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InvisibleAdden
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Scientists Figured Out How to Block Pot’s Effect on Memory * 1
    #21960545 - 07/18/15 01:07 PM (8 years, 6 months ago)

Reposting this from the Pub post by Gottaloveacid.

Quote:

Gottaloveacid said:
Figured I would post this here so more people can see.

http://www.hightimes.com/read/scientists-figured-out-how-block-pot%E2%80%99s-effect-memory

A short breakdown of the article is CB1 receptors are directly connected to 5-HT2a receptors (the receptor mainly responsible for psychedelics' effects) and basically they work together in many very interesting ways. The biggest one is that they have found that the 5-HT2a receptor is what gives CB1 agonists such as THC their psychoactive effects, and when the CB1 and 5-HT2a receptors are split, THC only gave the medical effects you would expect from the CB1 receptor

I would highly recommend you read the article




Scientists Figured Out How to Block Pot’s Effect on Memory



Recent work published by researchers in Barcelona has just uncovered more details about the neurochemical pathway that leads to marijuana’s psychoactive effects, specifically its effects on memory. Not only did they make a breakthrough in the neurochemistry of cannabis, they also designed a compound that was able to block THC’s effects on memory in mice.

Since the discovery of the cannabinoid receptor by Raphael Mechoulam and colleagues, medical scientists have continued to investigate this newly found receptor and have found that it has a presence all over the body, not just in the brain. In fact, two cannabinoid receptors exist: CB1 and CB2. While the CB2 receptor stills retains some of its mystery, scientists have know for a while that the CB1 receptor is the one responsible for the “high” in cannabis.


More recently however, neuroscientists have found links between the certain serotonin receptors and the cannabinoid system. Not only do these receptors share a region in the brain, but also activation of the 5HT2A receptor causes a release of endocannabinoids, the body’s natural “darts” for the cannabinoid receptor’s “dartboard” (in a similar way that your body produces serotonin to act as a signal carrier in your serotonin system).


Going along this line of thought, researchers in Barcelona decided to look deeper into the serotonin receptor – cannabinoid receptor connection, and they found that the two receptors are literally connected to each other. The two receptors associate with each other to form what’s called a heteromer. Receptors are located on the cell wall of neurons in the brain, but the heteromer receptor was only found in certain areas.

By performing experiments on mice they found that THC’s effect on short-term memory is not the cannabinoid receptor’s “fault,” in a manner of speaking. The attached serotonin receptor seems like the culprit for certain psychoactive effects, while the pain relief and other medical benefits of THC stem from the cannabinoid receptor.




There you can see a schematic of what's going on in the neurons of some really high mice. Normally the cannabinoid receptor (CB1R) and the serotonin receptor (5HT2AR) form the heteromer, attached halfway in and out of the cell wall of a neuron. When THC binds to CB1R on the outside of the cell, it makes a signal on the inside that affects the neuron's behavior. Recent findings show that when THC hits CB1R, it also makes 5HT2AR produce a signal. This same serotonin receptor is also involved the hallucinogenic and psychedelic effects of famous substances like LSD and psilocybin, the active component of magic mushrooms.

When normal mice were given a special drug (the “interference peptide” from the drawing) that blocked the association between the two receptors, they didn’t get short-term memory loss when given THC but it still had its pain-relieving effects. Genetically modified mice without a 5HT2A receptor, but with an intact CB1 receptor, didn’t suffer short-term memory loss when given even high doses of THC, but they still got the pain-relieving effects.

The results of their work are highly important for the development of new medicines. Cannabis has great medical potential, but the effects on memory and anxiety are clearly not for everybody, even as a matter of taste. Hopefully this discovery will one day lead to a safer alternative to dangerous opiate pain relievers and habit-forming sleep aids.


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OfflineLSDaytripper
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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Adden]
    #21960655 - 07/18/15 01:33 PM (8 years, 6 months ago)

So where can I buy some of these "interference peptides?" :cool:


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***** (10:42:46 PM): This is so strange
***** (10:42:53 PM): Becuase I feel that I am very altered
***** (10:42:57 PM): But at the same exact time
***** (10:43:28 PM): I am closer to the real me, the real me who decides who I am, the entire me


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InvisibleAtreyu
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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: LSDaytripper]
    #21960741 - 07/18/15 01:57 PM (8 years, 6 months ago)

Cannabis helps with memory in the long term though, that's why it's good for alzheimers disease.

It can effect your memory in the short-term but over all it's actually good for your memory in the long term, this is true.


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つ ◕_◕ ༽つ N = R* • fp • ne • fl • fi • fc • L 


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Invisibletito123
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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Atreyu]
    #21960764 - 07/18/15 02:08 PM (8 years, 6 months ago)

Yeah I'd like some interference peptides. I don't like the high from pot since it makes my thoughts go everywhere and I feel anxious.


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Invisiblenooneman
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Registered: 04/24/09
Posts: 14,561
Loc: Utah
Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Adden]
    #21960848 - 07/18/15 02:34 PM (8 years, 6 months ago)

I honestly would have never guessed that there really is a relation between cannabinoid receptors and 5HT2A. I always thought that suggestions of a relation were complete bullshit. I was wrong.


