|
mrbart4444
The mycelium whisperer


Registered: 09/13/14
Posts: 2,266
|
Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day
#22015790 - 07/29/15 04:04 PM (8 years, 6 months ago) |
|
|
About time ive seen to many friends go down this road.
http://www.ft.com/cms/s/0/1476db54-359c-11e5-bdbb-35e55cbae175.html#axzz3hJuxcIOu
Thousands of recreational drug users are being recruited to clinical trials for pharmaceutical companies including Pfizer and Teva, as the industry races to develop a new generation of “abuse-deterrent” opioid painkillers designed to stem America’s addiction to prescription drugs.
The US Food and Drug Administration has declared the problem a “national epidemic”. Official estimates put the number of opioid abusers in the US at 2.1m and overdoses are responsible for roughly 45 deaths a day. One of the only ways of proving the new wave of “abuse-deterrent” pills are harder to abuse than existing opioid painkillers is to test whether real-life drug users enjoy taking them as much as the current crop of medicines. Ronny Gal, an analyst at Bernstein Research, said such studies were “the dark underbelly of the drug-testing world”. High quality global journalism requires investment.
The drug users are recruited by research clinics on behalf of the pharma companies, housed in special accommodation, and paid between $250 and $300 a day for the trials, which can last up to a month. One research clinic, Vince & Associates, was recently recruiting recreational drug users and offering to pay $3,700 for a 15-day study, although its focus was cocaine abuse rather than opioids. During the ”double blind” trials, participants are given a mixture of pills — without being told whether they are existing opioids, new tamper-proof drugs, or placebos — and asked to abuse them, often by snorting them, or taking several at once. They must then rate how enjoyable the experience is. The aim of the trials is to show that the newer abuse-deterrent drugs score less on a “drug-liking” scale. The number of these drug-liking or “human abuse liability” studies has surged in the past two years as US authorities demand that pharma groups build abuse-deterrent technology into opioid painkillers. Drugmakers are testing a range of approaches, from hard shells and coatings designed to make pills less enjoyable when chewed, snorted or injected, to so-called antagonists that counteract the effect of the opioid if the capsule is tampered with. The FDA, the US drugs watchdog, has strongly encouraged pharma companies to conduct the drug-liking studies before requesting approval for new opioid-based painkillers. “Studies should be conducted in opioid-experienced, recreational drug users who have experience with the particular route of abuse being studied,” the regulator said in final guidelines published in April. There are only a handful of centres in North America equipped to conduct the trials, and they are in many cases running at full capacity. Lifetree Clinical Research in Salt Lake City, Utah, has seen the number of participants enrolled in its drug-liking studies jump from 267 in 2012 to 677 last year, according to figures seen by the Financial Times. Lifetree has been contracted to run studies involving 582 participants so far this year. Shares in its parent company, PRA Health Sciences, have jumped nearly 90 per cent since its initial public offering on Nasdaq in November. Pfizer paid at least $3.1m to Lifetree in 2014 to carry out human abuse liability studies last year, according to an FT analysis of public disclosures. It is developing a range of tamper-proof opioids including a version of oxycodone, a commonly abused painkiller. A person who has participated in roughly 15 studies at Lifetree told the FT he was once asked to swallow 21 pills in five minutes to see if they would give him a sense of euphoria. Lifetree said the vast majority were placebos. Toronto-based INC Research, PRA’s main competitor, also said it had experienced an increase in the number of drug companies testing their tamper-proof medicines. “There’s been a lot of volume around abuse-deterrence,” said Beatrice Setnik, a vice-president at INC.
--------------------
|
nooneman


Registered: 04/24/09
Posts: 14,561
Loc: Utah
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: mrbart4444] 1
#22016271 - 07/29/15 05:53 PM (8 years, 5 months ago) |
|
|
I just found the perfect job for crystal g.
|
Cognitive_Shift
CS actual




Registered: 12/11/07
Posts: 29,591
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: nooneman]
#22017248 - 07/29/15 09:02 PM (8 years, 5 months ago) |
|
|
Quote:
During the ”double blind” trials, participants are given a mixture of pills — without being told whether they are existing opioids, new tamper-proof drugs, or placebos — and asked to abuse them, often by snorting them, or taking several at once. They must then rate how enjoyable the experience is.
Because an "abuse-deterrent" pill can stop some one from taking several pills at once
-------------------- L'enfer est plein de bonnes volontés et désirs
|
Denman
Stranger


