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Hurdy Gurdy Man
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LSD + Marijuana + Wellbutrin
#22536745 - 11/17/15 10:11 AM (8 years, 4 months ago) |
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Hi guys, I'm planning on dropping some acid this weekend but I have also started on 100 mg of Wellbutrin at the beginning of this week. I know Wellbutrin is an NDRI and not an SSRI but will it affect my trip in any way (dimininishing it or any weird reactions)? I read on here that LSD has an affect on the D2 dopamine receptor, I don't know if this is true but would it cause a weaker trip? I also plan to be smoking some marijuana during the trip, so is Wellbutrin known to interact in any way with LSD and weed?
I know some people don't think it's a good idea to be tripping while depressed but in my experience it helps me substantially. It would be great to know if anyone has any experience with these combinations.
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morrowasted
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Ugh I haaaate WellButrin.
The psychedelic aspect of the trip will almost certainly not be affected by the Wellbutrin, no. But you might want to consider not taking that shitty ass drug anymore, dude.
I'm not against antidepressants, but NDRIs are the dumbest way to address "depression" imaginable.
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Hurdy Gurdy Man
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Re: LSD + Marijuana + Wellbutrin [Re: morrowasted]
#22537396 - 11/17/15 12:38 PM (8 years, 4 months ago) |
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I know, it sucks cause none of the antidepressants have done anything for me except one giving me a seizure. I agreed to at least try it, but from what I've read there's not many positives that can come from taking it.
You're sure the Wellbutrin won't affect the euphoria that I get while tripping?
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morrowasted
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No, I can't say that I am sure.
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Hurdy Gurdy Man
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Anyone have any experience with this combination?
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Beanhead
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Re: LSD + Marijuana + Wellbutrin [Re: morrowasted]
#22537971 - 11/17/15 02:50 PM (8 years, 4 months ago) |
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Quote:
morrowasted said: Ugh I haaaate WellButrin.
The psychedelic aspect of the trip will almost certainly not be affected by the Wellbutrin, no. But you might want to consider not taking that shitty ass drug anymore, dude.
I'm not against antidepressants, but NDRIs are the dumbest way to address "depression" imaginable.
Ru kidding me SSRI's are dumb this shit gets me pumped also harder orgasms
Enlighten me how a catecholamine won't help against "depression"
@OP yeah don't worry.
Edited by Beanhead (11/17/15 02:51 PM)
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Hurdy Gurdy Man
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Re: LSD + Marijuana + Wellbutrin [Re: Beanhead]
#22538324 - 11/17/15 04:46 PM (8 years, 4 months ago) |
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Doesn't LSD have some impact on the dopamine receptors? Wouldn't the NDRI have some impact on the trip?
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circastes
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Careful with this I mixed a massive dose of mushrooms with Abilify and got this completely strange, long, numb trip and then I was depressed for about 6 months, I'm guessing from some kind of cell loss, from some nasty interaction or competition for receptors or idk I'm not a neuroscientist, but mixing pharma and psyches is not something I'm doing again.
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Apostle
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Isnt welbutrine related to cathinones?
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Hurdy Gurdy Man
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Re: LSD + Marijuana + Wellbutrin [Re: Apostle]
#22538407 - 11/17/15 05:07 PM (8 years, 4 months ago) |
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I read that it's a substituted cathinone and substituted amphetamine. I'm not really sure what that means compared to something like adderall though...
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luvdemboomers
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Re: LSD + Marijuana + Wellbutrin [Re: Apostle]
#22538425 - 11/17/15 05:13 PM (8 years, 4 months ago) |
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not sure about lsd but I took a lot of 2c's when I was on wellbutrin
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Shroomism
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There shouldn't be much of any reaction, or if anything it may be diminished slightly. Wellbutrin doesn't work on serotonin, which is the reason why SSRIs/stimulants + psychedelics = bad, because they both interact on serotonin in different ways.
Wellbutrin sucks tho. Definitely don't do LSD with SSRIs
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Hurdy Gurdy Man
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Re: LSD + Marijuana + Wellbutrin [Re: Shroomism]
#22538533 - 11/17/15 05:42 PM (8 years, 4 months ago) |
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Do you have any reason for why the effects could be diminished slightly?
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olson
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Not sure why people are bashing wellbutrin. It works for depression just as well as any SSRI with less side effects and like the SSRIs, it doesn't work for everyone of course.
To answer the OP, no it shouldn't affect the intensity of the trip but since you recently started on it, if you have any side effects they might become a lot more noticeable during the trip eg. insomnia or stimulation.
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pirate-blues
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Re: LSD + Marijuana + Wellbutrin [Re: Shroomism]
#22538750 - 11/17/15 06:47 PM (8 years, 4 months ago) |
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Quote:
Shroomism said: There shouldn't be much of any reaction, or if anything it may be diminished slightly. Wellbutrin doesn't work on serotonin, which is the reason why SSRIs/stimulants + psychedelics = bad, because they both interact on serotonin in different ways.
Wellbutrin sucks tho. Definitely don't do LSD with SSRIs
this.
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Hurdy Gurdy Man
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Re: LSD + Marijuana + Wellbutrin [Re: olson]
#22538798 - 11/17/15 06:59 PM (8 years, 4 months ago) |
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I'm going to keep an eye on any side effects cause they might not be pleasant during a trip (I'll be doing 200 mics so it should be pretty strong). I'm giving Wellbutrin a shot cause all the seratonergic antidepressants I've been prescribed have had pretty bad side effects like cymbalta which gave me a seizure by itself.
