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Offlinepipamperon
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Registered: 08/09/15
Posts: 1
Last seen: 8 years, 5 months
Psilocin + selective 5-HT2A antagonist, what will happen?
    #22065794 - 08/09/15 05:09 AM (8 years, 5 months ago)

Hi,

Recently i was put on risperidone for autism but it gave me akathisia and an annoying tiredness. Now i take pipamperon 20mg wich is a very selective 5-HT2A antagonist. I experience no side effects but i can clearly notice its antiserotonergic action because my pupils get very small.

In the past i have had good experience with low and moderate doses of psilocybin. They made me very sociable and extravert. However i did not like the hallucionations and visual disturbances and therefore i quit using them.

Now with this med i take, i would be interested to know what will happen if i combine it with psilocin. Perhaps the sociable and extravert properties will remain because of psilocins action on other 5-HTR's like 5-HT1A and 5-HT1D while blocking the "schizofrenic" 5-HT2A effects?


Does anyone have experiences with selective 5-HT2A antagonists in combination with psilocin or other psychedelics?


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InvisibleSteveRogers
gandy dancer
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Registered: 10/24/06
Posts: 3,450
Re: Psilocin + selective 5-HT2A antagonist, what will happen? [Re: pipamperon]
    #22065929 - 08/09/15 07:09 AM (8 years, 5 months ago)

It will reduce and alter the effects but not eliminate them. You made need to take a slightly larger dose to get where you want to be, however I cannot recommend this outright to someone with a mental ilness. You have to make that choice yourself.


--------------------
"General, I am loyal to nothing......except The Dream"


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