired420]
    #23600373 - 09/01/16 09:06 AM (7 years, 4 months ago)

I love living close to the netherlands at least i can rely on them hardly banning anything


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Invisibleferrel_human
stone eater
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Registered: 06/26/09
Posts: 16,320
Loc: Texas
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: howsyournaggerdoin]
    #23600653 - 09/01/16 10:26 AM (7 years, 4 months ago)

Quote:

howsyournaggerdoin said:
I love living close to the netherlands at least i can rely on them hardly banning anything




They sir are super smart.

I was watching a documentary on netflix on the failed drug war. They know it failed. They know its a complete and utter failure. They feel bad for all of the 'soldiers' who will most likely be out of a job and add to the ever growing populatiom of jobless. That and losing money from the big pharma. We all know its correlated.


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Nature is my church and walking through it is gospel. It tells no lies and reveals all to those who look, and listen, closely.
-Karode


Looking for Mimosa tenuiflora seeds. Buttons for trade


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OfflineTomcat420
Woodlander
Registered: 08/26/16
Posts: 12
Loc: Tejas
Last seen: 7 years, 2 months
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: ferrel_human]
    #23603029 - 09/01/16 10:19 PM (7 years, 4 months ago)

start planting kratom now lol. As for the farther north it prob wont like it I was reading it like humid climates? I don't know too much about the subject. It sounds better then K2.


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OfflineInebriaveritSaepe
Jack of all trades
Male

Registered: 05/19/15
Posts: 70
Loc: United States of America Flag
Last seen: 5 months, 20 days
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: Tomcat420]
    #23614033 - 09/05/16 08:05 AM (7 years, 4 months ago)

I've got two cuttings growing, seems to be doing alright indoors in my bedroom, no humidity tent. Had some wilting on the bigger one a week or so ago, but I misted it and it came right back.


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Check out my garden!
https://www.shroomery.org/forums/showflat.php/Number/24289947



PGP key: Profile or Journal @ shro omery .org/ forums/showflat.php/Number/24365166


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InvisibleMrGiraffe

Registered: 04/04/14
Posts: 3,149
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: InebriaveritSaepe]
    #23619739 - 09/06/16 08:57 PM (7 years, 4 months ago)

What are the rules/legality of live plants after the DEA bans it?


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Invisibleferrel_human
stone eater
Male User Gallery


Registered: 06/26/09
Posts: 16,320
Loc: Texas
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: MrGiraffe]
    #23620574 - 09/07/16 01:51 AM (7 years, 4 months ago)

Quote:

MrGiraffe said:
What are the rules/legality of live plants after the DEA bans it?



Depends on what they decide to ban. If they ban mitragynine then technically plants are that grey are like san pedro cactus. Maybe just processed is gonna be banned. I dont know how that works.


--------------------
Nature is my church and walking through it is gospel. It tells no lies and reveals all to those who look, and listen, closely.
-Karode


Looking for Mimosa tenuiflora seeds. Buttons for trade


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InvisibleMrGiraffe

Registered: 04/04/14
Posts: 3,149
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: ferrel_human]
    #23620898 - 09/07/16 06:26 AM (7 years, 4 months ago)

Hopefully it falls in that gray area.  I mean do they expect people to turn in and destroy trees?  Not that I'd put it past them.


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Offlinekactus.brand.g
Registered: 08/22/14
Posts: 6,886
Last seen: 6 years, 10 months
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: ferrel_human]
    #23620997 - 09/07/16 07:21 AM (7 years, 4 months ago)

Quote:

ferrel_human said:
Quote:

MrGiraffe said:
What are the rules/legality of live plants after the DEA bans it?



Depends on what they decide to ban. If they ban mitragynine then technically plants are that grey are like san pedro cactus. Maybe just processed is gonna be banned. I dont know how that works.




I would think the whole plant would be deemed illegal,and mark my words,every part of it will be illegal to posses,when that bill is passed;)

Kratom is a easy to grow,and once it starts producing leaves,it's already ready to be used.

On the other hand,San Pedro cacti take years from seed to produce anything worthwhile,and even then it takes a massive amount of material,or knowledge of extraction to even get anything out of it.

