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OfflineSexycybe
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Registered: 05/03/11
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sugar + yeast = opiates (article link)
    #21699472 - 05/19/15 06:11 PM (8 years, 8 months ago)

I know there has been tons of talk over the years on how Yeast can be used to make thc and other desirable products.
Not sure if this has been linked yet but here you go.
here is the article
Scientists have stopped one step short on completing the creation of yeast that produces opiates. Enjoy :smile:


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InvisibleGhatti
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Re: sugar + yeast = opiates (article link) [Re: Sexycybe]
    #21700067 - 05/19/15 08:48 PM (8 years, 8 months ago)

Sadly there's already talk of locking the DNA away.


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Offlinematsc
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Re: sugar + yeast = opiates (article link) [Re: Ghatti]
    #21706930 - 05/21/15 03:53 PM (8 years, 8 months ago)

Ok, modifying yeast to produce odd medicinal compounds that yeast should never be able to produce is quite literally my day job. I've made dozens of strains to date. I know EXACTLY how this would work.

The stuff my lab makes are all basically 2 step reaction products with 95%~ reaction efficiency, and we still get ~milligrams of final product per week long fermentation. Morphine on the other hand has a 6 (I think?) step reaction scheme with at least one of the enzymes having 50% efficiency. Even running huge bioreactors full time, it would take weeks to get a single dose of morphine, and thats assuming you can run the clean up properly.

Assuming they go the easy way and run each of the enzymes on plasmids, youd need to work with goofy multi-drop-out media or your cells would lose the plasmids within a few generations. D.O. media is relatively expensive, and relatively difficult to lay hands on. I suppose you could direct the genes to the nucleus, but that takes a lot more time, and a lot more effort. It can be done, but not a lot of reason too.

On the other hand you can get several thousand poppy seeds for a couple bucks at any grocery store, and grow them on marginal land in next to no time. Seriously, people, unless P. somniferum magically goes extinct next week this is NEVER going to be an issue. No chance. Maybe some bored grad student will work it up as a conversation piece, but other than a token article in Journal of Natural Products, it will never see the light of day.


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InvisiblebodhisattaMDiscordReddit
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Re: sugar + yeast = opiates (article link) [Re: matsc]
    #21729030 - 05/27/15 02:47 PM (8 years, 8 months ago)

it's very easy the funding isn't there for it, back in the 70's they made yeast produce glucoamylase from a bacterial gene. they made the yeast produce it extra-cellularly so that it could turn more starch into more sugar to ferment out and make light beer.

this is super duper old new science it's nothing new at all. the building blocks have been around decades, but the funding, grants, red tape, bureaucracy, profit stealing, etc.. has been in the way for these compounds to be produced in this way.


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OfflineSexycybe
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Registered: 05/03/11
Posts: 518
Last seen: 8 months, 15 days
Re: sugar + yeast = opiates (article link) [Re: bodhisatta]
    #21750804 - 06/01/15 10:30 PM (8 years, 7 months ago)

Never said it wasn't an old idea, just sharing an article.
Science is an amazing thing, wouldn't be surprised if they made yeast that could do this more efficiently than extracting it from plant material... I'll stick to that method tho haha :wink:


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