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What the professor is saying is that there should be a benefit in the genetic diversity of spores from two different prints sort of like breading outside of your own family (word of warning do not be your own grandpa). That is an interesting postulate there. I understand the problem with senescence from using tissue culture for cloning. Cells only reproduce so many times before they first decline in vigor, and then the DNA breaks down at which point you have serious problems. Each spore is geneticaly similar though different from every other spore in that cap, sort of like brothers sisters and cousins. I am a firm believer in getting some diversity in a collection once in a while, to keep the mix healthier. Narrow bloodlines in humans show problems after a few generations. while some of the children would have the strongest atributes of the parents some would also get the the worst. hemophelia was one problem expressed in narrow bloodlines in European royalty. The same can be said for pure bread dogs showing hip displasia and other problems. I would suspect the same in mushrooms after a while. I would assume that specimens from different vendor would have the greatest biodiversity, as mushrooms from the same patch would have the same parentage.
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