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Invisiblelessismore
Registered: 02/10/13
Posts: 6,268
Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Atreyu]
    #21960895 - 07/18/15 02:54 PM (8 years, 6 months ago)

Quote:

Atreyu said:
Cannabis helps with memory in the long term though, that's why it's good for alzheimers disease.

It can effect your memory in the short-term but over all it's actually good for your memory in the long term, this is true.



Maybe I need to smoke some, I think I got alzheimers from smoking my thoughts are like a thick mist?;-)

It's cloudy still years later, I only smoked for a few years

Head still feels funny 2 years later after stopping...


But interesting research, the effect on memory is the biggest side effect for me, and also the way it can give deluded thoughts with overuse. Maybe one day medical patients can get better memory due to this research...
The paranoia I'm not sure what they would do about though... , weed changes one thoughts in strange ways, sure it feels trippy, but it takes a long while, years, before your thoughts start to feel sane again.

It can give very strange thoughts... , you can even smoke yourself back to your childhood, regression

So it's not just the beauty molecule it's portrayed as, not for everyone. It may have medicinal benefits though..
Getting stoned everyday will only effect your memory, mind long term in usually very negative ways


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InvisibleGottaloveacid
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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: lessismore]
    #21961240 - 07/18/15 04:20 PM (8 years, 6 months ago)

Quote:

lessismore said:
Quote:

Atreyu said:
Cannabis helps with memory in the long term though, that's why it's good for alzheimers disease.

It can effect your memory in the short-term but over all it's actually good for your memory in the long term, this is true.



Maybe I need to smoke some, I think I got alzheimers from smoking my thoughts are like a thick mist?;-)

It's cloudy still years later, I only smoked for a few years

Head still feels funny 2 years later after stopping...


But interesting research, the effect on memory is the biggest side effect for me, and also the way it can give deluded thoughts with overuse. Maybe one day medical patients can get better memory due to this research...
The paranoia I'm not sure what they would do about though... , weed changes one thoughts in strange ways, sure it feels trippy, but it takes a long while, years, before your thoughts start to feel sane again.

It can give very strange thoughts... , you can even smoke yourself back to your childhood, regression

So it's not just the beauty molecule it's portrayed as, not for everyone. It may have medicinal benefits though..
Getting stoned everyday will only effect your memory, mind long term in usually very negative ways




Well basically the whole point of me posting the article originally was because I was fascinated by the fact that THC directly correlates with the 5-HT2a receptor, the one used to create psychedelic effects, which means the psychoactive effects of cannabis are 100% psychedelic

All of the negative effects from consuming cannabis (aside from smoke damage), such an anxiety, paranoia, temporary memory changes, time dilation (neutral) are all caused by the psychoactive 5-HT2a agonisation

So once doctors start doing these trials on humans, I would expect cannabis to be turned into more of a proper medicine that doesn't get you high, but has all of the same medicinal effects


--------------------
   
:mushroom2::mushroom2: The greatest story ever told is the story that never ends!:mushroom2::mushroom2:

wubba lubba dub dubstep :gimmebass:


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Invisiblelessismore
Registered: 02/10/13
Posts: 6,268
Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Gottaloveacid]
    #21961325 - 07/18/15 04:43 PM (8 years, 6 months ago)

Cannabis is as psychedelic for me as a medium dose LSD trip each time. I feel like in another reality if I take 2 puffs of strong stuff.

For many hours... can be great, but can also give anxiety


I stopped due to it giving me anxiety and showing me my problems in my face. Only smoke what your life situations supports ;-)


I always used grav bong bucket in kitchen btw... very psychedelic, visual too whole night.
Laundry basket is even better. Do it rarely, get the strongest stuff you can find, laundry basket + large coke bottle. Take 2-3 lungfulls, you will hallucinate the rest of the night and morning too.

It puts you in a new separate reality, you may even see faces and stuff overlapping reality, or what looks like spirits... strange visuals, You may hear audio hallucinations/the door ring many times too, but noone there when you check the door...


It's hard to say what is psychosis or cannabis psychedelic effect. Psychedelic effect is often psychosis like...

But the hallucinations are very close to psychedelics and I imagine it could give me trip as any psychedelic, LSD , mushrooms. I liked weed cupcakes too, which gave a really nice laughing experience whole night..

It can give you trip/good nights out youll never forget, But it can also do damage if overused


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Invisiblenooneman
Male

Registered: 04/24/09
Posts: 14,561
Loc: Utah
Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Gottaloveacid]
    #21961699 - 07/18/15 06:17 PM (8 years, 6 months ago)

Quote:

Gottaloveacid said:
Quote:

lessismore said:
Quote:

Atreyu said:
Cannabis helps with memory in the long term though, that's why it's good for alzheimers disease.

It can effect your memory in the short-term but over all it's actually good for your memory in the long term, this is true.