Registered: 03/16/15
Posts: 120
Last seen: 8 years, 5 months
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: Cognitive_Shift]
#22017488 - 07/29/15 09:50 PM (8 years, 5 months ago) |
|
|
I'm not gonna post it here, but there's a very simple way to break the "timex" abuse deterrent in OC, and it doesn't take a chemist. For every wall they put up there are already users finding ways to tear it down and get to the good part. It may stop a few people from snorting it, but as already said they'll just eat more, and OD that way. Sad, but it's the truth...
The other option is to turn to dope. Seen plenty of people doing that already.
Worst part of all is many real pain patients have terribe reactions to the new formulas and can't take them without nasty side effects. For others they simply dont work as well for pain, so they take their meds as rx'd and still suffer. I can tell u straight out the "OP"'s don't work for shit for pain. They take hours to begin working, and give half the pain relief of the original formula.
So now the ppl who need it are fucked cause Purdue wants to keep the patent for OxyContin by tweaking it every ten years. They don't give a fuck whos abusing it, lets be real.
For the record I've lost friends and family to dope, almost died myself. So I'm not some junkie crying for my right to get high. But I have also seen too many friends and family, myself included left to suffer from insufficient pain relief from tamper resistant garbage. It changes nothing, people will still abuse, and the only people who suffer are those in actual need of relief and take their meds as rx'd.
Another sad truth. Sorry for the rant, just my 2 cents... Everyone be well, stay safe and be happy 
Den
-------------------- All posts are for Entertainment purposes only... I have no actual experience. I've never even been laid. Isn't the Internet great?!
|
PanzerCubed



Registered: 11/22/12
Posts: 2,285
Loc: Nauru
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: Denman]
#22017733 - 07/29/15 10:49 PM (8 years, 5 months ago) |
|
|
Yup, i was on the original OC formula over here in Australia and only last year they switched to the OP formula so when the chemist ran out of his stock of the OC and started giving me the OP i got terrible side effects and jack all pain control. I asked my doctor to switch me over to ms-contin but he wanted to half my dose to do it so now im stuck with half my pain relief but at least it works.
|
nooneman


Registered: 04/24/09
Posts: 14,561
Loc: Utah
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: Cognitive_Shift]
#22018113 - 07/30/15 01:41 AM (8 years, 5 months ago) |
|
|
Quote:
Cognitive_Shift said:
Quote:
During the ”double blind” trials, participants are given a mixture of pills — without being told whether they are existing opioids, new tamper-proof drugs, or placebos — and asked to abuse them, often by snorting them, or taking several at once. They must then rate how enjoyable the experience is.
Because an "abuse-deterrent" pill can stop some one from taking several pills at once 
I'm guessing (and this is a total random guess) that maybe they're adding in a drug that is inactive when you take one pill (dose is too low), but if you take two or three it causes unpleasant symptoms like vomiting etc. Just a guess.
Or maybe they're just making shit up. Probably just making shit up.
Let's be honest, we all know the drug companies love highly abusable opiates, and the more abusable and addictive the better. Companies have even switched from less addictive and less abusable formulas to way more abusable and more addictive formulas.
|
dark3st
Stranger


Registered: 08/02/13
Posts: 3,332
Last seen: 8 years, 3 months
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: nooneman]
#22018525 - 07/30/15 06:36 AM (8 years, 5 months ago) |
|
|
Quote:
nooneman said:
Quote:
Cognitive_Shift said:
Quote:
During the ”double blind” trials, participants are given a mixture of pills — without being told whether they are existing opioids, new tamper-proof drugs, or placebos — and asked to abuse them, often by snorting them, or taking several at once. They must then rate how enjoyable the experience is.
Because an "abuse-deterrent" pill can stop some one from taking several pills at once 
I'm guessing (and this is a total random guess) that maybe they're adding in a drug that is inactive when you take one pill (dose is too low), but if you take two or three it causes unpleasant symptoms like vomiting etc. Just a guess.
Or maybe they're just making shit up. Probably just making shit up.
Let's be honest, we all know the drug companies love highly abusable opiates, and the more abusable and addictive the better. Companies have even switched from less addictive and less abusable formulas to way more abusable and more addictive formulas.
Then ill just take more zofran/diphenhydramine
-------------------- Back.. I'm going to do it...I'm getting sober from opiates ... I got weed, gabapentin, propranolol, and GHB, I have 100mg tramadol left. I can do this. I can do this. OFINTQWGVGAKGCYKBUBX free dark P. Tampanensis prints to ODD members.
no stamps atm FREE SEEDS for ODD WCA members ONLY I have these seeds: Orange, red, and yellow sweet peppers, Purple poppies, White Habanero, Yellow Thai, Bolivian rainbow peppers, milk thistle, red chilly pepper, HBWR.
|
Cognitive_Shift
CS actual




