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OfflineBaby_Hitler
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DNA explorer. New children's toy sequences DNA. Price: $80
    #2178962 - 12/15/03 08:46 AM (17 years, 5 months ago)

http://shopping.discovery.com/stores/ser...hKey=1767293959


I wish I were getting one of these for Christmas.




Explore one of the newest frontiers in science - DNA mapping. From science labs to courtrooms, few discoveries are as exciting as the world of DNA. With this deluxe, first-of-its-kind kit, you can extract, view and map real DNA yourself. Ideal for budding forensic-scientists or secret agents, the working lab and tools are just like the real thing. Plus, you'll have all the supplies needed for six fascinating DNA experiments. Extract DNA from vegetables, find out what actually makes ink colors and even grow crystal stalagmites!

Includes:

Centrifuge
Magnetic mixer
Electrophoresis chamber
Test vials
Ink samples
DNA stain (fabricated to mimic real DNA)
Mail order card for first two experiments*
And lots more
This innovative look at cutting-edge science gives kids a taste of the excitement of discovery and science.
*It will take approximately 2-3 weeks for you to receive your Lambda DNA samples. There is no charge for your initial shipment (postage is required on card). Kit includes instructions for ordering additional DNA samples for $11.50 per order.

Safety warning: This product contains small parts that may present a choking hazard for young children.


Ages: 10 +
Batteries: Requires six D and three 9V batteries (not included)
Gift Wrap: Available



Edited by Baby_Hitler (12/15/03 08:50 AM)


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Offlinemntlfngrs
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Baby_Hitler]
    #2178964 - 12/15/03 08:51 AM (17 years, 5 months ago)

Hey, that is cool. Can that centrifuge be used in an extraction process?


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OfflineBaby_Hitler
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: mntlfngrs]
    #2178971 - 12/15/03 09:00 AM (17 years, 5 months ago)

Dunno, but I bet there would be all kinds of wacky shit you could do with that.


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Offlinemntlfngrs
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Baby_Hitler]
    #2178983 - 12/15/03 09:19 AM (17 years, 5 months ago)

I bet it would cut down on separation time in a DMT extraction. Needs to be bigger.

Is it all fake DNA?


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OfflineBaby_Hitler
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: mntlfngrs]
    #2179050 - 12/15/03 10:31 AM (17 years, 5 months ago)

No, it really sequences real DNA.


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OfflineSeussA
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Baby_Hitler]
    #2179064 - 12/15/03 10:45 AM (17 years, 5 months ago)

> Can that centrifuge be used in an extraction process?

6 D-size and 3 9-volt batteries... After a few months of batteries you could have purchased a regular centrifuge.


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Seuss]
    #2179089 - 12/15/03 11:07 AM (17 years, 5 months ago)

Quote:

No, it really sequences real DNA.




You are kidding right? It's a neat kids' toy, but it doesn't sequence real DNA. You need TOPO cloning stuff or whatever to do that and a $225,000 sequencer. We don't even have a sequencer -- we just clone genes into TOPO and then send them to a company to have it done.

Quote:

DNA stain (fabricated to mimic real DNA)




The centrifuge won't help because it's not a real one -- it's a kids' toy....

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OfflineSeussA
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: micro]
    #2179108 - 12/15/03 11:17 AM (17 years, 5 months ago)

It does DNA mapping, and it is real and will work with real DNA... by what the literature says.


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OfflineMadtowntripper
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: micro]
    #2179127 - 12/15/03 11:29 AM (17 years, 5 months ago)

Quote:

It's a neat kids' toy, but it doesn't sequence real DNA. You need TOPO cloning stuff or whatever to do that and a $225,000 sequencer.




We did in High School. And I guarantee we didnt have no 225K machine.


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Invisiblemicro
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Seuss]
    #2179128 - 12/15/03 11:29 AM (17 years, 5 months ago)

No, it doesn't. Think about it -- why do waste tens of thousands of dollars, then, to map DNA when there's an $80 childrens toy available to do it....

Give me a break.

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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Madtowntripper]
    #2179134 - 12/15/03 11:32 AM (17 years, 5 months ago)

Quote:

Madtowntripper said:We did in High School. And I guarantee we didnt have no 225K machine.




