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morrowasted
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on LSD and SSRIs 1
#22271120 - 09/21/15 07:28 PM (8 years, 4 months ago) |
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http://collectivelyconscious.net/articles/scientist-recommends-taking-lsd-for-breakfast-yes-you-read-that-correctly/
I wouldn't buy into this guy's idea of microdosing LSD daily to make me happier, because it will only work about one day out each week. Tolerance to drugs like LSD builds very quickly. Furthermore, it isn't true that LSD is non-addictive. LSD binds directly the Dopamine-2 receptors in the ventral tegmental area of the mesolimbic system, which are the key receptors involved in compulsive behaviors.
One of the mechanisms by which chemicals like LSD work is to increase the rate of brain cell and pathway growth in the hippocampus. Evidence suggests that any drug which increases activation at the 5HT2a receptor in the hippocampus will increase the rate of cell and pathway growth in this area. Another class of drugs that increases activation at this receptor is the Selective Serotonin Reuptake Inhibitor class, including Prozac, Zoloft, and Celexa.
Tolerance to these drugs does not build as quickly, and thus the increased rate of pathway growth can be sustained for longer periods of time. Of course, there are significant side effects associated with SSRIs, the most significant of which is physical dependence.
I don't what role LSD and SSRIs have played in my personal and brain development, but I know they have played a role. I know that I learn things very quickly, and that I remember them for a very long time. I have had some heavenly experiences on LSD and similar drugs, and some hellish experiences. SSRIs may have given me intellectual wealth but have also left me more or less emotionally bankrupt.
In life, there is no such thing as a free lunch.
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morrowasted
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Shroomopotamus
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You won't buy into his idea, but have you actually tried it yourself?
There's a difference in have a full blown experience from it daily and getting beneficial effects from it daily.
Take a look at weed for example. You get stoned with no tolerance and you're STONED. Get high daily and it's just a routine. That doesn't mean you're not getting the medicine within every day.
As far as it being "Addictive" Well, I took it close to weekly for about 2 years while I was on probation. Not because I was addicted but because I enjoyed it and benefited from it. It's what got me through probation. When probation was over and I wasn't doing it so often, there was no need for not, no craving, no withdrawals. It's not any more addictive than a nice glass of orange juice.
-------------------- * Live by the mushroom, die by the mushroom
    This is a trap! A trap! You are all busted! Busted! You fools!
If a time comes where I fail to appear I've been abducted and I will miss you all Please smile and pet puppies as often as possible Be happy Be nice (<3);}
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morrowasted
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Quote:
Shroomopotamus said: You won't buy into his idea, but have you actually tried it yourself?
There's a difference in have a full blown experience from it daily and getting beneficial effects from it daily.
Take a look at weed for example. You get stoned with no tolerance and you're STONED. Get high daily and it's just a routine. That doesn't mean you're not getting the medicine within every day.
As far as it being "Addictive" Well, I took it close to weekly for about 2 years while I was on probation. Not because I was addicted but because I enjoyed it and benefited from it. It's what got me through probation. When probation was over and I wasn't doing it so often, there was no need for not, no craving, no withdrawals. It's not any more addictive than a nice glass of orange juice.
I haven't tried LSD daiy but there was a period of about 3 months were I took either mushrooms, 2c-x, mescaline, or LSD on a daily basis. I was taking massive doses though, not microdoses.
Just because LSD was not addictive for you does not mean it cannot be addictive. It is certainly addictive for me. I once went through a vial in a month.
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badchad
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Quote:
morrowasted said:
Just because LSD was not addictive for you does not mean it cannot be addictive. It is certainly addictive for me. I once went through a vial in a month.
Certainly, there is an individual component, but LSD's affinity for dopaminergic receptors is quite low and its negative in nearly all laboratory models of "abuse" (CPP, self-administration etc.).
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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Hobozen


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Quote:
morrowasted said:
Quote:
Shroomopotamus said: You won't buy into his idea, but have you actually tried it yourself?
There's a difference in have a full blown experience from it daily and getting beneficial effects from it daily.
Take a look at weed for example. You get stoned with no tolerance and you're STONED. Get high daily and it's just a routine. That doesn't mean you're not getting the medicine within every day.
As far as it being "Addictive" Well, I took it close to weekly for about 2 years while I was on probation. Not because I was addicted but because I enjoyed it and benefited from it. It's what got me through probation. When probation was over and I wasn't doing it so often, there was no need for not, no craving, no withdrawals. It's not any more addictive than a nice glass of orange juice.
