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Offlineblackparasite
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Registered: 09/03/15
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Mushrooms + Anafranil ?
    #22183984 - 09/03/15 05:35 PM (8 years, 4 months ago)

Has anyone here had experience with using psychedelics, specifically psilocybin mushrooms, alongside chronic administration of Anafranil? Did you find the effects to be diminished, enhanced, changed or unchanged?


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InvisibleZombi3
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Re: Mushrooms + Anafranil ? [Re: blackparasite]
    #22184041 - 09/03/15 05:50 PM (8 years, 4 months ago)

Quote:

BothHands said:
Anafranil acts as a very potent 5-HT2A antagonist, which means it directly blocks the receptor that mushrooms work on.  It has a very strong affinity for the receptor, so in order to knock it off, you would need a psychedelic with a stronger affinity. 



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