Home | Community | Message Board

Cannabis Seeds - Original Sensible Seeds
This site includes paid links. Please support our sponsors.


Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Shop: North Spore Cultivation Supplies   PhytoExtractum Buy Bali Kratom Powder   Kraken Kratom Kratom Capsules for Sale, Red Vein Kratom

Jump to first unread post Pages: < Back | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | Next >
OfflineRebelutionsssss
Mdmazing
I'm a teapot User Gallery


Registered: 07/23/14
Posts: 13,137
Loc: San Francisco
Last seen: 2 years, 2 months
Re: How dangerous do you guys feel MDMA truly is? [Re: Gottaloveacid]
    #22079522 - 08/12/15 12:26 AM (8 years, 5 months ago)

Thanks for posting that man! I'm going to be looking into some more recent studies tonight and see if I can't find some reliable evidence :cheers:


--------------------
:
To define is to confine.


Extras: Filter Print Post Top
Invisible404
error
 User Gallery

Registered: 08/20/10
Posts: 14,539
Re: How dangerous do you guys feel MDMA truly is? [Re: Sophistic Radiance]
    #22079533 - 08/12/15 12:29 AM (8 years, 5 months ago)

>>it would rapidly accumulate in the tetrabenzine receptors and physically block it off

you mean to say that methamphetamine has a higher affinity for that binding site on the VMAT2 than tetrabenzine, right? then, if meth binds to that site, that is how it shuts down the transporter protein

do ketones make a molecule less electronegative or less polar?


Extras: Filter Print Post Top
InvisibleSophistic Radiance
Free sVs!
Female

Registered: 07/11/06
Posts: 43,135
Loc: Center of the Universe
Re: How dangerous do you guys feel MDMA truly is? [Re: 404] * 1
    #22079549 - 08/12/15 12:35 AM (8 years, 5 months ago)

Ketones would make a molecule more electronegative, since oxygen is electronegative, and if this electronegativity is localized (i.e. the ketone group is isolated from adjacent electronegative elements or double bonds) they also make it more polar. But in the case of tetrabenezine, that aromatic chain is also highly electronegative due to those two -O-CH3 groups hanging off the side, so tetrabenazine is less polar due to its relatively even distribution of negative charge.

Nitrogen is not as electronegative as oxygen, but the fact that it is the only electronegative component of meth, and very localized, compared with the broadly distributed electronegative components of tetrabenazine, probably makes it more polar in spite of being less electronegative and thus more prone to rapid buildup, especially considering it is so much smaller and simpler of a molecule.


Extras: Filter Print Post Top
OfflineBitter Cactus
reformed bad boy
 User Gallery

Registered: 01/26/12
Posts: 11,773
Loc: Alberta, Canada
Last seen: 8 years, 4 months
Re: How dangerous do you guys feel MDMA truly is? [Re: mollymadman]
    #22079554 - 08/12/15 12:37 AM (8 years, 5 months ago)

Quote:

mollymadman said:
All I can say is that I do MDMA about once a week and I'm fine. You feel shitty for a few days but you just gotta sleep for a day and youll be fine. I usually dose about 300-400mg when I do it over the course of a night. Sometimes less tho. Tolerance sucks.





Holy shit! All I can say is god bless you that is gonna catch up to you mighty fast. I found when doing MDMA once a month my concentration was absolutely shot and I became depressed.

Good luck, you are going to need it. That must be so tough on your brain your serotonin levels are always gonna be very low unless you are peaking on the MDMA.


Honestly you should only be using it maybe three times a year max. Obviously people break those rules but I think even doing it monthly catches up on you.


--------------------
Taking acid and thinking you are a better man is a lot different then actually becoming a better man.




Edited by Bitter Cactus (08/12/15 12:38 AM)


Extras: Filter Print Post Top
Offlinemollymadman
love each other :)

Registered: 08/12/15
Posts: 456
Last seen: 8 years, 3 months
Re: How dangerous do you guys feel MDMA truly is? [Re: Bitter Cactus]
    #22079561 - 08/12/15 12:41 AM (8 years, 5 months ago)

Quote:

Bitter Cactus said:
Quote:

mollymadman said:
All I can say is that I do MDMA about once a week and I'm fine. You feel shitty for a few days but you just gotta sleep for a day and youll be fine. I usually dose about 300-400mg when I do it over the course of a night. Sometimes less tho. Tolerance sucks.





Holy shit! All I can say is god bless you that is gonna catch up to you mighty fast. I found when doing MDMA once a month my concentration was absolutely shot and I became depressed.

Good luck, you are going to need it. That must be so tough on your brain your serotonin levels are always gonna be very low unless you are peaking on the MDMA.


Honestly you should only be using it maybe three times a year max. Obviously people break those rules but I think even doing it monthly catches up on you.




