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Onlinerxb
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HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED
    #22090617 - 08/14/15 10:34 AM (8 years, 5 months ago)

http://www.popsci.com/home-brewed-synthetic-opioids-are-finally-reality

HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY
NO POPPIES REQUIRED
By Alexandra Ossola  Posted Yesterday at 2:00pm
  6

Yeast growing in a petri dish
Stephanie Galanie
Pain-relieving opioids, like morphine or codeine, are important for medical purposes. The drugs have been around for millennia however even today they are still made from poppy flowers, making the production of the drugs dependent on poppy farming. Now, for the first time, researchers from Stanford University have been able to synthesize opioids from yeast cultures grown in the lab, according to a study published today in Science.
This isn’t the first attempt to synthesize opioids. Researchers have been trying to do it for years in order to produce opioids more quickly, or even alter them to be less addictive. But the poppy plant’s chemical processes proved to be surprisingly difficult to replicate in the lab—in the most recent attempt, earlier this year, the researchers only made it two-thirds of the way to a full opioid.
But this study was different. The researchers engineered yeast to first synthesize thebaine, a basic ingredient and precursor to producing opioids, over a 72 hour period and using sugar as a food source. By further engineering the yeast they created hydrocodone, a common semi-synthetic opioid. The final pathway that yielded the hydrocodone, their final product, expressed 23 different enzymes usually found in plants, mammals, bacteria, and yeast.
The researchers note that this study was merely a proof of concept—the amount of opioid that the yeast can synthesize is way too small to make it commercially viable. That’ll also prevent those inclined to abuse them from making opioids at home. They write: “…a single dose of hydrocodone, as used in Vicodin, would require thousands of liters of fermentation broth, which no home brewer would reasonably pursue.” But that being said, in the next few years they do hope to engineer yeast that can produce much higher yields of opioids so that it can be commercially viable. No word on whether that will also bring brewed opiates into people's homes, too.


--------------------
->$10 FLOW HOOD ALTERNATIVE <-

. i cleaned a mold contaminated live culture and saved it. (might have useful applications)

[quote]Enlil said:
I'd be the guy with thousands of minions doing my bidding and all of the hot women locked in a cage for my use.[/quote]


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InvisibleScudreloaded
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: rxb]
    #22090654 - 08/14/15 10:51 AM (8 years, 5 months ago)

pitty opioids are so addictive
i'm all for new things being synthed, just hope it only gets into the right and proper hands
and opiate addiction is a horrible thing


--------------------
We were somewhere around Barstow on the edge of the desert when the drugs began to take hold. - Hunter S. Thompson

- believe what you may but take the internet with a grain of salt


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OfflineLuSiD enthusiast
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Scudreloaded] * 4
    #22090805 - 08/14/15 11:33 AM (8 years, 5 months ago)

This exact article gets posted like every month.


--------------------
I'm addicted to coke, weed, booze, ludes and speed.
Not LSD, you can't get addicted to LSD, it was built by scientists.

I ain't got no demons that gonna get woke.


In erowid we trust.

Just take your damn pills and don't ask any questions, you'll be fine.


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Onlinerxb
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: LuSiD enthusiast]
    #22090902 - 08/14/15 12:02 PM (8 years, 5 months ago)

this exact article was posted in popular science yesterday at 2pm according to the byline.

Quote:

By Alexandra Ossola  Posted Yesterday at 2:00pm




so if she's plagiarizing your should notify the popsci editors

and if not, you should look into the definition of exact.


Edited by rxb (08/14/15 12:05 PM)


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OfflineYukon Cornelius
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: rxb]
    #22090955 - 08/14/15 12:16 PM (8 years, 5 months ago)

Yeah I've seen the information in this article before, however the previous one was written in a way that implied it is still in development.

This might be the announcement of it being a successful process, just a matter of time before those cultures go loose on the black market. :excellent:


--------------------
"I didn't know chicken's wore suspenders" - Towelie



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OfflinePsilosopherr
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Yukon Cornelius]
    #22090997 - 08/14/15 12:25 PM (8 years, 5 months ago)

This wasn't new info to me either :shrug:


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Onlinerxb
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Psilosopherr]
    #22091002 - 08/14/15 12:26 PM (8 years, 5 months ago)

it wasnt new info to any of us as we've discussed it before, i do think there were some developments and published work added.


--------------------
->$10 FLOW HOOD ALTERNATIVE <-

. i cleaned a mold contaminated live culture and saved it. (might have useful applications)

[quote]Enlil said:
I'd be the guy with thousands of minions doing my bidding and all of the hot women locked in a cage for my use.[/quote]


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OfflineLuSiD enthusiast
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Psilosopherr]
    #22092342 - 08/14/15 06:45 PM (8 years, 5 months ago)

Quote:

rbalzer said:
This wasn't new info to me either :shrug:



Idk how anyone could forget a scientific breakthrough like that.


--------------------
I'm addicted to coke, weed, booze, ludes and speed.
Not LSD, you can't get addicted to LSD, it was built by scientists.

I ain't got no demons that gonna get woke.


In erowid we trust.

Just take your damn pills and don't ask any questions, you'll be fine.


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InvisibleSalomon
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: LuSiD enthusiast] * 1
    #22093141 - 08/15/15 12:04 AM (8 years, 5 months ago)

soo..... whose gonna send me a yeast culture? :aweohyou:


--------------------
EVERYTHING EVENTUALLY BECOMES A DESERT



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OfflineLaughingcowwa
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Salomon]
    #22093189 - 08/15/15 12:31 AM (8 years, 5 months ago)

I like it a lot, start of a beautiful thing.