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morrowasted
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Re: LSD + Marijuana + Wellbutrin [Re: olson]
#22539071 - 11/17/15 07:52 PM (8 years, 4 months ago) |
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Quote:
olson said: Not sure why people are bashing wellbutrin. It works for depression just as well as any SSRI with less side effects and like the SSRIs, it doesn't work for everyone of course.
To answer the OP, no it shouldn't affect the intensity of the trip but since you recently started on it, if you have any side effects they might become a lot more noticeable during the trip eg. insomnia or stimulation.
Less side effects my ass.
Wellbutrin makes me feel like I am coming down from cocaine or stimulants.
Releasing dopamine is a stupid way to treat ANY "disorder" in my opinion, be it ADHD or depression.
Even though I don't buy the monoamine deficiency model of depression, I think the newest generation of SNRI antidepressants (coupled with Turmeric, which replenishes neural stem tissue) is an excellent regimen for just about anyone who doesn't do A LOT of physical activity. They absolutely cause physical dependence, but they also accelerates learning and attention. Not only does serotonin agonism result in accelerated neurogenesis throughout the hippocampus/parahippocampus, but norepinephrine agonism results in a secondary increase in brain-derived neurotropic factor (BDNF) release, a molecule crucially involved in establishing long-term potentiation of synapses. The side-effect profile of the newest generation of SNRI drugs is low and not even comparable to the side effect profiles of older generation SSRI-type drugs, which caused all sorts of problems like sexual dysfunction, anxiety and irritability, night sweats, etc. Taking SNRIs has improved my retention and attention and overall mental performance dramatically, and I never feel a "come up" or "come down" or any kind of strange strung-out feelings like I did with Wellbutrin
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Beanhead
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Re: LSD + Marijuana + Wellbutrin [Re: morrowasted] 1
#22540098 - 11/18/15 01:05 AM (8 years, 4 months ago) |
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They absolutely cause dependence uh no thanks but nice info tho
I guess I was born to live hard & Bupropion doesn't release dopamine, I WISH, then it'd really be purrrrrfect
All i'm reading is "yo this medication didn't work for me, lolz you all suck why do you even take it" "hi, i'm using this obscure medication after trying so many and it works for me, this is the holy grail!"
ahahahah cracks me up
Edited by Beanhead (11/18/15 01:11 AM)
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olson
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Re: LSD + Marijuana + Wellbutrin [Re: morrowasted]
#22540182 - 11/18/15 01:56 AM (8 years, 4 months ago) |
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Quote:
morrowasted said:
Quote:
olson said: Not sure why people are bashing wellbutrin. It works for depression just as well as any SSRI with less side effects and like the SSRIs, it doesn't work for everyone of course.
To answer the OP, no it shouldn't affect the intensity of the trip but since you recently started on it, if you have any side effects they might become a lot more noticeable during the trip eg. insomnia or stimulation.
Less side effects my ass.
Wellbutrin makes me feel like I am coming down from cocaine or stimulants.
Releasing dopamine is a stupid way to treat ANY "disorder" in my opinion, be it ADHD or depression.
Even though I don't buy the monoamine deficiency model of depression, I think the newest generation of SNRI antidepressants (coupled with Turmeric, which replenishes neural stem tissue) is an excellent regimen for just about anyone who doesn't do A LOT of physical activity. They absolutely cause physical dependence, but they also accelerates learning and attention. Not only does serotonin agonism result in accelerated neurogenesis throughout the hippocampus/parahippocampus, but norepinephrine agonism results in a secondary increase in brain-derived neurotropic factor (BDNF) release, a molecule crucially involved in establishing long-term potentiation of synapses. The side-effect profile of the newest generation of SNRI drugs is low and not even comparable to the side effect profiles of older generation SSRI-type drugs, which caused all sorts of problems like sexual dysfunction, anxiety and irritability, night sweats, etc. Taking SNRIs has improved my retention and attention and overall mental performance dramatically, and I never feel a "come up" or "come down" or any kind of strange strung-out feelings like I did with Wellbutrin
Well it seems like you're speaking from your own experience. IT's been shown that the dopaminergic side of wellbutrin is far weaker than previously thought so it's effectively an NRI/ releasing agent.
As for the side effect profile, it lacks weight gain, somnolence, sexual dysfunction and its actually used to reverse these side effects in people taking SSRIs.
It's not for everyone but there are advantages of wellbutrin vs taking SSRIs depending on your depressive symptoms if fatigue and anhedionia are your main concerns.
-------------------- Kinesin, a motor protein, shuttling a vesicle full of cargo such as glucose or even neurotransmitters across a cell. This little guy struts along the microtubule using ATP as fuel.
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Hurdy Gurdy Man
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Re: LSD + Marijuana + Wellbutrin [Re: olson]
#22540980 - 11/18/15 09:11 AM (8 years, 4 months ago) |
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Like any drug, I think people react to antidepressants in different ways. The seratonergic ones seemed to give me more side effects. Effexor somewhat helped me be happier but still had side effects.
The main thing I'm concerned with is that Wellbutrin would weaken the trip and possibly cause agitation and uncomfortable stimulation. The LSD should either remain the same, be weakened, or potentiated. So which one of these is most likely to occur? Sorry I just don't want my trip to be impacted negatively.
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