Yeah, how? No, you didn't sequence DNA in high school. I only do this stuff for a living, people -- I think I have some idea about how it works.... I mean for fuck's sake -- you cannot sequence DNA without really expensive equipment.

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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: micro]
    #2179155 - 12/15/03 11:43 AM (17 years, 5 months ago)

BTW -- the electophoresis is fake, too, because you need mutagenic dyes to stain DNA and high-powered UV light.

Sorry to let your hopes down, kids....

EDIT: It is pretty misleading, though.

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Edited by micro (12/15/03 11:49 AM)


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OfflineMetaShroom
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: micro]
    #2179305 - 12/15/03 01:06 PM (17 years, 5 months ago)

Yeah it's a toy, to seperate DNA you need an far more powerful centrifuge than than that. If it was real the main safety warning wouldn't be "This product contains small parts that may present a choking hazard for young children".


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OfflineBaby_Hitler
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: micro]
    #2179755 - 12/15/03 04:01 PM (17 years, 5 months ago)

people have made homemade PCR machines for cheap. Yes, it used dangerous expensive chemicals.

What make commercial DNA sequencing so expensive is that you would need hundreds or thousands of devices similar to this in an array compiling data, and acting autonomously.


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Invisiblemicro
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Baby_Hitler]
    #2179846 - 12/15/03 04:22 PM (17 years, 5 months ago)

Actually I was wrong -- I checked the list prices just for fun and sequencers go for as low as $98,000.

A PCR machine is just a thermal cycler -- it just changes temperatures 3 times per cycle -- a denaturing temperature (breaks the ladder), an annealing temperature (where random base pairs that you add anneal to each seperated rung of the ladder) and an extension (kind of like an error preventing step to make sure all the DNA is complete.) A thermal cycler could be done by hand with 3 different water baths at different temperatures.

You'd still need the enzyme, though (polymerase) a buffer for the enzyme, DNTP's (base pairs, A,G,T+C) and primers to hook to one part of the sequence.

Most sequencing is done by taking out a gene using specific primers (a DNA sequence to start the PCR out that the enzyme binds to) but you need primers for this, which means you already need the sequence of DNA.

The easiest way (IMO) to sequence unknown DNA is to use these things called transposons that are like mobile DNA, and they bind to random parts of the genome. You can then take these out and clone them into cells (usually E. coli) and each colony will have a different part of the genome. These will have overlapping sections, and you can put all of this into a computer program which fills in the puzzle. With enough of these you can map the genome of anything.

It doesn't cost a lot of money per sample, but the cloning kits cost a lot, and altogether you have to invest at least $10,000 because you go through a lot of equipment.

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Offlinezbgeed
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Baby_Hitler]
    #2189164 - 12/19/03 01:25 AM (17 years, 4 months ago)

HAHAHAHAHA..............please tell me this is a joke......... please


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InvisiblePinhead
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: micro]
    #2197301 - 12/23/03 09:13 AM (17 years, 4 months ago)

Quote:

micro said:
Actually I was wrong -- I checked the list prices just for fun and sequencers go for as low as $98,000.

,




How much of this is to cover product liability? Remember when this is done on a professional level,people's lives can be at stake. I don't doubt that the toy works,but can you trust the results?


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Pinhead]
    #2197405 - 12/23/03 10:37 AM (17 years, 4 months ago)

(sigh)

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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: micro]
    #2197669 - 12/23/03 01:34 PM (17 years, 4 months ago)

I will have to admit that I don't know what the fuck I'm talking about.Might be a joke for all I know.


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: micro]
    #2197686 - 12/23/03 01:41 PM (17 years, 4 months ago)

It's probaly a ripoff. I bought a Dodo bird cloning kit last Christmas,made a fuckin Passenger pidgeon!


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Pinhead]
    #2197726 - 12/23/03 02:11 PM (17 years, 4 months ago)

lol

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OfflineBaby_Hitler
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: micro]
    #2201162 - 12/25/03 07:02 PM (17 years, 4 months ago)

I still think it does more than you think it does.


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OfflineBaby_Hitler
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: micro]
    #14497406 - 05/23/11 04:12 AM (9 years, 11 months ago)

Specifically, I think it probably does/did this:


http://makeprojects.com/Project/Home-Molecular-Genetics/239/1

Mystery solved.  :sherlock:


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Baby_Hitler]
    #14514245 - 05/26/11 11:17 AM (9 years, 11 months ago)

and it only took 7 years :vaped:


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Pscientist]
    #14529059 - 05/29/11 03:05 AM (9 years, 11 months ago)

Science never sleeps.

