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rxb
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HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED
#22090617 - 08/14/15 10:34 AM (8 years, 5 months ago) |
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http://www.popsci.com/home-brewed-synthetic-opioids-are-finally-reality
HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED By Alexandra Ossola Posted Yesterday at 2:00pm 6
Yeast growing in a petri dish Stephanie Galanie Pain-relieving opioids, like morphine or codeine, are important for medical purposes. The drugs have been around for millennia however even today they are still made from poppy flowers, making the production of the drugs dependent on poppy farming. Now, for the first time, researchers from Stanford University have been able to synthesize opioids from yeast cultures grown in the lab, according to a study published today in Science. This isn’t the first attempt to synthesize opioids. Researchers have been trying to do it for years in order to produce opioids more quickly, or even alter them to be less addictive. But the poppy plant’s chemical processes proved to be surprisingly difficult to replicate in the lab—in the most recent attempt, earlier this year, the researchers only made it two-thirds of the way to a full opioid. But this study was different. The researchers engineered yeast to first synthesize thebaine, a basic ingredient and precursor to producing opioids, over a 72 hour period and using sugar as a food source. By further engineering the yeast they created hydrocodone, a common semi-synthetic opioid. The final pathway that yielded the hydrocodone, their final product, expressed 23 different enzymes usually found in plants, mammals, bacteria, and yeast. The researchers note that this study was merely a proof of concept—the amount of opioid that the yeast can synthesize is way too small to make it commercially viable. That’ll also prevent those inclined to abuse them from making opioids at home. They write: “…a single dose of hydrocodone, as used in Vicodin, would require thousands of liters of fermentation broth, which no home brewer would reasonably pursue.” But that being said, in the next few years they do hope to engineer yeast that can produce much higher yields of opioids so that it can be commercially viable. No word on whether that will also bring brewed opiates into people's homes, too.
-------------------- ->$10 FLOW HOOD ALTERNATIVE <- . i cleaned a mold contaminated live culture and saved it. (might have useful applications) [quote]Enlil said: I'd be the guy with thousands of minions doing my bidding and all of the hot women locked in a cage for my use.[/quote]
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Scudreloaded
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: rxb]
#22090654 - 08/14/15 10:51 AM (8 years, 5 months ago) |
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pitty opioids are so addictive i'm all for new things being synthed, just hope it only gets into the right and proper hands and opiate addiction is a horrible thing
-------------------- We were somewhere around Barstow on the edge of the desert when the drugs began to take hold. - Hunter S. Thompson
- believe what you may but take the internet with a grain of salt
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LuSiD enthusiast
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Scudreloaded] 4
#22090805 - 08/14/15 11:33 AM (8 years, 5 months ago) |
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This exact article gets posted like every month.
-------------------- I'm addicted to coke, weed, booze, ludes and speed. Not LSD, you can't get addicted to LSD, it was built by scientists. I ain't got no demons that gonna get woke. In erowid we trust. Just take your damn pills and don't ask any questions, you'll be fine.
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rxb
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: LuSiD enthusiast]
#22090902 - 08/14/15 12:02 PM (8 years, 5 months ago) |
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this exact article was posted in popular science yesterday at 2pm according to the byline.
Quote:
By Alexandra Ossola Posted Yesterday at 2:00pm
so if she's plagiarizing your should notify the popsci editors
and if not, you should look into the definition of exact.
Edited by rxb (08/14/15 12:05 PM)
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Yukon Cornelius
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: rxb]
#22090955 - 08/14/15 12:16 PM (8 years, 5 months ago) |
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Yeah I've seen the information in this article before, however the previous one was written in a way that implied it is still in development.
This might be the announcement of it being a successful process, just a matter of time before those cultures go loose on the black market.
-------------------- "I didn't know chicken's wore suspenders" - Towelie
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Psilosopherr
A psilly goose



