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Shroomism
Space Travellin



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Why can I not get high from edibles? 2
#21853610 - 06/25/15 02:42 AM (8 years, 7 months ago) |
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This is science related I guess... I'm just wondering if there's any biology experts or whatever in here that can shed some light on this because it's been perplexing me for a while. Really, I would just like a logical/scientific explanation for why this happens.. or even just a guess. Please don't tell me the edibles are bunk or weak or the people making them don't know what they are doing because that is not the case at all. (see below).
I'm just going to copy and paste what I posted in another thread:
I've been smoking pot for ~20 years now, pretty much daily, although I do take tolerance breaks every once in a while. Even when I have a high tolerance, I can still get high just fine by smoking.
Over the years, I have eaten hundreds of different kinds of edibles.. at every stage of my cannabis use.. and they hardly effect me at ALL. I have never ONCE been blazed from edibles. At MOST, I get a VERY light.. mild buzz.
People always say oh you are just getting bunk or super weak edibles.. the people making them aren't doing them right.. yadda yadda blah blah... no.
- I have eaten numerous firecrackers made with 1-4g of top shelf kush - they do nothing. Meanwhile I can smoke a single bowl of that SAME WEED and get high.
- I have eaten numerous "super potent" edibles from dispensaries in EVERY form you can imagine - they all do practically nothing. Gummi bears, cookies, rice krispie treats, tinctures, chocolates, etc etc etc. It's a complete waste. The exact same edibles - other people can eat half of one and get zombified couch locked high as shit for 6-8 hours. I eat three to four times as many as they do and feel almost nothing.
- 1,000 mg THC bhang bars - I can eat 2 or 3 of them and might catch a super slight buzz
- I have eaten numerous batches of homemade brownies made with premium cannabutter that a grower friend made. Everyone else gets high as shit from one. I eat three... Almost Nothing. One friend put an OUNCE of top shelf in a small batch of brownies. Other people eat a quarter of ONE and get completely fried. I eat four or five of them and barely catch a buzz.
- My crazy pot scientist friend makes SUPER potent brownies... warns you "be careful bro.. only eat HALF or a QUARTER of one and don't have anything planned for the rest of the day... " I'll eat three or four of them, they are hard to get down because they taste so strongly of herb.... catch the lightest buzz possible, barely even noticeable. Other people eat half of the same brownies and can't move
- I've had a professional "pot chef" make me some cannabis food - nothing.
I've challenged people to make me an edible that can get me high. No one has been able to do it. I've been trying to like 15 years or something. An edible that everyone else says will get them completely fucked up, I can literally eat 5x as many as them, and barely even catch a tiny light buzz. That's the most I have EVER gotten from edibles... a SUPER light body buzz.. barely even noticeable. Every single time I feel like I got jipped. But it's just my biology it seems. I have tried taking a tolerance break for 3+ weeks, they still do nothing. Then I take one hit from a bong and get fried. It has absolutely nothing to do with the potency of the edibles or my tolerance. They can be the strongest edibles in the world and I could have zero tolerance and it would be the same thing.
It is a complete and absolute waste of weed for me to consume edibles. They do basically nothing for me.
We aren't talking an isolated incident or two with someone that didn't know what they were doing. I am talking about hundreds of different attempts, of some of the most potent edibles you can make. Believe me, I have tried... HARD. It has taken me many years and hundreds of attempts and experimentation to come to this conclusion. I'm practically immune from edibles.
For whatever weird reason... eating weed does not really effect me at all. Which sucks. Because I want to feel that lasting, super deep body high that everyone talks about from edibles.. But it's impossible for me. It doesn't matter what my tolerance is like. It's my liver.. my metabolism.. something with my body chemistry... I have no fucking clue what causes it.. but eating weed does nothing for me. So I just stick to smoking/vaping it. Works like a charm, every time.
In all my time here, I've only found one or two people on the shroomery here that have the same issue. It's extremely rare, but it happens for some reason.
I would really love to find a scientific explanation for why this happens. We need more studies on this.
(Note in case it's relevant.. I am not overweight by any means, in fact I am skinny. I am 6'2 and 175lbs)
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Oeric McKenna
LIFE CAPS


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Re: Why can I not get high from edibles? [Re: Shroomism]
#21853621 - 06/25/15 02:47 AM (8 years, 7 months ago) |
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Thats weird as hell man. The Russians taught me how make this concentrated bhang (milk) stuff thats so potent its practically poisonous.... Ive seen disasters from it
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Shroomism
Space Travellin



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Re: Why can I not get high from edibles? [Re: Oeric McKenna] 1
#21853624 - 06/25/15 02:50 AM (8 years, 7 months ago) |
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I have tried bhang bars too. Multiple times.... multiple bars too.. Same thing. I'm a freak of nature
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Rebelutionsssss
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Re: Why can I not get high from edibles? [Re: Shroomism]
#21853627 - 06/25/15 02:53 AM (8 years, 7 months ago) |
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A 4th of a bhang bar will get me beyond lit haha edibles will get me stupid high for hours
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Shroomism
Space Travellin



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Yeah same with everyone else.... I could eat 4 of those bars and maybe... maybe catch a light buzz.
... then I can go and take a bong hit and get high instantly.
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Rebelutionsssss
Mdmazing



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Re: Why can I not get high from edibles? [Re: Shroomism]
#21853635 - 06/25/15 02:56 AM (8 years, 7 months ago) |
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Have you tried the 51\50 bars? I believe they're like 60 something doses
-------------------- : To define is to confine.
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Shroomism
Space Travellin



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I don't think so on those particular ones... but I have essentially tried edibles that strong or even stronger before. I mean I've eaten some pretty ridiculous quantities of super potent edibles. I doubt they would be any different.
I'll give them a try if I see them at my dispensary... but yeah I have big doubts. I'm convinced it's something with my body. It has nothing to do with how potent the edibles are.
I got reminded of it after reading this article - http://www.marketwatch.com/story/i-tried-edible-marijuana-and-felt-nothing-2015-03-11 And I'm thinking that guy has the same issue. He's blaming the potency and consistency of the product. But edible companies don't sell completely bunk edibles... But it made me think back to all the HUNDREDS of times I have tried dosing edible cannabis, even QUADRUPLING or MORE the dose normal people take.
This has been going on for years now. I've tried just about everything out there. I'm just trying to figure out WHY.. it's really weird. I can smoke it and get high as shit. I can eat the shit all day long and feel basically nothing.
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Shroomism
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Re: Why can I not get high from edibles? [Re: Shroomism]
#21858277 - 06/26/15 01:21 AM (8 years, 7 months ago) |
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I'm not alone - http://www.reddit.com/r/eldertrees/comments/2purbf/i_have_never_experienced_any_effect_from_edibles/
Quote:
I've been a budtender for 6 years now, so I've had time to notice this in people.
Seems about 5%, maybe less, of folks just get no effect from edibles, regardless of dose. I'm one of them myself. I've eaten 300mg of THC with 0 effect.
/u/Brutal_Peacemaker has, in my opinion, the best theory on why that is. It seems the most likely culprit is some difference with our digestive system. It might be a problem with liver metabolism/first pass. It might be the lack of an enzyme that helps digest it.
One time I got a mild buzz from 75mg THC, and that was when I ate the edible 45min after a huge meal. I was stuffed, and ate the edible on top of it, and an hour later I felt a definite onset- much stronger than my previous 100mg+ experiences.
I've wasted hundreds of dollars trying to get edibles to work, taking quintuple doses and whatnot. I've given up, and just don't bother anymore.
You should know the vast majority of people will start to feel THC at a 10mg dose, and most experienced smokers with a tolerance tend to like 20-50mg doses.
Someone suggested I take lipase supplements with the edibles to see if it helps (lipase is an enzyme that can break down fatty substances) but I have not tried that yet.
Digestive system or enzymes or liver... that seems to make the most sense and that's always what I have assumed.
Lipase supplements are something I have not tried... so I'm going to give that a try sometime.
Also mangos are proven to potentiate cannabis significantly when eaten 45mins - 1hr before before smoking. So I'm going to try that with edibles.
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Byrain

Registered: 01/07/10
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Re: Why can I not get high from edibles? [Re: Shroomism]
#21859057 - 06/26/15 09:12 AM (8 years, 7 months ago) |
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1. Science doesn't prove, it explains. 2. Where is it explained how mango's potentiate Cannabis? If you have any sources I'd be interested in reading them.
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Shroomism
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Re: Why can I not get high from edibles? [Re: Byrain]
#21859413 - 06/26/15 10:42 AM (8 years, 7 months ago) |
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Here ya go http://www.theweedblog.com/mangos-increase-the-effects-of-consuming-marijuana/ http://www.medicaldaily.com/mangoes-elevate-high-smoking-marijuana-are-they-healthier-alternative-munchies-247892 http://berkeleypatientscare.com/2010/10/08/terpenes-terpenoids-and-cannabis/
It has to do with the myrcene terpenes in mangoes allowing THC to pass the blood brain barrier much faster.. resulting in the high hitting faster and lasting longer. It definitely works for smoking, so I assume it would work for edibles as well, but maybe not. The lipase thing sounds like a good idea.
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DieCommie