I haven't tried LSD daiy but there was a period of about 3 months were I took either mushrooms, 2c-x, mescaline, or LSD on a daily basis. I was taking massive doses though, not microdoses.
Just because LSD was not addictive for you does not mean it cannot be addictive. It is certainly addictive for me. I once went through a vial in a month.
Bullshit, you weren't addicted to lsd
Also, lsd works more than once a.week LOL. The fuck you trying to prove?
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MinnesnowtaNice
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Re: on LSD and SSRIs [Re: Hobozen]
#22282306 - 09/24/15 06:50 AM (8 years, 4 months ago) |
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I honestly believe that I don't experience that much of a tolerance on LSD if it's good shit.
I can trip a day after alreading tripping with the same dose
-------------------- we are all thought forms in a cloud of synchronistic events.
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morrowasted
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Quote:
Bullshit, you weren't addicted to lsd
How can you tell me what I was and wasn't? I used it compulsively. I told myself on Thursday, I am not going to do this tomorrow. Then I woke up on Friday and said, fuck it, and took 5 hits. And on Friday, I said, I am not going to use this tomorrow. And I woke up on Saturday and said Fuck it, and took 5 more.
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morrowasted
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Re: on LSD and SSRIs [Re: Hobozen]
#22282605 - 09/24/15 08:35 AM (8 years, 4 months ago) |
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Quote:
blankk said:
Quote:
morrowasted said:
Quote:
Shroomopotamus said: You won't buy into his idea, but have you actually tried it yourself?
There's a difference in have a full blown experience from it daily and getting beneficial effects from it daily.
Take a look at weed for example. You get stoned with no tolerance and you're STONED. Get high daily and it's just a routine. That doesn't mean you're not getting the medicine within every day.
As far as it being "Addictive" Well, I took it close to weekly for about 2 years while I was on probation. Not because I was addicted but because I enjoyed it and benefited from it. It's what got me through probation. When probation was over and I wasn't doing it so often, there was no need for not, no craving, no withdrawals. It's not any more addictive than a nice glass of orange juice.
I haven't tried LSD daiy but there was a period of about 3 months were I took either mushrooms, 2c-x, mescaline, or LSD on a daily basis. I was taking massive doses though, not microdoses.
Just because LSD was not addictive for you does not mean it cannot be addictive. It is certainly addictive for me. I once went through a vial in a month.
Bullshit, you weren't addicted to lsd
Also, lsd works more than once a.week LOL. The fuck you trying to prove?
It "works" many times a week, but you have to take a larger dose the second time to get the same effects. Maybe a week is too much of a stretch. Your tolerance may return to baseline after 4-5 days, but the point still remains.
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morrowasted
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Re: on LSD and SSRIs [Re: badchad]
#22282611 - 09/24/15 08:37 AM (8 years, 4 months ago) |
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Quote:
badchad said:
Quote:
morrowasted said:
Just because LSD was not addictive for you does not mean it cannot be addictive. It is certainly addictive for me. I once went through a vial in a month.
Certainly, there is an individual component, but LSD's affinity for dopaminergic receptors is quite low and its negative in nearly all laboratory models of "abuse" (CPP, self-administration etc.).
Do they involve humans, or other animals? I can see why other animals wouldn't want to abuse LSD.
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morrowasted
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Sam Harris - Drugs and the Meaning of Life
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Achillita
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When you stopped did you have any withdrawal? It just sounds like you were being compulsive.
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morrowasted
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Re: on LSD and SSRIs [Re: Achillita]
#22282645 - 09/24/15 08:48 AM (8 years, 4 months ago) |
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Quote:
Achillita said: When you stopped did you have any withdrawal? It just sounds like you were being compulsive.
Addiction does not necessarily have to be characterized by withdrawal. Speed addicts don't really have a withdrawal in the same way that heroin or alcohol addicts do. Gambling addicts definitely don't have a withdrawal. Compulsivity is a defining feature of addictive behavior.
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OhMrJohnson
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When I take LSD it makes me not want to take psyches again for a while
As long as I fry my eyeballs out that is, if the trip is mild then it makes me want more but a good strong trip always leaves me fully satisfied
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Diminish the sub-principle and leave its toxic trace.. Once and for all!
