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Jokeshopbeard
Humble Student

Registered: 11/30/11
Posts: 26,088
Loc: Deep in the system
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Re: How long do you guys usually wait in between LSD trips? [Re: KaptKid] 1
#23539701 - 08/14/16 02:27 AM (7 years, 5 months ago) |
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Experience has taught me that time between trips should be a minimum of 2 weeks, preferably a month, in order to counter any kind of diminished effects.
I wish it wasn't so, but science backs it up. Someone shared this handy chart with me the other day so you can see which receptors in the brain are becoming desensitised by various compounds:
-------------------- Let it be seen that you are nothing. And in knowing that you are nothing... there is nothing to lose, there is nothing to gain. What can happen to you? Something can happen to the body, but it will either heal or it won't. What's the big deal? Let life knock you to bits. Let life take you apart. Let life destroy you. It will only destroy what you are not. --Jac O'keeffe
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Sophistic Radiance
Free sVs!



Registered: 07/11/06
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Re: How long do you guys usually wait in between LSD trips? [Re: Jokeshopbeard]
#23539704 - 08/14/16 02:28 AM (7 years, 5 months ago) |
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That's a neat chart.
-------------------- Enlil said: You really are the worst kind of person.
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404
error


Registered: 08/20/10
Posts: 14,539
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Re: How long do you guys usually wait in between LSD trips? [Re: Jokeshopbeard]
#23540266 - 08/14/16 09:44 AM (7 years, 5 months ago) |
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Quote:
Jokeshopbeard said: Experience has taught me that time between trips should be a minimum of 2 weeks, preferably a month, in order to counter any kind of diminished effects.
I wish it wasn't so, but science backs it up. Someone shared this handy chart with me the other day so you can see which receptors in the brain are becoming desensitised by various compounds:

No affinity from mescaline for the 5ht2a? uhmmm also, 5ht3 isn't mentioned either, and there's others missing... i don't trust that chart
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Jokeshopbeard
Humble Student

Registered: 11/30/11
Posts: 26,088
Loc: Deep in the system
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Re: How long do you guys usually wait in between LSD trips? [Re: 404]
#23540410 - 08/14/16 10:41 AM (7 years, 5 months ago) |
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Quote:
404 said: i don't trust that chart
If you can find anything you believe is more accurate I'd really appreciate it.
-------------------- Let it be seen that you are nothing. And in knowing that you are nothing... there is nothing to lose, there is nothing to gain. What can happen to you? Something can happen to the body, but it will either heal or it won't. What's the big deal? Let life knock you to bits. Let life take you apart. Let life destroy you. It will only destroy what you are not. --Jac O'keeffe
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404
error


Registered: 08/20/10
Posts: 14,539
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Re: How long do you guys usually wait in between LSD trips? [Re: 404] 1
#23540490 - 08/14/16 11:04 AM (7 years, 5 months ago) |
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If mescaline is a partial agonist of the 5ht2a receptor and that chart doesn't even bother to acknowledge that, I'd completely discount whatever is on that chart as you can't fully trust whatever else is on there. Pretty sure agonists reduce receptor sites at post-synaptic synapses, while antagonists increase receptor sites at post-synaptic synapses as a biological response, typically speaking. (Edit: didn't finish that thought out) This results in 'downregulation' and 'upregulation' respectively - desensitizing and sensitizing.
Edited by 404 (08/14/16 03:36 PM)
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Jokeshopbeard
Humble Student

Registered: 11/30/11
Posts: 26,088
Loc: Deep in the system
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Re: How long do you guys usually wait in between LSD trips? [Re: 404]
#23540498 - 08/14/16 11:08 AM (7 years, 5 months ago) |
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I hear what you're saying, but I'm a layman when it comes to such things. All I really want to know is how to plan my trip schedules.
I mean, you sound like you know enough to discount it, but as a rough guide I've nothing better to work with. Hence why I asked if you can show me something that you feel is more accurate.
-------------------- Let it be seen that you are nothing. And in knowing that you are nothing... there is nothing to lose, there is nothing to gain. What can happen to you? Something can happen to the body, but it will either heal or it won't. What's the big deal? Let life knock you to bits. Let life take you apart. Let life destroy you. It will only destroy what you are not. --Jac O'keeffe
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Into The Woods
Quarantine King


Registered: 04/20/13
Posts: 10,864
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Re: How long do you guys usually wait in between LSD trips? [Re: Jokeshopbeard] 1
#23540645 - 08/14/16 12:02 PM (7 years, 5 months ago) |
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Lol, that chart is as vague as summertime hell
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Sophistic Radiance
Free sVs!



Registered: 07/11/06
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Re: How long do you guys usually wait in between LSD trips? [Re: Into The Woods]
#23540815 - 08/14/16 01:05 PM (7 years, 5 months ago) |
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Yeah, it looks like it came from some larger article, I wish it came with a link.
-------------------- Enlil said: You really are the worst kind of person.
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nooneman


Registered: 04/24/09
Posts: 14,568
Loc: Utah
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Re: How long do you guys usually wait in between LSD trips? [Re: Jokeshopbeard] 1
#23541124 - 08/14/16 02:40 PM (7 years, 5 months ago) |
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Quote:
Jokeshopbeard said: Experience has taught me that time between trips should be a minimum of 2 weeks, preferably a month, in order to counter any kind of diminished effects.
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