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Invisible4HO-DMT
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Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells
    #22289522 - 09/25/15 05:59 PM (8 years, 4 months ago)

Source

Quote:

You may know them as “shrooms”, “Magic mushrooms”, psilocybic mushrooms, or you may not know them at all. They are a natural plant that, like marijuana, is banned by the U.S. Government. But like marijuana, these mushrooms may not be without medical properties. Like marijuana, they could deserve a place on natural medicine shelves for their ability to treat depression, eradicate mental illness, and improve cognition – not in police evidence rooms.

According to research from the University of South Florida, psilocybin, the active component within psychedelic mushrooms, is able to grow new brain cells—potentially offering treatment for mental illness and improving cognition.

The study, published in Experimental Brain Research, says psilocybin is able to bind to special receptors in the brain that stimulate healing and growth. In the case of these mushrooms, brain cell growth occurs. In mice, the researchers found psilocybin to actually help repair damaged brain cells and cure or relieve PTSD and depression.

Lead researcher, Dr. Juan R. Sanchez-Ramos, tested the effects of psilocybin by training mice to fear an electric shock when they heard a noise associated with the shock. Then, by giving them psilocybin, the mice were able to stop reacting to the noise-trigger much faster than those mice not treated with the mushroom compound.

    “The proposition that psilocybin impacts cognition and stimulates hippocampal neurogenesis is based on extensive evidence that serotonin (5-hydroxytryptamine or 5-HT) acting on specific 5-HT receptor sub-types (most likely the 5-HT2A receptor) is involved in the regulation of neurogenesis in hippocampus,” says Dr. Sanchez-Ramos according to NaturalNews. “The in vitro and in vivo animal data is compelling enough to explore whether psilocybin will enhance neurogenesis and result in measurable improvements in learning.”

Other research also shows that this same compound could greatly help with depression, helping the majority of participants in one study achieve great well-being.

Psilocybin is referred to as a “nootropic” agent, or one that has numerous functions in the brain that can improve hippocampus health. The hippocampus is part of the brain responsible for learning as well as converting short-term memory to long-term memory. New brain cells in the hippocampus from the psilocybin translates into a healthier and sharper brain overall.

The research on psychedelic mushrooms is limited—far more limited than the research on marijuana. Because these mushrooms are known for causing hallucinations, unguarded self-treatment isn’t recommended. However, this plant, like marijuana, does not deserve a place in the Schedule I classification of illegal substances. Like marijuana, the U.S. government has determined ‘shrooms as having no medicinal value’—an obviously-flawed determination.

Read more: http://naturalsociety.com/research-suggests-psychedelic-mushrooms-offer-valuable-brain-treatments/#ixzz3mnXWKw5u
Follow us: @naturalsociety on Twitter | NaturalSociety on Facebook





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Offlineolson
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: 4HO-DMT]
    #22289712 - 09/25/15 06:59 PM (8 years, 4 months ago)

The study is from 2013. I'm wondering why it's popping up now. Also bear in mind the increase in neurogenesis only occurs with low doses. High doses (ie. recreational doses) actually have the opposite effect.


--------------------

Kinesin, a motor protein, shuttling a vesicle full of cargo
such as glucose or even neurotransmitters across a cell.
This little guy struts along the microtubule using ATP as fuel.


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Offlinetopdog82
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: olson]
    #22289908 - 09/25/15 07:52 PM (8 years, 4 months ago)

Quote:

olson said:
The study is from 2013. I'm wondering why it's popping up now. Also bear in mind the increase in neurogenesis only occurs with low doses. High doses (ie. recreational doses) actually have the opposite effect.



higher doses are neurotoxic? Please link
:feelsbadman:


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OfflineKonyap

Registered: 06/30/07
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: topdog82]
    #22290015 - 09/25/15 08:23 PM (8 years, 4 months ago)

he's not saying that

i beleive when too many connection are made as you age they degrade faster


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Invisiblesh4d0ws
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: olson]
    #22290027 - 09/25/15 08:27 PM (8 years, 4 months ago)

Quote:

olson said:
The study is from 2013. I'm wondering why it's popping up now. Also bear in mind the increase in neurogenesis only occurs with low doses. High doses (ie. recreational doses) actually have the opposite effect.




Can you link a source that high doses have the opposite effect of neurogenesis ?


Would love to see one. Sounds like bull shit to me.


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Offlineolson
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: topdog82]
    #22290039 - 09/25/15 08:31 PM (8 years, 4 months ago)

Quote:

topdog82 said:
higher doses are neurotoxic? Please link
:feelsbadman:



I think what means is that high doses suppress neurogenesis. This doesn't mean neurotoxicity.


--------------------

Kinesin, a motor protein, shuttling a vesicle full of cargo
such as glucose or even neurotransmitters across a cell.
This little guy struts along the microtubule using ATP as fuel.


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Offlineolson
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: sh4d0ws]
    #22290071 - 09/25/15 08:38 PM (8 years, 4 months ago)

sh4d0ws said:
Quote:




Can you link a source that high doses have the opposite effect of neurogenesis ?


Would love to see one. Sounds like bull shit to me.