I dunno man, I mean I see what you're saying but I get very pure mdma (tests purple/black). I find I only get negative aide effects when its dirty molly. I've been doing this for about 4 months and feel alright though, in fact I feel better than ever.


--------------------
:heart::grin::heart: Finding the answer... Finding that there ain't no answer to find.


Extras: Filter Print Post Top
Invisible404
error
 User Gallery

Registered: 08/20/10
Posts: 14,539
Re: How dangerous do you guys feel MDMA truly is? [Re: Sophistic Radiance]
    #22079562 - 08/12/15 12:42 AM (8 years, 5 months ago)

so again this increase in polarity translates into higher affinities for receptor sites? so if 25c has a higher affinity for the 5ht2a than LSD, does this mean it binds 'tighter' to the site? and does this mean it is more polar than LSD?


Extras: Filter Print Post Top
OfflineBitter Cactus
reformed bad boy
 User Gallery

Registered: 01/26/12
Posts: 11,773
Loc: Alberta, Canada
Last seen: 8 years, 4 months
Re: How dangerous do you guys feel MDMA truly is? [Re: mollymadman]
    #22079568 - 08/12/15 12:46 AM (8 years, 5 months ago)

Quote:

mollymadman said:
Quote:

Bitter Cactus said:
Quote:

mollymadman said:
All I can say is that I do MDMA about once a week and I'm fine. You feel shitty for a few days but you just gotta sleep for a day and youll be fine. I usually dose about 300-400mg when I do it over the course of a night. Sometimes less tho. Tolerance sucks.





Holy shit! All I can say is god bless you that is gonna catch up to you mighty fast. I found when doing MDMA once a month my concentration was absolutely shot and I became depressed.

Good luck, you are going to need it. That must be so tough on your brain your serotonin levels are always gonna be very low unless you are peaking on the MDMA.


Honestly you should only be using it maybe three times a year max. Obviously people break those rules but I think even doing it monthly catches up on you.




I dunno man, I mean I see what you're saying but I get very pure mdma (tests purple/black). I find I only get negative aide effects when its dirty molly. I've been doing this for about 4 months and feel alright though, in fact I feel better than ever.




Single doses of MDMA can cause serotonergic nerve damage in laboratory animals, with repeated doses causing extensive loss of distal axon terminals. Huether's explanatory model for this 5-HT neurotoxicity will be briefly described. There is an increasing body of evidence for equivalent neuropsychobiological damage in humans. Abstinent regular Ecstasy users often show: reduced cerebrospinal 5-HIAA, reduced density of 5-HT transporters, blunted response to a fenfluramine challenge, memory problems, higher cognitive deficits, various psychiatric disorders, altered appetite, and loss of sexual interest. Functional deficits may remain long after drug use has ceased and are consistent with serotonergic axonal loss in higher brain regions.


--------------------
Taking acid and thinking you are a better man is a lot different then actually becoming a better man.




Extras: Filter Print Post Top
InvisibleMagicalOrangutan
Curious Cat
Male


Registered: 06/29/12
Posts: 3,538
Re: How dangerous do you guys feel MDMA truly is? [Re: 404]
    #22079572 - 08/12/15 12:47 AM (8 years, 5 months ago)

I learned in the first chemistry course at OSU how to estimate polarity of a molecule..might be hard to figure that out with LSD lol. Simple rules, complicated molecular example :S


--------------------
On the ground you lay, with your dogs you pray, at a neon hieroglyph sky you gaze

Hugging your mind, praying to survive, feeling the love of the hieroglyphs in the sky
We all need more love, and mainly less hate
Hate is the blind that covers the heart's eye
That makes the heart's eye cry
Locked deep away in the skies of our minds

It's all in the mind


Extras: Filter Print Post Top
OfflineRebelutionsssss
Mdmazing
I'm a teapot User Gallery


Registered: 07/23/14
Posts: 13,137
Loc: San Francisco
Last seen: 2 years, 2 months
Re: How dangerous do you guys feel MDMA truly is? [Re: Bitter Cactus]
    #22079575 - 08/12/15 12:48 AM (8 years, 5 months ago)

Sounds like you're copying and pasting off the DEA website


--------------------
:
To define is to confine.


Extras: Filter Print Post Top
Invisible404
error
 User Gallery

Registered: 08/20/10
Posts: 14,539
Re: How dangerous do you guys feel MDMA truly is? [Re: Rebelutionsssss]
    #22079581 - 08/12/15 12:50 AM (8 years, 5 months ago)

http://www.maps.org/images/pdf/2002_parrott_1.pdf

it is actually copypasta from MAPS


Extras: Filter Print Post Top
Offlinemollymadman
love each other :)

Registered: 08/12/15
Posts: 456
Last seen: 8 years, 3 months
Re: How dangerous do you guys feel MDMA truly is? [Re: Bitter Cactus]
    #22079582 - 08/12/15 12:50 AM (8 years, 5 months ago)

I guess I feel a little spacey most of the time, but I eat fine and definetly have a healthy sex drive lol:laugh:

I won't keep doing this forever anyways, just til I get sick of it.