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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Yukon Cornelius]
#22090997 - 08/14/15 12:25 PM (8 years, 5 months ago) |
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This wasn't new info to me either
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rxb
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Psilosopherr]
#22091002 - 08/14/15 12:26 PM (8 years, 5 months ago) |
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it wasnt new info to any of us as we've discussed it before, i do think there were some developments and published work added.
-------------------- ->$10 FLOW HOOD ALTERNATIVE <- . i cleaned a mold contaminated live culture and saved it. (might have useful applications) [quote]Enlil said: I'd be the guy with thousands of minions doing my bidding and all of the hot women locked in a cage for my use.[/quote]
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LuSiD enthusiast
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Psilosopherr]
#22092342 - 08/14/15 06:45 PM (8 years, 5 months ago) |
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Quote:
rbalzer said: This wasn't new info to me either 
Idk how anyone could forget a scientific breakthrough like that.
-------------------- I'm addicted to coke, weed, booze, ludes and speed. Not LSD, you can't get addicted to LSD, it was built by scientists. I ain't got no demons that gonna get woke. In erowid we trust. Just take your damn pills and don't ask any questions, you'll be fine.
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Salomon
ಠ︵ಠ balance ಠ_ಠ weaver ಠ‿ಠ

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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: LuSiD enthusiast] 1
#22093141 - 08/15/15 12:04 AM (8 years, 5 months ago) |
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soo..... whose gonna send me a yeast culture?
-------------------- EVERYTHING EVENTUALLY BECOMES A DESERT
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Laughingcowwa
Your mum loves it.



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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Salomon]
#22093189 - 08/15/15 12:31 AM (8 years, 5 months ago) |
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I like it a lot, start of a beautiful thing.
-------------------- Those who doubt me, suck cock by choice
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Ogla



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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Salomon]
#22093221 - 08/15/15 12:56 AM (8 years, 5 months ago) |
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Quote:
Salomon said: soo..... whose gonna send me a yeast culture? 
I'd like some of that culture too
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rxb
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Ogla] 1
#22093550 - 08/15/15 05:03 AM (8 years, 5 months ago) |
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so much culture in the myco community
-------------------- ->$10 FLOW HOOD ALTERNATIVE <- . i cleaned a mold contaminated live culture and saved it. (might have useful applications) [quote]Enlil said: I'd be the guy with thousands of minions doing my bidding and all of the hot women locked in a cage for my use.[/quote]
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Psilosopherr
A psilly goose



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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: rxb]
#22095481 - 08/15/15 04:23 PM (8 years, 5 months ago) |
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Quote:
rxb said: so much culture in the myco community
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Pastywhyte
Say hello to my little friend



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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Psilosopherr]
#22095898 - 08/15/15 06:10 PM (8 years, 5 months ago) |
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Alert me when they can do this with LSD. . .
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CLIT
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Scudreloaded]
#22100883 - 08/16/15 10:59 PM (8 years, 5 months ago) |
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I still haven't tried any percocets or opioids. I wonder what's so addictive about it.
Quote:
Scudreloaded said: pitty opioids are so addictive i'm all for new things being synthed, just hope it only gets into the right and proper hands and opiate addiction is a horrible thing
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sunkeep
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Pastywhyte]
#22101367 - 08/17/15 02:44 AM (8 years, 5 months ago) |
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Quote:
Pastywhyte said: Alert me when they can do this with LSD. . .
Won't happen, sorry
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Salomon
ಠ︵ಠ balance ಠ_ಠ weaver ಠ‿ಠ

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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: sunkeep]
#22101383 - 08/17/15 03:08 AM (8 years, 5 months ago) |
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Quote:
sunkeep said:
Quote:
Pastywhyte said: Alert me when they can do this with LSD. . .
Won't happen, sorry 
well it could sort of happen, you could engineer yeast tyo make efficient precursor to, or perhaps lyersgic acid itself.
you'd still need to either synthesize lysergic acid out of the precursor, and some how acquire diethylamide
and do some chemistry
-------------------- EVERYTHING EVENTUALLY BECOMES A DESERT
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rxb
n00b-sabot


