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OfflineLoveNaborFuckHater
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Registered: 02/13/15
Posts: 861
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Re: People selling "LSB" at a party? [Re: trippinballs420]
    #22037896 - 08/03/15 02:17 PM (8 years, 5 months ago)

Quote:


while lysergic acid 2-butyl amide is more potent than LSD as a 5-HT1A agonist, it is slightly less potent as a 5-HT2A agonist, and so would probably be slightly less potent than LSD as a hallucinogen in humans.




--------------------
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Offlinetwighead
mͯó
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Registered: 08/27/08
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Re: People selling "LSB" at a party? [Re: Bassfreak]
    #22037902 - 08/03/15 02:19 PM (8 years, 5 months ago)

Quote:

Bassfreak said:
Quote:

twighead said:
Alright cum shot queen :highdog:





lol if i could only get fake drugs id be making insults too

have a great day!



All my droogs have more shrooms than you!


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InvisibleMagicalOrangutan
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Re: People selling "LSB" at a party? [Re: twighead]
    #22037917 - 08/03/15 02:24 PM (8 years, 5 months ago)

Fuck all you drug elitists. Bassfreak proves yet again that LSD and mdma are so hyped because people who have them, use that as a way to brag that they can get "real acid and Molly dudez!!"

DMT and cacti > LSD and mdma


--------------------
On the ground you lay, with your dogs you pray, at a neon hieroglyph sky you gaze

Hugging your mind, praying to survive, feeling the love of the hieroglyphs in the sky
We all need more love, and mainly less hate
Hate is the blind that covers the heart's eye
That makes the heart's eye cry
Locked deep away in the skies of our minds

It's all in the mind


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InvisibleBoomerMan420
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Re: People selling "LSB" at a party? [Re: MagicalOrangutan] * 1
    #22037935 - 08/03/15 02:30 PM (8 years, 5 months ago)

Fuck anyone selling false advertised substances.. pieces of shit Nbombing muthafuckas should be ashamed of yourself


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InvisibleMagicalOrangutan
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Re: People selling "LSB" at a party? [Re: BoomerMan420]
    #22037948 - 08/03/15 02:33 PM (8 years, 5 months ago)

Yes..fuck them too. Even more so


--------------------
On the ground you lay, with your dogs you pray, at a neon hieroglyph sky you gaze

Hugging your mind, praying to survive, feeling the love of the hieroglyphs in the sky
We all need more love, and mainly less hate
Hate is the blind that covers the heart's eye
That makes the heart's eye cry
Locked deep away in the skies of our minds

It's all in the mind


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OfflineDurgaDurg
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Re: People selling "LSB" at a party? [Re: BoomerMan420] * 1
    #22037949 - 08/03/15 02:33 PM (8 years, 5 months ago)

What kind of a clown would choose nbome over lsd? Thats like choosing rubbing alcohol over vodka


--------------------
When you see him look him in the eye, look him in the eye and he won’t dare to follow
If you need to, hook him with your right, hook him with your right till he wiggles and wallows

He sleeps atop a bag of raven’s legs, curled up rats napping by his head
Takes his eye out with a ball point pen
And makes nunchaku with his torn off legs

You wake up with a hatchet over your head
You wake up with a hatchet over your head


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OfflineThatKidWithTheFace
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Re: People selling "LSB" at a party? [Re: DurgaDurg]
    #22037979 - 08/03/15 02:44 PM (8 years, 5 months ago)

Fuck LSD


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[quote]Sheekle said:
[quote]ThatKidWithTheFace said:
Is this the same aunt that fucks dogs?[/quote]
u bet ur ass it is.[/quote]


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Invisible404
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Re: People selling "LSB" at a party? [Re: Bassfreak]
    #22037987 - 08/03/15 02:46 PM (8 years, 5 months ago)

Quote:

Bassfreak said:
ive heard of people dying on NBOME on like 2 hits

its a luck of the draw thing. eating 2 hits is normal for lsd

with heroin you can control your dosage. with NBOME a totally normal dose could go wrong and fucking kill you

psychonautica, the heroin comparison was laughable at best dude





i know i'm kind of late here but i'd like to interject.


it is entirely possible to die from taking your normal dose of heroin that your body is used to taking. if you take it outside of the scenario and setting you normally take it in that is. this is because the setting 'cues' are no longer there to trigger your body to start up the metabolic processes to help process the drug. the body knows when it's going to get high.

say for instance you normally use in your house. but one day you decide to dose at your friends house. this is one of those scenarios, roughly.



in my experience, nbome blotters have been very uneven. this is critical, as getting to a certain point, taking a few milligrams or more can be a very serious thing since it's so potent in the microgram range.

considering these substances have only been in existence for 5 years (created in 2010 i believe) i think a lot more needs to be researched on them. their danger i think comes with their play on the body's temperature regulation, kind of like how people can die from overheating on mda and mdma, which both of those two substances can and have caused rhabdomyolysis as well. someone correct me if i am wrong here.


