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InvisibleOgla
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Registered: 02/16/04
Posts: 11,314
synthetic medical marijuana being developed by pharmaceutical company
    #23542504 - 08/14/16 11:16 PM (7 years, 5 months ago)

August 15, 2016

Australia-
Botanix Pharmaceuticals Ltd (ASX:BOT) is expected to benefit from the U.S. Drug Enforcement Agency’s (DEA) decision last week to keep cannabis and its constituent chemicals as Schedule 1 drugs.

Botanix is developing a synthetic form of cannabidiol for a range of skin diseases and is preparing to conduct its first human studies in acne with its lead product BTX1503.

The DEA’s decision was in response to petitions that argued that cannabis should be rescheduled out of Schedule 1 and be subject to less regulation, in order to provide easier access to the drug.

DEA’s written response affirmed that the FDA drug approval process is the most appropriate way to assess whether a product derived from cannabis is safe and effective.

This bodes well for Botanix which is currently undertaking manufacturing and testing activities of its BTX1503 acne product in the U.S and plans to conduct its first human studies in the first half of 2017.

Acne is one of the most common skin diseases in the world, and was reported to cost more than $2.3 billion in prescriptions in 2013.

Synthetic cannabidiol used by Botanix is of high purity and does not vary in strength or composition due to growing conditions or genetics of the source plant.

This represents a significant advantage as the company will not be required to comply with the extensive controls by FDA that apply to natural cannabidiol extract based products.

Botanix relisted on the ASX last month after raising $3.5 million at $0.02 per share. The share price has climbed to $0.043 since listing.

http://www.proactiveinvestors.com.au/companies/news/70435/botanix-pharmaceuticals-ltd-to-benefit-from-us-decision-on-cannabis-70435.html


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OfflineXingu
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Registered: 10/20/12
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Re: synthetic medical marijuana being developed by pharmaceutical company [Re: Ogla] * 1
    #23543030 - 08/15/16 06:30 AM (7 years, 5 months ago)

Quote:

losfreddy said:
Synthetic cannabidiol used by Botanix is of high purity and does not vary in strength or composition due to growing conditions or genetics of the source plant.





This is one of the most unscientific shill lines I've ever heard. If you want consistent strength and composition, just isolate and mix well the cannabinoids from the actual plant and then use titrations to adjust once you have a large batch, then make into oil, tincutre, capsules, edibles, whatever. Larger organic "contaminants" can be all be microfiltered out without any chemical processes. How fucking hard is that?

I don't get how shit like this is considered medicinal science, it's really an afront to the intellect and rationality of anyone who paid attention in HS Chemistry.

Fwiw, it does make sense to use cannabinoids to treat acne, though, as many of them (maybe all? not sure) have antioxidant properties, which are known to help topically with acne.


Edited by Xingu (08/15/16 06:34 AM)


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OfflineFractal420
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Registered: 06/21/13
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Re: synthetic medical marijuana being developed by pharmaceutical company [Re: Xingu] * 1
    #23543100 - 08/15/16 07:23 AM (7 years, 5 months ago)

So basically, they SHUT DOWN vendors who were making synthetic cannabinoids, by the hundreds, didnt check for any medicinal value, just ban and arrest. But then some Pharm company can make their own cannabinoids. Its not unexpected but its so fucking shameless. Proof that the reason they made RCs such a big deal in the first place was simply because they were in Big Pharma's territory. I suspected that, but this just proves it.

But hey, might be a good analog of CBD or something
this is kind of a *facepalm* article for me


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It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,372
Re: synthetic medical marijuana being developed by pharmaceutical company [Re: Fractal420]
    #23543323 - 08/15/16 09:37 AM (7 years, 5 months ago)

Quote:

Fractal420 said:
So basically, they SHUT DOWN vendors who were making synthetic cannabinoids, by the hundreds, didnt check for any medicinal value, just ban and arrest. But then some Pharm company can make their own cannabinoids. Its not unexpected but its so fucking shameless.




The vendors could have done the same thing.