Most everyday people aren't going to go through all that trouble,and this is what has kept San Pedro legal up until this day.
If all you had to do was take a few bites out of a San Pedro cactus,and trip,you can guarantee it would be banned too,just as Lophophora are:yesnod:


Edited by kactus.brand.g (09/07/16 07:44 AM)


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Invisiblehowsyournaggerdoin
Happy


Registered: 02/04/16
Posts: 1,600
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: kactus.brand.g]
    #23621122 - 09/07/16 08:13 AM (7 years, 4 months ago)

Kratom trees grown outside of their natural habitat are usually of very low potency tho. Also to get enough leaves to sustain daily use youd need a bunch of them.


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OfflinetheMallacht
Clandestine Hero


Registered: 04/25/09
Posts: 3,428
Last seen: 1 year, 1 month
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: howsyournaggerdoin]
    #23621174 - 09/07/16 08:33 AM (7 years, 4 months ago)

Quote:

howsyournaggerdoin said:
Kratom trees grown outside of their natural habitat are usually of very low potency tho. Also to get enough leaves to sustain daily use youd need a bunch of them.




Everyone seems to spread this, and I'm not saying it's necessarily untrue... But do you have any scholarly report whatsoever that claims this with any amount of certainty?


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OfflineStupendous-Yappi
Anomaly XB-311394
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Registered: 09/23/13
Posts: 778
Loc: USA Flag
Last seen: 3 months, 11 days
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: theMallacht]
    #23621461 - 09/07/16 10:28 AM (7 years, 4 months ago)

The notice of intent the DEA made makes it look like just the chemicals in kratom are being scheduled.


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Invisibleferrel_human
stone eater
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Registered: 06/26/09
Posts: 16,320
Loc: Texas
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: Stupendous-Yappi]
    #23621871 - 09/07/16 12:33 PM (7 years, 4 months ago)

Quote:

Stupendous-Yappi said:
The notice of intent the DEA made makes it look like just the chemicals in kratom are being scheduled.




:aweshit:


--------------------
Nature is my church and walking through it is gospel. It tells no lies and reveals all to those who look, and listen, closely.
-Karode


Looking for Mimosa tenuiflora seeds. Buttons for trade


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Offlinepinedownpioneer
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Registered: 03/28/10
Posts: 2,536
Loc: TX
Last seen: 4 years, 8 months
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: ferrel_human]
    #23621981 - 09/07/16 01:13 PM (7 years, 4 months ago)

Not sure on potency of kratom as I have yet to try it but resisting the urge to pick leafs along with tending, regular feeding, and ideal humidity of the south has allowed it to grow huge...I have a special heater for it in the winter.  It does not blow air so it won't dry out.


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Trade list

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Offlinemyceliups
Builder
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Registered: 01/24/15
Posts: 1,671
Loc: Philthadelphia
Last seen: 5 months, 2 days
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: pinedownpioneer]
    #23623510 - 09/07/16 08:07 PM (7 years, 4 months ago)



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Invisibleferrel_human
stone eater
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Registered: 06/26/09
Posts: 16,320
Loc: Texas
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: myceliups]
    #23624453 - 09/08/16 12:59 AM (7 years, 4 months ago)



--------------------
Nature is my church and walking through it is gospel. It tells no lies and reveals all to those who look, and listen, closely.
-Karode


Looking for Mimosa tenuiflora seeds. Buttons for trade


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Invisibleferrel_human
stone eater
Male User Gallery


Registered: 06/26/09
Posts: 16,320
Loc: Texas
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: ferrel_human]
    #23624456 - 09/08/16 01:00 AM (7 years, 4 months ago)

I say we just go about our business as if nothing is wrong. Whattayasay?:hmm:


--------------------
Nature is my church and walking through it is gospel. It tells no lies and reveals all to those who look, and listen, closely.
-Karode


Looking for Mimosa tenuiflora seeds. Buttons for trade


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Invisiblehowsyournaggerdoin
Happy


Registered: 02/04/16
Posts: 1,600
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: myceliups]
    #23624503 - 09/08/16 01:35 AM (7 years, 4 months ago)

Quote:

