Home | Community | Message Board

Original Seeds Store
This site includes paid links. Please support our sponsors.


Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Shop: North Spore North Spore Mushroom Grow Kits & Cultivation Supplies   Left Coast Kratom Buy Kratom Extract   Mushroom-Hut Mono Tub Substrate   OlympusMyco.com Olympus Myco Bulk Substrate   MagicBag.co All-In-One Bags That Don't Suck   PhytoExtractum Maeng Da Thai Kratom Leaf Powder

Jump to first unread post Pages: 1
Some of these posts are very old and might contain outdated information. You may wish to search for newer posts instead.
Offlineamyloid
Stranger
Registered: 03/08/03
Posts: 980
Last seen: 10 years, 3 months
information pool: aeruginascin
    #2224594 - 01/06/04 11:06 PM (20 years, 4 months ago)

http://www.cognitiveliberty.org/shulgin/adsarchive/aeruginascin.htm

interesting read, anyone hear of aeruginascin or know anything more about it?  when i get home to my merck index ill spit out what it says.  considering this chem apparently modifies the intensity :loveeyes: of psilocybin this is pretty interesting.

the archive of questions and answers by Dr. Shulgin(author of pihkal/tihkal) is extremely interesting

(post may not be in correct forum, appologies in advance)

Extras: Filter Print Post Top
InvisibleYesItsMe
Homeless GOHOME !...
Registered: 10/29/03
Posts: 253
Loc: Working for Piss ;...
Re: information pool: aeruginascin [Re: amyloid]
    #2224811 - 01/07/04 12:43 AM (20 years, 4 months ago)

Thank u for ur link , really interresting !


--------------------
God save the Queen

Extras: Filter Print Post Top
Offlineamyloid
Stranger
Registered: 03/08/03
Posts: 980
Last seen: 10 years, 3 months
Re: information pool: aeruginascin [Re: amyloid]
    #2231020 - 01/09/04 12:23 PM (20 years, 4 months ago)

not in my edition of merck index =(

Extras: Filter Print Post Top
Invisiblefastfred
Old Hand
Male User Gallery

Folding@home Statistics
Registered: 05/17/04
Posts: 6,899
Loc: Dark side of the moon
Re: information pool: aeruginascin [Re: amyloid]
    #6437226 - 01/08/07 02:59 AM (17 years, 4 months ago)

Get these articles while they're hot, as they have a bad habit of disappearing after awhile. I had a hard time finding the first one since my journal service doesn't include Planta Medica.


Aeruginascin, a Trimethylammonium Analogue of Psilocybin from the Hallucinogenic Mushroom Inocybe aeruginascens
by Niels Jensen, Jochen Gartz, Hartmut Laatsch

http://wwwuser.gwdg.de/~ucoc/laatsch/168_Aeruginascin_col.pdf





Tryptamines as Ligands and Modulators of the Serotonin 5-HT2A Receptor and the Isolation of Aeruginascin from the Hallucinogenic Mushroom Inocybe aeruginascens

http://deposit.ddb.de/cgi-bin/dokserv?idn=973960833&dok_var=d1&dok_ext=pdf&filename=973960833.pdf
http://webdoc.sub.gwdg.de/diss/2004/jensen/jensen.pdf


-FF

Edited by fastfred (01/08/07 03:21 AM)

Extras: Filter Print Post Top
Invisiblefastfred
Old Hand
Male User Gallery

Folding@home Statistics
Registered: 05/17/04
Posts: 6,899
Loc: Dark side of the moon
Re: information pool: aeruginascin [Re: fastfred]
    #6437231 - 01/08/07 03:02 AM (17 years, 4 months ago)



This looks very, very interesting!!!

Anybody have any information about the cultivation of Inocybe aeruginascens?

Please tell me there is a source for this species!?!


-FF

Extras: Filter Print Post Top
InvisibleZen Peddler
Male User Gallery

Registered: 06/18/01
Posts: 6,379
Loc: orbit
Re: information pool: aeruginascin [Re: fastfred]
    #6444024 - 01/10/07 01:35 AM (17 years, 4 months ago)

Ask MJ - he is adament that it has no affect on psychoactivity. I dont know whether he bases that comment on any specific evidence.


--------------------

Extras: Filter Print Post Top
Invisiblefastfred
Old Hand
Male User Gallery

Folding@home Statistics
Registered: 05/17/04
Posts: 6,899
Loc: Dark side of the moon
Re: information pool: aeruginascin [Re: Zen Peddler]
    #6445540 - 01/10/07 02:37 PM (17 years, 4 months ago)

It probably can't pass the blood-brain barrier. But it still might have interesting peripheral effects.


