|
trscstghst
stranger



Registered: 10/14/07
Posts: 786
Loc: here
|
Re: Why can I not get high from edibles? [Re: LogicaL Chaos] 1
#24290534 - 05/02/17 06:26 PM (6 years, 8 months ago) |
|
|
form a heavy drinking habit, that should elevate your liver enzymes.
jk that sucks. edibles always knock me on my ass even with small doses
-------------------- Why use up the forests which were centuries in the making and the mines which required ages to lay down, if we can get the equivalent of forest and mineral products in the annual growth of the hemp fields? o Henry Ford
|
RiceToastedTreat
Stranger
Registered: 05/12/17
Posts: 1
Last seen: 6 years, 7 months
|
Re: Why can I not get high from edibles? [Re: trscstghst]
#24315557 - 05/12/17 10:54 PM (6 years, 8 months ago) |
|
|
I know this thread is a bit dated but it comes up in a google search so I figure it'd be ok to keep it updated to help us unfortunate souls find an answer.
I also thought it would be good for anyone who doesn't feel anything from edibles to list a bit of their medical history.
So edibles don't do anything for me either. I can try to go the route of wasting money to buy some huge dosage, but I sure it will result in the same thing. The highest dosage I've tried has been 200mg. Now I haven't done nearly as much as OP, but 200mg from a good dispensary would affect anyone who's body is digestin THC nomally so obviously there's a problem. Another thing I'd like to point out for me is that I tried oxy for the first time a couple months ago. Like 15mg and it didn't do anything to me. Again people tried telling me to try a higher dose and all that but 15mg of oxy to a new user is going to feel something. So it's a little annoying how people just assume there's no problem and you just need a higher dose. Ok so a couple of thing I wanted to list about my medical history and eating habits just to see if maybe anyone else can draw a correlation and maybe get some sort of answer. I suffer from migraines and frequent headaches. Migraines that'll make me throw up. I've suffered from this all my life. So as a kid I've taken a good amount of headache relief medication. More than the average persons. My father suffers from the same issue and he now has liver and stomach problems from all the pills he has taken. So that could be a cause for me. I consume a large amount of soda which I'm thinking could make my stomach acid more acidic than normal? No science to back that up or anything just an uneducated guess. I'm currently having some stomach pains and issues as well atm. Could be IBS, I'm going to the doctor soon. Now my main concern isn't so much about the edibles, but how is this affecting my body in other ways? What other nutrients is my body not absorbing correctly? I take a vitamin supplement could this mean I'm not absorbing correctly? Probably not something to worry about and maybe my body is absorbing these things, but for the THC is just passing the blood-brain barrier. I would've just assumed it was a THC exclusive problem, but now that I see oxy didn't even effect me I'm just thinking if this is a indicator of a different problem. Also THC in general just affects me differently than it did when I was a kid. I don't mean because of a higher tolerance, by it's just a different high all together. Well slightly different. I smoked when I was like 12/13 and came back to it at 19 and noticed that high just wasn't exactly the same as I remembered. Could be a logical reason for that one though. Also vaporizers don't work too well on me. There's like this limit with vaporizers on how high I'll get which is less than what I would like. Once I hit that limit no matter how much I vape I just won't get any higher.
Anyways if anyone shares some similarities I'd like to know just so we could maybe draw a pattern between us and narrow down the cause.
In case anyone cares, the oxy was a one time thing. Had a bottle a friend gave me and I took three and flushed the rest right after. A supplier causes addiction and I don't have one of those so I wasn't very worried about trying the oxy.
|
Shroomism
Space Travellin



Registered: 02/13/00
Posts: 66,015
Loc: 9th Dimension
|
|
I don't know what to tell you. I'm pretty healthy in most other regards. No IBS or anything like that. Don't have any significant health problems or digestive problems really, pretty damn healthy for 35. Haven't noticed any difference in anything with any other medications, or food or anything.. everything effects me as it should. THC just seems to effect me completely differently when smoked. I don't really drink alcohol at all, or hardly ever. Maybe that has something to do with it, my liver is too strong or something. Or lack the proper enzyme to process it properly. Kinda like how most Asians lack that liver enzyme to properly process alcohol so they turn red Don't know.. don't really care anymore at this point. I do have a SUPER insane metabolism as I mentioned earlier, I suspect that may be part of it. That... plus being a chronic pothead for the past 20 years may have a slight impact on the results. My cannabinoid receptors are already over-saturated? lol... dunno, don't care.. I get high perfectly fine from smoking so I stick with that.
--------------------
|
Bird_Guts
Ser Peniswrinkle



