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InvisibleOgla
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Registered: 02/16/04
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why did Albert Hoffman choose diethylamide to make LSD?
    #22445826 - 10/28/15 05:17 PM (8 years, 3 months ago)

Its said Albert Hoffman decided to take LSA and wash off the amide and replace it with something more psychedelic? Why did he choose diethylamide? What influenced him to choose that on top of whatever else he could've chose?


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OfflineMental Taco
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Registered: 07/02/14
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Re: why did Albert Hoffman choose diethylamide to make LSD? [Re: Ogla]
    #22445874 - 10/28/15 05:29 PM (8 years, 3 months ago)

What says this?
I dont think he was knowingly trying for anything psychedelic at all.


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InvisibleOgla
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Re: why did Albert Hoffman choose diethylamide to make LSD? [Re: Mental Taco]
    #22445901 - 10/28/15 05:36 PM (8 years, 3 months ago)

Well,  I know he wasn't. He was aiming for a respiratory aid or something. It did happen to make it more psychedelic. I'm just wondering what made him choose that. Kinda curious about his reasoning


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OfflineStarless
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Re: why did Albert Hoffman choose diethylamide to make LSD? [Re: Ogla]
    #22445915 - 10/28/15 05:39 PM (8 years, 3 months ago)

Albert Hofmann was developing a new migraine medication for Sandoz Pharmaceuticals in Switzerland when he inadvertently invented LSD. He wasn't trying to make anything psychedelic, in fact quite little was known about psychedelics at the time. Turns out LSD was a very effective migraine medication, among other things.

IIRC, he was experimenting with various substances and substitutions at the time. It's not like he instantly knew to throw lysergic acid monohydrate and diethylamide together, perseverance, creativity and no small amount of luck went into it.


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Think, it ain't illegal yet. - George Clinton

Substances I have allegedly taken: Cannabis (bud, edibles, and concentrates), Mushrooms (P. Cubensis), LSD, ETH-LAD, ALD-52, DMT, MDMA, Mescaline (Peruvian Torch), 25I-NBOMe, Salvia Divinorum (10x), Syrian Rue, Amanita Muscaria (10x), Cocaine, Nightshade (Henbane).

All posts are hypothetical or entirely fictional.


Edited by Starless (10/28/15 05:44 PM)


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Offlinesatch1234
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Registered: 08/12/11
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Re: why did Albert Hoffman choose diethylamide to make LSD? [Re: Starless]
    #22445959 - 10/28/15 05:57 PM (8 years, 3 months ago)

Diethylamine was actually the 25th derivative he tried, hence the name lsd-25. This is not unusual to try a huge range of substituted molecules when looking for the desired activity.

I do think its interesting how an extra NH2 group can make something so much more active. Amphetamine to Methamphetamine is another one.. Complex biological mechanisms.


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