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North Spore Shop: Injection Grain Bag

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OfflineEggtimer
HotSauce Lover

Registered: 05/04/13
Posts: 3,097
Last seen: 4 days, 3 hours
Dihydromyricetin for hangovers and getting too drunk
    #22262858 - 09/19/15 11:41 PM (8 years, 4 months ago)

Could this help with benzos too? Surprised I've never heard of it before.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292407/

Quote:

Dihydromyricetin (DHM, 1 mg/kg, i.p. injection), a flavonoid component of herbal medicines, counteracted acute alcohol (EtOH) intoxication, and also withdrawal signs in rats including tolerance, increased anxiety and seizure susceptibility; DHM greatly reduced EtOH consumption in an intermittent voluntary EtOH intake paradigm in rats. GABAA receptors (GABAARs) are major targets of acute and chronic EtOH actions on the brain. At the cellular levels, DHM (1 μM) antagonized both acute EtOH-induced potentiation of GABAARs and EtOH exposure/withdrawal-induced GABAAR plasticity, including alterations in responsiveness of extra- and post-synaptic GABAARs to acute EtOH, and most importantly, increases in GABAAR α4 subunit expression in hippocampus and cultured neurons. DHM anti-alcohol effects on both behavior and CNS neurons were antagonized by flumazenil (10 mg/kg in vivo, 10 μM in vitro), the benzodiazepine (BZ) antagonist. DHM competitively inhibited BZ-site [3H]flunitrazepam binding (IC50, 4.36 μM), suggesting DHM interaction with EtOH involves the BZ-sites on GABAARs. In summary, we determined DHM anti-alcoholic effects on animal models, and determined a major molecular target and cellular mechanism of DHM for counteracting alcohol intoxication and dependence. We demonstrated pharmacological properties of DHM consistent with those expected to underlie successful medical treatment of AUD; therefore DHM is a therapeutic candidate.




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It's all for the :lol:s


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OfflineDetached
You know where...


Registered: 02/27/15
Posts: 2,942
Last seen: 10 months, 15 days
Re: Dihydromyricetin for hangovers and getting too drunk [Re: Eggtimer]
    #22262865 - 09/19/15 11:45 PM (8 years, 4 months ago)

I'd be down to try it after a bender


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InvisibleDoctor Sponge
He's off on a tangent
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Registered: 05/03/12
Posts: 11,795
Loc: the desert Flag
Re: Dihydromyricetin for hangovers and getting too drunk [Re: Detached]
    #22262998 - 09/20/15 12:26 AM (8 years, 4 months ago)

how bout just a dose of MAN THE FUCK UP:crankey:


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OfflineEggtimer
HotSauce Lover

Registered: 05/04/13
Posts: 3,097
Last seen: 4 days, 3 hours
Re: Dihydromyricetin for hangovers and getting too drunk [Re: Doctor Sponge]
    #22263065 - 09/20/15 12:50 AM (8 years, 4 months ago)

Quote:

learning sponge said:
how bout just a dose of MAN THE FUCK UP:crankey:



After my ex cut my dick off I tried to man up and sow it back on...
turned green, got gangrene, and lost my balls too.


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OfflineDetached
You know where...


Registered: 02/27/15
Posts: 2,942
Last seen: 10 months, 15 days
Re: Dihydromyricetin for hangovers and getting too drunk [Re: Eggtimer]
    #22263068 - 09/20/15 12:52 AM (8 years, 4 months ago)

:feelsbadman:


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OfflineBitter Cactus
reformed bad boy
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Registered: 01/26/12
Posts: 11,773
Loc: Alberta, Canada
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Re: Dihydromyricetin for hangovers and getting too drunk [Re: Doctor Sponge]
    #22263086 - 09/20/15 12:58 AM (8 years, 4 months ago)

Quote:

learning sponge said:
how bout just a dose of MAN THE FUCK UP:crankey:




:whathesaid:


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Taking acid and thinking you are a better man is a lot different then actually becoming a better man.




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North Spore Shop: Injection Grain Bag


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