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Re: Why can I not get high from edibles? [Re: Shroomism]
#21859446 - 06/26/15 10:52 AM (8 years, 7 months ago) |
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Cool idea, I'll read the link tonight.
Edibles do nothing for me either, I have given up on them.
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Shroomism
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Re: Why can I not get high from edibles? [Re: DieCommie]
#21859497 - 06/26/15 11:00 AM (8 years, 7 months ago) |
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I've not completely given up just yet.... I am determined. The lipase supplement thing sounds logical enough.. I will give that a try next time and see if it does anything. But if that and mangoes doesn't work... then yeah I give up.
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StygianKnight
A Mushroom

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Re: Why can I not get high from edibles? [Re: Shroomism]
#21862942 - 06/27/15 07:36 AM (8 years, 6 months ago) |
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Have you tried a sublingual tincture? (alcohol extract). I know it's not quite a brownie or something but I've had good results holding a strong tincture under the tongue for 5-10 min before swallowing, although edibles do work for me, so it's not the best comparison.
I agree with Shroomism, it's possible enzymes are screwing you over. Another possibility is digestion time. I've found pot can build a strong temporary tolerance, if your body is digesting the THC slower than it builds tolerance, it might lead to nothing. However, given the amount you have thrown at it, it's clear something is making sure it doesn't go from your stomach to brain.
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Shroomism
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Re: Why can I not get high from edibles? [Re: StygianKnight]
#21864565 - 06/27/15 02:30 PM (8 years, 6 months ago) |
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Yeah tinctures are the same deal. I've also tried various things to potentiate it like alcohol, coconut oil etc etc. Only things I haven't really tried that seems worth it is the mango thing and lipase supplements. So that's worth a go at least. I used to think I was just a complete freak of nature, but now I know at least some other people have the exact same issue. I would be interested to know exactly why this occurs. It's quite a strange thing. Now that cannabis is becoming more and more accepted hopefully we will get more studies.
I am guessing my metabolism has something to do with it. I have always had a SUPER crazy metabolism. I can pretty much eat whatever I want without gaining weight and it has always been this way, I'm 33 now and it hasn't really slowed down much at all. I also often sweat profusely at night when I sleep... as in wake up and the blankets are completely drenched in sweat.. I am a hot sleeper.. but I almost never get sick. Haven't been sick in about 12 years. But there doesn't seem to be any rhyme or reason to the sweating thing, regardless of the temperatures. Sometimes it happens and sometimes it doesn't. Maybe it's after I've been eating too much junk food or something and my body needs to get purge all the toxins, dunno.
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Le_Canard
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Re: Why can I not get high from edibles? [Re: Shroomism]
#21867476 - 06/28/15 07:37 AM (8 years, 6 months ago) |
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Hm, strange. I dunno Shroo. Maybe you have some unique gut bugs that gobble up THC.
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ReposadoXochipilli
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Re: Why can I not get high from edibles? [Re: Le_Canard]
#21868853 - 06/28/15 02:34 PM (8 years, 6 months ago) |
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It is a very different high for me as well, I find to actually get lit from edibles I have to take so much that it isn't even fun, more of I have had to piss for two hours but too lazy to get up and do it feeling.
I only use them that I make myself for things like movies ect. But it only is to supplement the buzz I have, standalone it feels like a waste.
Ime club edibles are weak due to liability of idiots eating too much and having bad things happen.
Nothing like that combustion of a bong rip.
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grownright
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Dude that's crazy. Could it be because of the method of ingestion? Maybe weed has a more intense effect smoked than orally. Sort of like DMT in a way, haha.
I have a hard time getting high with edibles too, if I can taste the weed in it more than I can the edible itself I know I'll get high. This one time a buddy of mine had inherited a kilo from a friend that was growing. He would help the guy out each week and come back with an oz every Friday, it was awesome cause he smoked me out all the time haha. The guy moved to Oregon though, so he had to leave behind a lot of his weed. So my friend and I decided to make most of this kilo of primo headband buds into cannabutter over at another friends house, I had school that morning though, so they started without me. I arrived at the house in the afternoon and walked in the kitchen to help. There were two trays of brownies laying on the stove, my friends being pranksters told me one, which had no brownies missing from it had weed in it, and the other didnt. so I ate two brownies. Started helping them, taking a smoke break or two in between, and eating another 2 brownies (I was very fat at the time lol). well while pouring off the finished cannabutter he spilled a little bit and dared me to eat the small bit off the counter. It was about a spoonfull, I didnt think that was shit so I did. He said that amount was probably gonna get me very lit, so I upped the game and grabbed two more brownies and dipped them in the crockpot of cannabutter and ate both of them, and then they revealed that the brownies had weed in them. After that I rushed home and blacked out lmao
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Edited by grownright (07/01/15 08:35 AM)
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Atreyu
Never Ending


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Re: Why can I not get high from edibles? [Re: grownright]
#21893341 - 07/03/15 04:07 PM (8 years, 6 months ago) |
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I've never felt much from eating edibles, even smoking (after vaping herb for 5 yrs) cannabis doesn't hit me like vaping does.
I get a lot more benefit from vaping now than smoking, where as smoking use to get me really high and was a really effective method for consuming.
Unless the herb is mixed with keef, I don't get as much of an effect as I feel I should.
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IcLife


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Re: Why can I not get high from edibles? [Re: Atreyu]
#21909350 - 07/07/15 11:42 AM (8 years, 6 months ago) |
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I don't get high from edibles either. I get very high from just 1 toke of good weed, I feel it before I blow the smoke out.
Alcohol made me feel great and help me sleep when I was young, now it depresses me and gives me insomnia.
Its been 25 years since I tripped, if I ever get shrooms I wonder how that will make me feel.
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Big_Dave

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Re: Why can I not get high from edibles? [Re: IcLife]
#22005531 - 07/27/15 05:02 PM (8 years, 6 months ago) |
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I cant seem to get high from edibles either. I've tried home made, professional cookies, and the tincture. Never felt anything from any of them except for the last time. I made firecrackers with ~2g of some dank. Felt the smallest buzz for maybe an hour. Then the next day at work we ate lunch like normal. I think it was a potbelly's sandwich. After lunch I get up to use the bathroom. Mid piss I realize that all of the sudden I'm fucking blitzed. I work construction so being high at work isnt really an issue but I almost told my boss i was too fucked up and I was going home cause I could barely stand or talk. It lasted about an hour and a half and then I was back sober.
I dont really understand. I had practically no tolerance at the time. But then again I didnt get high the first time I smoked either. At least now I know im not the only one.
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resonant111
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Re: Why can I not get high from edibles? [Re: Big_Dave]
#22017743 - 07/29/15 10:50 PM (8 years, 5 months ago) |
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idk man that's fucking bizarre. the best guide for edibles is this dude's firecracker guide, gets me toasted every time and SUPER easy: http://forum.grasscity.com/incredible-edible-herb/445852-my-ultimate-marijuana-firecracker-recipe-pics.html
if you don't follow those simple steps and get high as fuck then i don't know...you're a mutant or something. i've made firecrackers for my friends too using that guide and they were fucking ripped as hell. i set the temperature lower than he suggests though, because his is over the THC boiling point. i do it under 300 F to be safe.
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Edited by resonant111 (07/29/15 11:00 PM)
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CosmicJoke
happy mutant



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Re: Why can I not get high from edibles? [Re: resonant111]
#22027638 - 08/01/15 10:21 AM (8 years, 5 months ago) |
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i will believe you after you try one of these, 200mg of cannibinoids, most people will only eat 1/6th a bar at the max and are obliterated
-------------------- Everything is better than it was the last time. I'm good. If we could look into each others hearts, and understand the unique challenges each of us faces, I think we would treat each other much more gently, with more love, patience, tolerance, and care. It takes a lot of courage to go out there and radiate your essence. I know you scared, you should ask us if we scared too. If you was there, and we just knew you cared too.
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Shroomism
Space Travellin



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Re: Why can I not get high from edibles? [Re: CosmicJoke]
#22028494 - 08/01/15 01:26 PM (8 years, 5 months ago) |
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Have tried very similar things. "only eat a quarter of it" they say... everyone get's completely wasted. Eat the whole thing anyway. Is that a slight micro buzz I feel? Or maybe that's the bowl I smoke an hour or two ago. But send me one and I will experiment
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tnnursery
Stranger
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Re: Why can I not get high from edibles? [Re: Shroomism]
#22038885 - 08/03/15 06:30 PM (8 years, 5 months ago) |
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we hunt dry land fish mushrooms, they come up in late summer. They are delicious. I don't know the scientific name for them but we've eat them for years.
I'd love information on wild grown Tennessee edible mushrooms. We grow plant and trees and stay out in the fields and woods tending to our greenhouses. We have several different species here but I sure don't want something that will kill us.
Tammy Tree Nursery Co
Edited by automan (04/09/16 04:58 PM)
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Yukon Cornelius
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Re: Why can I not get high from edibles? [Re: tnnursery]
#22039000 - 08/03/15 06:54 PM (8 years, 5 months ago) |
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I suggest making your own edibles, I had this same issue for years until I made my own properly.
However most people just have a naturally high tolerance for edibles, I'm that way with opiates.
The most I've had to put in an edible for me to start feeling it was about 2g potent herb and 1g hash oil. Threw about an ounce into a crockpot with 1 stick of butter and water (along with a half oz of hash) then set it on low overnight.
I enjoy making edibles for other people but personally it's a waste for me.
Also somebody suggested eating fresh mangos, I recommend that as well. It contains B-myrcene which increases the permeability of THC across the blood-brain barrier, it's also a naturally occurring terpenoid in cannabis.
-------------------- "I didn't know chicken's wore suspenders" - Towelie
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Shroomism
Space Travellin