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OfflineBassfreak
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Re: People selling "LSB" at a party? [Re: MagicalOrangutan]
    #22038015 - 08/03/15 02:56 PM (8 years, 5 months ago)

Quote:

MagicalOrangutan said:
Fuck all you drug elitists. Bassfreak proves yet again that LSD and mdma are so hyped because people who have them, use that as a way to brag that they can get "real acid and Molly dudez!!"

DMT and cacti > LSD and mdma





lol it means you know what to look for. honestly its something you earn and i think its worth bragging about. im spoiled as fuck and its bc i took the time to learn about drugs then apply that knowledge to when i meet good people. you can tell who knows what theyre talking about and whos a fucking clown

sometimes people get lucky and find good shit but im not lucky, i earned high quality drugs. so if you dont like me bragging then oh well. but times are tough and you really gotta watch yourself. im proud to have high quality cuz not only is it fun but its just safer too. you know exactly what youre getting into


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OfflineYukon Cornelius
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Re: People selling "LSB" at a party? [Re: Bassfreak] * 4
    #22038035 - 08/03/15 03:01 PM (8 years, 5 months ago)

Bragging about your drugs is like bragging that your dad can beat up someone else's dad.


--------------------
"I didn't know chicken's wore suspenders" - Towelie



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InvisibleMagicalOrangutan
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Registered: 06/29/12
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Re: People selling "LSB" at a party? [Re: Bassfreak] * 1
    #22038039 - 08/03/15 03:02 PM (8 years, 5 months ago)

Mdma isn't as safe as any of the classic psychedelics. And people who brag about being able to get drugs are retarded as shit. Period.


--------------------
On the ground you lay, with your dogs you pray, at a neon hieroglyph sky you gaze

Hugging your mind, praying to survive, feeling the love of the hieroglyphs in the sky
We all need more love, and mainly less hate
Hate is the blind that covers the heart's eye
That makes the heart's eye cry
Locked deep away in the skies of our minds

It's all in the mind


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OfflineDurgaDurg
Stranger


Registered: 09/27/13
Posts: 576
Loc: Tangled In The Willows
Last seen: 6 years, 6 months
Re: People selling "LSB" at a party? [Re: Bassfreak]
    #22038048 - 08/03/15 03:04 PM (8 years, 5 months ago)

He says were drug elitist's but then says dmt cacti over lsd hahaha

I like all psychedelics that are proven to be physically safe in high doses. Wouldn't put one over the other. I just really enjoy acid at this time in my life.


--------------------
When you see him look him in the eye, look him in the eye and he won’t dare to follow
If you need to, hook him with your right, hook him with your right till he wiggles and wallows

He sleeps atop a bag of raven’s legs, curled up rats napping by his head
Takes his eye out with a ball point pen
And makes nunchaku with his torn off legs

You wake up with a hatchet over your head
You wake up with a hatchet over your head


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Invisible404
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Registered: 08/20/10
Posts: 14,539
Re: People selling "LSB" at a party? [Re: MagicalOrangutan]
    #22038105 - 08/03/15 03:27 PM (8 years, 5 months ago)

Quote:

MagicalOrangutan said:
Mdma isn't as safe as any of the classic psychedelics. And people who brag about being able to get drugs are retarded as shit. Period.




took the words right out of my mouth. mdma and mda are both neurotoxic when metabolized by the liver, not only that but you can overdose on them and many people have.


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InvisibleSirShroomsAlott
Howdy
I'm a teapot


Registered: 05/15/14
Posts: 6,945
Loc: United States Flag
Re: People selling "LSB" at a party? [Re: 404]
    #22038120 - 08/03/15 03:33 PM (8 years, 5 months ago)

Not defending it because I'm not too knowledgeable on the subject, but I knew MDA was neurotoxic, but I thought mdma was proven to be safe (much safer) as long as it wasn't used too frequently, and only if used frequently could it become neurotoxic. I'm not saying this is right, I was just under this impression.


