Amanita Muscaria Grape TEK (Muscimol Mulled Wine) - The Psychedelic Experience

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Jiemba
Shamanaut Australis

Registered: 02/17/16
Posts: 37
Last seen: 5 years, 9 months

Amanita Muscaria Grape TEK (Muscimol Mulled Wine)

8
#23155612 - 04/26/16 12:01 AM (7 years, 11 months ago)

Hello everyone, [This TEK is still UNDER CONSTRUCTION]

History

Amanita Muscaria, commonly known as the fly agaric, is a psychoactive mushroom notorious for mis-preparation inducing sickness and bad trips. It is unfortunate that amanita is given such a bad reputation.

Amanita muscaria has been widely used as an entheogen by the indigenous peoples of Siberia; northern Norway, Sweden and Finland, the Kola Peninsula of Russia, Afghanistan, and north America. In western Siberia, the use of Muscaria is usually restricted to shamans, but in eastern Siberia it is unrestricted and freely used by anyone with an interest in exploring the Muscaria entheogenic state. The traditional use of Amanita in other countries is less certain in academia - as the topic has been poorly studied, or information has been lost over the years.

The consumption of raw Muscaria seems to be one of the better explanations for how the tribes of northern Europe would turn warriors into berzerkers. The berzerker stereotype involves performing a war dance, and screaming, to induce excitement and frenzy, then at the peak, there is a period of inhuman strength, rage, ignorance to damage and pain, followed by a period of exhaustion and a sleep... state-spaces similar to this is what is seen when Muscaria is consumed at the right dose, as one active compound metabolizes into the secondary active compound. If a non-warrior takes the same doses, without performing an excitatory war dance with screaming, the mushroom would instead induce nausea and mood bipolarity.

My hypothesis is that mulled wine exists as a culturally popular concept today because, historically, the consumption of Amanita Muscaria can be an enjoyable experience, and mulled wine was the traditional preparation of Amanita Muscaria in Europe.
Without special equipment, it is much easier and more consistent to brew muscimol mulled wine than it is to brew alcohol - there is less chance of contamination, and Muscaria literally grow on trees.

Mulled wine is well known as a winter beverage because ibotinic acid, one of the compounds found in Muscaria, is thermogenic (warms you up). The same compound is antibiotic and fungicidal, so allows people to store grape juice for years without it going off (similar to alcoholic wine).

Experiences

If prepared well, you'll experience a period of deep sleepiness and physical disability (you will probably need to lie down), your body temperature will decrease, and if you try to stay awake you will remain disoriented and sensitive to light. Allowing yourself to fall asleep, you will slip out of reality and into an entheogenic, lucid, (often) narrative, altered state of consciousness. It might be comparable to something in between a GHB, and a high dose of Galantamine. Musicmol also has dissociative effects, and can induce hypnagogia, lucid dreaming, astral projections and outer body experiences. If you don't reach these states (and just sleep) then you've likely taken too little muscimol for the acetylcholine release, or if you go unconscious and/or seizure you've taken too much. Like other hallucinogens, set and setting are important, you can have bad trips, as well as good.

The relaxation/high is different to opioids, and the entheogenicity is different to tryptamine-land, not really comparable, both it's relaxation and entheogenicity are best compared to intense lucid dream states. Like psychedelics, you will find that the quality changes depending on your setting... lights and music is going to be different to silent darkness, and being outside in nature is going to be different to being indoors. It might be that you don't like one setting but you like another, so try them all out when you're getting to know the muscaria wine.

Peak experiences with muscimol can include full dissociation, ego-death and universe traversal, like with other entheogens.

Ibotenic Acid, the main active compound in raw Muscaria, at high doses, causes thermogenicity and sweating, nausea and frothing, racing thoughts, certainty and meaningness, feelings of vigor/strength, feelings of distortion of size, disorientation/confusion, and depending on set and setting will exacerbate primal feelings such as rage, terror, grief, ecstasy or glee, e.g. if starting anxious will increase anxiety/panic, if starting angry will increase anger. Ibotinic acid is neurotoxic. Ibotinic acid at extremely high doses will induce seizures.. So, if you feel you'll feel any strong bouts of any of the symptoms listed above, you have left too much ibotinic acid in the brew and should boil your batches longer. If your trips are too cold, devoid of energy, devoid of emotion and meaningness, then you might like to boil your batches less and leave some more ibotinic acid in your brew.