--------------------
Those who doubt me, suck cock by choice


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InvisibleOgla
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Salomon]
    #22093221 - 08/15/15 12:56 AM (8 years, 5 months ago)

Quote:

Salomon said:
soo..... whose gonna send me a yeast culture? :aweohyou:




I'd like some of that culture too


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Onlinerxb
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Ogla] * 1
    #22093550 - 08/15/15 05:03 AM (8 years, 5 months ago)

so much culture in the myco community


--------------------
->$10 FLOW HOOD ALTERNATIVE <-

. i cleaned a mold contaminated live culture and saved it. (might have useful applications)

[quote]Enlil said:
I'd be the guy with thousands of minions doing my bidding and all of the hot women locked in a cage for my use.[/quote]


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OfflinePsilosopherr
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: rxb]
    #22095481 - 08/15/15 04:23 PM (8 years, 5 months ago)

Quote:

rxb said:
so much culture in the myco community



:ohyou:


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InvisiblePastywhyteMDiscord
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Psilosopherr]
    #22095898 - 08/15/15 06:10 PM (8 years, 5 months ago)

Alert me when they can do this with LSD. . .


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OfflineCLIT
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Scudreloaded]
    #22100883 - 08/16/15 10:59 PM (8 years, 5 months ago)

I still haven't tried any percocets or opioids. I wonder what's so addictive about it.

Quote:

Scudreloaded said:
pitty opioids are so addictive
i'm all for new things being synthed, just hope it only gets into the right and proper hands
and opiate addiction is a horrible thing




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Offlinesunkeep
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Pastywhyte]
    #22101367 - 08/17/15 02:44 AM (8 years, 5 months ago)

Quote:

Pastywhyte said:
Alert me when they can do this with LSD. . .



Won't happen, sorry :shrug:


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InvisibleSalomon
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: sunkeep]
    #22101383 - 08/17/15 03:08 AM (8 years, 5 months ago)

Quote:

sunkeep said:
Quote:

Pastywhyte said:
Alert me when they can do this with LSD. . .



Won't happen, sorry :shrug:





well it could sort of happen, you could engineer yeast tyo make efficient precursor to, or perhaps lyersgic acid itself.


you'd still need to either synthesize lysergic acid out of the precursor, and some how acquire diethylamide

and do some chemistry


--------------------
EVERYTHING EVENTUALLY BECOMES A DESERT



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Onlinerxb
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Salomon]
    #22101421 - 08/17/15 04:04 AM (8 years, 5 months ago)

Quote:

Salomon said:
Quote:

sunkeep said:
Quote:

Pastywhyte said:
Alert me when they can do this with LSD. . .



Won't happen, sorry :shrug:





well it could sort of happen, you could engineer yeast tyo make efficient precursor to, or perhaps lyersgic acid itself.


you'd still need to either synthesize lysergic acid out of the precursor, and some how acquire diethylamide

and do some chemistry




he still wont be alerted.


--------------------
->$10 FLOW HOOD ALTERNATIVE <-

. i cleaned a mold contaminated live culture and saved it. (might have useful applications)

[quote]Enlil said:
I'd be the guy with thousands of minions doing my bidding and all of the hot women locked in a cage for my use.[/quote]


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Offlinesunkeep
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Salomon]
    #22101813 - 08/17/15 08:06 AM (8 years, 5 months ago)

Quote:

Salomon said:
Quote:

sunkeep said:
Quote:

Pastywhyte said:
Alert me when they can do this with LSD. . .



Won't happen, sorry :shrug:





well it could sort of happen, you could engineer yeast tyo make efficient precursor to, or perhaps lyersgic acid itself.


you'd still need to either synthesize lysergic acid out of the precursor, and some how acquire diethylamide

and do some chemistry



Lysergic acid producing yeast have been engineered. LSD cannot be produced biosynthetically because there is no enzyme to add diethylamine to the carboxyl group in the acid. Unless you engineer such an enzyme yourself you'd find yourself relying on highly qualified chemists for all your LSD needs.


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OfflineLuSiD enthusiast
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Re: HOME-BREWED SYNTHETIC OPIOIDS ARE FINALLY A REALITY NO POPPIES REQUIRED [Re: Salomon]
    #22103012 - 08/17/15 02:33 PM (8 years, 5 months ago)

Quote:

Salomon said:
Quote:

sunkeep said:
Quote:

Pastywhyte said:
Alert me when they can do this with LSD. . .



Won't happen, sorry :shrug:





well it could sort of happen, you could engineer yeast tyo make efficient precursor to, or perhaps lyersgic acid itself.


you'd still need to either synthesize lysergic acid out of the precursor, and some how acquire diethylamide

and do some chemistry



I've read somewhere that you can distill diethelymide from deet(chemical in bug spray right?)

So all you gotta do is boil a bunch of bug spray, and mix it in with some ergot and voila, your own batch of lsd. I'll try some of it after one of you guys try this of course.:lol:


--------------------
I'm addicted to coke, weed, booze, ludes and speed.
Not LSD, you can't get addicted to LSD, it was built by scientists.

I ain't got no demons that gonna get woke.


In erowid we trust.

Just take your damn pills and don't ask any questions, you'll be fine.


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