Registered: 05/10/17
Posts: 1,014
Loc: Cold 9 months out of the ...
Last seen: 6 years, 5 days
|
Re: Why can I not get high from edibles? [Re: Shroomism]
#24325751 - 05/16/17 10:29 PM (6 years, 8 months ago) |
|
|
Smoking weed for 20 years is definitely not it, been smoking weed for 25 years, chronically, and edibles work for me
I don't understand when people say " weed edibles get me so high and couch locked for hours", the edibles I make don't couch lock you, they make you trip . Seriously.
Dispensarys suck, period.
I want to feed you one of my edibles so bad , if mine don't fuck you up nothing will.
I know you said the edibles you get are not weak,, but 1 ounce for a batch of brownies is not very strong IMO, not for a veteran smoker of 20 years
Tinctures suck IMO, especially alcohol
So weird you get high from smoking but not eating....
I wish I could overnight you one of my brownies lol
Fuck man we gotta get you high from an edible!!
--BG--
Edit: I know a lot of people that think they make super good edibles, I go to a lot of festivals whereeople have all kinds of "potent" edibles, lots of my friends are caregivers in the state I live in, they say they make super strong edibles, and I find 97% are not strong . I think most people don't know what a potent edible is. Edibles are nothing at all like smoking weed
Edited by Bird_Guts (05/16/17 10:37 PM)
|
Big Worm
Perf


Registered: 04/20/09
Posts: 7,642
Last seen: 3 years, 9 months
|
Re: Why can I not get high from edibles? [Re: Bird_Guts]
#24325773 - 05/16/17 10:37 PM (6 years, 8 months ago) |
|
|
That's crazy.
I am a heavy smoker and edibles will always have me knocked.
The only time I have seen drugs being "blocked" were due to certain medications people were on, but never thc edibles.
|
ephedup
Stranger
Registered: 05/19/17
Posts: 3
Last seen: 6 years, 8 months
|
Re: Why can I not get high from edibles? [Re: Big Worm] 1
#24334125 - 05/19/17 08:30 PM (6 years, 8 months ago) |
|
|
I am glad I found this thread. I too have the same exact issue. very high doses to absolutely nothing for me as well. I am going to paste below what I posted in another forum the other night because I am starting to think this is purely a liver enzyme issue but who knows.
"So the main reason for this post is that about a month ago I took one of those DNA tests to find out my ancestry, which also came with raw data which I uploaded to another site which gave me my health information. So after this experience last night with no results at a pretty high dose I got to thinking and remembered seeing a few things in my health data related to my body not being able to metabolize some medications, drugs, and lipids. It said I was a CYP3A5 non-expressor. I am no geneticist so most of this info is a little confusing to me, but I think I may be onto something here. I noticed that it is related to the Cytochrome P450 enzymes which are responsible for metabolizing thc into 11-OH-THC which is what causes the high with consumed edibles.
There was another gene that caught my eye which is CYP1A2*1F. Which means I am a fast metabolizer of caffeine and other drugs "resulting in faster breakdown of drugs metabolized by CYP1A2 and the possibility of insufficient drug concentrations in the body to yield much therapeutic benefit". This is also related to the same family of P450 enzymes as above.
So what I am really curious about is if anyone else with the same non response to edibles has had one of these tests done and can confirm if they also exhibit this same genetic traits that are showing on my reports. Perhaps there is a way to inhibit these enzymes, similar to how grapefruit juice and antacids react with opiates which will allow our bodies time to metabolize more efficiently so we stop wasting our money time and time again hoping for different results. I am going to continue research into the science behind this and would love some input and thoughts on this."
I have been looking into this more over the past few nights and it seems there may be multiple enzymes that play a role in metabolizing thc but I need to do some more digging. I have read that Cimetidine (antacid) is an inhibitor if the CYP1A2 emzyne, as well as milk thistle. Omega 3s are said to help repair cb receptors, and mangos which has been spoken about. I guess it is time to start testing.
|
LogicaL Chaos
Ascension Energy & Alien UFOs




Registered: 05/12/07
Posts: 69,297
Loc: The Inexpressible...
Last seen: 6 seconds
|
Re: Why can I not get high from edibles? [Re: Shroomism]
#24334412 - 05/19/17 10:38 PM (6 years, 8 months ago) |
|
|
Do u have kids shroomism?
U should give your kids edibles when they are 19-21 and see what happens. Should be interesting.
|
LogicaL Chaos
Ascension Energy & Alien UFOs




