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Gorlax



Registered: 05/06/08
Posts: 6,695
Last seen: 16 days, 19 hours
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Re: This shits retarded [Re: The Moose]
#22357660 - 10/10/15 04:44 AM (8 years, 3 months ago) |
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Yeah I mean a vic is a vic but I grew a fondness to the blue ones. Maybe because I was spoiled with them for so long. Literally had prescription for 180 every month. Then the pharmacy started with the yellow ones. Then yah those fucking white M360s or whatever.
If you go into with opiod pills you have every person telling you which is better. I don't even fuck with oxycodone but when I was prescribed them post dental surgery those M box ones fucked me up way more then any other brand I tried of those.
Like I said it has to come down to it being a cleaner easily metabolized product or simply in your head. They have already proven placebo affect to be better then pain killers in some situations.
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psi
TOAST N' JAM


Registered: 09/05/99
Posts: 31,456
Loc: 613
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My impression is that different preparations of a drug (i.e. choice of pill binding agents etc, the drug molecule itself is the same) can result in significant differences in bioavailability. A lot of money goes into testing bioavailability of new generic preparations of existing drugs (when people become medical test subjects for money, this is what they're doing a lot of the time.) Presumably they try to get it as close as they can to the preparation they're trying to emulate. For the actual milligram value printed on the package, I wouldn't think they'd be allowed to print a different value than the actual amount because it's considered "equivalent" to x milligrams, but I'm not 100% sure that isn't the case.
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Prisoner#1
Even Dumber ThanAdvertized!


Registered: 01/22/03
Posts: 193,665
Loc: Pvt. Pubfag NutSuck
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Re: This shits retarded [Re: Amanita86]
#22357961 - 10/10/15 08:10 AM (8 years, 3 months ago) |
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Quote:
Amanita86 said: Generics have a little more leeway in terms of the ingredient's measurements. Brand name has to "be", generics just 'represent' the brand name recipe.
if a drug is claimed to be 7mg of something that ingredient has to be 7mg, there may be a few micrograms difference in weight but then it's the allowable variance throughout the industry whether it's the brand name or the generic, that means it can be over or under what ever that variance allow, if it's 2mg over or under the claimed weight it may not seem like that big of a deal but with some drugs it means it could be lethal
the leeway they're given is in the binders and fillers, the generic may contain acetominiphin while the brand name will contain ibuprofin or one may contain more starch than the other
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Niffla



Registered: 06/09/08
Posts: 46,489
Loc: Texas
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Your friend's shit's all retarded
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HAIL OUR NEW OTD KING
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AkaAlias
Pondering Pondscum

Registered: 09/25/15
Posts: 63
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Re: This shits retarded [Re: Niffla]
#22358119 - 10/10/15 09:03 AM (8 years, 3 months ago) |
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Personally, I've never experienced any difference between different brands of diazepam for instance.
My ex on the other hand had a tantrum/breakdown when her ex-doc wouldn't prescribe her a certain brand of meds. To her, there were substantial differences in effect, even though that shouldn't be possible, as generic and branded product should contain the same substance and dosage. Then again, she also contributed some of her strange moods to what phase the moon was in. Go figure..
-------------------- This and that for tit for tat Gobbledygook in my top hat Bricks for breakfast what a feast Will you join unleash the beast?
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psi
TOAST N' JAM


Registered: 09/05/99
Posts: 31,456
Loc: 613
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Re: This shits retarded [Re: AkaAlias] 1
#22358151 - 10/10/15 09:15 AM (8 years, 3 months ago) |
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It definitely isn't impossible, since the amount of the active compound isn't the only thing affecting the response curve over time of drug available in your system. Binding agents etc can affect that response as well.
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Big Worm
Perf



Registered: 04/20/09
Posts: 7,642
Last seen: 3 years, 9 months
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Re: This shits retarded [Re: psi]
#22358192 - 10/10/15 09:26 AM (8 years, 3 months ago) |
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When I would eat benzo's often. (Clonazepam)
Teva was the highest quality brand IMO.
Sandoz and Mylan are the worst.
All labeled as Clonaz. but I don't know what the other two companies would do, but it didn't feel the same at all.
So I don't know where the variation comes into play, maybe certain things were derived from a different source so they differ in quality or something.
Even people I knew that had a prescription for clonazepam would say they were terrible and would end up going to a different pharmacy.
I don't really know what i'm trying to get at.
But I figured I would share.
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Prisoner#1
Even Dumber ThanAdvertized!


Registered: 01/22/03
Posts: 193,665
Loc: Pvt. Pubfag NutSuck
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Re: This shits retarded [Re: AkaAlias]
#22358206 - 10/10/15 09:33 AM (8 years, 3 months ago) |
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Quote:
AkaAlias said: Personally, I've never experienced any difference between different brands of diazepam for instance.
My ex on the other hand had a tantrum/breakdown when her ex-doc wouldn't prescribe her a certain brand of meds. To her, there were substantial differences in effect, even though that shouldn't be possible, as generic and branded product should contain the same substance and dosage. Then again, she also contributed some of her strange moods to what phase the moon was in. Go figure..
you are aware that some doctards receive perks from pharmaceutical reps for pushing branded meds
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Turtletotem
Dutch Delight



Registered: 09/02/13
Posts: 3,763
Last seen: 4 years, 11 months
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Quote:
Rebelutionsssss said: My friends called me stupid for thinking that a generic drug with the same amount of actives as the brand name are the same. Everyone thought I was stupid even though I explained it pisses me off
Some people can't be helped, they will never understand no matter how much you try to explain it.
I don't know why.
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makaveli8x8
Stranger

Registered: 02/28/06
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Re: This shits retarded [Re: The Moose]
#22358742 - 10/10/15 11:29 AM (8 years, 3 months ago) |
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Quote:
The Moose said: I mean when I've had pills I get them in a bottle lol
generic meds can be found out on the isles too, those all come in box's. and on those box's it lists the meds in them and the percentages. Sometimes even that is slightly vague however as it lists main ingredients and then it will list a bunch of them under "other ingredients" or something like that and i think it lists the percent for all of those together or something, and that is most likely where generics are different than name brand.
The main ingredients are the same, its all the other shit in them thats different.
Plus they attain the ingredients different, a name brand might use a highly advanced process involving modified yeast, while a generic brand might involve killing kittens and extracting the chemicals from its various body parts then sending them to china to have them contaiminated with heavy metals and sent back
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  We were sent to hell for eternity Ø h® We play on earth to pass the time Over-population the root of all Evil-brings the Elites Closer to the gates.
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Dark_Star
train driver pervading a desktop


Registered: 08/20/04
Posts: 31,859
Loc: Uranus
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Sometimes the generics don't work the same as the brand name. I'm not sure why this is, but it's true. Not necessarily with psychoactives, but other pharms. I've seem people not get the benefits from some generics, and therefore have to take the brand name. Trying to get insurance companies on board with this is a real bitch.
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Pariahprose
I'm Thinking Arby's...


Registered: 09/10/14
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Re: This shits retarded [Re: Dark_Star]
#22358860 - 10/10/15 11:55 AM (8 years, 3 months ago) |
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Never heard 20%. I always heard of a 10% variant in generic vs. Name brand, but the only medication that was found to have a real difference was K cut klonopins vs. Generic.
Maybe its not the make of the main ingredient, but the fillers used by generic companies?
-------------------- Pariahprose, an outcast even among the Devil's Demons.
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Dark_Star
train driver pervading a desktop


Registered: 08/20/04
Posts: 31,859
Loc: Uranus
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Yeah the fillers are a major component.
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