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Offlinepslyke
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Morphine is about to get much more accesible...
    #21695755 - 05/18/15 07:52 PM (8 years, 8 months ago)

What do you guys think of this?

http://www.newyorker.com/tech/elements/home-brewed-heroin?intcid=mod-yml

Conceivably yeast cultures could be traded like spore prints here at the shroomery.


--------------------
"What appears impenetrable to us does exist, manifesting itself in the deepest wisdom and the most radiant beauty" Einstein

"The conservatives of 70 years ago would be outraged at what has come to pass. It embodies everything they took up arms for to defeat"Asante


:kratom:


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OfflineLuSiD enthusiast
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Re: Morphine is about to get much more accesible... [Re: pslyke] * 1
    #21695766 - 05/18/15 07:55 PM (8 years, 8 months ago)

I feel like i've read this somewhere, maybe a that mushroom based internet forum? What was that website called?:hmm:


--------------------
I'm addicted to coke, weed, booze, ludes and speed.
Not LSD, you can't get addicted to LSD, it was built by scientists.

I ain't got no demons that gonna get woke.


In erowid we trust.

Just take your damn pills and don't ask any questions, you'll be fine.


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OfflineConnoisseur

Registered: 05/13/11
Posts: 34,686
Last seen: 5 years, 2 months
Re: Morphine is about to get much more accesible... [Re: pslyke]
    #21696223 - 05/18/15 09:32 PM (8 years, 8 months ago)

300 liters makes 30mg of morphine which is barely anything, this will never go anywhere


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Invisiblerackem
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Registered: 11/27/09
Posts: 14,024
Re: Morphine is about to get much more accesible... [Re: Connoisseur]
    #21696241 - 05/18/15 09:35 PM (8 years, 8 months ago)

yet..

the technology is still in its infancy. give it a minute.


--------------------


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OfflineConnoisseur

Registered: 05/13/11
Posts: 34,686
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Re: Morphine is about to get much more accesible... [Re: rackem]
    #21696248 - 05/18/15 09:36 PM (8 years, 8 months ago)

Truth, I did consider that factor

If this can ever be done with less material it will revolutionize the opiate world


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Offlinesanchothestoner
Satan's Grandson
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Registered: 12/06/11
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Re: Morphine is about to get much more accesible... [Re: Connoisseur]
    #21696253 - 05/18/15 09:37 PM (8 years, 8 months ago)

morphine isn't all that great.  extended release pills seem to be the most popular form.  it's fucking great when shot though.  i've had iv morphine quite a bit now, thanks to my hospital trips.  today i was in the hospital and i got a shot, told my nurse i needed more, and she came back with a fucking fat shot of morphine for me.  i actually felt that morphine rush.... twas amazing.


--------------------
I fucking hate you... God damn, I love you...
But we both know if we stick together, we'll just tear ourselves apart
You are my sunshine, my only sunshine, you make me happy, when skies are grey
You are my heroin, but there's an abscess... God damn, I miss the vein!


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OfflineConnoisseur

Registered: 05/13/11
Posts: 34,686
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Re: Morphine is about to get much more accesible... [Re: sanchothestoner]
    #21696261 - 05/18/15 09:39 PM (8 years, 8 months ago)

morphine is amazing it just had poor bio availability when taken without a :syringe:


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Invisiblekr0nik0
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Re: Morphine is about to get much more accesible... [Re: pslyke]
    #21696267 - 05/18/15 09:41 PM (8 years, 8 months ago)

Very interesting.

300 liters for 30mg is obviously of little to no value, but reduce that number of precursor tenfold and this could turn out to be a wonderful thing.


--------------------

“[...]the only people for me are the mad ones,
the ones who are mad to live, mad to talk,
mad to be saved,
desirous of everything at the same time, the ones who never yawn or say a commonplace thing, but burn, burn, burn like fabulous yellow roman candles exploding like spiders across the stars and in the middle you see the blue centerlight pop and everybody goes “Awww!”



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Offlinesanchothestoner
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Re: Morphine is about to get much more accesible... [Re: Connoisseur]
    #21696271 - 05/18/15 09:42 PM (8 years, 8 months ago)

Quote:

Connoisseur said:
morphine is amazing it just had poor bio availability when taken without a :syringe:




that's what i'm saying.  but i feel like most don't really ever shoot it.


--------------------
I fucking hate you... God damn, I love you...
But we both know if we stick together, we'll just tear ourselves apart
You are my sunshine, my only sunshine, you make me happy, when skies are grey
You are my heroin, but there's an abscess... God damn, I miss the vein!