--------------------
:heart::grin::heart: Finding the answer... Finding that there ain't no answer to find.


Extras: Filter Print Post Top
InvisibleSophistic Radiance
Free sVs!
Female

Registered: 07/11/06
Posts: 43,135
Loc: Center of the Universe
Re: How dangerous do you guys feel MDMA truly is? [Re: 404]
    #22079583 - 08/12/15 12:50 AM (8 years, 5 months ago)

The physical structure of a molecule plays a role in its agonism as well. Given the big, weird floppy structure of the NBOMEs, I'm guessing they are such competitive agonists because they stack in a way that more effectively blocks the receptor. They basically function as 2C drugs but with an extra hydrocarbon chain added on that blocks the approach of other monoamines to the receptor. This is also why meth's small size and simple structure needs to be taken into account in addition to its polarity: it is more prone to predictable, uniform stacking. Effectively, tetrabenazine wiggles and bounces a lot as it approaches VMAT2 whereas meth stacks in a very uniform fashion.

God fucking dammit I love organic chemistry, I can NOT wait for this fall. :crazyeyes:


--------------------
Enlil said:
You really are the worst kind of person.



Edited by Sophistic Radiance (08/12/15 12:56 AM)


Extras: Filter Print Post Top
InvisibleGottaloveacid
Weedbass
Male


Registered: 10/20/14
Posts: 3,421
Loc: Colorado, USA
Re: How dangerous do you guys feel MDMA truly is? [Re: mollymadman]
    #22079588 - 08/12/15 12:52 AM (8 years, 5 months ago)

Quote:

mollymadman said:
I guess I feel a little spacey most of the time, but I eat fine and definetly have a healthy sex drive lol:D

I won't keep doing this forever anyways, just til I get sick of it.





Are you more/less tired than normal?


--------------------
   
:mushroom2::mushroom2: The greatest story ever told is the story that never ends!:mushroom2::mushroom2:

wubba lubba dub dubstep :gimmebass:


Extras: Filter Print Post Top
OfflineRebelutionsssss
Mdmazing
I'm a teapot User Gallery


Registered: 07/23/14
Posts: 13,137
Loc: San Francisco
Last seen: 2 years, 2 months
Re: How dangerous do you guys feel MDMA truly is? [Re: Gottaloveacid]
    #22079599 - 08/12/15 12:58 AM (8 years, 5 months ago)

To really get a difiative answer they need to have a study where 2 healthy groups of people who have never taken any drug and have had their cognition and overal mental/psychical health documented. Then one side take MDMA over the course of a few years while the control abstains from any drug use and document the negative effects MDMA had on the brain. But that will never happen so


--------------------
:
To define is to confine.


Extras: Filter Print Post Top
Offlinemollymadman
love each other :)

Registered: 08/12/15
Posts: 456
Last seen: 8 years, 3 months
Re: How dangerous do you guys feel MDMA truly is? [Re: Gottaloveacid]
    #22079603 - 08/12/15 01:03 AM (8 years, 5 months ago)

Quote:

Gottaloveacid said:
Quote:

mollymadman said:
I guess I feel a little spacey most of the time, but I eat fine and definetly have a healthy sex drive lol:D

I won't keep doing this forever anyways, just til I get sick of it.





Are you more/less tired than normal?




To be honest I do have a very fucked up sleep schedule. I slept 3x today lol. But I was festing this weekend so that makes sense. I'm pretty much back to normal now.


--------------------
:heart::grin::heart: Finding the answer... Finding that there ain't no answer to find.


Extras: Filter Print Post Top
OfflineBitter Cactus
reformed bad boy
 User Gallery

Registered: 01/26/12
Posts: 11,773
Loc: Alberta, Canada
Last seen: 8 years, 4 months
Re: How dangerous do you guys feel MDMA truly is? [Re: mollymadman]
    #22079621 - 08/12/15 01:10 AM (8 years, 5 months ago)

Quote:

mollymadman said:
Quote:

Gottaloveacid said:
Quote:

mollymadman said:
I guess I feel a little spacey most of the time, but I eat fine and definetly have a healthy sex drive lol:D

I won't keep doing this forever anyways, just til I get sick of it.





Are you more/less tired than normal?




To be honest I do have a very fucked up sleep schedule. I slept 3x today lol. But I was festing this weekend so that makes sense. I'm pretty much back to normal now.