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OfflineYukon Cornelius
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Re: People selling "LSB" at a party? [Re: SirShroomsAlott]
    #22038132 - 08/03/15 03:38 PM (8 years, 5 months ago)

That's incorrect, they are both slightly neurotoxic. However that word does not deter me whatsoever, alcohol is a neurotoxin too.

It all comes down to responsible use.


--------------------
"I didn't know chicken's wore suspenders" - Towelie



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InvisibleSirShroomsAlott
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I'm a teapot


Registered: 05/15/14
Posts: 6,945
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Re: People selling "LSB" at a party? [Re: Yukon Cornelius]
    #22038145 - 08/03/15 03:42 PM (8 years, 5 months ago)

MDMA is the one I've wanted to do the most, been nervous about it but I should be good as long as I don't do it frequently right? Like literally every 3 months at the very minimum type of use. Not even saying I'd do it that frequently but with all drugs I think I'll like I set a time limit before I can do it again just in case I like it a lot lol


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Invisible404
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Re: People selling "LSB" at a party? [Re: SirShroomsAlott]
    #22038165 - 08/03/15 03:48 PM (8 years, 5 months ago)

well, i've been reading conflicting reports. there's a rather long and well invested post in reddit somewhere with links and everything.

it was saying that MDA and MDMA are not neurotoxic when injected directly into the brain.

http://www.reddit.com/r/DrugNerds/comments/13lp0b/mdma_neurotoxicity_part_1_metabolites/

Quote:

This is probably going to be the first in a series of discussions I start about MDMA. There's just too much information for one post. Therefore, I am going to start with one that is very interesting to me: MDMA's metabolites and their role in neurotoxicity. I pre-appologise for the length and terminology used.

First off, let's discuss how MDMA is metabolized. The human cytochrome CYP450 is responsible for the metabolism of MDMA. The primary enzyme responsible is CYP2D6, using O-demethylation. This process adds two hydrogen atoms to the two open oxygen atoms in MDMA to create HHMA. Let's look at the structure for a minute.

MDMA is 3,4-methylenedioxy-N-methylamphetamine

HHMA is 3,4-dihydroxy-N-methylamphetamine

So your CYP2D6 enzyme added two hydrogen atoms to the methylenedioxy structure to create a dihydroxy structure. Once it's been o-demethylated to HHMA, it is no longer active like MDMA is. HHMA can then be 0-methylated further to HMMA, or 4-hydroxy-3-methoxy-N-methylamphetamine. Here is an image to help you visualize this process.

This is the primary route of metabolism.

Is that the end of the story? Nope! Yes MDMA is primarily metabolized by CYP2D6. However, a portion of your dose (~10%) is also metabolized by your CYP3A4 enzyme using N-demethylation. What substance is created by this process? MDA, or 3,4-methylenedioxyamphetamine. You see, this time your CYP3A4 enzyme changed the methyl group at the N position, and not the O position. This modified the methyl group into an amine group. We are now left with MDMA's more neurotoxic brother in our blood stream.

Let's add this into the picture from above.

MDA is then metabolized in the exact same manner MDMA was, o-demetylation by CYP2D6. So we add two hydrogen atoms to the O position to create HHA, or 3,4-dihydroxyamphetamine. So we essentially end up with HHMA with an amine group at the N position instead of a methyl group. It can also be o-methylated further (like HHMA) into HMA 4-hydroxy-3-methoxyamphetamine. Same thing as HMMA, just with an amine group instead of the methyl group.

So at this point you might be thinking how this all really matters. Well MDMA and MDA injected directly into the brain have been shown to NOT be neurotoxic. Well shit, there we go. Metabolism is to blame.

Not so fast! A study showed that individuals with lower CYP2D6 did not show lower neurotoxicity. In fact, they showed slightly higher. It may have led to some deaths as well. This led to the notion being tabled for a while.

So what is up then? Well where is the next logical place to look? Perhaps CYP3A4!!!!!

A person that has a genetic condition resulting in lower CYP2D6 enzyme is going to have what happen to their MDMA? A greater percentage will be N-demethylated to MDA by CYP3A4.

This is going to lead to what? Higher HHA serum levels.

