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Invisiblemicro
bunbun has a gungun
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Registered: 05/09/03
Posts: 7,532
Loc: Brick City Flag
info regarding use of cinnamic aldehyde as fungicide / insecticide
    #22425310 - 10/23/15 11:30 PM (8 years, 3 months ago)

I found a bunch of stuff regarding this; apparently it's safe and seems pretty effective. I wasn't able to get a consistent mechanism of action; something in 2008 said interference making the cell walls and another paper in 2013 said it is unknown. I was able to get genetic info on Cinnamoyl-CoA reductase but I'm not sure if it would still be harmful as a fungicide at that point.

Turns out it is even more effective in combination with eugenol (oral topical anesthetic)

Antifungal activity of cinnamaldehyde and eugenol congeners against wood-rot fungi.
http://www.ncbi.nlm.nih.gov/pubmed/17945485

Recent Trends in Studies on Botanical Fungicides in Agriculture
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174793/

Characterization of a cinnamoyl-CoA reductase 1 (CCR1) mutant in maize: effects on lignification, fibre development, and global gene expression
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134344/

Wohlriechender Mückentod (German - regarding use as pesticide)
http://www.wissenschaft.de/home/-/journal_content/56/12054/1116703/




Anyone have experience or more info on this?


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Offlinecheesie
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Registered: 07/03/06
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Last seen: 10 months, 29 days
Re: info regarding use of cinnamic aldehyde as fungicide / insecticide [Re: micro]
    #22426279 - 10/24/15 08:58 AM (8 years, 3 months ago)

Quote:

micro said:
I found a bunch of stuff regarding this; apparently it's safe and seems pretty effective. I wasn't able to get a consistent mechanism of action; something in 2008 said interference making the cell walls and another paper in 2013 said it is unknown. I was able to get genetic info on Cinnamoyl-CoA reductase but I'm not sure if it would still be harmful as a fungicide at that point.

Turns out it is even more effective in combination with eugenol (oral topical anesthetic)

Antifungal activity of cinnamaldehyde and eugenol congeners against wood-rot fungi.
http://www.ncbi.nlm.nih.gov/pubmed/17945485

Recent Trends in Studies on Botanical Fungicides in Agriculture
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174793/

Characterization of a cinnamoyl-CoA reductase 1 (CCR1) mutant in maize: effects on lignification, fibre development, and global gene expression
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134344/

Wohlriechender Mückentod (German - regarding use as pesticide)
http://www.wissenschaft.de/home/-/journal_content/56/12054/1116703/




Anyone have experience or more info on this?



Quote:

micro said:
I found a bunch of stuff regarding this; apparently it's safe and seems pretty effective. I wasn't able to get a consistent mechanism of action; something in 2008 said interference making the cell walls and another paper in 2013 said it is unknown. I was able to get genetic info on Cinnamoyl-CoA reductase but I'm not sure if it would still be harmful as a fungicide at that point.

Turns out it is even more effective in combination with eugenol (oral topical anesthetic)

Antifungal activity of cinnamaldehyde and eugenol congeners against wood-rot fungi.
http://www.ncbi.nlm.nih.gov/pubmed/17945485

Recent Trends in Studies on Botanical Fungicides in Agriculture
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174793/

Characterization of a cinnamoyl-CoA reductase 1 (CCR1) mutant in maize: effects on lignification, fibre development, and global gene expression
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134344/

Wohlriechender Mückentod (German - regarding use as pesticide)
http://www.wissenschaft.de/home/-/journal_content/56/12054/1116703/




Anyone have experience or more info on this?






Don't know about mushroom growing but they are used for other chemical stuff :wink:


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InvisibleToadstool5
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Registered: 01/22/15
Posts: 1,359
Loc: The Golden State
Re: info regarding use of cinnamic aldehyde as fungicide / insecticide [Re: cheesie]
    #22427098 - 10/24/15 12:36 PM (8 years, 3 months ago)

http://www.ncbi.nlm.nih.gov/pubmed/21708228

Quote:

Abstract

Fluconazole resistance is becoming an important clinical concern. We studied the in vitro effects of cinnamaldehyde against 18 fluconazole-resistant Candida isolates. MIC(90) of cinnamaldehyde against different Candida isolates ranged 100-500 μg/ml. Growth and sensitivity of the organisms were significantly affected by cinnamaldehyde at different concentrations. The rapid irreversible action of this compound on fungal cells suggested membrane-located targets for its action. Insight studies to mechanism suggested that cinnamaldehyde exerts its antifungal activity by targeting sterol biosynthesis and plasma membrane ATPase activity. Inhibition of H(+) (-)ATPase leads to intracellular acidification and cell death. Toxicity against H9c2 rat cardiac myoblasts was studied to exclude the possibility of further associated cytotoxicity. The observed selectively fungicidal characteristics against fluconazole-resistant Candida isolates signify a promising candidature of this essential oil as an antifungal agent in treatments for candidosis.




This seemed interesting but I'm not sure if it would apply to other fungi? Maybe there is more than one mechanism against fungi depending on the species and conditions.


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Invisiblemicro
bunbun has a gungun
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Registered: 05/09/03
Posts: 7,532
Loc: Brick City Flag
Re: info regarding use of cinnamic aldehyde as fungicide / insecticide [Re: Toadstool5]
    #22428233 - 10/24/15 05:03 PM (8 years, 3 months ago)

Quote:

cheesie said:
Don't know about mushroom growing but they are used for other chemical stuff :wink:




Well, I think eugenol can be used along with catechol to make safrole...

Cinnamic aldehyde you lost me though. Meth?

Either way, the stuff is easy enough to obtain.

Quote:

Toadstool5 said:
This seemed interesting but I'm not sure if it would apply to other fungi? Maybe there is more than one mechanism against fungi depending on the species and conditions.




Maybe; reading that it makes sense how it could be interpreted as interference at the cell walls. It seems pretty ubiquitous among yeasts and fungi; I want to know if there's a way to use it to gain an advantage with cultivation.


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Any research paper or book for free
(Avatar is Maxxy, a character by Mizzyam, RIP)


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