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Mostly_Harmless
wyrd bið ful aræd



Registered: 05/12/09
Posts: 5,043
Loc: Perfidious Albion
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Scientists use YEAST to brew THC 1
#22254502 - 09/18/15 04:27 AM (8 years, 4 months ago) |
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http://www.dailymail.co.uk/news/article-3234730/Scientists-use-yeast-brew-THC-main-chemical-cannabis-lead-better-drugs-suffering-HIV-cancer.html
Quote:
15 September 2015
Scientists use YEAST to brew THC: Chemical usually found in cannabis could lead to better HIV and cancer drugs
- Hyasynth Bio has refined a genetically engineered yeast that produces THC
- THC is the primary psychoactive chemical found in cannabis plants
- Experts now hope to develop a more efficient method for synthesising yeast for drug research
An active ingredient typically found in cannabis has been genetically engineered in the lab for the first time.
Scientists in Germany have created a strain of yeast that makes the plant's primary psychoactive chemical, tetrahydrocannabinol or THC.
They believe the breakthrough will lead to more effective and easier-to-manufacture cancer and HIV drugs and now hope to perfect the technique.
 A form of yeast (left) has been genetically engineered to produce various cannabinoids that are typically found in cannabis plants (right). THC- and cannabidiol-producing yeast could prove integral to developing more clinical applications for the compound
Yeast is a tiny bacteria and is used to make bread rise and produce in beer.
Researchers at the Technical University of Dortmund in Germany and firm Hyasynth Bio have now found a way to genetically engineer a strain of this bacteria to produce THC.
The yeast needs to be placed in just the right conditions in order for them to make THC - and even then, the quantity is exceptionally small.
Although a significant breakthrough, this still means that cannabis plants are by far the best producer of the psychoactive molecule.
'This is something that could literally change the lives of millions of people,' Kevin Chen, chief executive of Hyasynth Bio told The Times.
'People keep asking about it,' a researcher added, 'but there's bigger potential there than just making a beer.
The newly engineered yeast could not only enable scientists produce THC and cannabidiol more easily, but also help them understand how the compounds work.
There's already evidence to suggest certain compounds in marijuana might be helpful for certain medical conditions.
For example, cannabidivarin (one of those many compounds) has been shown to help control seizures when tested in animals.
Scientists said the real challenge is to devise a method that works better than cannabis plants themselves.
The experts have been working on this process for a while.
Progress was made recently when the scientists were able to take advantage of a recent decoding of which genes marijuana uses to make THC and other compounds.
They were then able to engineer those genes into yeast.
Synthetic THC already exists in pill form and is sold under brand names such as Cesamet.
 Ordinarily, the chemicals are stripped from the plants themselves, but using yeast could greatly reduce the cost of their production compared to conventional chemical synthesis. The pharmaceutical industry is especially eager to develop a more efficient method for synthesising yeast for drug research
 Synthetic THC already exists in pill form and is sold under brand names such as Cesamet. It's often used to treat nausea associated with HIV or cancer therapies (illustrated), but this new process could offer a less expensive, easier way to create this cannabis component from scratch
It's often used to treat nausea associated with HIV or cancer therapies, but this new process could offer a less expensive, easier way to create this cannabis component from scratch,
Ordinarily, the chemicals are stripped from the plants themselves, but using yeast could greatly reduce the cost of their production compared to conventional chemical synthesis.
Japanese experimenters were among the first to extract the necessary THC enzymes from yeast nearly a decade ago, and since then, less expensive and quicker DNA technology has helped scientists across the board find the rest of the genes needed to make THC.
There's already evidence to suggest certain compounds in marijuana might be helpful for certain medical conditions.
For example, cannabidivarin (one of those many compounds) has been shown to help control seizures when tested in animals.
Scientists said the real challenge is to devise a method that works better than cannabis plants themselves.
Progress was made recently when the scientists were able to take advantage of a recent decoding of which genes marijuana uses to make THC and other compounds.
They were then able to engineer those genes into yeast.
Synthetic THC already exists in pill form and is sold under brand names such as Cesamet.
It's often used to treat nausea associated with HIV or cancer therapies, but this new process could offer a less expensive, easier way to create this cannabis component from scratch.
Ordinarily, the chemicals are stripped from the plants themselves, but using yeast could greatly reduce the cost of their production compared to conventional chemical synthesis.
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Ogla



