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OfflineSabnock
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LSD and MAO-A inhibition?
    #22441530 - 10/27/15 06:50 PM (8 years, 3 months ago)

I took 2 hits (approx 200 micrograms) yesterday with 300mgs of Moclobemide and had a very awesome time. Definitely increased visual activity for me and changed the feel of experience around a bit. In a week i'll try out 3 or 4 hits with a dose of Rue and see how that goes :smile:

Anyone else combine an MAO-A inhibitor with LSD?


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OfflineStarless
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Re: LSD and MAO-A inhibition? [Re: Sabnock]
    #22442218 - 10/27/15 09:10 PM (8 years, 3 months ago)

I've been quite interested in this too, but I haven't tried it yet. Apparently people have gotten the best results using banisteriopsis caapi. What needs to be determined is whether the resulting experience is simply the combined effects of the two substances or if there is actually some potentiation.

The molecular structure of lysergimides share characteristics of both tryptamine and phenethylamine. Since tryptamines are metabolized by MAO-A, but phenethylamines are metabolized by MAO-B, a wider range inhibitor may be more effective. A reversible inhibitor of both MAO-A and MAO-B would be ideal. On the other hand, I have heard from some sources that LSD isn't metabolized by monoamine oxidase at all.

If anyone tries this, make sure that what you're taking is really LSD. A DOX or 25X-NBOMe compound combined with an MAO inhibitor could easily be deadly.


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Think, it ain't illegal yet. - George Clinton

Substances I have allegedly taken: Cannabis (bud, edibles, and concentrates), Mushrooms (P. Cubensis), LSD, ETH-LAD, ALD-52, DMT, MDMA, Mescaline (Peruvian Torch), 25I-NBOMe, Salvia Divinorum (10x), Syrian Rue, Amanita Muscaria (10x), Cocaine, Nightshade (Henbane).

All posts are hypothetical or entirely fictional.


Edited by Starless (10/27/15 09:27 PM)


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OfflineSabnock
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Re: LSD and MAO-A inhibition? [Re: Starless]
    #22442828 - 10/28/15 12:04 AM (8 years, 3 months ago)

Quote:

Starless said:
If anyone tries this, make sure that what you're taking is really LSD. A DOX or 25X-NBOMe compound combined with an MAO inhibitor could easily be deadly.




I agree, do make sure you have legit LSD, we don't need people taking Nbome with MAO-A inhibition, even if there's a chance it'd be safe, because afaik Nbomes are not very safe and should only be used with extreme caution (and not in combination with MAO-A inhibition). Though i will admit i did smoke some Rue extract during my last 25-D Nbome experience to counteract some of that hardcore vasoconstriction (which worked well btw and i didn't notice any negative interactions, but that's from smoked extract), and the Nbome vasoconstriction, to me, is scary stuff, i do not like the feel of it at all, it does NOT feel the least bit healthy to me personally.

As for the Caapi, i haven't been able to work with the Caapi yet, though i hope to one day. For me, Rue is wonderful, has multiple uses/benefits, and get's the job done well. To me, it's equally as powerful as Caapi, and they both deserve to share first place, imo.

And judging by what i had experienced with the LSD and Moclobemide, the MAO-A inhibition itself is what caused the LSD experience to change a bit. Moclobemide, unlike Rue and Caapi, is transparent in it's effects, it causes no effects other than it's MAO-A inhibition, so you'll feel a rise in the levels of Serotonin, Dopamine, Adrenaline/Noradrenaline, from the MAO-A inhibition, but that's it, anything else comes merely from the Psychedelic combined with it, or from the synergy of the combination. So it offers you a clear view at a Psychedelic without altering it with other effects aside from MAO-A inhibition, like Rue and Caapi (Harmalas in general) would, since they have other effects than just MAO-A inhibition, unlike Moclobemide.

I got the sense during the experience, that perhaps LSD and other Psychedelics, cause a direct or indirect release of certain neurotransmitters in certain parts of the brain, which with MAO-A inhibition, potentiates the effects of the neurotransmitters at those parts of the brain, so things have a more pronounced effect, it seems. I could be wrong on that, and perhaps i could've worded it a bit better, but i hope you get what i mean, it seemed to make sense to me at the time, and still does tbh.

And as for using an MAO-B inhibitor, one could try that, but they'd have to follow the MAOI diet because both enzymes would be inhibited and Tyramine wouldn't be able to be broken down. Though since LSD is Dopaminergic as well, and MAO-A inhibition also raises Dopamine levels, then LSD's Dopaminergic effects would also be potentiated.

I myself have noticed increased Dopamine while smoking Cannabis on both Rue and Moclobemide, and the MAO-A inhibition potentiates Cannabis, especially with the Rue. I also tried out Ritalin sometime last year for a couple of days, and noticed when i smoked Cannabis on it, i had a very similar effect with the Dopamine potentiation, so it lets me know the MAO-A inhibition does very well work for Dopamine as well.


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Edited by Sabnock (10/28/15 12:10 AM)


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