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OfflineJacksonMetaller
Stranger

Registered: 03/13/11
Posts: 13,361
Last seen: 1 year, 1 month
Re: MDMA neurotoxicity/brain damage [questions] [Re: micro]
    #22536055 - 11/17/15 05:24 AM (8 years, 2 months ago)

Quote:

micro said:
Quote:

halo said:
Here are some studies I found just today which are recent and examine Serotonin damage from MDMA:

http://www.nature.com/npp/journal/v38/n1/full/npp2012178a.html

http://www.ncbi.nlm.nih.gov/pubmed/22147810




I'm not a huge fan of those studies and I'll explain why.

They both seem to say the same thing but the first article is talking about actual neuronal pathology in the beginning, they cite two very general articles about serotonin signaling which is no surprise and the only findings are the brain doing what it is supposed to do. Same with the second one. They mention loss of axons and I was like "wtf?" and kept reading and the only thing they studied was the prevalence of receptors. Lack of receptors does not signify axon loss. If anything it signifies neuroreceptor downregulation which *is expected* in anyone taking a drug frequently that stimulates those receptors.

I'm honestly not sure what to make out of that :\

Quote:

halo said:
There's not a lot of studies out there and in many of the older studies the methodology is flawed (such as the primate study which used meth instead of mdma).




Haha, yeah I still don't understand how that could realistically occur >.<

I doubt too many researchers are very interested in this anymore and I doubt anyone wants to throw grant money at it when they can't reasonably expect to find something new. Like you said later on -- it's most likely safe albeit in proper amounts and in the right set and setting. Again, people *can* get overheated and stuff which really *can* cause brain damage.

If you look at this realistically though, it is a drug that is similar to other drugs in structure that activates receptors like many drugs do. Yes, this will cause changes in the amount of serotonin and when stopped this will eventually reverse itself. It is a pretty big leap of logic though to assume it has pathological effects on brain tissue, especially when nobody even has a reason why that would be the case other than "it's an illegal drug."




The last study halo posted actually discussed the confusion of "lost axons" vs "downregulation". Apparently there are two hypotheses going around due to the facts that the staining methods used can be interpreted both ways. Ie no staining from lost axon or no staining from no 5-ht. in both cases however, the loss of function is significant enough to classify it as neurotoxicity. Or so says the author.

The thing I hate about these studies is the the liberal use of words like "low dose" to describe a dose of 5.7mg/kg :rolleyes: Makes it really hard to interpret the clinical significance


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OfflineGreenBean
Stranger

Registered: 10/29/15
Posts: 489
Last seen: 8 years, 2 months
Re: MDMA neurotoxicity/brain damage [questions] [Re: JacksonMetaller]
    #22536122 - 11/17/15 06:05 AM (8 years, 2 months ago)

There's been studies that say smoking weed on the comedown actually makes mdma less neurotoxic

And plus, smoking weed is fun and it'll bring your roll back a bit too

So smoke weed!


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Offlinecircastes
Big Questions Small Head
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Registered: 01/14/10
Posts: 8,781
Loc: straya Flag
Last seen: 7 years, 8 months
Re: MDMA neurotoxicity/brain damage [questions] [Re: GreenBean]
    #22552852 - 11/20/15 07:13 PM (8 years, 2 months ago)

Such fun times, but this drug definitely destroys da brain if you're abusive. We would do like 5+ of these strong, strong pills back in the day, then we'd wait until the next night and do it all over again. Then maybe take two days off and hit it again.

Needless to say I got severe depression, panic disorder and it must have contributed to the already (but unknowingly) active schizophrenia. In the comedown it would feel like my brain was melting.

Lately I feel great and am very functional and getting into all sorts of things, my humor is back and I feel confident. It's all because my brain started randomly regenerating after some mushroom use. No kidding. I can occasionally feel it turn some whole morbid area of the brain into living cells again. Sounds insane but I'm used to that.

If you're thinking you've damaged the brain do mushrooms and try to "ask" the "experience" to target your brain, or focus on your brain the whole time and how you want it to regenerate. idk, it's happening for me, so it's worth a shot. It has something to do with the fact that this is all a mental, subjective thing, similar to a dream, if it's not literally a dream. So keep your mind open.

You'd think I'd be running down the street naked yelling "Eureka" but I know this is all going to work out for all of us, so fuck you govt., it's my little secret. :lolsy:


--------------------
My solitude...
My shield...
My armour...

TESTED
WITH
FULL
FORCE


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InvisibleyogabunnyM
fancy cat
Female User Gallery


Registered: 11/01/09
Posts: 11,281
Loc: Nasty Women Get Shit Done
Re: MDMA neurotoxicity/brain damage [questions] [Re: PsychedelicSwede]
    #22556048 - 11/21/15 03:32 PM (8 years, 2 months ago)

Quote:

PsychedelicSwede said:
Hi! I have a few questions regarding MDMA. I´ve rolled three times and I really enjoy this drug :smile: however I´m aware of the risks and try to space out my rolls with at least 2-3 months in between just to get my serotonin levels back to normal. I always take vitamin c, magnesium and fish oil before and after my rolls. So far I´ve never had a come down from MDMA.

1. How neurotoxic is MDMA? Is there any evidence regarding irreversible brain damage in humans? Do axons regrow?

2. Has anyone here got any permanent damage from their mdma-use? I read online some abusers of mdma never come back to normal, however I´ve met a guy who ate this stuff like candy and he seemed pretty normal to me. According to himself he´s doing fine now. I understand this drug should be used with respect like any other drug. Especially since serotonin is a such important chemical in our body! :tongue2:





Moderation is key!

Having said that I definitely abused the stuff pretty heavily during a couple periods of my life and I feel like I came out fine. I wouldn't recommend this though because everyone is different. I find now that a couple or a few times a year is good.

:bunnypeace:


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