Registered: 02/16/04
Posts: 11,314
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first opium, now THC. Hope these guys make a yeast that will ferment into LSD or Mescaline or something.
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rubberlizard
Brewer and hobbymycologist


Registered: 10/26/10
Posts: 388
Loc: Probably my brewery
Last seen: 2 years, 7 months
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Re: Scientists use YEAST to brew THC [Re: Ogla] 1
#22256562 - 09/18/15 02:52 PM (8 years, 4 months ago) |
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Quote:
losfreddy said: first opium, now THC. Hope these guys make a yeast that will ferment into LSD or Mescaline or something.
Hope its comming and getting out among the general population: http://www.shroomery.org/forums/showflat.php/Number/14652801#14652801
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LittleDaddy



Registered: 11/20/13
Posts: 1,072
Last seen: 2 years, 8 months
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Re: Scientists use YEAST to brew THC [Re: rubberlizard]
#22264715 - 09/20/15 12:45 PM (8 years, 4 months ago) |
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"Yeast is a tiny bacteria?" Lolololol
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The hotter the battle, the sweeter Jah victory. Put the heathen's back upon the wall.
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AEL1911
Stranger



Registered: 09/27/13
Posts: 342
Loc: Japan
Last seen: 6 years, 8 months
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Re: Scientists use YEAST to brew THC [Re: LittleDaddy]
#22267454 - 09/20/15 10:41 PM (8 years, 4 months ago) |
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Quote:
Japanese experimenters were among the first to extract the necessary THC enzymes from yeast nearly a decade ago, and since then, less expensive and quicker DNA technology has helped scientists across the board find the rest of the genes needed to make THC.
Your kidding me right? I would've assumed that any research would be strictly banned.
Low THC hemp is still being grown by a handful of farmers under permit, recreational MJ is around but hard to get and there is a place close to Tokyo growing cannabis, poppies and maybe other legally prohibited plants for research or preservation I assume. That place must have a cconnection with the government or maybe a university, I don't know well though.
Edited by AEL1911 (09/20/15 10:49 PM)
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Salomon
ಠ︵ಠ balance ಠ_ಠ weaver ಠ‿ಠ

Registered: 01/17/09
Posts: 25,128
Loc: America, FUCK YEAH
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Re: Scientists use YEAST to brew THC [Re: AEL1911]
#22272712 - 09/22/15 05:45 AM (8 years, 4 months ago) |
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Quote:
AEL1911 said:
Quote:
Japanese experimenters were among the first to extract the necessary THC enzymes from yeast nearly a decade ago, and since then, less expensive and quicker DNA technology has helped scientists across the board find the rest of the genes needed to make THC.
Your kidding me right? I would've assumed that any research would be strictly banned.
Low THC hemp is still being grown by a handful of farmers under permit, recreational MJ is around but hard to get and there is a place close to Tokyo growing cannabis, poppies and maybe other legally prohibited plants for research or preservation I assume. That place must have a cconnection with the government or maybe a university, I don't know well though.
money gets shit done.
-------------------- EVERYTHING EVENTUALLY BECOMES A DESERT
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TheSlapnCapn
Slappin' thangs.



Registered: 08/08/03
Posts: 2,138
Loc: zee mountain state
Last seen: 4 years, 8 months
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Re: Scientists use YEAST to brew THC [Re: Salomon]
#22290865 - 09/25/15 10:59 PM (8 years, 4 months ago) |
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I've been waiting for a patent technology to emerge that removes that cannabis plant from the "medicinal" industry, before it becomes federally accepted in the US. The day has arrived.
-------------------- I promise to live, love, exist, and be, and hope that all life will love to be in existence with me. Also, fuck you. -j
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Achillita
Back to the basics



Registered: 05/26/14
Posts: 4,565
Last seen: 3 years, 10 days
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Re: Scientists use YEAST to brew THC [Re: TheSlapnCapn]
#22294488 - 09/26/15 04:29 PM (8 years, 4 months ago) |
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Ehh I doubt it. THC is only one part of cannabis being used for medicinal purposes.
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