Registered: 12/11/07
Posts: 29,591
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: nooneman]
#22018715 - 07/30/15 08:11 AM (8 years, 5 months ago) |
|
|
That's the only way I can think of to do it. Even then people are prescribed to take several pills at once
-------------------- L'enfer est plein de bonnes volontés et désirs
|
mrbart4444
The mycelium whisperer


Registered: 09/13/14
Posts: 2,266
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: Cognitive_Shift]
#22018726 - 07/30/15 08:16 AM (8 years, 5 months ago) |
|
|
is this why Tramadol makes you sick if you take more than recommended?
--------------------
|
Cognitive_Shift
CS actual




Registered: 12/11/07
Posts: 29,591
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: mrbart4444]
#22018735 - 07/30/15 08:20 AM (8 years, 5 months ago) |
|
|
Quote:
mrbart4444 said: is this why Tramadol makes you sick if you take more than recommended?
I don't believe so.
-------------------- L'enfer est plein de bonnes volontés et désirs
|
PurpleHaze147



Registered: 04/09/13
Posts: 657
Last seen: 6 years, 2 months
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: Cognitive_Shift]
#22019091 - 07/30/15 09:57 AM (8 years, 5 months ago) |
|
|
Quote:
Cognitive_Shift said:quote
Quote:
During the ”double blind” trials, participants are given a mixture of pills — without being told whether they are existing opioids, new tamper-proof drugs, or placebos — and asked to abuse them, often by snorting them, or taking several at once. They must then rate how enjoyable the experience is.
Because an "abuse-deterrent" pill can stop some one from taking several pills at once 
Are you being sarcastic? Yea they can its as simple as putting something unpleasant in them. This can also cause an increased risk of overdose if abused or make them not as effective for the people who need them unfortunately.
I hope this is a failure. Opiates feel enjoyable. The mechanisim that makes them feel enjoyable is what also causes them to kill pain. Leave the pills alone. I'd be pissed if I was prescribed Oxycontin and wasn't abusing them and had to switch to the crush proof formula which doesnt work as well because the stomach can't break em down as well.
|
PurpleHaze147



Registered: 04/09/13
Posts: 657
Last seen: 6 years, 2 months
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: mrbart4444]
#22019114 - 07/30/15 10:01 AM (8 years, 5 months ago) |
|
|
Quote:
mrbart4444 said: is this why Tramadol makes you sick if you take more than recommended?
It's proabably because it's a serotonin releaser and adrenalin reuptake inhibitor also instead of a pure opioid receptor agonist. I never really felt sick from them though, I remember they felt really nice when I didn't have a huge tolerance to opiates.
|
mrbart4444
The mycelium whisperer


Registered: 09/13/14
Posts: 2,266
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: PurpleHaze147]
#22019122 - 07/30/15 10:03 AM (8 years, 5 months ago) |
|
|
idk ive tried hydros tramadol and codeine (pill and syrup form) and i aint ever felt shit . Besides the Tramadol that made me puke.
--------------------
|
PurpleHaze147



Registered: 04/09/13
Posts: 657
Last seen: 6 years, 2 months
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: PurpleHaze147]
#22019168 - 07/30/15 10:14 AM (8 years, 5 months ago) |
|
|
^ yea the increased serotonin & adrenalin levels from tramadol make it way more likely to induce nausea & other side effects than codeine, hydrocodone, & other typical opioids.
|
Denman
Stranger


Registered: 03/16/15
Posts: 120
Last seen: 8 years, 5 months
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: nooneman]
#22019318 - 07/30/15 10:58 AM (8 years, 5 months ago) |
|
|
Quote:
nooneman said:
I'm guessing (and this is a total random guess) that maybe they're adding in a drug that is inactive when you take one pill (dose is too low), but if you take two or three it causes unpleasant symptoms like vomiting etc. Just a guess.
Or maybe they're just making shit up. Probably just making shit up.
Let's be honest, we all know the drug companies love highly abusable opiates, and the more abusable and addictive the better. Companies have even switched from less addictive and less abusable formulas to way more abusable and more addictive formulas.
About 2 years ago I read a study on tamper resistant meds. Learned some interesting new tricks big pharma is working on... In the US there are currently trials being done with MS capsules with nalaxone pellets mixed in. If you swallow it whole, the Naloxone pellets won't digest and will pass thru your body untouched. (Idk how its done, i have no idea on the chemistry of how it goes undigested). Crush it though, and the Naloxone is released and the morphine is useless. Plus if u have a habit and take nalaxone it makes u sick as hell. I've yet to see or hear of it on the market tho. Like I said tho, for every wall put up users will find a way around it.
But you're not actually making stuff up in that sense lol...
As for more a usable formulas, absolutely... Once the OP's came out, the 30mg instant release Roxie's flooded the market. So what was the point really? Now they're "working" on those as well from what I understand, but there's still Zohydro to deal with as well... Which to my knowledge is not tamper proof yet. (May e that's changed?) But 50-100mg of time released hydrocodone is ready to take the place of Roxie's if the time comes...
I don't even partake in pills anymore, (maybe once a year for extreme pain) and yet I'd know exactly what to get and why... I'm all for helping to stop people from ODing on their DOC, but in the end the ONLY people who suffer at all are the actual pain patients, just as PanzerCubed described his/her experience.
Ah well, life goes on. Wish that job offer would come around this way tho lol
-------------------- All posts are for Entertainment purposes only... I have no actual experience. I've never even been laid. Isn't the Internet great?!
Edited by Denman (07/30/15 10:59 AM)
|
Cognitive_Shift
CS actual