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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Salomon]
#22101421 - 08/17/15 04:04 AM (8 years, 5 months ago) |
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Quote:
Salomon said:
Quote:
sunkeep said:
Quote:
Pastywhyte said: Alert me when they can do this with LSD. . .
Won't happen, sorry 
well it could sort of happen, you could engineer yeast tyo make efficient precursor to, or perhaps lyersgic acid itself.
you'd still need to either synthesize lysergic acid out of the precursor, and some how acquire diethylamide
and do some chemistry
he still wont be alerted.
-------------------- ->$10 FLOW HOOD ALTERNATIVE <- . i cleaned a mold contaminated live culture and saved it. (might have useful applications) [quote]Enlil said: I'd be the guy with thousands of minions doing my bidding and all of the hot women locked in a cage for my use.[/quote]
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sunkeep
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Salomon]
#22101813 - 08/17/15 08:06 AM (8 years, 5 months ago) |
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Quote:
Salomon said:
Quote:
sunkeep said:
Quote:
Pastywhyte said: Alert me when they can do this with LSD. . .
Won't happen, sorry 
well it could sort of happen, you could engineer yeast tyo make efficient precursor to, or perhaps lyersgic acid itself.
you'd still need to either synthesize lysergic acid out of the precursor, and some how acquire diethylamide
and do some chemistry
Lysergic acid producing yeast have been engineered. LSD cannot be produced biosynthetically because there is no enzyme to add diethylamine to the carboxyl group in the acid. Unless you engineer such an enzyme yourself you'd find yourself relying on highly qualified chemists for all your LSD needs.
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LuSiD enthusiast
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Salomon]
#22103012 - 08/17/15 02:33 PM (8 years, 5 months ago) |
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Quote:
Salomon said:
Quote:
sunkeep said:
Quote:
Pastywhyte said: Alert me when they can do this with LSD. . .
Won't happen, sorry 
well it could sort of happen, you could engineer yeast tyo make efficient precursor to, or perhaps lyersgic acid itself.
you'd still need to either synthesize lysergic acid out of the precursor, and some how acquire diethylamide
and do some chemistry
I've read somewhere that you can distill diethelymide from deet(chemical in bug spray right?)
So all you gotta do is boil a bunch of bug spray, and mix it in with some ergot and voila, your own batch of lsd. I'll try some of it after one of you guys try this of course.
-------------------- I'm addicted to coke, weed, booze, ludes and speed. Not LSD, you can't get addicted to LSD, it was built by scientists. I ain't got no demons that gonna get woke. In erowid we trust. Just take your damn pills and don't ask any questions, you'll be fine.
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Stonehenge
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: LuSiD enthusiast]
#22112914 - 08/19/15 04:34 PM (8 years, 5 months ago) |
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Those specially engineered yeast cultures lose the special genes that were inserted in them rapidly. The reason is that it does not give any advantage to the yeast, they have no use for opiods. So the yeast that does not produce it out multiplies the yeast that does which gets buried in the pack and finally vanishes. That is probably the main reason they could only make a tiny tiny bit of opiods. Its just a proof of concept not a workable plan.
-------------------- “A democracy cannot exist as a permanent form of government. It can only exist until the voters discover that they can vote themselves largesse from the public treasury. From that moment on, the majority always votes for the candidates promising the most benefits from the public treasury with the result that a democracy always collapses over loose fiscal policy, always followed by a dictatorship.” (attributed to Alexis de Tocqueville political philosopher Circa 1835) Trade list http://www.shroomery.org/forums/showflat.php/Number/18047755
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Psilosopherr
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Stonehenge]
#22113189 - 08/19/15 05:33 PM (8 years, 5 months ago) |
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Quote:
Stonehenge said: Those specially engineered yeast cultures lose the special genes that were inserted in them rapidly. The reason is that it does not give any advantage to the yeast, they have no use for opiods. So the yeast that does not produce it out multiplies the yeast that does which gets buried in the pack and finally vanishes. That is probably the main reason they could only make a tiny tiny bit of opiods. Its just a proof of concept not a workable plan.
do poppy plants have use for opiods? Do any psychoactive plants have use for their alkaloids?
(not trying to poke holes in your statement; thats a genuine question)
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Stonehenge
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Psilosopherr]
#22113217 - 08/19/15 05:39 PM (8 years, 5 months ago) |
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>do poppy plants have use for opiods? Do any psychoactive plants have use for their alkaloids?
Of course. Poppy alkaloids are known to induce sedation and even death. An animal who is buzzed on morphine will likely get caught by a predator. Some compounds are just really nasty tasting as well as having psychoactive properties which helps the plant survive.
-------------------- “A democracy cannot exist as a permanent form of government. It can only exist until the voters discover that they can vote themselves largesse from the public treasury. From that moment on, the majority always votes for the candidates promising the most benefits from the public treasury with the result that a democracy always collapses over loose fiscal policy, always followed by a dictatorship.” (attributed to Alexis de Tocqueville political philosopher Circa 1835) Trade list http://www.shroomery.org/forums/showflat.php/Number/18047755
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Psilosopherr
A psilly goose