Combinations

Opiates like poppy seed tea are highly synergistic. Soaking poppy at the end of the brewing process can make the trip more hedonically uplifting and reduce the risk of a bad trip.

Marijuana can make the trip more uplifting too, but usually reduces lucidity and makes the trip harder to process and remember.

Acetylcholinesterase inhibitors like huperzine or galantamine will potentiate muscimol's lucidity effects, but this combination could be harmful.

Anti-muscarinics like belladona/datura can make the Muscaria experience incredibly intense, potentiating the clarity and the dissociation, reducing the lucidity. As with any anti-muscarinic administration if dosages are not correct this can lead to hospitalization. "Hot as a hare, blind as a bat, dry as a bone, red as a beet, and mad as a hatter".

Nootropics like memantine or piracetam may protect the brain by reducing the excitotoxic effects of ibotinic acid, but little data exists for such combinations.

Psilocybin and other psychedelics combine well with muscimol mulled wine, but it does change the quality of the trip. Adding mushrooms to the hot brew at the end is equivalent to making a muscimol infused lemon-tek mushroom tea. Serotonergics reduce sleepiness, so it might be harder to get to sleep and you may find yourself stuck in hyper-lucid half-wake/sleep states, or states that are both more realistically wake-like but also more trippy and confusing.

Sedatives like benzos, alcohol, will potentiate muscimol but also reduce the clarity and lucidity. Do not combine GHB with muscimol, as like GHB, muscimol already has a small theraputic range, and stacking them may lead to seizures, respiratory depression, or even coma. No data on combining with phenibut.

I've found little data on combining muscimol with stimulants. I would be very wary of adding amphetamines to the mix, as I predict high doses of both would lead to an energized, feverish delirium.

No reports were found for combining NMDA antagonists like Ketamine and Muscimol. I can't see how this combo would be dangerous, but I'm not sure if it would synergize or diminish the muscimol experience.

I've found little data on combining muscimol with MAOIs. I make no predictions about what might happen.

Pharmacology

Muscimol is a neuroprotective, orthosteric GABA-A agonist. Muscimol's direct stimulation of GABAergic interneurons in the striatum, visual cortex, and other brain regions, forces the release of acetylcholine which is the likely cause of it's hallucinogenic properties. This differs to alcohol, which is a neurotoxic allosteric GABA-A agonist, and differs to Phenibut and GHB, which are GABA-B agonists.

Ibotinic acid converts to muscimol in the body, and muscimol is then filtered by the kidneys into the urine. This is why there are tribal methods of consuming Muscaria that involve drinking a shaman's urine. We can replicate this process ex vivo by using acid to catalyse the reaction of the toxin into the entheogen, donating protons to the position of the toxin's carboxyl group. I find it hilarious that in this day and age people still consider drinking piss when, with a bit of chemistry, one can decarboxylate ibotinic acid to muscimol in a tasty beverage without a problem.

Foreword

Often we see people making a basic Amanita Tea, but as elucidated above, neutral pHs does not effectively decarboxylate ibotinic acid, which is completely stable in tap water at room temperature. To break down ibotinic acid, we want hot acidic solutions like grape juice.

NOTE: This guide works with measured averages, but at certain climates and seasons Amanitas can be much more and much less potent than the listed average.

THE RECIPE

0. Pick whole Amanita mushrooms.

1. Clean Amanitas with toothbrush and chop into small pieces.
Like when picking psilocybe, mix the pieces to average out the active content across fruits.

2. Set some cap aside for making mycelium, ambrosias and fly-traps, then
Dehydrate Amanita until cracker dry.

3. Add 60g dried Amanita into 1L grape juice and stir.
Get creative with fruit, herbs and spices, you're making mulled wine now!
If unsure, start with slices of orange, ginger, mint, a cinnamon stick, an anise star, a few cloves, and a dash of apple cider vinegar.
You may pasteurize, bottle and store it at this point, ibotenic acid will give this liquid a decent shelf-life, but to drink it you'll need to follow the steps below.