Registered: 05/12/07
Posts: 69,297
Loc: The Inexpressible...
Last seen: 6 seconds
|
Re: Why can I not get high from edibles? [Re: LogicaL Chaos]
#24334416 - 05/19/17 10:40 PM (6 years, 8 months ago) |
|
|
I got an idea. Hire a chemist to convert thc to delta-thc (as in the thc form that is naturally made in the stomach from enymes) then eat that.
Would u do it shroomism?
|
ephedup
Stranger
Registered: 05/19/17
Posts: 3
Last seen: 6 years, 8 months
|
Re: Why can I not get high from edibles? [Re: LogicaL Chaos] 1
#24334748 - 05/20/17 02:14 AM (6 years, 8 months ago) |
|
|
I have been reading all night and this is the best info I can find so far but here are 2 good links that explain how enzymes metabolize thc in your body. How Your Genes Affect Your Cannabis High – The Case of CYP2C9 A guide to the science of how your body metabolizes cannabinoids such as THC and CBD.
Still wonder if more than one enzyme plays a roll in this since the artical don't mention the enzymes I mentioned above but they're all in the P450 family. But as far as CYP2C9 goes, apparently there are some herbs, drugs, and meds that inhibit this enzyme and slow down down the breakdown of the thc which should make the high stronger. Most seem pretty nasty with the likes of ssri,antibiotics,statins, etc. Not things I would experiment with. The only exceptions seem to be quercetin which is a flavonoid from plants and veggies but may be a weak inhibitor, and Apigenin which is said to be a strong inhibitor and is also flavonoid which also has protective qualities. I just ordered a bottle of Apigenin as well as biopeperine to increase absorption. I will be testing this out while there are some gummies left from the same batch. Look forward to updating you guys most likely Monday.
Edited by ephedup (05/20/17 02:55 AM)
|
ephedup
Stranger
Registered: 05/19/17
Posts: 3
Last seen: 6 years, 8 months
|
Re: Why can I not get high from edibles? [Re: ephedup] 1
#24344237 - 05/23/17 08:05 PM (6 years, 8 months ago) |
|
|
Test 1: 400mg of Cimetidine, 500mg of Quercetin, and 5mg of biopeperine. Washed it down with some mango juice 45 min prior to eating gummies. I ate the same 8 gummies as last time.
I would rate last weeks attempt with no aids a 1/10, no effects at all. This last attempt I would rate a 3/10. I felt a little something coming on about and hour in but was short lived and went about my day as normal. No red eyes or munchies as well. I don't think this is a quality issue because 3 friends ate a single gummmy and were very baked. I had 8. It also can't be a tolerance issue because I have not smoked in almost 3 weeks.
Cimetidine is an antacid. It is also a CYP2C9, CYP2C19, and CYP3A4 enzyme inhibitor. Quercetin also inhibits CYP2C9 inhibitor. Mangos contain myrcene which is said to allow thc to more easily cross the blood brain barrier. So if inhibiting these enzymes to slow down liver metabolism of thc isn't really helping, what gives? What else can be causing this?
The only thing left to try is the apigenin and also Amentoflavone which are both said to be strong Inhibitors. If that doesn't work, I giving up on edibles. Also I don't want to be screwing around with my liver and enzymes any further than doing these 2 tests, even though these supplements are pretty safe as long as you are not on any kind of medication which I am not.
Just a word of caution: DO NOT ATTEMPT USING ANY OF THESE INHIBITORS IF YOU ARE TAKING ANY KIND OF MEDICATION at all!! certain drugs can have very bad interactions with inhibitors and can lead to high levels building up in your system causing serious issues or possibly death!!
|
LogicaL Chaos
Ascension Energy & Alien UFOs