In this work, we have presented the first thorough, in vitro
characterization of the opioid receptor pharmacology and
signaling of the natural Mitragyna alkaloids in receptor-level
functional assays. The partial agonist activity of (−)-mitragynine
at MOR is likely to account for many of the effects of
Mitragyna speciosa extracts in humans. However, the other
major alkaloids isolated from the plant, paynanthiene,
speciogynine, and speciociliatine, all exhibited competitive
antagonist activity at this receptor. Considering that cumulatively,
these secondary alkaloids accounted for an approximately
equal percentage of the total alkaloid content compared
to mitragynine in our extracts, the gross psychoactive effects of
crude plant material are likely to represent a complex interplay
of competing agonist and antagonist effects at the opioid
receptors. It was also found that the potent oxidized analogue
7-OH is not necessarily present in all extracts of plant material
(as previously suggested), so the potential contribution of this
alkaloid to the effects of Mitragyna speciosa is not general, unless
7-OH is formed as a metabolite.
Exploration with several synthetic mitragynine analogues
allowed us to define basic SAR at each of the existing
substituents, including in regions (the D ring) that were only
accessible to derivatization via total synthesis. This work
revealed that opioid activity in the mitragynine scaffold is quite
sensitive to structural modification and suggested that the
Mitragyna alkaloids adopt a unique binding pose at MOR,
distinct from that of classical opioids. This possibility was
further supported by molecular docking studies at MOR. The
first total synthesis of the unnatural enantiomer, (+)-mitragynine,
likewise allowed us to confirm that the naturally occurring
isomer is the more active opioid agonist.
We also found that mitragynine and 7-OH display biased
signaling at MOR, being selective for the G protein pathway.
Thus, it is hoped that this scaffold may represent a starting
point for the development of novel opioid analgesics with
reduced side effects. Relatedly, the finding that, in addition to
their activity at MOR, both mitragynine and 7-OH are KOR
antagonists, suggests that Mitragyna alkaloids or their synthetic
derivatives may also serve as leads for novel dual-action
antidepressants. In this regard, mitragynine itself is of particular
interest, as it acts as both a low efficacy MOR partial agonist,
and a KOR antagonist. Both of these mechanisms have been
shown to elicit antidepressant effects in animals, and in the case
of MOR, humans as well (see above). However, modulators of
the KOR have received considerably more attention in the
psychiatry community in recent years, likely due to their
apparent lack of abuse potential. Antagonists of this receptor
are antidepressant in animal models and oppose a variety of
stress-related responses that are believed to be mediated
through the endogenous KOR agonists, dynorphins.61−63
Further, several agents in this class have entered clinical trials
for MDD, but none have yet reached the market.64 Given the
ability of mitragynine to perturb both of these opioid signaling
systems in the direction consistent with mood enhancement, it
is unsurprising that it has been shown to exhibit antidepressant
activity in the forced swim test (a rodent model of
depression).65 Therefore, Mitragyna alkaloids also hold promise
in the treatment of mood disorders.




http://pubs.acs.org/doi/full/10.1021/jacs.6b00360

Well theyve put a lot of work into this and found out some interesting stuff. They say here that mitragynine activity is pretty senstitive to molecular changes. This means they might not be able to find something thats superior to it.


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Offlinemyceliups
Builder
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Registered: 01/24/15
Posts: 1,671
Loc: Philthadelphia
Last seen: 5 months, 2 days
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: ferrel_human]
    #23624868 - 09/08/16 06:38 AM (7 years, 4 months ago)

Quote:

ferrel_human said:
I say we just go about our business as if nothing is wrong. Whattayasay?:hmm:



I like that idea


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Offlineimpaired420
Everything Is Nothing
Male


Registered: 11/10/14
Posts: 1,390
Loc: Somewhere
Last seen: 3 years, 3 months
Re: Kratom to be placed in schedule 1. Petition to stop it. [Re: myceliups]
    #23625196 - 09/08/16 09:28 AM (7 years, 4 months ago)



--------------------
"Our task must be to free ourselves...
By widening our circle of compassion,
To embrace all living creatures and the whole of nature and its beauty." -Albert Einstein


Offering salvia divinorum clones, leaf, and extracts for trades legal states.


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