There is a difference between selling RCs by the pound and doing research.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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Invisible36fuckin5
Alchemycologist


Registered: 08/11/03
Posts: 12,079
Loc: Diving into Mystical Territori...
Re: synthetic medical marijuana being developed by pharmaceutical company [Re: Xingu]
    #23546610 - 08/16/16 11:21 AM (7 years, 5 months ago)

Quote:

Xingu said:
Quote:

losfreddy said:
Synthetic cannabidiol used by Botanix is of high purity and does not vary in strength or composition due to growing conditions or genetics of the source plant.




If you want consistent strength and composition, just isolate and mix well the cannabinoids from the actual plant and then use titrations to adjust once you have a large batch, then make into oil, tincutre, capsules, edibles, whatever. Larger organic "contaminants" can be all be microfiltered out without any chemical processes. How fucking hard is that?





Seeing as how we haven't even IDENTIFIED all the cannabinoids in pot, extremely hard. Then consider that they're very, very similar in structure, making them extremely hard to separate through normal means.

The FDA will never let a mix of some random chemicals in random amounts be approved. That's what pot is. We don't know the composition of every plant. We can't keep dosages consistent.

We can't even properly test THC levels right now. You take a sample to 3 different labs and you're likely to get 3 different results depending on how they test the material.


--------------------
Redd Foxx said:
If you're offended I don't give a shit and don't come see me no more.

Pat The Bunny said:
A punk rock song won't ever change the world, but I can tell you about a couple that changed me.

bodhisatta said:
i recommend common sense and figuring it out.

These are the TEKs I use. They're all as cheap and easy as possible, just like your mom.


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Offlinespacechimp
touching the cosmos
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Registered: 12/01/13
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Re: synthetic medical marijuana being developed by pharmaceutical company [Re: Ogla] * 1
    #23547272 - 08/16/16 03:49 PM (7 years, 5 months ago)

Fuck that synthetic marijuana and all the goofy products they are making from it. All you need is good seeds, good soil, and the sun. fucking easy as that!:solidnod: Maybe these lab rats need to take off their white coats and smoke some organic next to a redwood....god I hate big pharma


Edited by spacechimp (08/16/16 03:53 PM)


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OfflineFractal420
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Registered: 06/21/13
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Re: synthetic medical marijuana being developed by pharmaceutical company [Re: spacechimp]
    #23549111 - 08/17/16 06:24 AM (7 years, 5 months ago)

too much of a stigma already against synthetic cannabinoids. Also these guys care no less than the RC vendors about $$. Its pretty much just competition. Some of those cannabinoids were def orally active and perhaps cancer cures. People could still research them... There are hundreds of "cannamimetic" agent profiles. I always thought HU looked interesting? Only tried one of them, pure form not some crazy blend


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



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OfflineXingu
Stranger
Registered: 10/20/12
Posts: 932
Loc: NC
Last seen: 6 years, 7 months
Re: synthetic medical marijuana being developed by pharmaceutical company [Re: 36fuckin5]
    #23551450 - 08/17/16 09:53 PM (7 years, 5 months ago)

Quote:

36fuckin5 said:
The FDA will never let a mix of some random chemicals in random amounts be approved. That's what pot is. We don't know the composition of every plant. We can't keep dosages consistent.





Cigarettes are a random mix of known dangerous chemicals and are perfectly legal. A lot of psychoactive herbs and roots with unknown mixes are also legal...and clones are consistent enough. Research needs to be done, but that's the point. Research has significant roadblocks right now because of its scheduling.


Edited by Xingu (08/17/16 09:57 PM)


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Offlinespacechimp
touching the cosmos
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Registered: 12/01/13
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Re: synthetic medical marijuana being developed by pharmaceutical company [Re: Xingu]
    #23551548 - 08/17/16 10:23 PM (7 years, 5 months ago)

just ingest the whole product and get the benefits of the whole product. Broccoli pills aren't actually as good as eating broccoli because there are like 2000 other chemicals/reactions that add to the benefits of broccoli.


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