4. Bring to boil and simmer with the lid closed for 5-10 minutes, or up to 180 minutes depending on your preferred ibotinic acid content (longer = less ibotinic acid, I prefer shorter boils)
Note: active compounds might be lost in the steam. I like to use a pressured lid or slow cooker.

Alternatively, follow one of the steps below.

4B. (Alternative) Dilute 1:1 (total of 2L), add 1/3 cup raw sugar, 1/4 tsp baking powder, the lacto-probiotic, and ferment for 48h.
If unsure, use grape-adapted kefir. Find more information here: Grape Juice Kefir.

4C. (Alternative) Add 14mg GAD and 0.3mg P5P (B6) and stir. Wait 4 hours.

5. Add any combinatorial additions to the brew (poppy, huperzine, psilocybin, etc)
If liquid is lost you may like to top it back up.

6. Strain out all non-liquids and squeeze juices back into the brew.
You might like to use muslin and rubber gloves.
The end product is acidic, I recommend diluting 1:1 or 1:2 before drinking.
If it's not sweet enough you can add extra honey/sugar.
Serve and drink.

This recipe makes four 'serves', each serve has an estimated ~100mg actives.
Remember that potency varies across seasons and areas, so if you do not know the average strength of your dried mix, or are inexperienced, do not drink more than 2 serves in one sitting.

These estimates are for a 70kg male. If you are a 40kg woman, halve all these values, if you're 140kg you may be able to double all these value (but not without heavy precaution). If you have kidney damage then do not consume this at all. Depending on bodyweight (take mg/kg into account) and metabolism, for single doses:
Muscimol is anxiolytic at ~1-2mg
a relaxant at ~2-5mg
a sleep aid at ~5-50mg
lightly entheogenic at ~50-100mg (half to one serve of this recipe)
moderately entheogenic at ~100-150mg (one and a half serves)
heavily entheogenic above ~150-200mg (two serves)
A "Siberian Shamanic" dose is ~250mg (two and a half serves)
Muscimol is a general anaesthetic (temporarily coma-inducing) somewhere above this dosage
Muscimol is possibly lethal at ~500mg+???

If Pantherina is used instead of Muscaria, assume that all mg/g is at least 1.6x more potent.

Assumptions, Calculations and Other Details

These values are very different to what's found on Wikipedia and Erowid. When Cooper (1977) reports 8.5mg as an active dose, it is not taking into account that there was likely an accompanying 76.5mg ibotinic acid which was then metabolised to muscimol in his body. Erowid reports ibotenic acid is entheogenically active at 50-100 mg (Ott and Stafford) and muscimol displays activity at 10-15 mg, but again they are not taking into account metabolism.

The levels of muscimol detected in samples were of 0.19% d.w. (A. muscaria), and 0.3% d.w. (A. pantherina). Considering we currently have no measurements of ibotenic content, Pantheria tek might exceed the 1.6x potency.

Catalfomo & Eugster 1970a, Ott, Preston & Chilton 1975 report maximum ibotenic content in fresh fruit of up to 100mg per 100g. In contrast, another paper (Gennaro et al. 1997) reported average ibotenic content of 99mg/100g (caps) and 23mg/100g (stems), and muscimol content of 38mg/100g (caps) and 8mg/100g (stems). The patent claims 9:1 ibo to musc ratio, but according to this study, fresh mushrooms have a ~3:1 ibo to musc ratio. If one is to cut the stem at the bulb, it is reported that caps are on average ~66% and stems are ~33% of the total fruit weight. This means that at these proportions there's on average ~1mg of actives per 1g whole fresh fruit, or ~7mg of actives per 1g whole dried powder.

Assuming the patent's reports of ~9:1 ibotinic to muscimol ratio in fresh Amanita, we can calculate averages:
~90mg ibotinic and 10mg muscimol per 100g fruit.
~100g fresh fruit will dehydrate down to ~15g dry
The patent reports a change to ~3:2 in dried, which implies:
~60mg ibotinic and 40mg muscimol per 15g dry, which is:
~4mg ibotinic and 2.67mg muscimol per 1g dry.
The patent reports a change to 1:50 after ~3h acidic heat treatment.