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OfflineMinnesnowtaNice
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Registered: 09/18/13
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Re: Morphine is about to get much more accesible... [Re: sanchothestoner]
    #21696290 - 05/18/15 09:46 PM (8 years, 8 months ago)

Quote:

sanchothestoner said:
morphine isn't all that great.  extended release pills seem to be the most popular form.  it's fucking great when shot though.  i've had iv morphine quite a bit now, thanks to my hospital trips.  today i was in the hospital and i got a shot, told my nurse i needed more, and she came back with a fucking fat shot of morphine for me.  i actually felt that morphine rush.... twas amazing.




I never thought morphine was all that great either, felt good, not great. But I know a bunch of people where it's there jam and they will do anything for it. Very interesting, this could be huge


--------------------
we are all thought forms in a cloud of synchronistic events.




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OfflineConnoisseur

Registered: 05/13/11
Posts: 34,686
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Re: Morphine is about to get much more accesible... [Re: MinnesnowtaNice]
    #21696296 - 05/18/15 09:46 PM (8 years, 8 months ago)

Now that I think of it I dont know the actual bio availability for vaporizing freebase morphine, that might be a more bio availably practical roa as well.

Anyone know what the BA is for vaporizing freebase morphine?


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Invisiblekr0nik0
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Re: Morphine is about to get much more accesible... [Re: Connoisseur]
    #21696317 - 05/18/15 09:52 PM (8 years, 8 months ago)

No idea on the vaporization but IIRC 10mg's orally equals roughly 1mg of oxycodone as far as potency goes.

This conversion makes it hard to find out what the BA would be since with oxy the BA is much higher oral than any other ROA besides the needle. I'd expect the same to be true for morphine, but not sure.


--------------------

“[...]the only people for me are the mad ones,
the ones who are mad to live, mad to talk,
mad to be saved,
desirous of everything at the same time, the ones who never yawn or say a commonplace thing, but burn, burn, burn like fabulous yellow roman candles exploding like spiders across the stars and in the middle you see the blue centerlight pop and everybody goes “Awww!”



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InvisiblePrisoner#1
Even Dumber ThanAdvertized!
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Re: Morphine is about to get much more accesible... [Re: rackem]
    #21696485 - 05/18/15 10:29 PM (8 years, 8 months ago)

Quote:

rackem said:
yet..

the technology is still in its infancy. give it a minute.






GMO heroin, what will monsatan think of next to give us all cancer and murder the bees


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Invisiblerackem
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Registered: 11/27/09
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Re: Morphine is about to get much more accesible... [Re: Prisoner#1]
    #21696501 - 05/18/15 10:31 PM (8 years, 8 months ago)

give it a few minutes im sure they will think of something clever


--------------------


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InvisiblePrisoner#1
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Re: Morphine is about to get much more accesible... [Re: rackem]
    #21696508 - 05/18/15 10:33 PM (8 years, 8 months ago)

Quote:

rackem said:
give it a few minutes im sure they will think of something clever





like GMO marijuana?


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Invisiblemoonrockmushy
High on Spite
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Registered: 07/01/05
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Re: Morphine is about to get much more accesible... [Re: Prisoner#1]
    #21696607 - 05/18/15 11:02 PM (8 years, 8 months ago)

This is kinda like the futuristic drugs I imagine, which are actually engineered infectious agents which have a specific effect until the "cure" is taken.  Imagine just giving someone a yeast infection instead of pills, twould save so much money.


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Invisiblerackem
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Re: Morphine is about to get much more accesible... [Re: Prisoner#1]
    #21696613 - 05/18/15 11:04 PM (8 years, 8 months ago)

dude, you are a thinker!

or gmo molly.  the list could go on.


--------------------


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OfflineUzziel
O_o


Registered: 12/30/10
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Re: Morphine is about to get much more accesible... [Re: rackem]
    #21696724 - 05/18/15 11:46 PM (8 years, 8 months ago)

Can we get a tree that grows meth?

I'd like to eat some meth apples.


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Invisiblekr0nik0
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Registered: 02/13/12
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Re: Morphine is about to get much more accesible... [Re: rackem]
    #21696751 - 05/18/15 11:55 PM (8 years, 8 months ago)

Quote:

rackem said:
dude, you are a thinker!

or gmo molly.  the list could go on.




GMO molly. Yes, please.

GMOLLY - patent pending


--------------------

“[...]the only people for me are the mad ones,
the ones who are mad to live, mad to talk,
mad to be saved,
desirous of everything at the same time, the ones who never yawn or say a commonplace thing, but burn, burn, burn like fabulous yellow roman candles exploding like spiders across the stars and in the middle you see the blue centerlight pop and everybody goes “Awww!”



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Invisiblerackem
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Re: Morphine is about to get much more accesible... [Re: Uzziel]
    #21696752 - 05/18/15 11:55 PM (8 years, 8 months ago)

sure meff apple trees for errybody.


--------------------


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InvisibleGottaloveacid
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Re: Morphine is about to get much more accesible... [Re: rackem]
    #21696762 - 05/18/15 11:57 PM (8 years, 8 months ago)

This is really cool!

