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OfflinePurpleHaze147
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Tryptamine + MAOI
    #21979879 - 07/22/15 10:59 AM (8 years, 6 months ago)

I want to take tryptamine orally with an MAOI. The same way N,N-dimethyl-tryptamine is taken with an MAOI; Ayahusca. I predict it would give very similar effects compared to DMT with an MAOI.

Baeocystin, de-methylated psilocybin, was reported to have the same psychoactive effects as psilocin. The de-methylated substituted tryptamines seem to have the psychoactive effects as the methylated tryptamine. So tryptamine should have very similar effects to DMT.

Tryptamine has a very good pharmacological profile; it's a TAAR1 agonist (triple monoamide releaser; serotonin, dopamine, and adrenaline) and a 5-HT2R agonist. It might be a twist of MDMA and Ayahusca.

Has anyone ever done this or without an MAOI with the trypamine either smoked, snorted, plugged, or injected?


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Offlines240779
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Re: Tryptamine + MAOI [Re: PurpleHaze147] * 1
    #21979916 - 07/22/15 11:10 AM (8 years, 6 months ago)

Interesting topic. I want to emphasize that MAOIs really don't have too many drug contraindications and that many MAOIs do not produce a hazardous reaction when combined with those foods; these MAOIs include harmine and harmaline, well known to our psychonaut community. But more importantly, an article entitled 'MAO Inhibitors: Risks, Benefits, and Lore' points out that many foods have been wrongly added to MAOI diet lists. It actually seems to me like many people in the Western part of the world have never even violated the MAOI diet in their entire life. Anyway, if the diet is violated when on harmine, I believe it actually wastes the harmine — kicks it out of your system. It is only certain pharmaceuticals that present a hazardous reaction in the same scenario.

If anybody wants to read more into the true danger level of MAOIs, read this post and this post.


Edited by s240779 (07/22/15 11:17 AM)


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OfflinePurpleHaze147
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Re: Tryptamine + MAOI [Re: s240779]
    #21979998 - 07/22/15 11:33 AM (8 years, 6 months ago)

@Da2ra You have to be very careful of what medicines/drugs you take when you take a MAOI. Lots of psychiatric medications, many, increase the brain's natural monoamine levels &/or are monoamines themselves.

Some,  not all, of the drugs u can't take a week b4 or a week after a MAOI: (on the safe side because it depends on the medications' half life) all amphetamines; all anti-depressants; all decongestants including most allergy meds; ephedrine; phenethylamine*; cocaine; methylphenidate; epinephrine (Epi-Pen), etc.


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Re: Tryptamine + MAOI [Re: PurpleHaze147] * 1
    #21980059 - 07/22/15 11:51 AM (8 years, 6 months ago)

Oh god, you didn't even read my linked-to posts. You completely ignored me, despite the fact that I backed up what I said, which is pathetic.


Quote:

PurpleHaze147 said:
all anti-depressants;




We have found all antidepressants that do not involve significant serotonin reuptake inhibition (e.g., bupropion, trazodone, and tricyclics other than clomipramine) can be safely administered with MAOIs. Combination therapy is worth considering because it may be effective when other approaches have failed.

Cole J, Bodkin A. MAO inhibitors: An option worth trying in treatment-resistant cases. Current Psychiatry, Vol. 1, No. 6, June 2002


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Re: Tryptamine + MAOI [Re: s240779]
    #21984088 - 07/23/15 11:01 AM (8 years, 6 months ago)

^ Trycylics are typically serotonin / noradrenaline reuptake inhibitors. Serotonin sydrome aside, I wouldnt risk having a hypertensive crisis from too much adrenaline.


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Re: Tryptamine + MAOI [Re: PurpleHaze147] * 1
    #21984135 - 07/23/15 11:17 AM (8 years, 6 months ago)

And if you read the second link, you would have seen two reports by people who are using amphetamines in combination with MAOIs. I think almost everything you ignorantly red flagged is safe in combination with MAOIs.


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Re: Tryptamine + MAOI [Re: s240779]
    #21984988 - 07/23/15 02:01 PM (8 years, 6 months ago)

I read the links. It's still too dangerous to recommend. A casual user is sure to have serious complications with those mixes. There's hundreds of legit sources, not bluelight, that say dont mix those meds with MAOIs because of potentially fatal interactions. I'm pretty sure a therapeutic dose of an MAOI lower than one used with Ayahusca. Harmine isn't even used medically. Yea u can get away with taking a low dose of an MAO(A)I on amphetamine bcuz its mostly metabolsed by MAO-B which breaks down only dopamine to a signicant degree. TCAs' main mechanisms of action is serotonin reuptake inhibition, theyre also antagonists at same time but still.

"The reversibility and MAO-A selectivity of harmala alkaloids do not, however, prevent potentially fatal interactions with common medications such as antihistamines, most antidepressants, many stimulants, common migraine medications, some herbs, decongestants, expectorants, and common cough and cold medications."


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Edited by PurpleHaze147 (07/27/15 08:27 PM)


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