From the spoilered information above, can infer that there is:
~0.13mg ibotenic and 6.54mg muscimol per 1g dried then acid-heat treated Amanita Muscaria

Grape juice has a pH between 3 and 4 via tartaric, malic, and citric acids. This is a big variance, and will effect the results. If your grape juice's pH is not low enough, this is why you add extra acid.

Kefir needs a certain sugar content and pH level to thrive. This is why we add bicarbonate, to make it more basic. Diluting it allows us to reduce acidity slightly more, and reduce sugar concentration (which is then topped up with kefir's preferred food cane sugar). If you dilute, then take note of this change in concentration for tracking the estimated g/100ml active compounds.

Both the ibotinic acid and the spices are anti-bacterial, and if too concentrated, the kefir may fail to thrive. You might like to try both steps 4 and 4B, slow cook, then ferment? If fermenting you probably don't want to too spicy.

Other Notes:

Muscimol increases the power of all brain wave frequency bands. It's effect on sleep depends on the dose taken, your level of sleep deprivation, the time of day and circadian rhythm. If tired, lower doses will deepen deep sleep. If taken around dawn, it makes dreams more vivid, if you are into lucid dreaming and do the WBTB method, you can drink muscimol during your wake and you'll dream very intensely when you go back to bed. If you're really high and need to come down, it will help bring you down. In comparison, benzos will get you to sleep but will reduce slow wave frequencies and not recover you very well, even impede memory consolidation. I personally think that, if you know your correct dosages, it is superior to a benzo. Muscimol can quieten the mind chatter, and as it increases theta brain waves, it lends itself nicely to meditation. Ibotinic acid will ruin your sleep quality, and possibly keep you awake.

Muscimol can lower blood pressure and heart rate. If you already have low blood pressure you might not be able to move around too much. If you or friend are afflicted with a bit of serotonin syndrome, muscimol can help mitigate some of the symptoms and increase survival like a benzo does. I mention this because I know how many people here might have had to deal with a bit of SS by pharmacological accident, though don't rely on it as a wonder cure for SS, it is no replacement for serotonin-production blocking agents.

Don't take muscimol too often if you've got a typical immune system. A bit like alcohol, muscimol is anti-inflammatory, but also immuno-suppressive, so would be bad if you're fighting off a cold or infection.

At low doses ibotinic acid may be an acute memory enhancer and treatment for Seasonal Affective Disorder. Ibotenic Acid is dosed at 3-8mg for these purposes, which is usually 4-5g of fresh cap or ~1 gram of dry. However long term use of Ibotenic is has not been studied and chronic use may age the brain faster via NMDA receptor excitotoxicity. Things to help prevent excitotoxicity are nicotine, melatonin and funnily enough... muscimol!

Amanita Muscaria toxicity case reports describe repeated cycles of periods of seizure and periods of unconsciousness. One explanation for these symptoms are that the ibotinic acid induces seizures then the body converts enough to muscimol to make the body unconscious for a while, then the kidneys filter the muscimol out and the seizures start again. Another explanation for these symptoms could be cholinergic toxicity due to muscimol's direct action on acetylcholine release. It could be a combination of the two.

Do be careful about the potency of your Amanita wine. Due to seasonal fluctuations, you could have much more or much less than the average calculated muscimol. If concerned about safety, start by drinking only a small amount of liquid, and work your way up until you have established your personal threshold dose in mls of liquid for that particular amount of g/100ml.

If you try this tek, you can help compile data by reporting the potency of your formula, and what ingredients you used:
Grams of Amanita per 100ml of liquid.
Mls of tekked liquid required for various effects and hallucinogenic threshold dose.
Grams of tekked amanita required for various effects and hallucinogenic threshold dose.
And as always, post any reports of toxic effects or recipe troubles.

I hope some shroomers will help me compile some reports for this tek before sharing with noobies, I'd hate for a noobie to accidentally poison themselves or put themselves in a coma. Having said that:
1. Properly treated Amanita is an unappreciated shroom
2. Ibotenic acid is neurotoxic and in high doses induces seizures, we need to agree upon a safe ibotenic conversion tek
3. Amanita is unappreciated becausethere have been no good teks and so people revert to unsafe practices leading to bad trips.

Good luck!

--------------------
:sporedrop:

Guide for consuming Amanita Muscaria, click here. :sporedrop:

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Edited by Jiemba (06/18/18 12:27 AM)

Extras:

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