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Update.
Month ago I got a 2oz canister of canister of some "canna-milk" which supposedly had 1200+mg of THC/CBD in it. This was from my regular herb guy who I sincerely trust, grows the best buds around and makes some of the dankest edibles known to man according to everyone else. He told me to just sip it, and maybe only drink about a quarter of the bottle unless I really didn't have any plans for the next 2 days.
I ate a super ripe mango like an hour before ingesting it. That shit was good. After I felt the analgesic effects of the myrcene had fully kicked in, I drank the entire bottle of the canna milk. I could very clearly taste the super high potency of this shit.
Waited about 2-3 hours for effects, I did get a very mild/light body buzz.. I then said fuck this shit and smoked a bowl and got high. I did feel a bit of an "extra kick" to my high after I smoked.. a little bit deeper of a body buzz.. but nothing really profound.. especially for a dose that high. I went to sleep a few hours later and got up at 3am and went to work, completely fine.
The end.
That's enough edibles for me. I give up. Not worth it at all.
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CosmicJoke
happy mutant



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Re: Why can I not get high from edibles? [Re: Shroomism]
#22922462 - 02/19/16 09:47 AM (7 years, 11 months ago) |
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I can't get that chocolate bar atm, is fucked because Colorado has 'em and I live 10mins away from WA wnere they are produced, but they are evil w/ their taxes, I paid $20-25 for one..... and that much TCH now costs too much money. Life was better in the interim between pot being legalized and stores opening.
I don't care how many milligrams your canna-milk claims to have, this chocolate will destroy you. It's like $18.19 for one on Colorado, and I dunno things like 85mg are $35 in Washington...
-------------------- Everything is better than it was the last time. I'm good. If we could look into each others hearts, and understand the unique challenges each of us faces, I think we would treat each other much more gently, with more love, patience, tolerance, and care. It takes a lot of courage to go out there and radiate your essence. I know you scared, you should ask us if we scared too. If you was there, and we just knew you cared too.
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Shroomism
Space Travellin



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Re: Why can I not get high from edibles? [Re: CosmicJoke]
#22922470 - 02/19/16 09:52 AM (7 years, 11 months ago) |
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fucked taxes.. jesus
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occollegeboi
MushroomSpaceGod



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Re: Why can I not get high from edibles? [Re: Shroomism]
#23073871 - 04/02/16 03:18 AM (7 years, 9 months ago) |
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I'm the same way.
What you need to do is just eat a CRAZY amount of edibles. At this point, it won't make you overdose. After experimenting with edibles from the medical shops, I have figured out that if I want to get as high as I like, I need to eat 800mg of thc in edibles. Yes, 800mg.
Try eating that much and then come back here and tell us what happened.
Edibles only give you a BODY high though. They're really good for sleep and insomnia.
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Cujllickduo