-FF

Extras: Filter Print Post Top
OfflineExplosiveMango
HallucinogenusDigitallus
Male User Gallery

Registered: 07/12/05
Posts: 3,222
Last seen: 14 years, 6 months
Re: information pool: aeruginascin [Re: fastfred]
    #6461403 - 01/15/07 07:26 AM (17 years, 4 months ago)

Yeah I also read it cannot pass the blood brain barrier, due to the ammonium component.


--------------------
Know your self.
Know your substance.
Know your source.

The most distorted perspective possible is the perspective that yours is not distorted.

Extras: Filter Print Post Top
Invisiblefastfred
Old Hand
Male User Gallery

Folding@home Statistics
Registered: 05/17/04
Posts: 6,899
Loc: Dark side of the moon
Re: information pool: aeruginascin [Re: ExplosiveMango]
    #6461708 - 01/15/07 10:10 AM (17 years, 4 months ago)

That's all just speculation. Gartz isolated it though so you would think that he would have tested that aspect. OTOH in the paper he used only small amounts for the experiments.

The extraction and chromatographic separation of aeruginascin is described in the paper, so it wouldn't be all that hard to get some pure aeruginascin to test out. All you'd need is a supply of Inocybe aeruginascens, some common solvents, and a chromatography column.

Muscarine (another quaternary ammonium compound) can't pass the BBB, but it's quite polar.

Aeruginascin is fairly polar, but if it is dephosphorylated in the same way that psilocybin is, then it's dephosphorylated counterpart would be significantly less polar.

Choline is actively transported across the BBB. It has a quaternary ammonium on one end and a hydroxyl group on the other end. That makes it somewhat similar to dephosphorylated aeruginascin. Perhaps the choline BB transport mechanism would also transport aeruginascin!

Here are a few snips...

"The BBB choline transporter transports choline, and perhaps other quaternary ammonium molecules."

"CMT systems for hexoses, monocarboxylic acids such as lactic acid, neutral amino acids such as phenylalanine, basic amino acids such as arginine, quaternary ammonium molecules such as choline, purine nucleosides such as adenosine, and purine bases such as adenine, are shown in Figure 5, which represents the luminal membrane of the brain capillary endothelium."

"It is suggested that hematoencephalic barrier of mice is permeable to quarternary ammonium compounds. The differences in the central effects of the tertiary and quaternary ammonium bases in animals should not be attributed to the varying hematoencephalic barrier."


So just the quaternary ammonium component doesn't necessarily mean that it can't pass the BBB.


-FF

Extras: Filter Print Post Top
OfflineExplosiveMango
HallucinogenusDigitallus
Male User Gallery

Registered: 07/12/05
Posts: 3,222
Last seen: 14 years, 6 months
Re: information pool: aeruginascin [Re: fastfred]
    #6463016 - 01/15/07 04:43 PM (17 years, 4 months ago)

Ah... well I was just regurgitating from the PDF anyway, haha. Haven't done my neuro chem degree just yet. :smile:


--------------------
Know your self.
Know your substance.
Know your source.

The most distorted perspective possible is the perspective that yours is not distorted.

Extras: Filter Print Post Top
Jump to top Pages: 1

Shop: North Spore North Spore Mushroom Grow Kits & Cultivation Supplies   Left Coast Kratom Buy Kratom Extract   Mushroom-Hut Mono Tub Substrate   OlympusMyco.com Olympus Myco Bulk Substrate   MagicBag.co All-In-One Bags That Don't Suck   PhytoExtractum Maeng Da Thai Kratom Leaf Powder


Similar ThreadsPosterViewsRepliesLast post
* Cultivation of Inocybe aeruginascens? fastfred 9,296 14 04/07/08 02:26 AM
by Ophanim
* kiddie pool croping container random777 2,251 15 02/04/04 12:42 PM
by mycofile
* gene pools and strain degredation BrainFarmer 795 5 06/13/03 04:44 PM
by Raadt
* Mr. G. Wrong Information Again FMRC 1,810 12 05/20/02 11:33 AM
by rain_angel
* radioactive microwave information? BeppoMarx 856 3 10/18/01 10:34 AM
by BeppoMarx
* Composting Information, courtesy EPA germin8tionn8ion 903 4 04/28/04 02:18 AM
by Anno
* Casing mixture Information please themills 1,005 3 07/27/04 05:26 PM
by micro
* A Bibliography of Psychoactive Fungi by MJ and Gartz Joshua 1,190 5 02/17/05 07:31 AM
by mjshroomer

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: RogerRabbit, Pastywhyte, bodhisatta
1,894 topic views. 1 members, 2 guests and 2 web crawlers are browsing this forum.
[ Show Images Only | Sort by Score | Print Topic ]
Search this thread:

Copyright 1997-2024 Mind Media. Some rights reserved.

Generated in 0.02 seconds spending 0.004 seconds on 12 queries.