Registered: 05/12/07
Posts: 69,297
Loc: The Inexpressible...
Last seen: 6 seconds
|
Re: Why can I not get high from edibles? [Re: ephedup]
#24351372 - 05/26/17 11:16 AM (6 years, 7 months ago) |
|
|
Interesting....so it had an effect huh?
Could be placebo.....or could be real!
|
TONKOL
Stranger
Registered: 01/31/18
Posts: 1
Last seen: 5 years, 10 months
|
Re: Why can I not get high from edibles? [Re: Shroomism] 1
#24957656 - 01/31/18 05:24 PM (5 years, 11 months ago) |
|
|
I know this is a very old post, however I did not see any actual scientific reasoning to why you don't get stoned.
Including myself, a certain percentage of the population does not get stoned when they ingest cannabis. Depending on certain Gastro-intestinal issues, such as crohns, ibs, or GERD. Even some gluten and lactose intollerances can prevent the intestinal cillia from properly absorbing fats and oils.
Now lets say you're perfectly medically fine, and maintain a good diet.
Some people lack the actual enzymes to break down cannibis in the liver. Similarly to codeine the CPY34A enzyme is inhibited and cannabis THC turns into 11 - hydroxy THC (insert joe rogan meme) If this was the case you would also have negative reactions to ceratins SNRI's, and a pre-disposition to addition when prescribed opiates.
There are also potential medicinal interactions, as we aren't your doctor. Do a 23 and me DNA test and go though it with a doctor. I would be interested int the results, as I have the same weird tolerance and found out I have IBS in the process.
Thanks for the read,TLDR stomach/gut problems or missing liver enzyme?
|
LogicaL Chaos
Ascension Energy & Alien UFOs




Registered: 05/12/07
Posts: 69,297
Loc: The Inexpressible...
Last seen: 6 seconds
|
Re: Why can I not get high from edibles? [Re: TONKOL]
#24957661 - 01/31/18 05:26 PM (5 years, 11 months ago) |
|
|
Ooou, a DNA sequencing on people who cant stoned from edibles would be super interesting.
|
psilly the kid
Hedge wizard/ Cultist



Registered: 05/17/16
Posts: 4,615
Loc: Stoprock City
Last seen: 1 year, 2 months
|
Re: Why can I not get high from edibles? [Re: LogicaL Chaos] 1
#24957814 - 01/31/18 06:32 PM (5 years, 11 months ago) |
|
|
id dig on seeing that research
-------------------- CA weed @ all times unless specified currently this high pebbles suck its turtles all the way down
|
Apples in Mono
Not a puppet


Registered: 09/21/17
Posts: 3,240
|
Re: Why can I not get high from edibles? [Re: psilly the kid]
#24975533 - 02/08/18 12:10 AM (5 years, 11 months ago) |
|
|
I'm one of em too. Been trying since the late 90s. Never once have been significantly affected. And i've eaten lots and lots of the strong stuff too. I've watched other people green-out and literally become completel paralyzed while i got no more than slightly drowsy from 3 or 4 times as much. I still try every once in a while. Maybe someday my body chemistry will change and it'll finally work
|
Shroomism
Space Travellin



Registered: 02/13/00
Posts: 66,015
Loc: 9th Dimension
|
Re: Why can I not get high from edibles? [Re: TONKOL] 1
#24980936 - 02/10/18 11:11 AM (5 years, 11 months ago) |
|
|
Quote:
TONKOL said: I know this is a very old post, however I did not see any actual scientific reasoning to why you don't get stoned.
Including myself, a certain percentage of the population does not get stoned when they ingest cannabis. Depending on certain Gastro-intestinal issues, such as crohns, ibs, or GERD. Even some gluten and lactose intollerances can prevent the intestinal cillia from properly absorbing fats and oils.
Now lets say you're perfectly medically fine, and maintain a good diet.
Some people lack the actual enzymes to break down cannibis in the liver. Similarly to codeine the CPY34A enzyme is inhibited and cannabis THC turns into 11 - hydroxy THC (insert joe rogan meme) If this was the case you would also have negative reactions to ceratins SNRI's, and a pre-disposition to addition when prescribed opiates.
There are also potential medicinal interactions, as we aren't your doctor. Do a 23 and me DNA test and go though it with a doctor. I would be interested int the results, as I have the same weird tolerance and found out I have IBS in the process.
Thanks for the read,TLDR stomach/gut problems or missing liver enzyme?
Very good post. And your first one! Welcome!
I haven't been to a doctor in ~14 years Aside from going to the hospital last year for a car wreck.. they said my health was amazing for my age (35). No chrohns, IBS, gerd or lactose intolerant (that I know of.) I don't eat a perfect diet by any means, but I try to eat healthy even though I love sugar. I have a really weird diet style actually, but it works for me. I tend to not eat anything or very little during the day and eat most of my food in the evening or late at night. One big meal late and snacks throughout the day. I'm almost never hungry enough to eat breakfast in the morning. I know I have a 'stomach of steel' as other people comment because I can eat practically anything without getting too stomach upset like some people. Unless it's just plain nasty.
Gut problems or missing liver enzymes is the best guess I've been able to come up with, you're probably spot on there. I have a weird gut.
I actually did get DNA tested recently through a company my work hired... "colors"... but it was more a hereditary cancer test. Results were
Quote:
No mutations were identified.
This means no pathogenic or likely pathogenic genetic variants associated with an increased risk of colorectal, male breast, melanoma, pancreatic, prostate, or stomach cancers were identified in any of the 30 genes analyzed.
This result does not eliminate your risk of developing cancer. Inherited mutations explain some cases of cancer, but most are not inherited and can not be explained by a single cause. Some non-genetic factors that can influence cancer risk include environment and lifestyle, as well as family history without a known genetic link. Your healthcare provider can help determine how your screening plan might be influenced by your health history and other factors.
Genes that were analyzed:
APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A (p14ARF), CDKN2A (p16INK4a), CHEK2, EPCAM, GREM1, MITF, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53
--------------------
|
LogicaL Chaos
Ascension Energy & Alien UFOs




