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OfflineBANANA.MAN
Turd Ferguson
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Registered: 01/11/15
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Ibuprofen side effects
    #22174305 - 09/01/15 02:46 PM (8 years, 4 months ago)

Hi I just got braces on for the second time and they are causing me alot of pain, i am trying to cut out inflammatory foods from my diet but I have also been taking alot of Ibuprofen which i normally dont take because of the damage I heard it can cause to the liver. I just wanted to know what dose you have to take and in what amount of time to cause side effects like organ damage, and the LD-50 would be good to know too thanks!


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InvisibleSun King
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Re: Ibuprofen side effects [Re: BANANA.MAN]
    #22174414 - 09/01/15 03:15 PM (8 years, 4 months ago)

Take with food and learn to google.


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OfflineBANANA.MAN
Turd Ferguson
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Registered: 01/11/15
Posts: 7,474
Loc: Ontario Canada
Last seen: 6 months, 2 days
Re: Ibuprofen side effects [Re: Sun King]
    #22174571 - 09/01/15 03:57 PM (8 years, 4 months ago)

I have googled it and i can find what the side effects are and what the recomended dose is but not at what does the side effects begin, if you aren't going to answer my question then please do not respond


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InvisibleSun King
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Re: Ibuprofen side effects [Re: BANANA.MAN]
    #22177091 - 09/02/15 05:39 AM (8 years, 4 months ago)

http://livertox.nih.gov/Ibuprofen.htm

Hepatotoxicity

Rates of serum aminotransferase elevations during low-dose, chronic ibuprofen therapy are comparable to those that occur with placebo controls (0.4%).  However, higher rates of ALT elevations occur with high, full doses of 2,400 to 3,200 mg daily (up to 16%). Generally, ALT elevations are mild and rarely above 100 U/L.  Ibuprofen overdose (> 5-10 grams) is characterized by onset of agitation and stupor 3 to 6 hours after ingestion, followed by coma, respiratory depression and lactic acidosis which can be fatal.  Most cases of ibuprofen overdose, however, have not been accompanied by prominent liver injury or jaundice.


Idiosyncratic, clinically apparent liver injury due to ibuprofen is very rare (estimated to occur at a rate of 1.0-1.6 cases per 100,000 prescriptions).  However, several convincing reports have been published of acute liver failure and death attributed to ibuprofen, usually after presentation with an immunoallergic-like reaction within days of starting (Cases 1 and 2). Some instances are associated with severe hypersensitivity reactions, such as Stevens Johnson syndrome or toxic epidermal necrolysis usually with a mixed or cholestatic pattern of liver injury.  The time to onset is usually within a few days to 3 weeks of starting, rare cases arising after 3 to 6 weeks.  Immunoallergic features are prominent (fever, rash, eosinophilia, facial edema, lymphadenopathy).  Most cases are mild-to-moderate in severity and rapidly reversible on stopping ibuprofen. Rare instances of cholestatic liver injury due to ibuprofen were followed by severe, protracted cholestasis, vanishing bile duct syndrome and chronic liver failure (Case 3). 


The appearance of clinically apparent liver injury during long-term or chronic ibuprofen therapy has not been convincingly demonstrated. However, instances of asymptomtic flares of chronic hepatitis C have been reported after initiation of ibuprofen therapy with ALT levels rising to more than 1000 U/L and rapidly resolving with stopping. 



Mechanism of Injury

The mechanism of ibuprofen-induced liver injury is not completely known, but may be multi-factorial. The rapid onset suggests a toxic metabolic by-product, while the hypersensitivity responses that accompany the liver injury point to an immuno-allergic reaction.



Outcome and Management

The severity of the liver injury from ibuprofen ranges from asymptomatic elevations in serum aminotransferase levels to acute cholestatic hepatitis to acute liver failure and the need for transplantation. Several instances of chronic vanishing bile duct syndrome have been attributed to ibuprofen use. In most instances, however, complete recovery is expected after stopping the drug and usually takes several months.  Re-exposure to ibuprofen usually causes recurrence of the hepatic injury and should be avoided.  There is little information on cross-sensitivity to liver injury among the various NSAIDs, but it is probably prudent to avoid the other propionic acid forms (naproxen, oxaprozin, fenoprofen among others) and to monitor patients carefully who start other forms of NSAIDs.


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Edited by Sun King (09/02/15 06:41 AM)


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OfflineBANANA.MAN
Turd Ferguson
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Registered: 01/11/15
Posts: 7,474
Loc: Ontario Canada
Last seen: 6 months, 2 days
Re: Ibuprofen side effects [Re: Sun King]
    #22179659 - 09/02/15 07:02 PM (8 years, 4 months ago)

Thank you! You even gave me the mechanism of injury which is more than i asked for. I should be fine, I am not taking more than 2 grams a day for a few days each time I get my braces tightened which is every 2 months. Thanks man I appreciate it.


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