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Re: Why can I not get high from edibles? [Re: occollegeboi]
#23094180 - 04/07/16 05:06 PM (7 years, 9 months ago) |
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How to Make hooch or prison alcohol
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Chakanooga
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Re: Why can I not get high from edibles? [Re: Cujllickduo]
#23095721 - 04/08/16 01:35 AM (7 years, 9 months ago) |
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The most logical explination as far as biology can explain would be,
A, the fact your body isnt breaking it down inside, causing the food to sit there and not activate the THC.
B, your body has a natural tolerance to edibles, and you can only consume THC through smoke inhalation.
Source: A guess.
Goodluck.
-------------------- Official: Facemelter HyperspaceTraveller NostalgicGamer
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occollegeboi
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Re: Why can I not get high from edibles? [Re: Chakanooga]
#23119026 - 04/14/16 10:50 PM (7 years, 9 months ago) |
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Ok so when you EAT marijuana, the thc metabolizes into delta 11 thc. When you SMOKE or vaporize weed, it turns into delta 9 THC. THAT is why the high is so different.
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Snazz
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Re: Why can I not get high from edibles? [Re: occollegeboi]
#23157276 - 04/26/16 01:26 PM (7 years, 8 months ago) |
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Time to test the pooper :p
Or perhaps isomerization. They selling any of that yet in dispensaries?
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ideletemyself
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Re: Why can I not get high from edibles? [Re: Shroomism] 1
#23973440 - 01/01/17 04:08 PM (7 years, 27 days ago) |
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Sorry to necrobump but I feel I can give some helpful input perhaps and maybe build some answers for myself hopefully.. I have the same problem. Live in a state with medical cannabis & have a VERY good/reputable dispensaries in as far as what you see IS what you get by state law..
Edibles & tinctures do nothing except a slight buzz no matter how much I dose. I've tried eating a shit ton of mango as well, like tons before hand lol...
I do however have some form of IBS. My question was always why doesn't a tincture work when it bypasses digestion completely? Then I found this article, which was a subject others have brought up before, that tincture's don't work as intended and instead end up being swallowed & ingested BEFORE absorbtion due to salivation: Why cannabis tinctures don't work.. Granted that seems to be a company that will eventually sell some nano-cannabinoid product that MIGHT perhaps solve our problem. I've heard these issues come up before but some people claim to feel the effects of a tincture as intended meaning within a couple minutes not 30-90 minutes. That could perhaps be a placebo effect or just the initial buzz caught from any cannabinoids that did make it in via subligual or oral mucosal. Or maybe these people produce less saliva then others.
If that article is true though, that would make more sense since we get the same effect as if we'd just eaten an edible. I want to try taking a digestive enzyme & see if that helps any. What enzymes to get I dunno & they vary greatly in price & what's included. If anyone knows the specific liver enzymes produced that act on the cannabinoids please share this info & if there's a supplement we could take for those enzymes.
I'm going to try posting to other forums as well & see if I get any good feedback. At this point I'm with Shroomism, I pretty much gave up but I did purchase a 200mg tincture just the other day to try again, again no results & I REALLY tried keeping it under my tongue by putting just a drop by drop but still just that stupid slight buzz...
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Prem. Kissoff
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Re: Why can I not get high from edibles? [Re: Shroomism]
#24005177 - 01/12/17 06:50 PM (7 years, 16 days ago) |
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Im in the same boat, daily smoker and edibles just dont have the same impact at all that they used to. Interesting.
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psilly the kid
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Re: Why can I not get high from edibles? [Re: Prem. Kissoff]
#24009131 - 01/14/17 08:25 AM (7 years, 14 days ago) |
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Same here im a heavy smoker as is my brother and I take 400 mg rso brownies to get a good buzz My brother takes two of them
-------------------- CA weed @ all times unless specified currently this high pebbles suck its turtles all the way down
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ideletemyself
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Re: Why can I not get high from edibles? [Re: Prem. Kissoff]
#24012570 - 01/15/17 04:30 PM (7 years, 13 days ago) |
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Quote:
Prem. Kissoff said: Im in the same boat, daily smoker and edibles just dont have the same impact at all that they used to. Interesting.
No, I don't think you or Psilly the Kid are experiencing the same problem as Shroomism or myself.. We can literally eat THOUSANDS of mg in edibles and only feel a very VERY slight buzz, like not even smoking a good hit worth of buzz, that light. It's always been this way for me, no matter how much or little I smoke/vape.
A slight update: I did try a brand of digestive enzymes that included the most comprehensive list of substances I could find in my town. It wasn't cheap either, like $25 for the bottle but since I'm also lactose intolerant & it has an enzyme for that in there & also for fats for meats which I have a problem digesting normally as well it hasn't been a complete waste of money.
So yeah, the digestive enzmes did nothing for me. I tried it twice with what I had left of my tincture & both times I felt absolutely nothing. I even ate a bunch of frozen mango about an hour before as well. I took a good 1-2 droppers full which should have been plenty each time..
So, this leads me to conclude that the issue is most likely NOT in any type of digestion or issue therein. It's most likely due to some kind of absorbtion problem either in the small or large intestine I'd assume the small. Or it's due to the liver for some reason not creating the proper enzyme to metabolize the THC into 11-hydroxy-delta-9-THC. Or it could be a combination of both. It could also be that for some it's due to the poor absorbtion in the intestines while for others it's the liver problem. I could see any combination being possible. After these past few weeks I still can't find any info as to the exact enzymes the liver produces that metabolize the THC or anything in regards to that specific function like from A to B. There's TONS that spend 2 sentences explainging the function generally but nothing beyond that. Super annoying..
Anyways, I DO have some form of IBS & I believe Shroomism has said the same. That makes me think it's the intestinal absorbtion issue as well. So confusing.. Without getting a PHD & just conducting the tests my damn self I think we(the royal we) are just plain fucked for now.
I'm going to try the skin patch but that's a slow release deal & not really like eating an edible but the guy at the dispensary said it really worked well for his back & it's supposed to last 96 hours.. Side note: I wonder if these kinds of skin patches work like the fentanyl patches & if so, could one do the same thing some foolish people do with those & chew up the patch to get the full dosing all at once instead of the 96 hours or whatever it's supposed to be. And if so, would that result in the same effects an edible would have or would it be different at all?
What I really want to try is the inhaler. A dispensary in Phoenix sells an inhaler just like an asthmatic would use. They tout it as a solution for accurate dosing but I'm interested in it's effects in comparison to eating an edible. Perhaps it would just be like smoking or vaporizing since it's going via the lungs at the end of the day.
If I find any further info I'll report back. Please do the same if anyone finds anything on cannabinoid absorbtion via the intestines and/or liver enzyme production for cannabinoid metabolization..
Edited by ideletemyself (01/15/17 04:44 PM)
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Cattlecruiser
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Re: Why can I not get high from edibles? [Re: ideletemyself]
#24020106 - 01/18/17 02:03 PM (7 years, 10 days ago) |
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I no longer feel anything from edibles either. As a new user, edibles produced an extremely powerful body high. As a chronic user edibles do nothing. I only have a B.S. in neurobiology but my best guess is that tolerance at least partially develops from increased availability of enzymes that break down cannabinoids and their metabolites. Many of these enzymes reside in the liver so when THC is taken orally it must make a first-pass through the liver before reaching the brain, where much of it is broken down, I'm guessing, in an individual with high tolerance.
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Blipstir
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Re: Why can I not get high from edibles? [Re: Shroomism]
#24287826 - 05/01/17 07:36 PM (6 years, 8 months ago) |
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I have the exact same problem OP, anyone I asked would say I had weak or improperly cooked edibles. Too many times I would be sober and my friends would be straight up tripping off whatever we shared. the only time I was able to get a noticable effect was after I ate alot of turky And some fruit. The effect was still I think dulled down a bit but it was better than any of my previous experiences. But This was a good thread, got some new things to try. sorry for the extremely late reply.
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LogicaL Chaos
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Re: Why can I not get high from edibles? [Re: Shroomism]
#24288136 - 05/01/17 09:29 PM (6 years, 8 months ago) |
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That sucks man.
U have an insanely naturally high tolerance to edibles but not smoked weed. Amazing.
I bet its hertitary. Can u experiment on your parents? Or if u have brothers and sisters? Can u dose them with edibles? (start small first!) Curious to know.
-------------------- "What you must understand is that your physical dimension affects everyone in the higher dimensions as well. All things are interconnected. All things are One. Therefore, if one dimension is broken or out of balance, then all other dimensions will experience repercussions." - Pleiadian Prophecy 2020 The New Golden Age by James Carwin PROJECT BLUE BOOK ANALYSIS! (312 pages!) | Psychedelics & UFOs | Ready to Contact UFOs? | The Source on Mushrooms | Trippy Gematrix | Dj TeknoLogical | Fentanyl Test Kits R.I.P. Big Worm || The Start of the Ascension Process was 2020. Welcome to the Next Great Era of Earth 🌎🌍🌏
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Re: Why can I not get high from edibles? [Re: LogicaL Chaos] 1
#24290534 - 05/02/17 06:26 PM (6 years, 8 months ago) |
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form a heavy drinking habit, that should elevate your liver enzymes.
jk that sucks. edibles always knock me on my ass even with small doses
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RiceToastedTreat
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Re: Why can I not get high from edibles? [Re: trscstghst]
#24315557 - 05/12/17 10:54 PM (6 years, 8 months ago) |
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I know this thread is a bit dated but it comes up in a google search so I figure it'd be ok to keep it updated to help us unfortunate souls find an answer.
I also thought it would be good for anyone who doesn't feel anything from edibles to list a bit of their medical history.