Registered: 05/12/07
Posts: 69,297
Loc: The Inexpressible...
Last seen: 6 seconds
|
Re: Why can I not get high from edibles? [Re: Shroomism]
#24981454 - 02/10/18 11:43 AM (5 years, 11 months ago) |
|
|
Do u have any unique mixed ancestry by chance? Like Native American or Alaskan or anything unique/unusual?
|
Shroomism
Space Travellin



Registered: 02/13/00
Posts: 66,015
Loc: 9th Dimension
|
Re: Why can I not get high from edibles? [Re: LogicaL Chaos]
#24983544 - 02/10/18 04:01 PM (5 years, 11 months ago) |
|
|
like 1/16th native american lol, 75% Italian and some Irish/german. Pretty standard American euro trash
--------------------
|
mmcc
Stranger

Registered: 10/31/17
Posts: 451
Last seen: 2 years, 1 month
|
Re: Why can I not get high from edibles? [Re: Shroomism]
#24983581 - 02/10/18 04:22 PM (5 years, 11 months ago) |
|
|
I grew some Caitlyn Jenners and decided not to smoke it and instead simmered it in coconut milk which I add to my coffee and gives me a good high for about 2 hours and it settles my stomach if it’s feeling shitty. I though edibles aren’t supposed to make you feel high like when you smoke.
|
MissAnthropy
Stranger


Registered: 02/28/18
Posts: 1
Loc: California
Last seen: 3 years, 9 months
|
Re: Why can I not get high from edibles? [Re: mmcc] 2
#25030051 - 02/28/18 08:13 PM (5 years, 10 months ago) |
|
|
So I am an herbalist that works with all plants and a bunch of plant constituents but I do a ton of work in the cannabis industry too and I can tell you your predicament is 100% not uncommon.
I am certainly not a statistician but I can say I personally know about 12 people who have the same experience.
Some of them are people who cannot AT ALL get high from edibles and a few need insanely high dosages (without having built up a tolerance). Several of them have been clients that I recommended cannabis edibles for who told me they do nothing for them.
Another one of them is my brother in law and one of them is my best friend.
If I had to make a guess I would say that it has to do with metabolism, and ones digestive system, and maybe other factors related to auto-immune disorders.
My brother in law for example. If he and I smoke a joint... that guy is TOASTED pretty immediately. YET he can eat 2000mg of an edible to zero effect. Meanwhile I can outsmoke him anyday and I am over here having a freak out if I eat more than 10 mg! I am super sensitive to edibles! To the point where sometimes I will feel as though I am no longer stoned only to wake up in a cold sweat 2 hours after going to sleep!!
He also has Crohns disease (which is a severe intestinal autoimmune disorder). Part of the way that impacts him is that he cannot get certain vitamins from his foods, caffeine doesn't seem to impact him in the same way either. For him I would say it is a digestive issue. My sister has Crohns and she needs a higher edible dosage but it does absolutely work for her at 25-50 mg.
My best friend on the other hand. She needs 300 mg to feel anything. She needs like 2000 mg to get high. She also has an auto-immune disorder but not Crohns or digestive related! She finds that edibles made from sativa do nothing and she gets a better response from indica and hybrids.
I find all of these things very interesting and I wonder if there could be a cannabis study on people who feel like edibles do not work for them.
|
|