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InvisibleNiffla
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Registered: 06/09/08
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Hypothetical question about LSD tolerance
    #22127182 - 08/22/15 02:02 PM (8 years, 5 months ago)

Let's assume each trip is in the same exact set & setting.

TRIP A) You haven't tripped in two full months. Your dosage is 150 mcg, and you also smoke weed on this trip.

TRIP B) This trip comes exactly 6 full days after trip A. It also is a 150 mcg dose. But this time, the trip is weed free.

Is trip A, due to the fact that there were two months between trips (and add in the weed factor as well) guaranteed to be the harder of the two trips 100 out of 100 times?


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Edited by Niffla (08/22/15 02:03 PM)


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OfflineStarless
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Registered: 05/05/14
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Re: Hypothetical question about LSD tolerance [Re: Niffla]
    #22127230 - 08/22/15 02:16 PM (8 years, 5 months ago)

Quote:

Niffla said:
Let's assume each trip is in the same exact set & setting.

TRIP A) You haven't tripped in two full months. Your dosage is 150 mcg, and you also smoke weed on this trip.

TRIP B) This trip comes exactly 6 full days after trip A. It also is a 150 mcg dose. But this time, the trip is weed free.

Is trip A, due to the fact that there were two months between trips (and add in the weed factor as well) guaranteed to be the harder of the two trips 100 out of 100 times?




I would say that trip A is almost guaranteed to be stronger. I would recommend waiting longer than six days between trips of the same substance or cross-tolerant substances, two weeks seems to work well for most people. Keep in mind that while setting can be made consistent, it's virtually impossible to have exactly the same set on two different trips, so YMMV.


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Think, it ain't illegal yet. - George Clinton

Substances I have allegedly taken: Cannabis (bud, edibles, and concentrates), Mushrooms (P. Cubensis), LSD, ETH-LAD, ALD-52, DMT, MDMA, Mescaline (Peruvian Torch), 25I-NBOMe, Salvia Divinorum (10x), Syrian Rue, Amanita Muscaria (10x), Cocaine, Nightshade (Henbane).

All posts are hypothetical or entirely fictional.


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InvisibleNiffla
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Registered: 06/09/08
Posts: 46,489
Loc: Texas
Re: Hypothetical question about LSD tolerance [Re: Starless]
    #22127293 - 08/22/15 02:28 PM (8 years, 5 months ago)

Quote:

Starless said:
Keep in mind that while setting can be made consistent, it's virtually impossible to have exactly the same set on two different trips, so YMMV.




Yeah that's true. Well, for argument's sake -- as close as the set can be, I guess.


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OfflineSabnock
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Registered: 01/02/14
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Re: Hypothetical question about LSD tolerance [Re: Niffla]
    #22127355 - 08/22/15 02:42 PM (8 years, 5 months ago)

If i had access to L, i'd try mixing it with some Rue or Moclobemide, it might counteract the down-regulation of the receptors L binds to, and could potentially remove tolerance. Some say L doesn't work well with MAO-A inhibition, but then again i don't think people have experimented around with the combo enough to really say for sure. I would most certainly try it, perhaps i will one day when L is around my parts again.


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