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Offlinedaz01
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Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells
    #23396820 - 06/30/16 08:46 AM (7 years, 7 months ago)

Quote:

For hundreds – perhaps thousands – of years, Amazonian shamans have protected the health of their communities using a sacred hallucinogenic brew, said to be capable of healing all manner of physical and psychological ailments. Known as ayahuasca, this traditional medicine contains a potent psychoactive compound called DMT, which has been shown in several studies to ease symptoms of depression and other mental disorders. Though scientists are yet to uncover most of the secrets behind the healing power of this plant-based medicine, researchers from the Beckley/Sant Pau Research Programme – in collaboration with the Spanish Medical Research Council – have now revealed that certain compounds in ayahuasca can actually stimulate the birth of new neurons.

Given that many cognitive disorders such as Alzheimer’s disease are associated with neuron death in key regions of the brain, the team behind this stunning discovery believe that ayahuasca’s potential to bring about neurogenesis could one day lead to new treatments for many such ailments.

For instance, those who suffer from Alzheimer’s often experience a significant reduction in the volume of their hippocampus – a part of the brain that is responsible for learning and memory. However, a team of researchers led by Jordi Riba were able to successfully stimulate the development of hippocampal stem cells into both young and mature neurons by mixing them in a petri dish with two compounds found in ayahuasca: harmine and tetrahydroharmine.

Reacting to this groundbreaking discovery, Beckley Foundation founder and director Amanda Feilding told IFLScience that “we were pretty amazed at the results – the fact that we were able to generate new brain cells and then mature brain cells from harmine and tertrahydroharmine. They seem to be remarkably prolific.”

Though a full study outlining this research is yet to be published, the team have released a series of images that illustrate just how successful their experiments have been, as can be seen below.

content-1467218111-aya-neuro-1.jpg

The first image shows the stem cells – stained blue – before the addition of either harmine or tetrahydroharmine. No neurons are present at this stage. Jordi Riba – Beckley/Sant Pau Research Programme

As exciting as this finding may be, however, Feilding insists that “it’s early days. We’ve only done it in a dish, we haven’t done it in vivo yet. But if it is as good as it looks, it could be an indication for a new treatment [for cognitive disorders] down the line.”

The second image reveals the presence of young neurons (stained green) and mature neurons (stained red) after the addition of harmine to hippocampal stem cells. Jordi Riba – Beckley/Sant Pau Research Programme





“The fact that [we’ve created] hippocampus cells could be good in the sense that one hopes that they’ll help with Alzheimer’s and possibly even strokes. It’s much too early days to say if it would, but it possibly could indicate that,” she continues.

Looking ahead, Feilding explains that “this is just phase one,” adding that the next step is to try and replicate these results using other components of ayahuasca, including DMT, before then carrying out in vivo experiments.

“I’m very much wanting to do it with LSD as well,” she says, “because I wouldn’t be at all surprised if we get the same results.” Like an ever-growing number of neuroscientists around the world, Feilding has a great deal of belief in the healing properties of acid, saying “I think LSD is particularly cognitive. It potentiates creativity – and after all, in a way our civilization’s survival depends on a propensity to be creative.”

As the body of scientific evidence regarding the drug’s cognitive benefits continues to expand, she tells us she hopes to launch a new study confirming her theory about LSD and creativity, by seeing if taking the substance can increase participants’ success when playing the famously cerebral game Go.




Hallucinogenic Amazonian Medicine Stimulates Generation Of New Brain Cells

More proof and evidence to the "non-believers" that psychedelics are amazing and not evil! :hellyeah:


--------------------
Pain is temporary. It may last for a minute or an hour or a day or even a year but eventually it will subside and something else will take its place. If I quit, however, it will last forever.

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Invisible404
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Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: daz01]
    #23396839 - 06/30/16 08:54 AM (7 years, 7 months ago)

They have known this for some time. Even other similar substances including mushrooms and I'm sure even so far as LSD and Mescaline achieve this effect, I would imagine because of their similar mechanisms of action on the serotonergic and adrenergic systems in the body.

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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,374
Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: 404] * 2
    #23396938 - 06/30/16 09:39 AM (7 years, 7 months ago)

This is excellent news for neurons growing in petri dishes around the world!


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...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436

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Invisible404
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Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: badchad]
    #23396948 - 06/30/16 09:49 AM (7 years, 7 months ago)

You mean in relation to in vivo/ in vitro arguments correct? Like, not being proven in the actual body yet

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Invisiblebadchad
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Registered: 03/02/05
Posts: 13,374
Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: 404] * 1
    #23397016 - 06/30/16 10:27 AM (7 years, 7 months ago)

Quote:

404 said:
You mean in relation to in vivo/ in vitro arguments correct? Like, not being proven in the actual body yet



Yes.  While I was being sarcastic, translatability is a huge issue in terms of medications treatment. Even when moving from non-clinical to clinical work, there is a large failure rate.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436

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OfflinePaulMaster
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Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: badchad]
    #23397039 - 06/30/16 10:38 AM (7 years, 7 months ago)

I've always believed that some version of the Stoned Ape theory was accurate.