So edibles don't do anything for me either. I can try to go the route of wasting money to buy some huge dosage, but I sure it will result in the same thing. The highest dosage I've tried has been 200mg. Now I haven't done nearly as much as OP, but 200mg from a good dispensary would affect anyone who's body is digestin THC nomally so obviously there's a problem. Another thing I'd like to point out for me is that I tried oxy for the first time a couple months ago. Like 15mg and it didn't do anything to me. Again people tried telling me to try a higher dose and all that but 15mg of oxy to a new user is going to feel something. So it's a little annoying how people just assume there's no problem and you just need a higher dose. Ok so a couple of thing I wanted to list about my medical history and eating habits just to see if maybe anyone else can draw a correlation and maybe get some sort of answer. I suffer from migraines and frequent headaches. Migraines that'll make me throw up. I've suffered from this all my life. So as a kid I've taken a good amount of headache relief medication. More than the average persons. My father suffers from the same issue and he now has liver and stomach problems from all the pills he has taken. So that could be a cause for me. I consume a large amount of soda which I'm thinking could make my stomach acid more acidic than normal? No science to back that up or anything just an uneducated guess. I'm currently having some stomach pains and issues as well atm. Could be IBS, I'm going to the doctor soon. Now my main concern isn't so much about the edibles, but how is this affecting my body in other ways? What other nutrients is my body not absorbing correctly? I take a vitamin supplement could this mean I'm not absorbing correctly? Probably not something to worry about and maybe my body is absorbing these things, but for the THC is just passing the blood-brain barrier. I would've just assumed it was a THC exclusive problem, but now that I see oxy didn't even effect me I'm just thinking if this is a indicator of a different problem. Also THC in general just affects me differently than it did when I was a kid. I don't mean because of a higher tolerance, by it's just a different high all together. Well slightly different. I smoked when I was like 12/13 and came back to it at 19 and noticed that high just wasn't exactly the same as I remembered. Could be a logical reason for that one though. Also vaporizers don't work too well on me. There's like this limit with vaporizers on how high I'll get which is less than what I would like. Once I hit that limit no matter how much I vape I just won't get any higher.
Anyways if anyone shares some similarities I'd like to know just so we could maybe draw a pattern between us and narrow down the cause.
In case anyone cares, the oxy was a one time thing. Had a bottle a friend gave me and I took three and flushed the rest right after. A supplier causes addiction and I don't have one of those so I wasn't very worried about trying the oxy.
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Shroomism
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I don't know what to tell you. I'm pretty healthy in most other regards. No IBS or anything like that. Don't have any significant health problems or digestive problems really, pretty damn healthy for 35. Haven't noticed any difference in anything with any other medications, or food or anything.. everything effects me as it should. THC just seems to effect me completely differently when smoked. I don't really drink alcohol at all, or hardly ever. Maybe that has something to do with it, my liver is too strong or something. Or lack the proper enzyme to process it properly. Kinda like how most Asians lack that liver enzyme to properly process alcohol so they turn red Don't know.. don't really care anymore at this point. I do have a SUPER insane metabolism as I mentioned earlier, I suspect that may be part of it. That... plus being a chronic pothead for the past 20 years may have a slight impact on the results. My cannabinoid receptors are already over-saturated? lol... dunno, don't care.. I get high perfectly fine from smoking so I stick with that.
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Bird_Guts
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Re: Why can I not get high from edibles? [Re: Shroomism]
#24325751 - 05/16/17 10:29 PM (6 years, 8 months ago) |
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Smoking weed for 20 years is definitely not it, been smoking weed for 25 years, chronically, and edibles work for me
I don't understand when people say " weed edibles get me so high and couch locked for hours", the edibles I make don't couch lock you, they make you trip . Seriously.
Dispensarys suck, period.
I want to feed you one of my edibles so bad , if mine don't fuck you up nothing will.
I know you said the edibles you get are not weak,, but 1 ounce for a batch of brownies is not very strong IMO, not for a veteran smoker of 20 years
Tinctures suck IMO, especially alcohol
So weird you get high from smoking but not eating....
I wish I could overnight you one of my brownies lol
Fuck man we gotta get you high from an edible!!
--BG--
Edit: I know a lot of people that think they make super good edibles, I go to a lot of festivals whereeople have all kinds of "potent" edibles, lots of my friends are caregivers in the state I live in, they say they make super strong edibles, and I find 97% are not strong . I think most people don't know what a potent edible is. Edibles are nothing at all like smoking weed
Edited by Bird_Guts (05/16/17 10:37 PM)
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Big Worm
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Re: Why can I not get high from edibles? [Re: Bird_Guts]
#24325773 - 05/16/17 10:37 PM (6 years, 8 months ago) |
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That's crazy.
I am a heavy smoker and edibles will always have me knocked.
The only time I have seen drugs being "blocked" were due to certain medications people were on, but never thc edibles.
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ephedup
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Re: Why can I not get high from edibles? [Re: Big Worm] 1
#24334125 - 05/19/17 08:30 PM (6 years, 8 months ago) |
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I am glad I found this thread. I too have the same exact issue. very high doses to absolutely nothing for me as well. I am going to paste below what I posted in another forum the other night because I am starting to think this is purely a liver enzyme issue but who knows.
"So the main reason for this post is that about a month ago I took one of those DNA tests to find out my ancestry, which also came with raw data which I uploaded to another site which gave me my health information. So after this experience last night with no results at a pretty high dose I got to thinking and remembered seeing a few things in my health data related to my body not being able to metabolize some medications, drugs, and lipids. It said I was a CYP3A5 non-expressor. I am no geneticist so most of this info is a little confusing to me, but I think I may be onto something here. I noticed that it is related to the Cytochrome P450 enzymes which are responsible for metabolizing thc into 11-OH-THC which is what causes the high with consumed edibles.
There was another gene that caught my eye which is CYP1A2*1F. Which means I am a fast metabolizer of caffeine and other drugs "resulting in faster breakdown of drugs metabolized by CYP1A2 and the possibility of insufficient drug concentrations in the body to yield much therapeutic benefit". This is also related to the same family of P450 enzymes as above.
So what I am really curious about is if anyone else with the same non response to edibles has had one of these tests done and can confirm if they also exhibit this same genetic traits that are showing on my reports. Perhaps there is a way to inhibit these enzymes, similar to how grapefruit juice and antacids react with opiates which will allow our bodies time to metabolize more efficiently so we stop wasting our money time and time again hoping for different results. I am going to continue research into the science behind this and would love some input and thoughts on this."
I have been looking into this more over the past few nights and it seems there may be multiple enzymes that play a role in metabolizing thc but I need to do some more digging. I have read that Cimetidine (antacid) is an inhibitor if the CYP1A2 emzyne, as well as milk thistle. Omega 3s are said to help repair cb receptors, and mangos which has been spoken about. I guess it is time to start testing.
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LogicaL Chaos
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Re: Why can I not get high from edibles? [Re: Shroomism]
#24334412 - 05/19/17 10:38 PM (6 years, 8 months ago) |
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Do u have kids shroomism?
U should give your kids edibles when they are 19-21 and see what happens. Should be interesting.
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LogicaL Chaos
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Re: Why can I not get high from edibles? [Re: LogicaL Chaos]
#24334416 - 05/19/17 10:40 PM (6 years, 8 months ago) |
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I got an idea. Hire a chemist to convert thc to delta-thc (as in the thc form that is naturally made in the stomach from enymes) then eat that.
Would u do it shroomism?
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ephedup
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Re: Why can I not get high from edibles? [Re: LogicaL Chaos] 1
#24334748 - 05/20/17 02:14 AM (6 years, 8 months ago) |
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I have been reading all night and this is the best info I can find so far but here are 2 good links that explain how enzymes metabolize thc in your body. How Your Genes Affect Your Cannabis High – The Case of CYP2C9 A guide to the science of how your body metabolizes cannabinoids such as THC and CBD.
Still wonder if more than one enzyme plays a roll in this since the artical don't mention the enzymes I mentioned above but they're all in the P450 family. But as far as CYP2C9 goes, apparently there are some herbs, drugs, and meds that inhibit this enzyme and slow down down the breakdown of the thc which should make the high stronger. Most seem pretty nasty with the likes of ssri,antibiotics,statins, etc. Not things I would experiment with. The only exceptions seem to be quercetin which is a flavonoid from plants and veggies but may be a weak inhibitor, and Apigenin which is said to be a strong inhibitor and is also flavonoid which also has protective qualities. I just ordered a bottle of Apigenin as well as biopeperine to increase absorption. I will be testing this out while there are some gummies left from the same batch. Look forward to updating you guys most likely Monday.
Edited by ephedup (05/20/17 02:55 AM)
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ephedup
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Re: Why can I not get high from edibles? [Re: ephedup] 1
#24344237 - 05/23/17 08:05 PM (6 years, 8 months ago) |
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Test 1: 400mg of Cimetidine, 500mg of Quercetin, and 5mg of biopeperine. Washed it down with some mango juice 45 min prior to eating gummies. I ate the same 8 gummies as last time.
I would rate last weeks attempt with no aids a 1/10, no effects at all. This last attempt I would rate a 3/10. I felt a little something coming on about and hour in but was short lived and went about my day as normal. No red eyes or munchies as well. I don't think this is a quality issue because 3 friends ate a single gummmy and were very baked. I had 8. It also can't be a tolerance issue because I have not smoked in almost 3 weeks.
Cimetidine is an antacid. It is also a CYP2C9, CYP2C19, and CYP3A4 enzyme inhibitor. Quercetin also inhibits CYP2C9 inhibitor. Mangos contain myrcene which is said to allow thc to more easily cross the blood brain barrier. So if inhibiting these enzymes to slow down liver metabolism of thc isn't really helping, what gives? What else can be causing this?
The only thing left to try is the apigenin and also Amentoflavone which are both said to be strong Inhibitors. If that doesn't work, I giving up on edibles. Also I don't want to be screwing around with my liver and enzymes any further than doing these 2 tests, even though these supplements are pretty safe as long as you are not on any kind of medication which I am not.
Just a word of caution: DO NOT ATTEMPT USING ANY OF THESE INHIBITORS IF YOU ARE TAKING ANY KIND OF MEDICATION at all!! certain drugs can have very bad interactions with inhibitors and can lead to high levels building up in your system causing serious issues or possibly death!!
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LogicaL Chaos
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Re: Why can I not get high from edibles? [Re: ephedup]
#24351372 - 05/26/17 11:16 AM (6 years, 7 months ago) |
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Interesting....so it had an effect huh?
Could be placebo.....or could be real!
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TONKOL
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Re: Why can I not get high from edibles? [Re: Shroomism] 1
#24957656 - 01/31/18 05:24 PM (5 years, 11 months ago) |
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I know this is a very old post, however I did not see any actual scientific reasoning to why you don't get stoned.
Including myself, a certain percentage of the population does not get stoned when they ingest cannabis. Depending on certain Gastro-intestinal issues, such as crohns, ibs, or GERD. Even some gluten and lactose intollerances can prevent the intestinal cillia from properly absorbing fats and oils.
Now lets say you're perfectly medically fine, and maintain a good diet.
Some people lack the actual enzymes to break down cannibis in the liver. Similarly to codeine the CPY34A enzyme is inhibited and cannabis THC turns into 11 - hydroxy THC (insert joe rogan meme) If this was the case you would also have negative reactions to ceratins SNRI's, and a pre-disposition to addition when prescribed opiates.