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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Stonehenge]
#22113325 - 08/19/15 06:01 PM (8 years, 5 months ago) |
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Quote:
Stonehenge said: >do poppy plants have use for opiods? Do any psychoactive plants have use for their alkaloids?
Of course. Poppy alkaloids are known to induce sedation and even death. An animal who is buzzed on morphine will likely get caught by a predator. Some compounds are just really nasty tasting as well as having psychoactive properties which helps the plant survive.
its all so obvious now
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KrishnaDreamer
I bleed nicotine...


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Posts: 4,132
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Scudreloaded]
#22173412 - 09/01/15 10:27 AM (8 years, 4 months ago) |
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Quote:
Scudreloaded said: pitty opioids are so addictive i'm all for new things being synthed, just hope it only gets into the right and proper hands and opiate addiction is a horrible thing
The only reason opiate addiction is bad is because it is so scarce and expensive. Imagine if you could get a dose of an opiate for 1 cent.
-------------------- Everybody's a ninja...
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rxb
n00b-sabot



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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: KrishnaDreamer]
#22174225 - 09/01/15 02:25 PM (8 years, 4 months ago) |
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my opiate habit is about $1 a day.
its not too bad, id prefer to not pay it.
-------------------- ->$10 FLOW HOOD ALTERNATIVE <- . i cleaned a mold contaminated live culture and saved it. (might have useful applications) [quote]Enlil said: I'd be the guy with thousands of minions doing my bidding and all of the hot women locked in a cage for my use.[/quote]
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Psilosopherr
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: rxb]
#22175028 - 09/01/15 06:07 PM (8 years, 4 months ago) |
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a dollar a day? Jesus. How is it even possible to get enough of an opiate to get high for one dollar?
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KrishnaDreamer
I bleed nicotine...


Registered: 09/23/07
Posts: 4,132
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Psilosopherr]
#22175530 - 09/01/15 08:02 PM (8 years, 4 months ago) |
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Mine was pretty much free since I was dealing... But I rarely made any money. But shit, whenever my dealers went to jail, or they couldn't reup for some reason, all hell broke loose.
Also, if I could get and stay high for a dollar a day... Shit, sign me up. Hah, like those "save starving African children" commercials... "For just fifty cents a day, you can help a junkie in need of your help.".
-------------------- Everybody's a ninja...
Edited by KrishnaDreamer (09/01/15 08:08 PM)
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fapjack
Title



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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: KrishnaDreamer]
#22175823 - 09/01/15 09:01 PM (8 years, 4 months ago) |
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Methadone is pretty cheap. I was prescribed 120 mgs of oxycodone a day and it cost me like $4.00 per day, didn't make my life any easier. Opioid addiction sucks because it's an empty existence, though the whole difficulty supporting a habit certainly adds to it.
--------------------
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rxb
n00b-sabot



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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Psilosopherr]
#22175919 - 09/01/15 09:23 PM (8 years, 4 months ago) |
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Quote:
rbalzer said: a dollar a day? Jesus. How is it even possible to get enough of an opiate to get high for one dollar?
50mics per hour fentynal costs me about $1 a day. its the equivilant of about 40mg of hydrophone (dilaudid) orally.
its a pretty hefty amount.
-------------------- ->$10 FLOW HOOD ALTERNATIVE <- . i cleaned a mold contaminated live culture and saved it. (might have useful applications) [quote]Enlil said: I'd be the guy with thousands of minions doing my bidding and all of the hot women locked in a cage for my use.[/quote]
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KrishnaDreamer
I bleed nicotine...


Registered: 09/23/07
Posts: 4,132
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: rxb]
#22176703 - 09/02/15 12:57 AM (8 years, 4 months ago) |
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I'm on 80mg meth a day, down from 170. Methadone is like the miracle drug, the only pain in the ass is going to the clinic every day. Wouldn't consider my existence meaningless at all.
I can't deny it, I fucking love opiates.
-------------------- Everybody's a ninja...
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