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OfflineAwesomeUsername
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Registered: 08/07/15
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Last seen: 6 years, 2 months
Drugs that stimulate neurogenesis?
    #22507961 - 11/11/15 04:11 AM (8 years, 2 months ago)

After my last acid and shroom trip it gave me some insight that I should take good care of my brain and it will take good care of me therefor I should also use drugs that are good for my brain.

Like most of people on this site, I genuinely enjoy altered states of mind, and I was wondering if all psychedelics actually stimulate neurogenesis?

There is some research that indicates that cannabis and magic mushrooms do that for sure, but what about LSD, mescaline/peyote, DMT/ayahuasca?

As far as personal experiences go, LSD made major improvements in the way I perceive life but did it grow new brain cells? I'm not really sure, it's hard to tell. With shrooms I could actually feel it making better connections, and I no longer felt brain damaged from bad weed, and cut ecstasy the day after. 

Now I have the opportunity to do heroic dosses of peyote and ayahuasca multiple times. I know it will change my life for better once again, but will it actually make my brain work better like shrooms and supposedly cannabis did?

Worth to note, I also feel in love with meditation, yoga, and natural sciences way to late and they do require quite a bit of concentration. My mind means everything to me, so anything that could repair the foolish choices I made when I was younger is advisable.


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Invisiblepablokabute
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Registered: 11/22/11
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Re: Drugs that stimulate neurogenesis? [Re: AwesomeUsername]
    #22508014 - 11/11/15 05:10 AM (8 years, 2 months ago)

LOok into Lions mane mushrooms If ya haven't yet. You might like it.


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Fermented Mushrooms!!
--- https://www.shroomery.org/forums/showflat.php/Number/23378638/fpart/1/vc/1

'The second seal: “All CONTAMINATED things and events are unsatisfactory.”'



"I envy you. You North Americans are very lucky. You are fighting the most important fight of all - you live in THE HEART OF THE BEAST."

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Offlineergoticmandala
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Re: Drugs that stimulate neurogenesis? [Re: pablokabute]
    #22508066 - 11/11/15 06:14 AM (8 years, 2 months ago)

The thing is that there has not been enough research to prove if other psychedelics do this but chances are that dmt does, it is shown that people in peru or the amazon who took it often had higher levels of happy chemicals and were just happier on a general note. So for dmt i can pretty much say yea it will leave your brain just as well as it was before if not better kind of lile mushrooms.

Peyote however is a phenylethlamine which is a stimulant/psychedelics and is different than acid, shrooms and dmt in that way. But its still very safe for you brain.

I would put dmt and psilocybin as being the most benign, possibly even leading to neurogenesis, but wasn't that just preliminary research which suggested that? I mean either way you can feel how they seem positive while and after tripping.

Either way these 4 psychedelics are probably the safest drugs with the most possible benefits.Safer than processed sugar and caffeine for sure


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OfflineJacksonMetaller
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Registered: 03/13/11
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Re: Drugs that stimulate neurogenesis? [Re: ergoticmandala]
    #22510396 - 11/11/15 05:22 PM (8 years, 2 months ago)

Don't focus too much on neurogenesis. 5-ht receptor agonism stimulates cell division in several tissues including the cardiac valves which can become problematic. Further more the effect is likely different for various receptor subtypes and the psychedelics which stimulate them differently. While there may be some beneficial effects described from psychedelic induced neurogenesis, my point here is that these things are poorly understood and it's not always necessarily a good thing. These receptors are part of tightly regulated processes which are supposed to respond to the natural ebb and flow of signals in the microenvironment. Introducing potent drugs is by definition disturbing that process and while some positive effects might be noted this is often the result of short-sighted research.

That said I'm not discouraging drug use. I think psychedelics are very therapeutic and thought stimulating and certainly have some wonderful long term benefits. Just don't go chasing "neurogenesis" because we really don't know what it means in this context yet or how the secondary effects of the experiential aspect will shape brain chemistry.

That said, from personal experience ayahuasca certainly left a long lasting positive impact on my mind. But it was also the strongest and most unpleasant psychedelic experience I've had :lol: It's been a couple years now and those experiences are still present in my every day life mainly through the songs from the ceremony. Occasionally they still give me intense emotional flashbacks enough to draw a couple tears out.


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Invisiblemicro
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Re: Drugs that stimulate neurogenesis? [Re: JacksonMetaller]
    #22512304 - 11/12/15 01:05 AM (8 years, 2 months ago)

Apparently, SSRI's do.

Also, NAMPT activators

A pathway involving Sonic The Hedgehog proteins (god, I love saying that)

NMDA agonists, in the event that you aren't born yet and suffer a hypoxic‑ischemic brain injury.

Adiponectin, a hormone secreted from your fat cells apparently but I'm sure you could inject it.



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Edited by micro (11/12/15 01:33 AM)


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Invisiblepassifloracaerulea
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Re: Drugs that stimulate neurogenesis? [Re: micro]
    #22516974 - 11/13/15 07:13 AM (8 years, 2 months ago)

Books stimulate neurogenesis better than any drug. Having said that, herb and phenibut have worked wonders for me.


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Invisiblemicro
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Re: Drugs that stimulate neurogenesis? [Re: passifloracaerulea]
    #22517211 - 11/13/15 08:54 AM (8 years, 2 months ago)

Quote:

passifloracaerulea said:
Books stimulate neurogenesis better than any drug.




[citation needed]

Quote:

passifloracaerulea said:
Having said that, herb and phenibut have worked wonders for me.




