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OfflinemotamanM
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Home-brewed heroin? Scientists create yeast that can make sugar into opiates
    #21694607 - 05/18/15 01:36 PM (8 years, 8 months ago)

http://www.theguardian.com/science/2015/may/18/home-brewed-heroin-scientists-yeast-that-can-make-sugar-into-opiates?CMP=share_btn_tw


Home-brewed heroin? Scientists create yeast that can make sugar into opiates

Researchers have managed to reproduce the way poppies create morphine in the wild, but warn that the technology needs urgent regulation


Home-brewed heroin could become a reality, scientists have warned, following the creation of yeast strains designed to convert sugar into opiates.

The advance marks the first time that scientists have artificially reproduced the entire chemical pathway that takes place in poppy plants to produce morphine in the wild.

Scientists warned that the findings could pave the way for opium poppy farms being replaced by local morphine “breweries” and called for urgent regulation of the technology. In theory, opium brewing would be no more difficult to master than DIY beer kits, raising the possibility of people setting up Breaking Bad-style drug laboratories in their own homes.

Tania Bubela, a public health professor at the university of Alberta and co-author of a commentary on the research in the journal Nature, said: “In principle, anyone with access to the yeast strain and basic skills in fermentation could grow morphine-producing yeast using a home-brew kit for beer making.”

The team behind the advance have stopped one step short of linking together the entire chemical chain within a single easy-to-brew yeast strain, and announced a self-imposed moratorium on the work to allow law enforcement agencies and regulators time to catch up.

“We’re certainly not aiming for the illicit drugs market, that’s for sure,” said Vincent Martin, a microbiologist at Concordia University in Québec and co-author. “We realised that we’re entering into a brave new territory here. Me and my collaborators felt that various regulatory bodies should be consulted and talked to and we should build a consensus of how to take this forward.”


The findings, published in the journal Nature Chemical Biology, mark a turning point in efforts that have been made for more than a decade to replicate in microbes the 15-step chemical pathway in the poppy plant.

Scientists had previously succeeded in reproducing the second half of the chemical pathway, but the initial conversion of glucose to a compound called reticuline had proved a sticking point. The latest study cracks this problem for the first time by inserting genes from the poppy plant, sugar beet and a soil-dwelling bacteria into yeast.

Several existing yeast strains are available that can turn reticuline into morphine, and the scientists said that combining the two halves of the process was now feasible – although they have not yet attempted this final step.

“What you really want to do from a fermentation perspective is to be able to feed the yeast glucose, which is a cheap sugar source, and have the yeast do all the chemical steps required downstream to make your target therapeutic drug,” said John Dueber, lead author and a bioengineer at the University of California, Berkeley. “With our study, all the steps have been described, and it’s now a matter of linking them together and scaling up the process. It’s not a trivial challenge, but it’s doable.”

He predicted a timeline of a “couple of years, not a decade” for the reliable production of controlled drugs by sugar-fed yeast.

Being able to synthesise opiates in the laboratory raises the possibility of engineering new therapeutic forms of the drug, designed to be less addictive, more powerful or longer lasting, for instance.

“It creates a platform for finding new chemical structures that could have a lot of potential benefits,” said Martin.

However, it also raises concerns about the yeast falling into the wrong hands. In their commentary, Bubela and colleagues at the Massachusetts Institute of Technology (MIT) call for urgent regulation of the technology warning that it could lead to an alternative system for current criminal networks, particularly in North America and Europe, where the drugs are in high demand. “Because yeast is so easy to conceal, grow and transport, criminal syndicates and law-enforcement agencies would have difficulty controlling the distribution of an opiate-producing yeast strain,” the authors write. “All told, decentralised and localised production would almost certainly reduce the cost and increase the availability of illegal opiates - substantially worsening a worldwide problem.”

Future strains of morphine-producing yeast could be designed to have unusual nutrient requirements as a biocontainment measure, Bubela suggests. Such strains should also be kept in bio-secure facilities in the future, with similar safeguards to those used by researchers working with anthrax or smallpox.

