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OfflinePurpleHaze147
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Registered: 04/09/13
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Re: Wanted: drug abuser who enjoys snorting opioids. Will pay $250 a day [Re: Denman] * 1
    #22046271 - 08/05/15 09:02 AM (8 years, 5 months ago)

^ The nalxone makes no noticeable difference when mixed with buprenorphine but it does when mixed with other opioids. This is because buprenorphine binds ridiculously strong to the opioid receptors, much stronger than naloxone. Naloxone, the antidote for opioid overdoses (heroin, oxy, etc), can't displace the opioid buprenorphine even when injected.

Buprenorphine on its own causes withdrawal if another opioid is in the blood stream just like naloxone. A partial agonist (like bupe) plus a full agonist makes the partial agonist act as an antagonist. There was no reason to put naloxone with bupe other than to get a new patent.


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