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Bitter Cactus
reformed bad boy


Registered: 01/26/12
Posts: 11,773
Loc: Alberta, Canada
Last seen: 8 years, 4 months
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Mucana Pruriens
#22057558 - 08/07/15 10:00 AM (8 years, 5 months ago) |
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Anyone have experience with this herb? I am considering trying it to get some more dopamine and want to hear what you guys think about this stuff. I just started my research on it now.
Discuss.
-------------------- Taking acid and thinking you are a better man is a lot different then actually becoming a better man.
Edited by Bitter Cactus (08/07/15 10:01 AM)
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SteveRogers
gandy dancer



Registered: 10/24/06
Posts: 3,450
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Mucana Pruriens does not actually increase dopamine. L-Dopa, the Parkinson's drug does and it has severe long term side effects.
-------------------- "General, I am loyal to nothing......except The Dream"
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Ncogneato
Patriot



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Re:want to spend money on bs [Re: SteveRogers]
#22059703 - 08/07/15 05:31 PM (8 years, 5 months ago) |
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Careful with that stuff. It's ok to take intermittently but long term use can lead to dementia. I learned the hard way by taking it for a few weeks on end. I knew something wasn't quite right but I couldn't put my finger on it. I came across an article pointing out it's short and long term effects when I realized what I was doing. I haven't touched it since. I would say it took a week or two before I started to feel normal again.
-------------------- Psilocybin.........the poor man's Cancun.
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psi
TOAST N' JAM


Registered: 09/05/99
Posts: 31,456
Loc: 613
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Re:want to spend money on bs [Re: SteveRogers]
#22059716 - 08/07/15 05:33 PM (8 years, 5 months ago) |
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Quote:
SteveRogers said: Mucana Pruriens does not actually increase dopamine. L-Dopa, the Parkinson's drug does and it has severe long term side effects.
But doesn't Mucuna pruriens contain L-DOPA?
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SteveRogers
gandy dancer



Registered: 10/24/06
Posts: 3,450
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Re:want to spend money on bs [Re: psi]
#22059723 - 08/07/15 05:35 PM (8 years, 5 months ago) |
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There is an enormous difference from the naturally occuring alkaloids in that vs. injected pharmaceutical l-dopa. The later has permanent long term side effects and the former does little if anything at all in controlled studies.
-------------------- "General, I am loyal to nothing......except The Dream"
Edited by SteveRogers (08/07/15 06:10 PM)
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psi
TOAST N' JAM


Registered: 09/05/99
Posts: 31,456
Loc: 613
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Re:want to spend money on bs [Re: SteveRogers]
#22059747 - 08/07/15 05:39 PM (8 years, 5 months ago) |
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Routes of administration aside, it does contain L-DOPA. You made it sound like it doesn't.
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SteveRogers
gandy dancer



Registered: 10/24/06
Posts: 3,450
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Re:want to spend money on bs [Re: psi]
#22059765 - 08/07/15 05:41 PM (8 years, 5 months ago) |
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Won't cross the blood brain barrier mang.
-------------------- "General, I am loyal to nothing......except The Dream"
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psi
TOAST N' JAM


Registered: 09/05/99
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Re:want to spend money on bs [Re: SteveRogers]
#22059826 - 08/07/15 05:52 PM (8 years, 5 months ago) |
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I'd be interested to see any links you have on that, but it definitely does contain L-DOPA.
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Adolin




Registered: 06/28/11
Posts: 8,292
Loc: USA
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Re:want to spend money on bs [Re: SteveRogers]
#22059829 - 08/07/15 05:53 PM (8 years, 5 months ago) |
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Quote:
SteveRogers said: Won't cross the blood brain barrier mang.
not true, mang. L-DOPA does cross the BBB, although it does have a lower oral bioavailability than it does IV
Edited by Adolin (08/07/15 05:55 PM)
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SteveRogers
gandy dancer



Registered: 10/24/06
Posts: 3,450
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Re:want to spend money on bs [Re: Adolin]
#22059866 - 08/07/15 05:59 PM (8 years, 5 months ago) |
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Nope. not from Macuna.
Do some research, mang.
-------------------- "General, I am loyal to nothing......except The Dream"
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SteveRogers
gandy dancer



Registered: 10/24/06
Posts: 3,450
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Re:want to spend money on bs [Re: SteveRogers]
#22059882 - 08/07/15 06:02 PM (8 years, 5 months ago) |
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OP can waste his money. He will not achieve the effect he is looking for with Macuna.
I am not having this argument here. pointless
-------------------- "General, I am loyal to nothing......except The Dream"
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psi
TOAST N' JAM


Registered: 09/05/99
Posts: 31,456
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Re:want to spend money on bs [Re: SteveRogers]
#22059886 - 08/07/15 06:04 PM (8 years, 5 months ago) |
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OK then, good talk.
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Adolin