Just to warn you bud, I consider a MDMA a hard drug in the same league as meth and heroin but it is used like a casual drug. I think the damage it does to your brain is immediate and very real, especially at the doses you are taking. It honestly probably takes a full month for your serotonin levels to get back up to par with everyone else, but even then it damages your serotonin neurons in the long term.

Once a week is way way way too much. You need to save it for very special occasions a couple times a year.


--------------------
Taking acid and thinking you are a better man is a lot different then actually becoming a better man.




Extras: Filter Print Post Top
Invisible404
error
 User Gallery

Registered: 08/20/10
Posts: 14,539
Re: How dangerous do you guys feel MDMA truly is? [Re: Bitter Cactus]
    #22079624 - 08/12/15 01:11 AM (8 years, 5 months ago)

yeah mollymadman. you need to "slow your roll"


Extras: Filter Print Post Top
OfflineBitter Cactus
reformed bad boy
 User Gallery

Registered: 01/26/12
Posts: 11,773
Loc: Alberta, Canada
Last seen: 8 years, 4 months
Re: How dangerous do you guys feel MDMA truly is? [Re: 404]
    #22079627 - 08/12/15 01:13 AM (8 years, 5 months ago)

Yeah bro before you know it the only time you will feel happy is when you are peaking on the molly and all week it will be all you think about and you will have trouble with reading comprehension and concentrating at school and you will feel depressed.

It is bad news bears just like meth. I see no difference between abusing the two. I think even once a week use of MDMA is abuse.


--------------------
Taking acid and thinking you are a better man is a lot different then actually becoming a better man.




Extras: Filter Print Post Top
OfflineRebelutionsssss
Mdmazing
I'm a teapot User Gallery


Registered: 07/23/14
Posts: 13,137
Loc: San Francisco
Last seen: 2 years, 2 months
Re: How dangerous do you guys feel MDMA truly is? [Re: Bitter Cactus]
    #22079637 - 08/12/15 01:16 AM (8 years, 5 months ago)

I'm an MDMA advocate by every sense of the word but even I have to agree once a week is pushing it bud. Your serotonin hasn't even fully recovered from your last use with that little time.


--------------------
:
To define is to confine.


Extras: Filter Print Post Top
Offlinemollymadman
love each other :)

Registered: 08/12/15
Posts: 456
Last seen: 8 years, 3 months
Re: How dangerous do you guys feel MDMA truly is? [Re: Bitter Cactus]
    #22079638 - 08/12/15 01:16 AM (8 years, 5 months ago)

Hmm, thanks for the concern. I'll consider what you guys said. I'm starting a new job soon anyways so I won't be able to keep this up much longer. I wouldn't recommend this type of use to anyone else, it just seems like I'm immune to the negative long term side effects. Either that or they creep up so slow you don't notice it.


--------------------
:heart::grin::heart: Finding the answer... Finding that there ain't no answer to find.


Extras: Filter Print Post Top
Jump to top Pages: < Back | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | Next >

Shop: North Spore Cultivation Supplies   PhytoExtractum Buy Bali Kratom Powder   Kraken Kratom Kratom Capsules for Sale, Red Vein Kratom


Similar ThreadsPosterViewsRepliesLast post
* Wikipedia says PCP and Ketamine are neurotoxins?
( 1 2 all )
Zardos 3,262 28 08/08/12 10:57 AM
by mazaloto
* I feel so silly... CeeEssGee 1,137 11 11/20/03 12:25 AM
by Osker246
* Im on Extasy right now and I feel like DEATH!!! MikeHuntShrooms 1,317 13 12/13/03 09:38 AM
by CeeEssGee
* Feeling like the oppression is really getting to you? MOTH 2,122 15 11/20/03 05:51 AM
by Lightningfractal
* Grateful Dead, the most dangerous band of all time
( 1 2 all )
LearyfanS 5,944 36 05/17/18 03:37 PM
by Boomer The Great
* Playing sad songs and feeling horrible.
( 1 2 all )
Fliquid 4,662 28 07/09/04 01:45 AM
by CaRnAgECaNdY
* Pooping etiquette (danger, very funny!)
( 1 2 all )
daba 6,381 30 12/23/15 06:35 PM
by Cowb0yNeal00
* MDMA DEA Approval Therapy Study ! Earth_Droid 948 5 03/12/04 09:32 PM
by fee

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: Entire Staff
13,848 topic views. 7 members, 63 guests and 53 web crawlers are browsing this forum.
[ Show Images Only | Sort by Score | Print Topic ]
Search this thread:

Copyright 1997-2024 Mind Media. Some rights reserved.

Generated in 0.031 seconds spending 0.01 seconds on 15 queries.