It's in the study the article referenced.
"Injection of PSOP(psilocybin), 25I-NBMeO or ketanserin resulted in significant dose-dependent decreases in number of newborn neurons in hippocampus"


Edited by olson (09/25/15 08:42 PM)


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Offlinemorrowasted
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: olson] * 1
    #22290271 - 09/25/15 09:19 PM (8 years, 4 months ago)

Just eat a nutritious diet and take a turmeric supplement if you really want to "grow new brain cells". And new brain cells in the hippocampus does NOT NECESSARILY translate into a "healthier and sharper brain overall", especially if all of those new brain cells are grown in pathways that are associated with episodic memories that are formed while you are hallucinating.


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Offlinetopdog82
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: olson]
    #22290273 - 09/25/15 09:19 PM (8 years, 4 months ago)

Quote:

olson said:
sh4d0ws said:
Quote:




Can you link a source that high doses have the opposite effect of neurogenesis ?


Would love to see one. Sounds like bull shit to me.





It's in the study the article referenced.
"Injection of PSOP(psilocybin), 25I-NBMeO or ketanserin resulted in significant dose-dependent decreases in number of newborn neurons in hippocampus"



Oh I didnt know that. Cool stuff


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Offlinetopdog82
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: morrowasted]
    #22290281 - 09/25/15 09:20 PM (8 years, 4 months ago)

Quote:

morrowasted said:
Just eat a nutritious diet and take a turmeric supplement if you really want to "grow new brain cells".



How about doing those in addition to taking a tryptamines? That is what I do at least...


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Offlinemorrowasted
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: topdog82]
    #22290306 - 09/25/15 09:25 PM (8 years, 4 months ago)

Quote:

topdog82 said:
Quote:

morrowasted said:
Just eat a nutritious diet and take a turmeric supplement if you really want to "grow new brain cells".



How about doing those in addition to taking a tryptamines? That is what I do at least...



Taking mushrooms probably doesn't hurt most people but I just get a little irritated with all these news stories from alternative health websites that are coming up that misrepresent the findings of ONE study to make it seem like mushrooms or LSD can be taken like a vitamin. Maybe they can, who knows, but there hasn't been nearly enough research to show what would happen if you microdosed mushrooms or LSD for a long period of time. There is just this study and a lot of conjecture.


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Invisibleellomello
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: olson]
    #22290367 - 09/25/15 09:38 PM (8 years, 4 months ago)

i was a bit confused before (and after) reading the whole thing
Abstract

Drugs that modulate serotonin (5-HT) synaptic concentrations impact neurogenesis and hippocampal (HPC)-dependent learning. The primary objective is to determine the extent to which psilocybin (PSOP) modulates neurogenesis and thereby affects acquisition and extinction of HPC-dependent trace fear conditioning. PSOP, the 5-HT2A agonist 25I-NBMeO and the 5-HT2A/C antagonist ketanserin were administered via an acute intraperitoneal injection to mice. Trace fear conditioning was measured as the amount of time spent immobile in the presence of the conditioned stimulus (CS, auditory tone), trace (silent interval) and post-trace interval over 10 trials. Extinction was determined by the number of trials required to resume mobility during CS, trace and post-trace when the shock was not delivered. Neurogenesis was determined by unbiased counts of cells in the dentate gyrus of the HPC birth-dated with BrdU co-expressing a neuronal marker. Mice treated with a range of doses of PSOP acquired a robust conditioned fear response. Mice injected with low doses of PSOP extinguished cued fear conditioning significantly more rapidly than high-dose PSOP or saline-treated mice. Injection of PSOP, 25I-NBMeO or ketanserin resulted in significant dose-dependent decreases in number of newborn neurons in hippocampus. At the low doses of PSOP that enhanced extinction, neurogenesis was not decreased, but rather tended toward an increase. Extinction of "fear conditioning" may be mediated by actions of the drugs at sites other than hippocampus such as the amygdala, which is known to mediate the perception of fear. Another caveat is that PSOP is not purely selective for 5-HT2A receptors. PSOP facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be explored as potential treatments for post-traumatic stress disorder and related conditions.

Most people won't be injecting extreme doses of psychedelics directly into their hippocampus,
sO it's all good old news, (except for those poor little mice) Just scientific proof the sky is blue.


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PAY NO ATTENTION TO THE MAN BEHIND THE CURTAIN get back to the garden

some came singing, some come to play, some come for keeping the dark away


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Offlinetopdog82
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Re: Psychedelic Mushroom Compound Found to Grow and Repair Brain Cells [Re: morrowasted]
    #22290401 - 09/25/15 09:46 PM (8 years, 4 months ago)

Quote:

morrowasted said:
Quote:

topdog82 said:
Quote:

morrowasted said:
Just eat a nutritious diet and take a turmeric supplement if you really want to "grow new brain cells".



How about doing those in addition to taking a tryptamines? That is what I do at least...



Taking mushrooms probably doesn't hurt most people but I just get a little irritated with all these news stories from alternative health websites that are coming up that misrepresent the findings of ONE study to make it seem like mushrooms or LSD can be taken like a vitamin. Maybe they can, who knows, but there hasn't been nearly enough research to show what would happen if you microdosed mushrooms or LSD for a long period of time. There is just this study and a lot of conjecture.



Well thats true.you gotta keep in mind, that these are all news stories, and not the actual studies themselves. and as such, you should not take them too seriously. News stories are meant to be sensational and grab peoples attention. IMO you should be more angry at modern media than the news stories or people. Between all the porn, facebook, and cocaine going around, noone has time to fully understand the science behind what they read. They want condensed information that will satisfy their intellect, possibly stroke their ego, and make them feel like they are being kept up to date


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