HHA is what? A potent neurotoxin!

So MDMA and MDA injected directly into the brain show NO neurotoxicity. Individuals with lower CYP2D6 enzyme show higher levels of neurotoxicity. This leads me to believe that HHMA is not the primary culprit (probably still a factor though).

MDA has been shown to be much more neurotoxic than MDMA. MDA is NOT neurotoxic when directly injected into the brain. MDA cannot be metabolized into HHMA, but is directly metabolized to HHA. HHA is a potent neurotoxin.

Is anybody smelling what I am cooking over here?!? MDA is the cause of MDMA's neurotoxicity through metabolism to HHA (Also known as alpha-methyldopamine). BOOM!

Alpha-methyldopamine causes neurotoxicity.

Another link

And another!

Now I have been taking quercetin and grapefruit juice with my MDMA for a while now. These substances are CYP3A4 inhibitors. I knew that CYP3A4 metabolized part of my dose to MDA. I knew it was more neurotoxic, which is why I did this. However, I did not connect the dots as to why it was more neurotoxic.

Many postulated it was because of MDA's higher affinity for dopamine. However, why then did direct injections of it in the brain not cause neurotoxicity? If it was dopamine being re-uptaked by your SERT that was causing the damage, it would still be present when MDMA or MDA was directly injected into the brain. In fact, it would be higher. Yet we saw NO neurotoxicity.

Others were skeptical because the metabolism to HHA was only seen in rats. However, the 2009 study proved it happened in humans too! So hot damn, I am pretty sure this is a verifiable theory here. We definitely need studies to prove it though.

TL;DR I postulate that MDMA induced 5-HT neurotoxicity arises from the metabolism to MDA, consequently creating HHA or alpha-methyldopamine. Another route of neurotoxicy comes from the ring-hydroxylation of MDA to THA, or 2,4,5-trihydroxyamphetamine. Inhibit CYP3A4 using grapefruit juice to stop the metabolism to MDA and prevent both metabolites from being created.

Now do NOT take what I am saying as the end all and be all of potential MDMA induced damage. There is excitotoxicity at your ion channels, as well as other oxidative damage that can come into play. I will speak to these in other posts. This has also not been proven yet. So please take this post as a starting point, not a final answer. Feel free to pick apart my theory and find anything that I may have overlooked. I would rather be wrong and find the truth, then think I'm right and perpetuate a fallacy.





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OfflineYukon Cornelius
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Re: People selling "LSB" at a party? [Re: SirShroomsAlott]
    #22038166 - 08/03/15 03:48 PM (8 years, 5 months ago)

You will be totally fine taking MDMA with that low a frequency. Personally I prefer MDA over MDMA, less abrasively euphoric and more psychedelic.

The comedown is much more gentle as well.


--------------------
"I didn't know chicken's wore suspenders" - Towelie



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Offlinetwighead
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Re: People selling "LSB" at a party? [Re: MagicalOrangutan]
    #22038181 - 08/03/15 03:53 PM (8 years, 5 months ago)

Quote:

MagicalOrangutan said:
Fuck all you drug elitists. Bassfreak proves yet again that LSD and mdma are so hyped because people who have them, use that as a way to brag that they can get "real acid and Molly dudez!!"

DMT and cacti > LSD and mdma



Only cause you can't get real LSD or MDMA :haha:


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OfflineBassfreak
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Re: People selling "LSB" at a party? [Re: 404]
    #22038185 - 08/03/15 03:54 PM (8 years, 5 months ago)

Quote:

404 said:
Quote:

MagicalOrangutan said:
Mdma isn't as safe as any of the classic psychedelics. And people who brag about being able to get drugs are retarded as shit. Period.




took the words right out of my mouth. mdma and mda are both neurotoxic when metabolized by the liver, not only that but you can overdose on them and many people have.





mdma is actually a really safe drug, especially in the right hands. most "ecstasy" related deaths are totally preventable and thats the saddest thing about it. like yeah in terms of health, mdma is def more dangerous than the classic psychedelics, but if people are doing mdma responsibly the chance that someone ODs is slim to none

lsd is the softest of the soft as far as drugs go and mdma is really only a step or 2 above it in the whole spectrum of drugs. people who die from mdma didnt test, or they didnt educate themselves before they did it or they just didnt take care of themselves. its sad to say but usually its something that coulda been avoided. that shit doesnt happen with responsible users


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