By the way to all you people hatin on morphine.... I have never touched a needle and have definitely nodded out off of 45mg morphine before. Simply plug it! It really isn't a big deal, it takes 5 minutes and it gets you nearly as high as IV and there IS a rush. Some people say it takes a minute or two to kick in, but personally as soon as the solution makes contact inside your bum, you instantly feel a wave of relaxation go over you.


--------------------
   
:mushroom2::mushroom2: The greatest story ever told is the story that never ends!:mushroom2::mushroom2:

wubba lubba dub dubstep :gimmebass:


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Invisiblekr0nik0
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Re: Morphine is about to get much more accesible... [Re: Gottaloveacid]
    #21696786 - 05/19/15 12:04 AM (8 years, 8 months ago)

I know your post wasn't directed at me but I don't hate on morphine at all. I've had some great experiences on it but always on 100+mg's
It's just that it's 10x less potent when the ROA is oral compared to oxycodone which was my opiate of choice when still using.

That's awesome you can nod off on 45mg, though. For me taking that much orally wouldn't do much of anything (I think) even though I have no tolerance. Never tried plugging it though. Never tried plugging anything actually, but next time I get my hands on a couple 50mg morphine pills they will be going up the booty.

:awesomenod:


--------------------

“[...]the only people for me are the mad ones,
the ones who are mad to live, mad to talk,
mad to be saved,
desirous of everything at the same time, the ones who never yawn or say a commonplace thing, but burn, burn, burn like fabulous yellow roman candles exploding like spiders across the stars and in the middle you see the blue centerlight pop and everybody goes “Awww!”



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OfflineConnoisseur

Registered: 05/13/11
Posts: 34,686
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Re: Morphine is about to get much more accesible... [Re: kr0nik0]
    #21697303 - 05/19/15 06:40 AM (8 years, 8 months ago)

Quote:

kr0nik0 said:
No idea on the vaporization but IIRC 10mg's orally equals roughly 1mg of oxycodone as far as potency goes.

This conversion makes it hard to find out what the BA would be since with oxy the BA is much higher oral than any other ROA besides the needle. I'd expect the same to be true for morphine, but not sure.




The BA of oral morphine is like 30% but snorting is even less


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Invisiblebadchad
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Re: Morphine is about to get much more accesible... [Re: rackem]
    #21697321 - 05/19/15 06:49 AM (8 years, 8 months ago)

Quote:

rackem said:
yet..

the technology is still in its infancy. give it a minute.




I'm not super familiar with this, but people have been genetically modifying yeast to produce things for decades, at least.  Yeast are unicellular organisms, there's a limit to how much the little buggers can produce.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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OfflineTheGreenArrow
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Re: Morphine is about to get much more accesible... [Re: badchad]
    #21697334 - 05/19/15 06:57 AM (8 years, 8 months ago)

If this were to be engineered to a point where it were feasable to whip up morophine as easily as say a batch of BRF cakes.  My question is wouldn't that be a good thing?  Wouldn't the average dose of opiates drastically fall due to availability?

I mean it costs the average addict what, $150-250 a day not to get sick?  What would happen to the illicit economy in places like Afghanistan or parts of South America if the opium trade were dismantled?


--------------------
A human being should be able to change a diaper, plan an
invasion, butcher a hog, design a building, conn a ship, write a
sonnet, balance accounts, build a wall, set a bone, comfort the
dying, take orders, give orders, cooperate, act alone, solve an
equation, analyze a new problem, pitch manure, program a
computer, cook a tasty meal, fight efficiently, die gallantly.
Specialization is for insects.- Robert A. Heinlein
Saint RedBow of the Shroomey Loomey-Patron Saint of Sandbaggin Sumbitchs


Edited by TheGreenArrow (05/19/15 06:58 AM)


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OfflineBeanhead
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Re: Morphine is about to get much more accesible... [Re: Connoisseur]
    #21697346 - 05/19/15 07:03 AM (8 years, 8 months ago)

Quote:

Connoisseur said:
300 liters makes 30mg of morphine which is barely anything, this will never go anywhere




Why not? can go on indefinetly :Awemazing:


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OfflineConnoisseur

Registered: 05/13/11
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Re: Morphine is about to get much more accesible... [Re: Beanhead]
    #21697550 - 05/19/15 08:33 AM (8 years, 8 months ago)

Well like I also said if the technique could be improved to take up less volume than it would become a very worthwhile venture but at a ratio of 300 liters for 30mg it wont do much of any good at all


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Invisiblemoonrockmushy
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Re: Morphine is about to get much more accesible... [Re: TheGreenArrow]
    #21697596 - 05/19/15 09:07 AM (8 years, 8 months ago)

Quote:

TheGreenArrow said:
If this were to be engineered to a point where it were feasable to whip up morophine as easily as say a batch of BRF cakes.  My question is wouldn't that be a good thing?  Wouldn't the average dose of opiates drastically fall due to availability?