This supports.

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InvisibleRas Rising
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Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: PaulMaster]
    #23397211 - 06/30/16 11:37 AM (7 years, 7 months ago)

Quote:

PaulMaster said:
I've always believed that some version of the Stoned Ape theory was accurate.

This supports.





Mckennas logic is flawed on several parts of that "theory". :flyagaric:  :mushroomgrow:

First off he fallaciously calls it a theory while it remains a hypothesis.

I do like the guy, but, he cleary does not have the expansive background to make such a claim on Developmental Neuro-biology though.

I do however believe there is SOME truth to it, and I have formulated a much more coherent and scientifically sound hypothesis.

Part of my life's work (Neuroscientist/Neurologist) will be dedicated to understanding the origins of the brain, and more importantly consciousness and "higher" intelligence.

In short: Look at mitochondria, chloroplasts, even our own guts/innards(microorganismal symbiosis). Now, with knowledge of chemistry (namely biochem, so obviously orgos in that), look at the world around you. Now, Look at the flora peer into its chemical make up, alkaloid contents, use of said compounds, genetics, environmental loci, etc. Take that same frame of thought and apply it to the fauna(including us). Specifically, our neuromodulators, neurotransmitters, and neurons, and other cells. Why is it we're able to take from nature, and metabolize it into our usable form? Where on gods green earth did we ever get these in us, to be used for above said purposes to begin with!?

If you're still following me, just as other symbiotic relations, our own neuro-chemical makeup is fine tuned for our use in perception, consciousness, and intelligence. Over time WAY before we even resembled humans somewhere down the genetic tree(think about when the ganglion appears, and then what we can actually call a brain). At this point in the natural history of earth, plants(or their ancestors) have appeared and more importantly evolved. They begin creating alkaloids, and other biochemicals (note here we're not sure why some plants have a lot of what they do.. as it appears as if there is NO purpose). However, they all are several or a few meta/catabolic "steps" away from every single one of our neurological components. The things that make us FEEL, THINK, PERCEIVE, EVERYTHING. Are in-fact derived from this highly complex interaction of ingestion/exposure of primal life to early Neurological precursors. Just as we have mitochondria, or plants chloroplasts. There is not a single logical path (that I can conjure and ascertain of as truth) that will lead you to this relationship and unseemly connection between our neurochemistry and the compounds found in nearly every plant known to man.

This is epigenetics at play, but more than that, it elucidates the complex pathology of(the) natural evolutionary process(s). We are part of everything we see(thats living), and our entire perception of reality was built from the symbiosis of life.

Mckenna fails to mention critical components to uphold his claims starting with the dawn of life itself, and even pre-life chemical soup supporting Abiogenesis. But anyways, If you're still reading the specific event which our hippo-campus's exploded and our brains developed so rapidly( in respect to other developments and how long it took to evolve in the first place) was not due to merely the mushroom. It was happening long before then, a series of events led up to the explosion which was a culmination of billions of years of evolution.



I will leave you with this:Rig-Veda Book 10, HYMN CXIX. Indra.

Quote:

1. THIS, even this was my resolve, to win a cow, to win a steed:
Have I not drunk of Soma juice?
2 Like violent gusts of wind the draughts that I have drunk have lifted me
Have I not drunk of Soma juice?
3 The draughts I drank have borne me up, as fleet-foot horses draw a car:
Have I not drunk of Soma juice?
4 The hymn hath reached me, like a cow who lows to meet her darling calf:
Have I not drunk of Soma juice?
5 As a wright bends a chariot-seat so round my heart I bend the hymn:
Have I not drunk of Soma juice?
6 Not as a mote within the eye count the Five Tribes of men with me:
Have I not drunk of Soma juice?
7 The heavens and earth themselves have not grown equal to one half of me
Have I not drunk of Soma juice?
8 I in my grandeur have surpassed the heavens and all this spacious earth
Have I not drunk of Soma juice?
9 Aha! this spacious earth will I deposit either here or there
Have I not drunk of Soma juice?
10 In one short moment will I smite the earth in fury here or there:
Have I not drunk of Soma juice?
11 One of my flanks is in the sky; I let the other trail below:
Have I not drunk of Soma juice?
12 1, greatest of the Mighty Ones, am lifted to the firmament:
Have I not drunk of Soma juice?
13 I seek the worshipper's abode; oblation-bearer to the Gods:
Have I not drunk of Soma juice?




Yes obviously psychoactive compounds have played a large role in this neuro-developmental process, but, was it the mushroom alone which sparked it? Or as I suggest the natural climax of billons of years of evolution and symbiosis?

To be clear, its not even certain as "the scholars" will tell you many identities for the fabled and revered "Soma". His insinuation that IT MUST BE a fungus doesn't sit right with me to begin with.

:2cents:  :blah:


--------------------
:bliss:To be altruistic and humble, to spread love and positivity where ever I go.*:bliss: 

*Does not include the Romp 
:inlove3::sunny::shroomeryhead::feelsshroomyman::shroomeryhead::sunny::inlove3:
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OfflinePaulMaster
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Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: Ras Rising]
    #23397358 - 06/30/16 12:28 PM (7 years, 7 months ago)

Ya, I mean, its not his details but the general idea that animals ate psychedelic plants that fostered the development of the brain that I've always believed was accurate.