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Achillita
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--------------------
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morrowasted
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Quote:
OhMrJohnson said: When I take LSD it makes me not want to take psyches again for a while
As long as I fry my eyeballs out that is, if the trip is mild then it makes me want more but a good strong trip always leaves me fully satisfied
That is you, and that is your brain. Do you drink compulsively? I do. I take any drug that feels good compulsively.
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badchad
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Quote:
morrowasted said:
Do they involve humans, or other animals? I can see why other animals wouldn't want to abuse LSD.
You're correct that many involve animal studies. This is somewhat of a scientific curiosity as most drugs of abuse are positive in these models (which is why they use them for screening in drug development).
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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morrowasted
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Re: on LSD and SSRIs [Re: badchad]
#22282852 - 09/24/15 09:34 AM (8 years, 4 months ago) |
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Quote:
badchad said:
Quote:
morrowasted said:
Do they involve humans, or other animals? I can see why other animals wouldn't want to abuse LSD.
You're correct that many involve animal studies. This is somewhat of a scientific curiosity as most drugs of abuse are positive in these models (which is why they use them for screening in drug development).
I think LSD presents a curiosity to human consciousness that isn't accessible to other animals
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badchad
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True, though its interesting that the effects of LSD can be blocked both in humans and animals with 5-HT2A antagonists. So it suggests that the pharmacological effects are mediated similarly in humans and critters. Whether or not the subjective effects are similar is questionable, but I think there is evidence to support the suggestion.
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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Shroomopotamus
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Quote:
morrowasted said:
Quote:
badchad said:
Quote:
morrowasted said:
Do they involve humans, or other animals? I can see why other animals wouldn't want to abuse LSD.
You're correct that many involve animal studies. This is somewhat of a scientific curiosity as most drugs of abuse are positive in these models (which is why they use them for screening in drug development).
I think LSD presents a curiosity to human consciousness that isn't accessible to other animals
For what reason could you have to possibly think that?
-------------------- * Live by the mushroom, die by the mushroom
    This is a trap! A trap! You are all busted! Busted! You fools!
If a time comes where I fail to appear I've been abducted and I will miss you all Please smile and pet puppies as often as possible Be happy Be nice (<3);}
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Achillita
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Elephants take Iboga and will teach child elephants to take iboga. So if elephants had the access to LSD, I'm sure they'd take it.
Tons of animals like to trip out. They just don't have the access that humans do.
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morrowasted
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Quote:
Shroomopotamus said:
Quote:
morrowasted said:
Quote:
badchad said:
Quote:
morrowasted said:
Do they involve humans, or other animals? I can see why other animals wouldn't want to abuse LSD.
You're correct that many involve animal studies. This is somewhat of a scientific curiosity as most drugs of abuse are positive in these models (which is why they use them for screening in drug development).
I think LSD presents a curiosity to human consciousness that isn't accessible to other animals
For what reason could you have to possibly think that?
You know they say that LSD is an ego-shattering, boundary-dissolving substance? Animals don't have much in the way of egos or boundaries.
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morrowasted
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Re: on LSD and SSRIs [Re: Achillita]
#22283034 - 09/24/15 10:11 AM (8 years, 4 months ago) |
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Quote:
Achillita said: Elephants take Iboga and will teach child elephants to take iboga. So if elephants had the access to LSD, I'm sure they'd take it.
Tons of animals like to trip out. They just don't have the access that humans do.
Elephants are known for having a very high encephalization quotient, their conscious lives may indeed be quite rich. Some of them might even abuse LSD given the chance.
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Shroomopotamus
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Quote:
morrowasted said:
Quote:
OhMrJohnson said: When I take LSD it makes me not want to take psyches again for a while
As long as I fry my eyeballs out that is, if the trip is mild then it makes me want more but a good strong trip always leaves me fully satisfied
That is you, and that is your brain. Do you drink compulsively? I do. I take any drug that feels good compulsively.
So basically what you're saying is that like previously stated, you're just a compulsive drug user. That doesn't mean LSD is addictive if you'll take anything and everything as often as possible. You're just a brainwashed nut.
-------------------- * Live by the mushroom, die by the mushroom
    This is a trap! A trap! You are all busted! Busted! You fools!
If a time comes where I fail to appear I've been abducted and I will miss you all Please smile and pet puppies as often as possible Be happy Be nice (<3);}
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