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Offlinetheorb
Stranger
Registered: 10/04/15
Posts: 5
Last seen: 5 years, 3 months
Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip
    #22440284 - 10/27/15 01:36 PM (8 years, 3 months ago)












Quicksilver wrote:
> I'm curious as to what peoples experiences are with mixing smart drugs
> with psychedelics and other drugs like LSD, shrooms, MDMA, or pot.


  MAOI + tryptophan + L-methionine (+ B12 + B6 + folic acid) = DMT

See Alexander Shulgin's new book 'TIHKAL'. This is a must for anyone
interested in psychedelics, it is destined to become a classic. I will
quote directly (without permission, sorry) where it describes the
chemistry and effects of tryptamine:


Experience report:
I took 500mg of l-tryptophan + 500mg of l-methionine + half oz of passionflower extract + (b6 + b12 + folic acid to help with synthesis) I added 20mg of melatonin, because I heard it could help out.


After about 30 minutes after ingesting the effects felt like salvia until i fell asleep. I tripped in my sleep often waking up. The next day my mind seem clearer.


page 283.
Quote:


  ..... Almost forty years ago a researcher in the National institute
  of Mental Health, in Maryland, discovered an enzyme in rabbit lung
  that could transfer a methyl group to a tryptamine from the amino
  acid donor, S-adenosyl-methione. With this system, sorotonin gave
  N-methylsorotonin, N-methylsorotonin gave bufotenine, trptamine gave
  N-methyltrptamine, and N-methyltrptamine gave DMT. What a fabulous
  black box that would make. Get two enzyme preparations, one that can
  methylate S-adenosyl-homocysteine to S-adenosyl-methionine and
  another that can regenerate S-adenosyl-homocysteine by transferring
  the methyl group to an available amine. Two catalysts in a chamber
  heated to 37 C, with a spigot adding tryptamine at the top, and
  another releasing DMT out the bottom. That's the science - I'll leave
  the details to the engineers.




page 582.

Quote:

  (with 15 g,  orally with 150 mg iproniazid) "this was a daily
  treatment given to schizophrenic patients, tryptophan along with an
  antidepressant which is a monoamine oxidase inhibitor. Most showed
  marked changes such as an elevation in mood, an increased
  involvement with other people in their ward, and an increased
  extrovertism. A separate study of this composition with the addition
  of the amino acid L_methionine produced in about half of these
  patients a toxic or deliriod state."

  ...... Tryptophan, a natural and nutritionally essential amino-acid,
  is a centrally active intoxicant and sleep provider in man. It is
  converted metabolicaly to tryptamine, which is a little bit
  psychedelic.  When administered with methionine (another amino-acid
  know to methylate things) it produces methylated tryptamines, the two
  best studied being N-methyltryptamine (NMT) and N,N-dimethytryptamine
  (DMT). The effects that result are hard to categorize, reflecting the
  the diagnostic state of the patient. But something happens. In short,
  tryptophan, alone or in combination with MAO inhibitors or methyl
  donors, is a fabulous tool for exploring brain function...........

A quick Web search turned up some useful information relating to
methionine (again without permission):

  The Cognitive Enhancement Research Institute
  S-adenosylmethionine (SAM)

  One of the essential metabolic functions of the body is active methyl
  donation (cycle A). The active methylation donor is S-adenosyl-
  methionine (SAM), which is produced from methionine by the addition
  of ATP (adenosine triphosphate). After the methyl group has been
  donated (reaction 3), homocysteine remains.  Because homocysteine has
  pro-oxidant properties (elevated levels are associated with cardio-
  vascular disease), it must be detoxified. Two separate mechanisms
  exist both of which are serine dependent. In the first (reaction 1),
  homocysteine is re-methylated by methyltetrahydrofolate (Me-THF, or
  "activated" folic acid) back to methionine, and the SAM cycle is
  closed.  Under most circumstances, this should be the dominant
  pathway. In the second mechanism (reaction 2), homocysteine is
  combined with serine to form cystathionine which is split back apart
  (slightly differently) to yield cysteine and homoserine. This
  reaction depends on the enzyme cystathionine beta-synthase which
  opens up the SAM cycle and results in loss of methionine (and
  accumulation of cysteine).