There are also potential medicinal interactions, as we aren't your doctor. Do a 23 and me DNA test and go though it with a doctor. I would be interested int the results, as I have the same weird tolerance and found out I have IBS in the process.
Thanks for the read,TLDR stomach/gut problems or missing liver enzyme?
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LogicaL Chaos
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Re: Why can I not get high from edibles? [Re: TONKOL]
#24957661 - 01/31/18 05:26 PM (5 years, 11 months ago) |
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Ooou, a DNA sequencing on people who cant stoned from edibles would be super interesting.
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psilly the kid
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Re: Why can I not get high from edibles? [Re: LogicaL Chaos] 1
#24957814 - 01/31/18 06:32 PM (5 years, 11 months ago) |
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id dig on seeing that research
-------------------- CA weed @ all times unless specified currently this high pebbles suck its turtles all the way down
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Apples in Mono
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Re: Why can I not get high from edibles? [Re: psilly the kid]
#24975533 - 02/08/18 12:10 AM (5 years, 11 months ago) |
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I'm one of em too. Been trying since the late 90s. Never once have been significantly affected. And i've eaten lots and lots of the strong stuff too. I've watched other people green-out and literally become completel paralyzed while i got no more than slightly drowsy from 3 or 4 times as much. I still try every once in a while. Maybe someday my body chemistry will change and it'll finally work
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Shroomism
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Re: Why can I not get high from edibles? [Re: TONKOL] 1
#24980936 - 02/10/18 11:11 AM (5 years, 11 months ago) |
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Quote:
TONKOL said: I know this is a very old post, however I did not see any actual scientific reasoning to why you don't get stoned.
Including myself, a certain percentage of the population does not get stoned when they ingest cannabis. Depending on certain Gastro-intestinal issues, such as crohns, ibs, or GERD. Even some gluten and lactose intollerances can prevent the intestinal cillia from properly absorbing fats and oils.
Now lets say you're perfectly medically fine, and maintain a good diet.
Some people lack the actual enzymes to break down cannibis in the liver. Similarly to codeine the CPY34A enzyme is inhibited and cannabis THC turns into 11 - hydroxy THC (insert joe rogan meme) If this was the case you would also have negative reactions to ceratins SNRI's, and a pre-disposition to addition when prescribed opiates.
There are also potential medicinal interactions, as we aren't your doctor. Do a 23 and me DNA test and go though it with a doctor. I would be interested int the results, as I have the same weird tolerance and found out I have IBS in the process.
Thanks for the read,TLDR stomach/gut problems or missing liver enzyme?
Very good post. And your first one! Welcome!
I haven't been to a doctor in ~14 years Aside from going to the hospital last year for a car wreck.. they said my health was amazing for my age (35). No chrohns, IBS, gerd or lactose intolerant (that I know of.) I don't eat a perfect diet by any means, but I try to eat healthy even though I love sugar. I have a really weird diet style actually, but it works for me. I tend to not eat anything or very little during the day and eat most of my food in the evening or late at night. One big meal late and snacks throughout the day. I'm almost never hungry enough to eat breakfast in the morning. I know I have a 'stomach of steel' as other people comment because I can eat practically anything without getting too stomach upset like some people. Unless it's just plain nasty.
Gut problems or missing liver enzymes is the best guess I've been able to come up with, you're probably spot on there. I have a weird gut.
I actually did get DNA tested recently through a company my work hired... "colors"... but it was more a hereditary cancer test. Results were
Quote:
No mutations were identified.
This means no pathogenic or likely pathogenic genetic variants associated with an increased risk of colorectal, male breast, melanoma, pancreatic, prostate, or stomach cancers were identified in any of the 30 genes analyzed.
This result does not eliminate your risk of developing cancer. Inherited mutations explain some cases of cancer, but most are not inherited and can not be explained by a single cause. Some non-genetic factors that can influence cancer risk include environment and lifestyle, as well as family history without a known genetic link. Your healthcare provider can help determine how your screening plan might be influenced by your health history and other factors.
Genes that were analyzed:
APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A (p14ARF), CDKN2A (p16INK4a), CHEK2, EPCAM, GREM1, MITF, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53
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LogicaL Chaos
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Re: Why can I not get high from edibles? [Re: Shroomism]
#24981454 - 02/10/18 11:43 AM (5 years, 11 months ago) |
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Do u have any unique mixed ancestry by chance? Like Native American or Alaskan or anything unique/unusual?
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Shroomism
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Re: Why can I not get high from edibles? [Re: LogicaL Chaos]
#24983544 - 02/10/18 04:01 PM (5 years, 11 months ago) |
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like 1/16th native american lol, 75% Italian and some Irish/german. Pretty standard American euro trash
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mmcc
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Re: Why can I not get high from edibles? [Re: Shroomism]
#24983581 - 02/10/18 04:22 PM (5 years, 11 months ago) |
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I grew some Caitlyn Jenners and decided not to smoke it and instead simmered it in coconut milk which I add to my coffee and gives me a good high for about 2 hours and it settles my stomach if it’s feeling shitty. I though edibles aren’t supposed to make you feel high like when you smoke.
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MissAnthropy
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Re: Why can I not get high from edibles? [Re: mmcc] 2
#25030051 - 02/28/18 08:13 PM (5 years, 10 months ago) |
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So I am an herbalist that works with all plants and a bunch of plant constituents but I do a ton of work in the cannabis industry too and I can tell you your predicament is 100% not uncommon.
I am certainly not a statistician but I can say I personally know about 12 people who have the same experience.
Some of them are people who cannot AT ALL get high from edibles and a few need insanely high dosages (without having built up a tolerance). Several of them have been clients that I recommended cannabis edibles for who told me they do nothing for them.
Another one of them is my brother in law and one of them is my best friend.
If I had to make a guess I would say that it has to do with metabolism, and ones digestive system, and maybe other factors related to auto-immune disorders.
My brother in law for example. If he and I smoke a joint... that guy is TOASTED pretty immediately. YET he can eat 2000mg of an edible to zero effect. Meanwhile I can outsmoke him anyday and I am over here having a freak out if I eat more than 10 mg! I am super sensitive to edibles! To the point where sometimes I will feel as though I am no longer stoned only to wake up in a cold sweat 2 hours after going to sleep!!
He also has Crohns disease (which is a severe intestinal autoimmune disorder). Part of the way that impacts him is that he cannot get certain vitamins from his foods, caffeine doesn't seem to impact him in the same way either. For him I would say it is a digestive issue. My sister has Crohns and she needs a higher edible dosage but it does absolutely work for her at 25-50 mg.
My best friend on the other hand. She needs 300 mg to feel anything. She needs like 2000 mg to get high. She also has an auto-immune disorder but not Crohns or digestive related! She finds that edibles made from sativa do nothing and she gets a better response from indica and hybrids.
I find all of these things very interesting and I wonder if there could be a cannabis study on people who feel like edibles do not work for them.
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LogicaL Chaos
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Re: Why can I not get high from edibles? [Re: MissAnthropy]
#25030840 - 03/01/18 03:34 AM (5 years, 10 months ago) |
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That is really interesting. Thanks for sharing.
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Mateo
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Re: Why can I not get high from edibles? [Re: LogicaL Chaos]
#25033589 - 03/02/18 12:34 PM (5 years, 10 months ago) |
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You probably have a very strong stomach acid that can break down THC or something similar. It obviosly works when you smoke so if you get it into the system it will work, ie. THC into the bloodstream. Putting something with THC up where the sun never shines would probably work.
-------------------- A wise rat has many holes
Edited by Mateo (03/02/18 01:40 PM)
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semil-in-bucks
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Re: Why can I not get high from edibles? [Re: Mateo]
#25043382 - 03/06/18 04:00 PM (5 years, 10 months ago) |
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Thinking it's down to your gut environment, absorption and that. Are you, by nature a skinny person, the kind of person to which weight gain just never happens? Possibly you're naturally indisposed to absorbing fats and oils?
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mndfreeze 
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Re: Why can I not get high from edibles? [Re: Shroomism]
#25047886 - 03/08/18 05:19 AM (5 years, 10 months ago) |
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Way to much TLDR to read the entire thread but I did go through your initial post.
Have you tried any sort of other injestion method besides inhalation and eating them? Like, are there any sort of sublingual pot related things you can try? Generally if you can get something that absorbs via the sublingual route then you can rule out a ton of body functions that could be the impairment of you getting impaired. 
Obviously as you know I haven't had anything to do with weed since before we even met, back in the dark ages of cannabis, so I have no idea if anyone has invented anything of the sort yet or if its even possible for THC to pass sublingually.
-------------------- Nothing says love like grannies prolapsed anus! quote]Urb said: I know... Its fucked up... Ill fix it minyana..[/quote]
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Shroomism
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Re: Why can I not get high from edibles? [Re: mndfreeze] 2
#25061640 - 03/13/18 09:51 PM (5 years, 10 months ago) |
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It's been a while, but I'm pretty sure I recall sublingual cannabis tincture working to a degree.. That's why I'm 95% sure it's something with the digestive tract. Will have to give it another try sometime. I don't think sublingual gives quite the same effects as eating it though
Quote:
semil-in-bucks said: Thinking it's down to your gut environment, absorption and that. Are you, by nature a skinny person, the kind of person to which weight gain just never happens? Possibly you're naturally indisposed to absorbing fats and oils?
Yes, 100%. I thought I explained this in the OP but I have been 6'2" ~160lbs-175lbs my whole adult life, I'm naturally skinny, it's REALLY hard for me to gain weight, like almost impossible. Like other people have gotten upset that I can eat whatever and still be skinny as fuck My metabolism is absolutely insane. If I eat too much junky food late at night, my body will flush it out by the morning.. through PROFUSE sweating while I sleep. Like I can wake up completely drenched from head to toe with soaking wet sheets. Not so great. Luckily that only seems to happen rarely.. usually when I gorge myself late at night before bed. Other people have also commented that I have a stomach of steel and can eat things that would give them crazy heartburn or bloating or whatever. I also have pretty oily hair/skin naturally.. them damn Italian genes. But yeah, I'm like 95% sure it boils down to something with my gut or metabolism. Gotta be.
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Psilosion