How did you verify nerogenesis o.O?


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Any research paper or book for free
(Avatar is Maxxy, a character by Mizzyam, RIP)


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Offlineolson
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Registered: 11/03/12
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Re: Drugs that stimulate neurogenesis? [Re: micro]
    #22517246 - 11/13/15 09:08 AM (8 years, 2 months ago)

-vigorous exercise
-diet low in saturated fat and sugar
-omega 3
-curcumin
-folic acid
-intermittent fasting
-prozac
-NSI 189 (probably the most potent)
-resveratrol
-low dose, but not high dose shrooms


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Kinesin, a motor protein, shuttling a vesicle full of cargo
such as glucose or even neurotransmitters across a cell.
This little guy struts along the microtubule using ATP as fuel.


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Invisiblepassifloracaerulea
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Re: Drugs that stimulate neurogenesis? [Re: micro]
    #22517380 - 11/13/15 09:46 AM (8 years, 2 months ago)

Quote:

micro said:
Quote:

passifloracaerulea said:
Books stimulate neurogenesis better than any drug.




[citation needed]

Quote:

passifloracaerulea said:
Having said that, herb and phenibut have worked wonders for me.




How did you verify nerogenesis o.O?



I had seizures from massive etizolam and alcohol addiction. The attending neurologist in the hospital said the marijuana likely kept my brain from serious damage through anti inflammatory action. The alcohol and etizolam decimated my memory and sociability long term. The marijuana keeps seizure pathways blocked which in turn causes the brain to make new pathways. I read that phenibut up regulates gaba, which was badly damaged after my abuse. I noticed immediately after starting phenibut that my memory was coming back to me, I've regained my witty and sarcastic personality, and the dosage I take now is the same as when I started, but I get so much higher now from it that I'm considering backing down to a lower dosage. The same dosage barely got me high the first month or two. I know these cases don't prove anything but the effects are plain as day to me.


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Offlineolson
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Re: Drugs that stimulate neurogenesis? [Re: passifloracaerulea] * 1
    #22517409 - 11/13/15 09:55 AM (8 years, 2 months ago)

Neurogenesis isn't really something you feel though. You can form new pathways in the brain without growing a single brain cell, its just a change in how the cells are wired up.


--------------------

Kinesin, a motor protein, shuttling a vesicle full of cargo
such as glucose or even neurotransmitters across a cell.
This little guy struts along the microtubule using ATP as fuel.


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Invisiblepassifloracaerulea
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Posts: 10,485
Re: Drugs that stimulate neurogenesis? [Re: olson]
    #22517523 - 11/13/15 10:34 AM (8 years, 2 months ago)

Ok well I assumed what neurogenesis was and it sounds like new pathways, but I'm just a miner with an interest in all things pharmacopeia, so what do I know haha!


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OfflineBoomertown
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Registered: 06/21/15
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Last seen: 5 years, 4 months
Re: Drugs that stimulate neurogenesis? [Re: passifloracaerulea]
    #22517565 - 11/13/15 10:50 AM (8 years, 2 months ago)

:threadmonitor:


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Invisiblemicro
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Registered: 05/09/03
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Re: Drugs that stimulate neurogenesis? [Re: passifloracaerulea]
    #22517657 - 11/13/15 11:18 AM (8 years, 2 months ago)

Exactly, neurogenesis refers to actually forming new brain cells. This is a lot more common at an early age but can occur in adults, as well. There is no such thing as "seizure pathways" but marijuauna (specifically CBD) can help mitigate inflammation that happens during and after seizures. This inflammation can lead to neurodegredation when it is frequent. While the CBD itself (or THC for that matter) probably doesn't have to do with forming new neural pathways it can prevent permanent damage in this respect that would lead to an inability to form new pathways.

Phenibut is a lot like gabapentin in its pharmacodynamics and is a GABAb agonist, and to a much lesser extent GABAa so it can probably help with seizures from alcohol withdrawal and possibly even benzodiazepine withdrawal as well. As for anything else, who cares? If it works for you it is working.


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(Avatar is Maxxy, a character by Mizzyam, RIP)


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Invisiblepablokabute
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Registered: 11/22/11
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Re: Drugs that stimulate neurogenesis? [Re: micro]
    #22519442 - 11/13/15 06:43 PM (8 years, 2 months ago)

Spirulina generates neurogenesis due to its high GLA, omega oils, pigments and whatnot.


--------------------

Fermented Mushrooms!!
--- https://www.shroomery.org/forums/showflat.php/Number/23378638/fpart/1/vc/1

'The second seal: “All CONTAMINATED things and events are unsatisfactory.”'



"I envy you. You North Americans are very lucky. You are fighting the most important fight of all - you live in THE HEART OF THE BEAST."

--Anonymous Guerilla, or is he..


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InvisibleJohn NadaDiscord
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Re: Drugs that stimulate neurogenesis? [Re: AwesomeUsername]
    #22528380 - 11/15/15 05:21 PM (8 years, 2 months ago)

Look into racetams. Aniracetam is one I remember that is said to stimulate neurogenesis. I take oxiracetam and like it's perceivable effects better (and it's way easier to take), but I couldn't find nearly as much info regarding it and specifically neurogenesis.


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Offlinecircastes
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Re: Drugs that stimulate neurogenesis? [Re: John Nada]
    #22529576 - 11/15/15 09:13 PM (8 years, 2 months ago)

If you are struggling with mental illness of some kind, encouraging regrowth of the brain is the way to go, rather than pharma or psychotherapy.


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