I like your hypothesis too :smile::thumbup:

Edited by PaulMaster (06/30/16 12:35 PM)

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InvisibleBill_Oreilly
ANIMALS (the RAINBOW SERPENT)


Registered: 11/12/11
Posts: 26,370
Loc: Boston
Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: daz01]
    #23397455 - 06/30/16 01:01 PM (7 years, 7 months ago)

The universe is trying to speak. That is what is pushing evolution.


--------------------
Something there is mysteriously formed,
Existing before Heaven and Earth,
Silent, still, standing alone, unchanging,
All-pervading, unfailing,
I do not know its name; I call it tao.
If forced to give it a name, I call it
Great (ta). Being great, it flows out;
Flowing out means far-reaching;
Being far-reaching, it is said to return.


It's just a shot away..

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InvisibleRas Rising
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Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: Bill_Oreilly] * 1
    #23397488 - 06/30/16 01:15 PM (7 years, 7 months ago)

Quote:

Bill_Oreilly said:
The universe is trying to speak. That is what is pushing evolution.




It would be unintelligible to us if the Universe did speak. We cant even communicate with any species on our own planet... or ourselves half the time :lol:.


I think more likely, the universe is trying to "fold-in" on itself, like a two-way mirror between two mirrors so to speak.

Universal awareness of the entirety of the universe. To become what we might call "intelligent" as if it wasn't already?

:shrug:


--------------------
:bliss:To be altruistic and humble, to spread love and positivity where ever I go.*:bliss: 

*Does not include the Romp 
:inlove3::sunny::shroomeryhead::feelsshroomyman::shroomeryhead::sunny::inlove3:
Test Kits? SurRealitys gocchu'!

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InvisibleMoonshoe
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Registered: 05/28/04
Posts: 27,202
Loc: Iceland
Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: daz01]
    #23397519 - 06/30/16 01:21 PM (7 years, 7 months ago)

So does weed and mushrooms (both cause neurogenesis)

I see a pattern


--------------------


Everything I post is fiction.

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Invisiblenooneman
Male

Registered: 04/24/09
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Loc: Utah
Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: daz01]
    #23397539 - 06/30/16 01:25 PM (7 years, 7 months ago)

To be clear, this is about harmine, not DMT. It might be more related to MAOIs than to psychedelics.

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InvisibleRas Rising
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Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: Moonshoe]
    #23397602 - 06/30/16 01:38 PM (7 years, 7 months ago)

I'd just like to point out...

Not all neurogenesis is beneficial.


--------------------
:bliss:To be altruistic and humble, to spread love and positivity where ever I go.*:bliss: 

*Does not include the Romp 
:inlove3::sunny::shroomeryhead::feelsshroomyman::shroomeryhead::sunny::inlove3:
Test Kits? SurRealitys gocchu'!

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InvisibleMoonshoe
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Loc: Iceland
Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: Ras Rising]
    #23397611 - 06/30/16 01:40 PM (7 years, 7 months ago)

Quote:

Ras Rising said:
I'd just like to point out...

Not all neurogenesis is beneficial.




Source/Explanation?


--------------------


Everything I post is fiction.

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InvisibleBill_Oreilly
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Registered: 11/12/11
Posts: 26,370
Loc: Boston
Re: Hallucinogenic Amazonian Medicine (Ayahuasca) Stimulates Generation Of New Brain Cells [Re: Ras Rising]
    #23397774 - 06/30/16 02:40 PM (7 years, 7 months ago)

Quote:

Ras Rising said:
Quote:

Bill_Oreilly said:
The universe is trying to speak. That is what is pushing evolution.




It would be unintelligible to us if the Universe did speak. We cant even communicate with any species on our own planet... or ourselves half the time :lol:.


I think more likely, the universe is trying to "fold-in" on itself, like a two-way mirror between two mirrors so to speak.

Universal awareness of the entirety of the universe. To become what we might call "intelligent" as if it wasn't already?

:shrug:




Very well could be the case.

I think nature finds a pathway and applies itself in all domains. She is relentless when it comes to finding a way from nothing. Shes beating. Pulsating. Vibrating. Connecting. Shes casting her image into time and we seem to be in a race with ignorance to catch up

Its as if we hear an angelic singing voice in the wilderness and we are locked in trying to find where it is coming from. As time goes on we began to become synical and think that its unreachable and lose our morals.

Perhaps in the end we will realize its everything around us that is making the tune. Animals and plants first in line.


--------------------
Something there is mysteriously formed,
Existing before Heaven and Earth,
Silent, still, standing alone, unchanging,
All-pervading, unfailing,
I do not know its name; I call it tao.
If forced to give it a name, I call it
Great (ta). Being great, it flows out;
Flowing out means far-reaching;
Being far-reaching, it is said to return.


It's just a shot away..

Edited by Bill_Oreilly (06/30/16 02:48 PM)

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