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Re: Why can I not get high from edibles? [Re: Shroomism]
#25061675 - 03/13/18 10:14 PM (5 years, 10 months ago) |
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Edibles have only worked on me once when I was around 18, and had no idea what to expect. I thought I was going to die, I could feel every cell in my body and the blood flow through my veins, my heart felt like a drum inside my chest. Also had lag from my brain to motor functions, anything I wanted to move would move 3 seconds later. I then slept for a good 10 hours and woke up a little high.
These brownies were from homemade special oil as well. I've try a few edibles every year just to see if anything happens and still nothing so far.
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serendipitythenot
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Re: Why can I not get high from edibles? [Re: Psilosion]
#25068435 - 03/16/18 11:00 AM (5 years, 10 months ago) |
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I realize this is a bit of an older topic but I wanted to ask anyways: have you experienced anything similar with any other ingested drugs as well, or just the edibles? Do you drink alcohol at all? Have you tried taking strong edibles following a short fast(8 - 12 hours)? Or, better yet, even following the breaking of a short fast with a small, light snack(such as a few crackers)? What's your diet like? Do you take any medications or supplements daily(or close to it)?
I ask because I've had similar sorts of issues in the past(albeit somewhat inconsistently), as has my dad; admittedly though this wasn't *just* edibles but with other drugs too... so perhaps a bit different from your situation but I find it all intriguing none the less =)
While I've yet to find the perfect answer, there were a few things that have helped, such as the fasting & quitting drinking. Interestingly, it sounds like the 3 of us have a similar body type & metabolism, too. I assume you're correct when you say it must have something to do with metabolism and/or the gut but beyond that....? Weird stuff!
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Blipstir
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Re: Why can I not get high from edibles? [Re: Shroomism]
#25069998 - 03/17/18 12:11 AM (5 years, 10 months ago) |
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I'm the same way OP. There has been well over 15 times where my friends and I make our own edibles or have gotten them through other friends and they are all borderline tripping rolling around on the ground, laughing at the dumbest shit and falling a sleep while I'm sitting there sober as fhug.
I've heard it all, edibles were not strong and your friends are high on placebo, you didn't eat enough, you didn't use enough weed, the edibles you bought were bunk.
My friends and I all had at least 6-10 years of cannabis use so we were no noobs. The only time I was able to get high off edibles was when I broke my 5 months no-smoking break. I ate 2 MEGA buttery cookies my friend made each with 2.5 grams in them and a third cookie with 5 grams in it back-to-back on a completely empty stomach. I waited for about 20 to 30 minutes and smoked a big bong bowl. after about an hour and a half I suddenly realized I was REALLY stoned, and then realized I was tripping lol. I tired the same dosage with the exact same batch of cookies a week later after not smoking the enitre week and had no effect.
after well over 20 separate times of edibles this has been the only time I was able to acquire an effect of anything. I should mention before my 5 month tolerance break I was smoking like 1-2.5 grams a day of prime bud.
So I guess all I can say would be find a recipe that calls for insane and ungodly amounts of butter, take a long tolerance break and do not eat anything before you go to bed and the day of dosing.
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ds442
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Re: Why can I not get high from edibles? [Re: Shroomism]
#25115383 - 04/05/18 08:36 AM (5 years, 9 months ago) |
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I have never really got high from edibles either. I have had oil my friend would make. I have made butter. I have also tried gummies before and nothing. I heard that its almost hallucinogenic. Doesnt do shit for me. I just take one hit of some good weed and get pretty high. I have never hallucinated from psychedelics either.
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occollegeboi
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Re: Why can I not get high from edibles? [Re: ds442] 1
#25116447 - 04/05/18 05:31 PM (5 years, 9 months ago) |
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Everyone does edibles all wrong. I've heard everything. Even with my high ass tolerance, this is what works for me:
1. I just won't fuck with anything lower than 300mg but if I'm using it for sleep I will go with 400 or 500mg. I can handle up to 800mg but I find that it's just a waste and causes my tolerance to skyrocket too much. 2. Eat a light meal, 300 calories or less. 3. WAIT AT LEAST AN HOUR BUT NO MORE THAN AN HOUR AND A HALF. This is critical. If you eat the edible directly after eating, it will be mixed in with all your other food and won't absorb into your intestines. If you eat the edible on an empty stomach, you can get sick and it also won't really work. Waiting an hour after you eat something will leave your stomach empty enough so that the weed can go into your digestive tract efficiently. I forgot where I read this but everyone else attested to it and validated that it worked. 4. Eat the edible. Chew it real good and get a lot of saliva in it. Saliva helps to digest food so that your stomach acids can dissolve it more easily. 5. Initial effects will start 1 hour after ingestion but the peak will not come for about 2 or 3 hours AFTER the initial effects come on. It's sort of like acid in this regard where you sort of think it's not kicking in but then it sort of surprises you a couple hours later.
Hope this helps.
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Shroomism
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Re: Why can I not get high from edibles? [Re: occollegeboi]
#25134440 - 04/12/18 10:37 PM (5 years, 9 months ago) |
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You definitely did not read the thread. I've also heard it all. You don't know how to do edibles, blah blah. 800mg isn't shit. I've eaten like 5,000mg on an empty stomach and get nothing. With ZERO tolerance. Then take like 2 hits off a bowl many hours later and get fried. You want to talk about wasting weed. I've eaten mountains of ganja food and it is ALWAYS a total waste. To the point where I'm gagging because I can't choke down all the ganja food. Hour and a half.. 6 hours.. 500mg.. 6,000mg.. brownies that killed 10 other people who are now glued on the floor, I eat the whole goddamn tray... doesn't matter. Tell me how I'm doing it wrong. This has been going on for a good 15 or so years now, I've given up and tried again like 20 different times. Every year or so, I will try eating a whole bunch of edibles all at once, to see if it has any effect... nope. (I save up edibles I get throughout the year) I've tried it so many times, it's almost verging on complete lunacy to continue trying.
Hope that helps.
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Shroomism
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Quote:
serendipitythenot said: I realize this is a bit of an older topic but I wanted to ask anyways: have you experienced anything similar with any other ingested drugs as well, or just the edibles? Do you drink alcohol at all? Have you tried taking strong edibles following a short fast(8 - 12 hours)? Or, better yet, even following the breaking of a short fast with a small, light snack(such as a few crackers)? What's your diet like? Do you take any medications or supplements daily(or close to it)?
I ask because I've had similar sorts of issues in the past(albeit somewhat inconsistently), as has my dad; admittedly though this wasn't *just* edibles but with other drugs too... so perhaps a bit different from your situation but I find it all intriguing none the less =)
While I've yet to find the perfect answer, there were a few things that have helped, such as the fasting & quitting drinking. Interestingly, it sounds like the 3 of us have a similar body type & metabolism, too. I assume you're correct when you say it must have something to do with metabolism and/or the gut but beyond that....? Weird stuff!
I do not drink alcohol. Well, only very rarely and in extreme moderation (like 1-2 beers every month or two srsly...) 2 beers is enough to get me buzzed as fuck. I do not have any issues processing any other drugs.. in fact I'm super sensitive to a lot of drugs. My diet is pretty good overall, although I do consume a lot of sugar. I don't take any medication or supplements. I have tried edibles after fasting - yes. After fasting with zero tolerance even. And massive.... massive doses. Nothing, light buzz at the absolute most. It's extremely odd.
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occollegeboi
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Re: Why can I not get high from edibles? [Re: Shroomism]
#25136217 - 04/13/18 04:06 PM (5 years, 9 months ago) |
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Quote:
Shroomism said: You definitely did not read the thread. I've also heard it all. You don't know how to do edibles, blah blah. 800mg isn't shit. I've eaten like 5,000mg on an empty stomach and get nothing. With ZERO tolerance. Then take like 2 hits off a bowl many hours later and get fried. You want to talk about wasting weed. I've eaten mountains of ganja food and it is ALWAYS a total waste. To the point where I'm gagging because I can't choke down all the ganja food. Hour and a half.. 6 hours.. 500mg.. 6,000mg.. brownies that killed 10 other people who are now glued on the floor, I eat the whole goddamn tray... doesn't matter. Tell me how I'm doing it wrong. This has been going on for a good 15 or so years now, I've given up and tried again like 20 different times. Every year or so, I will try eating a whole bunch of edibles all at once, to see if it has any effect... nope. (I save up edibles I get throughout the year) I've tried it so many times, it's almost verging on complete lunacy to continue trying.
Hope that helps.
I did read the thread. I even posted earlier. I'm sorry for offending you. I wonder if IV injection of delta-11 thc would create the same high as eating edibles.
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Shroomism
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Re: Why can I not get high from edibles? [Re: occollegeboi]
#25137951 - 04/14/18 09:19 AM (5 years, 9 months ago) |
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Perhaps, but mainlining THC is probably where I draw the line heh
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Bandboy
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I used to get loaded on edibles, especially when I was a teenager. Even a few years ago they worked. The last five years I get no effect at doses that are decimating all the other eaters. No problem smoking. A couple of hits and I am high. My dealer gave me some frozen cookie dough, warning not to eat more than half a cookie. I ate 3. Nothing. I am eating my last 4 cookies tonight, then it's just smoking.
I am also thinking if I am having a nutritional absorbing problem that could be a health problem. Next doctor visit I'll see what she thinks.
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Dannyvtine
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Re: Why can I not get high from edibles? [Re: Shroomism]
#25265789 - 06/13/18 02:09 PM (5 years, 7 months ago) |
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I also have this problem i drank a 1,000mg bottle of Moon walk and nothing but a buzz. I have a theory so first off we all know our bodies main function after a good sesh is removing the toxins aka the THC from your body. With that in mind, what if after constant ingestion of edible your stomach begins to react the same way it reacts when you over eat which is "the shits." Is it possible that instead of completely digesting the edible it breaks down the edible enough to be able to drop into your intestine.(in a case of undigested food your stool would appear green)
If that's the problem can a possible solution be a small meal prior to consumption to kick start your metabolism and allow the edible to be broken down further or even fully?
I'm just spit balling here and after reading so many different post its the best conclusion i drawn up. I apologize for my lack of punctuation don't forget to pause and breathe.
I will be testing my hypothesis myself aswell lol.
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Shroomism
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Re: Why can I not get high from edibles? [Re: Dannyvtine] 1
#25268961 - 06/14/18 10:22 PM (5 years, 7 months ago) |
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Not for me. I've tried literally everything I can thing of.
Eating a small meal before. Fasting... eating a big meal.. Eating Mangos an hour before. Lipase supplements.. Lemons.. Coconut oil And more edibiles and 10x higher doses then my friends who get completely fucked off the same batch. Nothing really helps at all. Really don't think it has anything to do with toxins or whatever... I've never been able to get fucked on edibles and was trying for like 15 years. Genes/Metabolism/Gut bacteria is my best guess at this point.
Latest trip to the dispensary, I talked to one of the workers about it and they told me it's not uncommon at all. She estimated like 1/10 people that she talks to has a similar issue and get nothing from edibles.
Glad at least, I'm not alone on this. Heh
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LogicaL Chaos
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Re: Why can I not get high from edibles? [Re: Shroomism]
#25269016 - 06/14/18 11:08 PM (5 years, 7 months ago) |
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U should form an NA, Not-getting-high Annoymous group
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Freakofnature
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Re: Why can I not get high from edibles? [Re: LogicaL Chaos]
#25289198 - 06/24/18 12:07 PM (5 years, 7 months ago) |
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I reckon you might be on to something with the gut flora Shroomism.
For years and years I was the same as you. No matter what I did, what recipes, how much I ate, I got absolutely no effect from them.
The only reason I can think of for suddenly being able to get effects ...was after having severe food poisoning.
I took antibiotics which I had never done before...and followed that up with plenty of probiotics.
These days I still seem to be less sensitive than most people for edibles...but they definitely finally work and it's fucking sweet (haha sorry). Maybe it was related, maybe it wasn't but it's the only thing I can think of. So yeah try probiotics?? I would say nuke your digestive track if you are super desperate but that has significant downsides and chances are I'm wrong so don't listed to me :P
Also I find they work best if you eat a highly fatty meal beforehand, say one hour (the fattier and bigger the better!)...then follow that up with a light meal an hour after taking them, really helps to get them to kick in.
Took a LOT of trial and error but that's how I get them to work. Either it was the gut bacteria that changed...or I wasn't eating enough fat beforehand to overcome first pass metabolism...I've got a fast metabolism which sounds similiar to yours, might also be playing a part.
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natzyshroomer
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Re: Why can I not get high from edibles? [Re: Freakofnature]
#25289993 - 06/24/18 09:31 PM (5 years, 7 months ago) |
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Similar prob so i just smoke... i think its metabolism
-------------------- All submitted posts are by Someone Who Isn't Me and in any event are works of pure fiction or outright lies. Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit
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BoolinOnMars
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Re: Why can I not get high from edibles? [Re: Shroomism]
#25367808 - 08/05/18 08:26 AM (5 years, 5 months ago) |
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I hate to necro but the purpose of this post outweighs breaking the rule. If you see this, hooray, because I want you to know you're not alone. I'm a 5'9 male and i weigh only 120 pounds, even though I eat LITERALLY WHATEVER I want. I actually have meals of ice cream just because I can and I lose weight doing that, NO JOKE. What I noticed is that I'm basically a younger version of you; my metabolism is so insane that i have weight problems even though I eat insane amounts of food and calories. Believe it or not, I eat atleast 1 big meal per couple hours just because I get hungry so quickly.
On top of all of that I have a history of stomach problems, nothing serious but I used to get DAILY stomach aches about 2 years in the past. Guess what... just like you I've only ever been barely buzzed off of eaten weed, and been made a bit tired, even though I'm the most ridiculous lightweight you'd ever see. One puff of even the shittiest weed has me floored, so this problem I have with getting high with edibles is frustrating and confusing. Actually, I even trip SUPER HARD on that single puff of weed. I mean that I'm such a light weight that 2 grams will last me a week of being high LITERALLY AT ALL TIMES, NOT SOBER UNLESS I JUST WOKE UP IN THE MORNING. And when I say trip, I mean seeing atoms, insane open eye visuals, true hallucinations, and all kinds of abnormal shit, which I believe to be due to HPPD caused by serious dxm and dph abuse.
Anyway, I've been researching my issue through threads and I've sort of connected the dots. It would appear that the only people with this issue are the people with the stupidly fast metabolisms or a history of stomach problems. I'm guessing that the metabolism is the main issue, considering that it showed up as what EVERYONE with this issue had in common from what I saw. Either way the situation is very unfortunate and I feel for anyone like myself that can't get high from edibles.
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Shroomism
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Re: Why can I not get high from edibles? [Re: BoolinOnMars]
#25392365 - 08/16/18 12:47 PM (5 years, 5 months ago) |
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It's not a "rule" not to necro old threads. Not at all. Just bad form, in some instances... like bumping a 10 year old thread to add some inane comment.
Anyway, yeah I've pretty much come to terms with this and after getting confirmation from lots of people on here and at the dispensary I go to.. it's not as uncommon as I thought.
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LogicaL Chaos
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Re: Why can I not get high from edibles? [Re: Shroomism]
#25393223 - 08/16/18 07:17 PM (5 years, 5 months ago) |
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Its too bad u cant get high off edibles.
Good news is its not an amazing drug in my experience. It can be but u can also take too much and get vertigo. Smoking weed is still great compared to edibles.
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LogicaL Chaos
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Re: Why can I not get high from edibles? [Re: Shroomism]
#25935523 - 04/15/19 07:12 AM (4 years, 9 months ago) |
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I may have some good news Shroomism.
According to Kr0ink0 in this thread, you should be able to get high from transdermal THC patches applied directly to the skin: https://www.shroomery.org/forums/showflat.php/Number/25935518/vc/1#25935518
Anyone ever try those?
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porter
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Re: Why can I not get high from edibles? [Re: LogicaL Chaos]
#25965082 - 04/30/19 07:55 PM (4 years, 8 months ago) |
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I don't do edible anymore because last time I took them it was 250mg at a Lil Peep concert and I barely remember it at all I was so high. He passed away exactly one month later :'(
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NatalieLawrence9
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Re: Why can I not get high from edibles? [Re: Shroomism]
#27053709 - 11/23/20 10:30 AM (3 years, 2 months ago) |
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I don't want to convince anyone to start Smoking or using cannabis, I just want to share my experience. For me, CBD has been a part of my life for a long time, it really helps me deal with stress and everyday problems. This is a good way to relax after work. I found out that the best way to use CBD is to use all-natural, high-quality CBD chewing gums. I buy these gummies KoalityMedicinals.com and I'm very happy. I found out that they make you feel much better.
Edited by NatalieLawrence9 (11/29/20 06:03 PM)
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HappyHigh
Stranger