Maybe I need to smoke some, I think I got alzheimers from smoking my thoughts are like a thick mist?;-)

It's cloudy still years later, I only smoked for a few years

Head still feels funny 2 years later after stopping...


But interesting research, the effect on memory is the biggest side effect for me, and also the way it can give deluded thoughts with overuse. Maybe one day medical patients can get better memory due to this research...
The paranoia I'm not sure what they would do about though... , weed changes one thoughts in strange ways, sure it feels trippy, but it takes a long while, years, before your thoughts start to feel sane again.

It can give very strange thoughts... , you can even smoke yourself back to your childhood, regression

So it's not just the beauty molecule it's portrayed as, not for everyone. It may have medicinal benefits though..
Getting stoned everyday will only effect your memory, mind long term in usually very negative ways




Well basically the whole point of me posting the article originally was because I was fascinated by the fact that THC directly correlates with the 5-HT2a receptor, the one used to create psychedelic effects, which means the psychoactive effects of cannabis are 100% psychedelic



Not 100%. It's still it's own receptor, but it does have some 5HT2A effects.


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OfflineKonyap

Registered: 06/30/07
Posts: 33,945
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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: nooneman]
    #21962251 - 07/18/15 08:24 PM (8 years, 6 months ago)

schizophrenia 1%
dementia - alzheimers .5% & .5%

If weed helps with alzheimers it's because the mind has colonized so hard it is rotten from the inside out, so the weed will give it some activity sites so it can become a more sentient being.

Weed doesn't help dementia at all and supposedly makes it worse, but by how much I don't know


Edited by Konyap (07/19/15 01:49 AM)


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InvisibleCognitive_Shift
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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Konyap]
    #21962438 - 07/18/15 09:11 PM (8 years, 6 months ago)

Okay this was one of the coolest reads I've had in this forum:thumbup:


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Invisibleroquet
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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Gottaloveacid]
    #21962440 - 07/18/15 09:12 PM (8 years, 6 months ago)

Quote:

Gottaloveacid said:
All of the negative effects from consuming cannabis (aside from smoke damage), such an anxiety, paranoia, temporary memory changes, time dilation (neutral) are all caused by the psychoactive 5-HT2a agonisation



Isn't "feeling stoned" one of the psychoactive effects, and main reason for recreational use of cannabis? It's not clear from the article if they count it as medical or psychoactive.


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InvisibleGottaloveacid
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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: roquet]
    #21962609 - 07/18/15 10:09 PM (8 years, 6 months ago)

Quote:

roquet said:
Quote:

Gottaloveacid said:
All of the negative effects from consuming cannabis (aside from smoke damage), such an anxiety, paranoia, temporary memory changes, time dilation (neutral) are all caused by the psychoactive 5-HT2a agonisation



Isn't "feeling stoned" one of the psychoactive effects, and main reason for recreational use of cannabis? It's not clear from the article if they count it as medical or psychoactive.




The "feeling stoned" is one of the psychoactive effects, and that is the main reason that this article is so important for future medical research. With this research, scientists can now work on human trials for this mysterious peptide that will block CH1 agonists like THC from entering the psychoactive 5-HT2a receptor, giving scientists a potent medicine that has virtually NO side effects (since most, if not all of the negative THC effects are caused by the 5-HT2a psychedelic agonism)


While this may not be good news for people who want to get high from weed, it is very important for medical advances in the future.


--------------------
   
:mushroom2::mushroom2: The greatest story ever told is the story that never ends!:mushroom2::mushroom2:

wubba lubba dub dubstep :gimmebass:


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OfflineKonyap

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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Gottaloveacid]
    #21963303 - 07/19/15 01:48 AM (8 years, 6 months ago)

anti-inflammatory


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InvisibleToadstool5
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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Konyap]
    #21963352 - 07/19/15 02:25 AM (8 years, 6 months ago)

Quote:

relation between cannabinoid receptors and 5HT2A




It explains the potentiating effect of cannabis with psilocybin but i wonder how it specifically effects its binding with this new heteromer dynamic.

Its not too surprising due to the fact that G protein coupled receptors form heteromers frequently (both CB receptors and 5HT are GPCRs) and cannabis is psychedelic enough to produce OEV with a strong enough dose. 5HT seems to almost always be involved with psychedelia. Definitely has been proven due to the amazing work of these guys and their stoned mice. :lol:

Awesome read OP! :awesomenod::thumbup:


--------------------
If you do not know where the mushroom products you are consuming are grown, think twice before eating them. :badshroom:
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OfflineDrumdude27
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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Toadstool5]
    #21967080 - 07/19/15 08:27 PM (8 years, 6 months ago)

+1 for the read
and your sig :wink:

I'm super interested to see where this takes us


--------------------



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Don't make me get the FemNazis involved guys.

420th post. No regrets. Only joy.


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OfflineKonyap

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Re: Scientists Figured Out How to Block Pot’s Effect on Memory [Re: Drumdude27]
    #21972631 - 07/20/15 08:07 PM (8 years, 6 months ago)

5hta2r is here
:love: is eternal


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