  The restoration of the SAM cycle is not solely dependent on
  increasing serine levels. The folate cycle (cycle B) is essential to
  close the SAM cycle and keep methionine available for producing SAM.

  The folate cycle not only requires folic acid, but also vitamins B6
  and B12, and NADH (a vitamin B3-containing reducing agent). NADH is
  now available as a dietary supplement in the US.




So it appears that to be safe methionine should be taken in combination
with vitamins B12, B6 and folic acid. Again on the down side I have read
that methionine has GI side effects such as nausea.

A safe MAOI could be Peganum harmala extract (harmine). With the
exception of tryptophan all the other ingredients are available from
health food stores.

Fat Freddie


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OfflineNamyellit
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Registered: 01/18/10
Posts: 109
Last seen: 1 year, 10 months
Re: Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip [Re: theorb]
    #22440685 - 10/27/15 03:24 PM (8 years, 3 months ago)

hmm


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Offlinemushpunx
Fungus Punk
 User Gallery


Registered: 04/20/14
Posts: 13,394
Last seen: 11 days, 10 hours
Re: Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip [Re: Namyellit] * 1
    #22441752 - 10/27/15 07:36 PM (8 years, 3 months ago)

There is a lot of misinformation spread around and mis quoted world about DMT in the human brain.

It was only speculated that it might be present in the human brain and that it might be produced in the pineal gland.  The chemicals that *could* become DMT are present but that is it.


I seriously doubt the effects of this combination will be anything close to DMT


--------------------

Amateur Mycologists United
AMU Q&A


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OfflineDr.LSD
Gonzo
Female

Registered: 10/27/15
Posts: 55
Last seen: 8 years, 2 months
Re: Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip [Re: mushpunx]
    #22441796 - 10/27/15 07:48 PM (8 years, 3 months ago)

I also think that this would not work. I have read TIHKAL and he is talking about reductive amination which involves synthesising DMT from the tryptophan. Simply eating what he lists will not create DMT in your body its a complicated reaction that is necessary to be done in lab glass. Your stomach is not the place to try and synthesis anything sorry friend.


--------------------


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Offlinetheorb
Stranger
Registered: 10/04/15
Posts: 5
Last seen: 5 years, 3 months
Re: Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip [Re: Dr.LSD]
    #22443563 - 10/28/15 07:16 AM (8 years, 3 months ago)

...... Tryptophan, a natural and nutritionally essential amino-acid,
  is a centrally active intoxicant and sleep provider in man. It is
  converted metabolicaly to tryptamine, which is a little bit
  psychedelic. 

When administered with methionine (another amino-acid
  know to methylate things) it produces methylated tryptamines, the two
  best studied being N-methyltryptamine (NMT) and N,N-dimethytryptamine
  (DMT).

The effects that result are hard to categorize, reflecting the
  the diagnostic state of the patient. But something happens. In short,
  tryptophan, alone or in combination with MAO inhibitors or methyl
  donors, is a fabulous tool for exploring brain function...........


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OfflinePandemoon
Ἧeẍeᾐmeḭsṫeŗ ͛
Male User Gallery

Registered: 01/28/14
Posts: 5,844
Loc: Europe
Last seen: 7 hours, 20 minutes
Re: Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip [Re: theorb]
    #22444002 - 10/28/15 09:21 AM (8 years, 3 months ago)

Quote:

theorb said:

When administered with methionine .. it produces methylated tryptamines, the two best studied being N-methyltryptamine (NMT) and N,N-dimethytryptamine (DMT).





It's not metabolized into DMT. Instead another but not exactly named "methylated tryptamin" is said to be formed in vivo..

-


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