Registered: 05/05/17
Posts: 892
Last seen: 1 day, 5 hours
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I have same issue... I think people like us are use to the instant come up from smoking, no way can eating hit you like smoking...we never get that instant BAM thc in your system. so to us it's weak...useless....
-------------------- Had I the heavens' embroidered cloths, Enwrought with golden and silver light, The blue and the dim and the dark cloths Of night and light and the half light, I would spread the cloths under your feet: But I, being poor, have only my dreams; I have spread my dreams under your feet; Tread softly because you tread on my dreams.
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Study The CNS
Anecdotal Subtext


Registered: 11/17/20
Posts: 1,588
Loc: Mexico
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Re: Why can I not get high from edibles? [Re: HappyHigh]
#27054635 - 11/23/20 08:58 PM (3 years, 2 months ago) |
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Has anyone looked into Tribulin levels and similar chemicals?
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LizardWizard
GnomeGrower




Registered: 01/07/15
Posts: 13,688
Loc: the parking lot
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Re: Why can I not get high from edibles? [Re: Study The CNS]
#27110671 - 12/27/20 01:03 PM (3 years, 1 month ago) |
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it's liver enzyme related, think that probably already got pinned down somewhere along the thread, but I got it too, though I haven't always had it, it's something that developed over the years... I do get high but only slightly and after very high edible doses, have to toke up to really get high.
-------------------- The best things in life can be smelled on one's fingers.
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LogicaL Chaos
Ascension Energy & Alien UFOs




Registered: 05/12/07
Posts: 69,297
Loc: The Inexpressible...
Last seen: 7 seconds
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Re: Why can I not get high from edibles? [Re: LizardWizard]
#27118754 - 12/31/20 04:18 PM (3 years, 27 days ago) |
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Aging immunity? Very curious
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Sleepingstar
Stranger
Registered: 10/20/20
Posts: 124
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Re: Why can I not get high from edibles? [Re: LizardWizard]
#27119329 - 12/31/20 09:21 PM (3 years, 27 days ago) |
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Lizard, have you tried adding lecithin or what’s it is called with your edibles or anything?
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LizardWizard
GnomeGrower




Registered: 01/07/15
Posts: 13,688
Loc: the parking lot
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Re: Why can I not get high from edibles? [Re: Sleepingstar]
#27119596 - 01/01/21 02:58 AM (3 years, 26 days ago) |
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yes and it makes it come on a bit faster but doesn't make it quantatively stronger. It will come on a bit stronger, but it'll fade faster too. Sometimes I think my liver enzymes got fucked by lyme or something, idk.
-------------------- The best things in life can be smelled on one's fingers.
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mcasa
ExplORer


Registered: 09/19/20
Posts: 86
Last seen: 1 year, 7 months
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Re: Why can I not get high from edibles? [Re: LizardWizard]
#27121134 - 01/01/21 08:56 PM (3 years, 26 days ago) |
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Man I feel you there. I eat a lot of weed stuff too and I can't get as lit as those around me. I could eat 10,000mg of some fine ass cookies by SDK and feel like I drank some cheap ass muscle relaxant Bev (one of those bull shit super supplement drinks). I really Wanna find your chemist, maybe chat him up and smoke him out and ask him to make me the most potent 100k mg thc caramel. Maybe then we can get the true high that snoop dogg gets off his platinum#1 kush. Fly High - Bruno Mars
Edited by mcasa (01/01/21 09:00 PM)
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