:billnye:


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Baby_Hitler]
    #14529963 - 05/29/11 11:47 AM (9 years, 11 months ago)

Heh, damn noobs bumping old threads. :grin:

Incidentally, look what 23andMe did for me a while back for just $100. It's genotyping, not sequencing, but still pretty friggin awesome. :rockon:



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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Ythan]
    #14530851 - 05/29/11 03:49 PM (9 years, 11 months ago)

That's pretty cool. Has any of that information made itself useful yet?


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OfflinePscientist
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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Ythan]
    #14533158 - 05/29/11 11:33 PM (9 years, 11 months ago)

Quote:

Ythan said:
Heh, damn noobs bumping old threads. :grin:

Incidentally, look what 23andMe did for me a while back for just $100. It's genotyping, not sequencing, but still pretty friggin awesome. :rockon:

<div style="width:816px;height:600px;overflow-y:scroll;overflow-x:hidden;border:0;padding:0;"><img src="https://files.shroomery.org/files/11-21/668279610-23andme.png" width="799" height="7291" style="border:0;padding:0;"></div>





I think genotyping would require sequencing wouldnt it?


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Baby_Hitler]
    #14535177 - 05/30/11 12:29 PM (9 years, 11 months ago)

Nah, except for telling me I have brown eyes, curly hair and psoriasis, which I already know. :grin: I'm not sure it's accurate enough to take seriously when it comes to health planning or medical treatment, although they're incorporating new studies all the time. But I'm not really good about taking care of my health to begin with... a brisk walk four times a week would probably do me a lot more good than all the genetic screening in the world. Mostly I just got it for entertainment purposes, and a morbid curiosity to see how I might die.

The genealogy part of the site seems good for getting in touch with long-lost relatives though. I don't have much interest in that, but I have an inbox full of like 80 people who are likely to be fifth cousins or closer and want to compare family trees.

Pscientist, I'm kind of confused about the terminology too and I might not be using it right but they do answer this question at https://www.23andme.com/you/faqwin/sequencing/.


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: Baby_Hitler]
    #14731698 - 07/07/11 05:06 PM (9 years, 10 months ago)

Yeah, all that is doing is extracting and running DNA on a gel. Bc you are not cutting it with any restriction enzymes, you couldn't tell one person from another... so it really isn't fingerprinting. Although they acknowledge that at the end, saying that the only thing you could do with that is tell apart different species.

On the subject of DNA sequencing, however, it shouldn't be too many more years b4 a company comes out with a bench-top size sequencer (process will be called 3rd generation sequencing I believe) that can sequence an entire organism in less than an hour with a recurring costs of under $100 (basically the reagents.)

The method is to utilize fluorescence molecules that will be attached to every nucleotide in the solution, so that each addition (via the polymerase) will generate a different color that will be picked up by a detector in real-time. I heard a talk on it last summer by someone at our university; I think I remembering it correctly more or less.

Prior to sequencing I think that aliquots of the genomic DNA get cut up separately with a few different REs so you are sequencing multiple pieces in separate reaction cells, & then the software puts them together by matching overlapping sequences.

Whatever company first comes out with such a machine will do very well. I'm inclined to say that such a machine will be very expensive, but apparently various companies (that anticipate they will be marketing such an item) are making claims that it won't be all that expense... so we'll see.


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: EntheogenicPeace]
    #14731874 - 07/07/11 05:47 PM (9 years, 10 months ago)

this is awesom eI want one


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: snoot]
    #14739840 - 07/09/11 09:10 AM (9 years, 10 months ago)

Lol, nice Ythan, I didn't realize they laid it out so nice, might have to consider that when I have $100 to throw.

To be honest, this is one of the times I don't mind a 7.5 year old thread getting bumped, even a previously useless one, because that link Baby_Hitler posted was pretty cool :thumbup:


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Re: DNA explorer. New children's toy sequences DNA. Price: $80 [Re: loucal]
    #15946483 - 03/14/12 04:13 PM (9 years, 2 months ago)

But does the kiddy toy work are not? Couldn't you even use it for small mammals or bugs or something like that?


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