I mean it costs the average addict what, $150-250 a day not to get sick?  What would happen to the illicit economy in places like Afghanistan or parts of South America if the opium trade were dismantled?




That's actually addressed in the article, suffice to say that pharm companies and those that profit off of the black market, who clearly are connected to people in very high positions of power, will never allow anything like this to happen without a massive campaign to hinder it and paint it as the next great evil facing America.  God forbid people should have to make the decision for themselves not to do heroin.  You'd think the fact that the nation which sets the standards for prohibition also sets the standard for consumption would be telling enough to voters and people in power, but alas we're drowning in a sea of fear and stupidity with very little cause for hope.


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OfflineTheGreenArrow
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Re: Morphine is about to get much more accesible... [Re: moonrockmushy]
    #21697605 - 05/19/15 09:12 AM (8 years, 8 months ago)

Beyond hat were dealing with people that have used coercion and covet means to intimidate and bribe politicians for centuries at this point.  Like it or not it seems that the power structure in place is not going anywhere anytime soon.  He'll take Ron Paul's republican nomination at the last convention. It's outright criminal what they did to that guy, but it seems to go all but unnoticed in today's world of media branded bullshit.


--------------------
A human being should be able to change a diaper, plan an
invasion, butcher a hog, design a building, conn a ship, write a
sonnet, balance accounts, build a wall, set a bone, comfort the
dying, take orders, give orders, cooperate, act alone, solve an
equation, analyze a new problem, pitch manure, program a
computer, cook a tasty meal, fight efficiently, die gallantly.
Specialization is for insects.- Robert A. Heinlein
Saint RedBow of the Shroomey Loomey-Patron Saint of Sandbaggin Sumbitchs


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Offlineleafing
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Re: Morphine is about to get much more accesible... [Re: TheGreenArrow]
    #21697623 - 05/19/15 09:20 AM (8 years, 8 months ago)

ummm like  poppy seed tea is already really easy and available  why breed this shit:sexymeow:


--------------------



"The psychedelic experience is just the temporary disruption of psychophysics and the telepathic emergence of synchronic linguistics "


~Leafing~


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Offlineleafing
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Re: Morphine is about to get much more accesible... [Re: TheGreenArrow]
    #21697624 - 05/19/15 09:20 AM (8 years, 8 months ago)

ummm like poppy seed tea is already really easy and available why breed this shit:sexymeow:


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Invisiblemoonrockmushy
High on Spite
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Re: Morphine is about to get much more accesible... [Re: TheGreenArrow]
    #21697633 - 05/19/15 09:24 AM (8 years, 8 months ago)

Yeah honestly I don't know anyone who even really adknowledges problems like this.  It seems like the few people who are together enough to care about anything at all are either blind supporters of whatever authority is visible, or convinced that everyone in the media and government are reptilian illuminaties or some nonsense.  Bunch of puppets and parrots :sad:


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InvisibleCorporal Kielbasa


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Re: Morphine is about to get much more accesible... [Re: pslyke]
    #21697705 - 05/19/15 09:50 AM (8 years, 8 months ago)

I guess they are planning on marking the strains so that they can track down the origins of a theft and illegal use of the culture.


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Offlinepslyke
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Re: Morphine is about to get much more accesible... [Re: Connoisseur]
    #21698887 - 05/19/15 03:45 PM (8 years, 8 months ago)

Quote:

Connoisseur said:
Well like I also said if the technique could be improved to take up less volume than it would become a very worthwhile venture but at a ratio of 300 liters for 30mg it wont do much of any good at all




You can bet the farm that will be the next major goal---how to make the entire process more efficient. There are well established genetic approaches to increase the yield of products being produced in yeast--often increasing yields from 100-1000 fold is acheivable. I would imagine that what these researchers have done is simply a 'proof of concept' set of experiments to show that the science is viable. That is, that they fully understand the metabolic pathway and all its intermediates between sugar and morphine. This is not like cloning a single gene into yeast that gives rise to a single protein. This is vastly more complex. These scientists engineered an entire plant metabolic pathway into yeast. Like wow! I have absolutely no doubt that yeast mediated production of morphine will become cornerstone to pharma production of morphine. Any production of plant based medicines that can be streamlined through chemical synthesis or batch fermentation (yeast, mammalian cells or bacteria) are almost universally adopted. This decreases some of the regulatory quality control hurdles that are associated with plant based products.


--------------------
"What appears impenetrable to us does exist, manifesting itself in the deepest wisdom and the most radiant beauty" Einstein

"The conservatives of 70 years ago would be outraged at what has come to pass. It embodies everything they took up arms for to defeat"Asante


:kratom:


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