Registered: 12/11/07
Posts: 29,591
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: PurpleHaze147]
#22019322 - 07/30/15 11:00 AM (8 years, 5 months ago) |
|
|
Quote:
Are you being sarcastic? Yea they can its as simple as putting something unpleasant in them.
"something unpleasant" What like hot chili peppers?
They're trying to alter the formulation, they can't add more drugs. Maybe they can alter the formulation to abuse taking several pills at once, but good luck!
-------------------- L'enfer est plein de bonnes volontés et désirs
|
PurpleHaze147



Registered: 04/09/13
Posts: 657
Last seen: 6 years, 2 months
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: Cognitive_Shift]
#22020191 - 07/30/15 02:49 PM (8 years, 5 months ago) |
|
|
Quote:
Cognitive_Shift said:
Quote:
Are you being sarcastic? Yea they can its as simple as putting something unpleasant in them.
"something unpleasant" What like hot chili peppers?
They're trying to alter the formulation, they can't add more drugs. Maybe they can alter the formulation to abuse taking several pills at once, but good luck!
No like I meant like atropaine, ipecac, or naltrexone. You sure it says they can't add new drugs because that isn't implied in alter formulation ?
|
Cognitive_Shift
CS actual




Registered: 12/11/07
Posts: 29,591
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: PurpleHaze147]
#22020412 - 07/30/15 03:33 PM (8 years, 5 months ago) |
|
|
They're trying to change the formulation of the pill to make it "abuse resistant." If they were to add another drug it would be an entirely new product which would take 10+ years of research, study and 100s of millions of dollars.
-------------------- L'enfer est plein de bonnes volontés et désirs
|
badchad
Mad Scientist

Registered: 03/02/05
Posts: 13,372
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: PurpleHaze147]
#22021814 - 07/30/15 08:03 PM (8 years, 5 months ago) |
|
|
Quote:
PurpleHaze147 said:
No like I meant like atropaine, ipecac, or naltrexone. You sure it says they can't add new drugs because that isn't implied in alter formulation ?
They could. This was what happened with Embeda. Especially in the case of combining two approved drugs, they can rely on the previous safety information.
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
|
Denman
Stranger


Registered: 03/16/15
Posts: 120
Last seen: 8 years, 5 months
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: badchad]
#22025804 - 07/31/15 07:18 PM (8 years, 5 months ago) |
|
|
Quote:
badchad said:
Quote:
PurpleHaze147 said:
No like I meant like atropaine, ipecac, or naltrexone. You sure it says they can't add new drugs because that isn't implied in alter formulation ?
They could. This was what happened with Embeda. Especially in the case of combining two approved drugs, they can rely on the previous safety information.
Suboxone is a good example of that. Buprenorphine and Nalaxone. It doesn't make it abuse resistant, just 2 known drugs combined into one. Not on point with the original topic, but it does keep people from enjoying other opiates. Just another example of what badchad pointed out. Bup worked fine by itself, then they threw in nalaxone and had a new (patented $$$) drug. Highly marketable now that it is "safe"...
-------------------- All posts are for Entertainment purposes only... I have no actual experience. I've never even been laid. Isn't the Internet great?!
|
PurpleHaze147



Registered: 04/09/13
Posts: 657
Last seen: 6 years, 2 months
|
Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: Denman] 1
#22046271 - 08/05/15 09:02 AM (8 years, 5 months ago) |
|
|
^ The nalxone makes no noticeable difference when mixed with buprenorphine but it does when mixed with other opioids. This is because buprenorphine binds ridiculously strong to the opioid receptors, much stronger than naloxone. Naloxone, the antidote for opioid overdoses (heroin, oxy, etc), can't displace the opioid buprenorphine even when injected.
Buprenorphine on its own causes withdrawal if another opioid is in the blood stream just like naloxone. A partial agonist (like bupe) plus a full agonist makes the partial agonist act as an antagonist. There was no reason to put naloxone with bupe other than to get a new patent.
|
|