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theorb
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Registered: 10/04/15
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Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip
#22440284 - 10/27/15 01:36 PM (8 years, 3 months ago) |
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Quicksilver wrote: > I'm curious as to what peoples experiences are with mixing smart drugs > with psychedelics and other drugs like LSD, shrooms, MDMA, or pot.
MAOI + tryptophan + L-methionine (+ B12 + B6 + folic acid) = DMT
See Alexander Shulgin's new book 'TIHKAL'. This is a must for anyone interested in psychedelics, it is destined to become a classic. I will quote directly (without permission, sorry) where it describes the chemistry and effects of tryptamine:
Experience report: I took 500mg of l-tryptophan + 500mg of l-methionine + half oz of passionflower extract + (b6 + b12 + folic acid to help with synthesis) I added 20mg of melatonin, because I heard it could help out.
After about 30 minutes after ingesting the effects felt like salvia until i fell asleep. I tripped in my sleep often waking up. The next day my mind seem clearer.
page 283.
Quote:
..... Almost forty years ago a researcher in the National institute of Mental Health, in Maryland, discovered an enzyme in rabbit lung that could transfer a methyl group to a tryptamine from the amino acid donor, S-adenosyl-methione. With this system, sorotonin gave N-methylsorotonin, N-methylsorotonin gave bufotenine, trptamine gave N-methyltrptamine, and N-methyltrptamine gave DMT. What a fabulous black box that would make. Get two enzyme preparations, one that can methylate S-adenosyl-homocysteine to S-adenosyl-methionine and another that can regenerate S-adenosyl-homocysteine by transferring the methyl group to an available amine. Two catalysts in a chamber heated to 37 C, with a spigot adding tryptamine at the top, and another releasing DMT out the bottom. That's the science - I'll leave the details to the engineers.
page 582.
Quote:
(with 15 g, orally with 150 mg iproniazid) "this was a daily treatment given to schizophrenic patients, tryptophan along with an antidepressant which is a monoamine oxidase inhibitor. Most showed marked changes such as an elevation in mood, an increased involvement with other people in their ward, and an increased extrovertism. A separate study of this composition with the addition of the amino acid L_methionine produced in about half of these patients a toxic or deliriod state."
...... Tryptophan, a natural and nutritionally essential amino-acid, is a centrally active intoxicant and sleep provider in man. It is converted metabolicaly to tryptamine, which is a little bit psychedelic. When administered with methionine (another amino-acid know to methylate things) it produces methylated tryptamines, the two best studied being N-methyltryptamine (NMT) and N,N-dimethytryptamine (DMT). The effects that result are hard to categorize, reflecting the the diagnostic state of the patient. But something happens. In short, tryptophan, alone or in combination with MAO inhibitors or methyl donors, is a fabulous tool for exploring brain function...........
A quick Web search turned up some useful information relating to methionine (again without permission):
The Cognitive Enhancement Research Institute S-adenosylmethionine (SAM)
One of the essential metabolic functions of the body is active methyl donation (cycle A). The active methylation donor is S-adenosyl- methionine (SAM), which is produced from methionine by the addition of ATP (adenosine triphosphate). After the methyl group has been donated (reaction 3), homocysteine remains. Because homocysteine has pro-oxidant properties (elevated levels are associated with cardio- vascular disease), it must be detoxified. Two separate mechanisms exist both of which are serine dependent. In the first (reaction 1), homocysteine is re-methylated by methyltetrahydrofolate (Me-THF, or "activated" folic acid) back to methionine, and the SAM cycle is closed. Under most circumstances, this should be the dominant pathway. In the second mechanism (reaction 2), homocysteine is combined with serine to form cystathionine which is split back apart (slightly differently) to yield cysteine and homoserine. This reaction depends on the enzyme cystathionine beta-synthase which opens up the SAM cycle and results in loss of methionine (and accumulation of cysteine).
The restoration of the SAM cycle is not solely dependent on increasing serine levels. The folate cycle (cycle B) is essential to close the SAM cycle and keep methionine available for producing SAM.
The folate cycle not only requires folic acid, but also vitamins B6 and B12, and NADH (a vitamin B3-containing reducing agent). NADH is now available as a dietary supplement in the US.
So it appears that to be safe methionine should be taken in combination with vitamins B12, B6 and folic acid. Again on the down side I have read that methionine has GI side effects such as nausea.
A safe MAOI could be Peganum harmala extract (harmine). With the exception of tryptophan all the other ingredients are available from health food stores.
Fat Freddie
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Namyellit
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Re: Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip [Re: theorb]
#22440685 - 10/27/15 03:24 PM (8 years, 3 months ago) |
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hmm
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mushpunx
Fungus Punk



Registered: 04/20/14
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Re: Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip [Re: Namyellit] 1
#22441752 - 10/27/15 07:36 PM (8 years, 3 months ago) |
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There is a lot of misinformation spread around and mis quoted world about DMT in the human brain.
It was only speculated that it might be present in the human brain and that it might be produced in the pineal gland. The chemicals that *could* become DMT are present but that is it.
I seriously doubt the effects of this combination will be anything close to DMT
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 Amateur Mycologists United AMU Q&A
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Dr.LSD
Gonzo


Registered: 10/27/15
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Re: Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip [Re: mushpunx]
#22441796 - 10/27/15 07:48 PM (8 years, 3 months ago) |
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I also think that this would not work. I have read TIHKAL and he is talking about reductive amination which involves synthesising DMT from the tryptophan. Simply eating what he lists will not create DMT in your body its a complicated reaction that is necessary to be done in lab glass. Your stomach is not the place to try and synthesis anything sorry friend.
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theorb
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Registered: 10/04/15
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Re: Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip [Re: Dr.LSD]
#22443563 - 10/28/15 07:16 AM (8 years, 3 months ago) |
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...... Tryptophan, a natural and nutritionally essential amino-acid, is a centrally active intoxicant and sleep provider in man. It is converted metabolicaly to tryptamine, which is a little bit psychedelic.
When administered with methionine (another amino-acid know to methylate things) it produces methylated tryptamines, the two best studied being N-methyltryptamine (NMT) and N,N-dimethytryptamine (DMT).
The effects that result are hard to categorize, reflecting the the diagnostic state of the patient. But something happens. In short, tryptophan, alone or in combination with MAO inhibitors or methyl donors, is a fabulous tool for exploring brain function...........
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Pandemoon
Ἧeẍeᾐmeḭsṫeŗ ͛


Registered: 01/28/14
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Re: Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip [Re: theorb]
#22444002 - 10/28/15 09:21 AM (8 years, 3 months ago) |
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Quote:
theorb said:
When administered with methionine .. it produces methylated tryptamines, the two best studied being N-methyltryptamine (NMT) and N,N-dimethytryptamine (DMT).
It's not metabolized into DMT. Instead another but not exactly named "methylated tryptamin" is said to be formed in vivo..
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