Registered: 06/28/11
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Re:want to spend money on bs [Re: SteveRogers]
#22059889 - 08/07/15 06:04 PM (8 years, 5 months ago) |
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Mucuna Puriens contains the same L-3,4-dihydroxyphenylalanine (L-DOPA) that the medication has.
it might not have Carbidopa (which inhibits the metabolism of L-DOPA), but the L DOPA is the same.
i think you should explain the difference exactly, if you seriously think you're more accurate than a thousand GCMS tests
Edited by Adolin (08/07/15 06:05 PM)
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SteveRogers
gandy dancer



Registered: 10/24/06
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Re:want to spend money on bs [Re: Adolin]
#22059907 - 08/07/15 06:09 PM (8 years, 5 months ago) |
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It's an ROA thing. I never said it didn't contain L-Dopa. OP wants to raise his Dopamine levels. Macuna will not do this in any measurable amount for him. A potent extract, maybe, but oral administration is not going to do anything from what he is proposing (raw material). Thats all I am saying.
-------------------- "General, I am loyal to nothing......except The Dream"
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Adolin




Registered: 06/28/11
Posts: 8,292
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Re:want to spend money on bs [Re: SteveRogers]
#22059927 - 08/07/15 06:15 PM (8 years, 5 months ago) |
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Quote:
SteveRogers said: It's an ROA thing. I never said it didn't contain L-Dopa. OP wants to raise his Dopamine levels. Macuna will not do this in any measurable amount for him. A potent extract, maybe, but oral administration is not going to do anything from what he is proposing (raw material). Thats all I am saying.
again, i dont think you have a fucking clue what your talking about.
if what you are saying is true, why do hundreds of thousands/millions of parkinsons patients take Parcopa? or Sinemet? in case you didnt know, parcopa/sinemet is a PILL containing Levo/Carbidopa. and it isnt the only brand that makes an oral preperation of L DOPA
EDIT: after some further looking into, i see that you're probably right. the only reason L-DOPA works orally in those preperations of because the carbidopa prevents it from breaking down before it reaches the brain.
still, L-DOPA definately does cross the BBB. and some of it probably still gets there with mucuna. just not much
Edited by Adolin (08/07/15 06:22 PM)
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mushypanda
Care Bear


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Re:want to spend money on bs [Re: SteveRogers]
#22059930 - 08/07/15 06:16 PM (8 years, 5 months ago) |
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Strange stuff imo 
I have some laying around that I take sporadically.
Lots of dangerous interactions with other drugs and strange side effects
-------------------- There is something to be said for nodding out to a spectacle of colors. Plus that body high & euphoria...._Dark-Star We are entirely defined by what we do and how we treat others._daytripper05
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psi
TOAST N' JAM


Registered: 09/05/99
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Re:want to spend money on bs [Re: Adolin]
#22059939 - 08/07/15 06:19 PM (8 years, 5 months ago) |
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Does carbidopa occur naturally in anything or is it just synthetic? I can't find anything on this. Apparently it potentiates 5-HTP as well.
The WP article on carbidopa claims you need about 4x as much L-DOPA to get the same effect without carbidopa.
Quote:
Carbidopa reduces the amount of levodopa required to produce a given response by about 75%
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Bitter Cactus
reformed bad boy


Registered: 01/26/12
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Re:want to spend money on bs [Re: psi]
#22060604 - 08/07/15 09:07 PM (8 years, 5 months ago) |
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What about adrafinil? I am looking for something to boost my concerta for school.
-------------------- Taking acid and thinking you are a better man is a lot different then actually becoming a better man.
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Adolin




Registered: 06/28/11
Posts: 8,292
Loc: USA
Last seen: 1 year, 2 months
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if youre already on mythylphenidate that should be all you need.
adding adrafinil sounds risky, maybe somewhater dangerous. but yes, modafinil/adrafinil will boost dopamine and serotonin in the nucleus accumbens and potentiate DRI's/amphetamines
Edited by Adolin (08/07/15 09:17 PM)
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SteveRogers
gandy dancer



Registered: 10/24/06
Posts: 3,450
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Re:Macuna Pruriens [Re: psi]
#22060632 - 08/07/15 09:17 PM (8 years, 5 months ago) |
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gresh/psi For the record, I apologize for coming off like a prick earlier. I think we were just misunderstanding each other on semantics. I work with Parkinson's patients in a volunteer medial center here in Chicago. The pharmaceutical L-Dopa/Carbidopa preparations work very very well. The oral less than the injectables, but they both serve a purpose. The issue is that cessation of treatment has very bad and often permanent side effects where the patient struggles to endogenously produce Dopamine again.
My point about raw Macuna Pruriens plant material, was that it won't get the OP to where he is trying to go without extracting/concentrating. Even if he were to sufficiently concentrate it, L-Dopa is not a joke and I was trying to steer him away from it if I could.
I respect the fact that you guys actually did some research and had it out with me using facts. That is a lot more than can be said for most of these guys.
Good looking out.
-------------------- "General, I am loyal to nothing......except The Dream"
Edited by SteveRogers (08/07/15 09:35 PM)
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