Globally, more than 16 million people use opiates illegally. The drugs come from the misuse of prescription pain medications and from illegally cultivated poppy crops in countries such as Afghanistan, Laos and Mexico.

“The time is now to think about policies to address this area of research,” said Dueber. “The field is moving surprisingly fast, and we need to be out in front so that we can mitigate the potential for abuse.”

Martin said the team had no plans to complete the chain until regulations were in place to do so safely. “If this is something that we shouldn’t do, let’s talk about it now,” he added.


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OfflineBeanhead
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: motaman]
    #21694622 - 05/18/15 01:41 PM (8 years, 8 months ago)

Buying yeast strains 1k each


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OfflineLSDreams
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Beanhead]
    #21694707 - 05/18/15 02:12 PM (8 years, 8 months ago)

Time to start learning about the process of yeast, lol.


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Plants of Interest ~ Lemon Balm, Cannabis, Ayahuasca, Datura, Salvia divinorum, Tabernanthe iboga, Opium poppy, Kratom, Khat, Coca, Ipomoea tricolor, Psilocybin mushrooms, Peyote ~ :peace: 


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Invisiblemuistrue
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: LSDreams]
    #21694738 - 05/18/15 02:25 PM (8 years, 8 months ago)

It takes 80 gallons of yeast to produce a single 30mg dose of morphine. I think most people will continue to take the easier route and just grow some poppies.


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InvisibleCognitive_Shift
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: muistrue]
    #21695258 - 05/18/15 05:22 PM (8 years, 8 months ago)

If i'm not mistaken I think they have used yeast making LSD too

Link to Harvard scientists to make LSD factory from microbes
http://www.theguardian.com/science/blog/2011/jun/21/scientists-make-lsd-from-microbes


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L'enfer est plein de bonnes volontés et désirs


Edited by Cognitive_Shift (05/18/15 05:31 PM)


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OfflineObservatory
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Cognitive_Shift]
    #21696314 - 05/18/15 09:51 PM (8 years, 8 months ago)

here comes the wave of the future


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Look around you


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OfflineLittleDaddy
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Cognitive_Shift] * 1
    #21696326 - 05/18/15 09:53 PM (8 years, 8 months ago)

I don't think you can make LSD from anything natural. the final step of converting the carboxylic acid on LSA to the diethylamide requires thionyl chloride or similarly reactive chemicals and there aren't any enzymes that cause that transformation in nature.


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The hotter the battle, the sweeter Jah victory.
Put the heathen's back upon the wall.


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OfflineBeanhead
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: LittleDaddy]
    #21696700 - 05/18/15 11:38 PM (8 years, 8 months ago)

Quote:

LittleDaddy said:
I don't think you can make LSD from anything natural. the final step of converting the carboxylic acid on LSA to the diethylamide requires thionyl chloride or similarly reactive chemicals and there aren't any enzymes that cause that transformation in nature.




They already did with yeast.


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OfflineCLIT
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: muistrue]
    #21697045 - 05/19/15 03:06 AM (8 years, 8 months ago)

Source?

How much can be made from a single poppy?

If they can make it from yeast I would assume they can make it out of poppy seeds as well (papaver somniferum).

Can something be made just by what part of the brain it affects then? Let's say since cocaine is an SNDRI, can a chemical with the same action be pass off as cocaine as well depending on how it was produced? St. John's Wort has SNDRI activity as well but it sure doesn't have the addictive potential of coke but it caused me serotonin syndrome the way coke would. Let me put it this way; St. John's Wort made me look or act as if I was on coke but I wasn't, and no euphoria was involved. Maybe mania and hypervigilance? I wonder if something can be made from St. John's Wort to make it have the euphoria the way coke does considering both have the same action (as an SNDRI).

I read the article, so for anyone to do what I am describing one would need to know molecular biology?

Quote:

muistrue said:
It takes 80 gallons of yeast to produce a single 30mg dose of morphine. I think most people will continue to take the easier route and just grow some poppies.




Edited by CLIT (05/19/15 03:14 AM)


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OfflineLittleDaddy
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Beanhead]
    #21697086 - 05/19/15 03:49 AM (8 years, 8 months ago)

Quote:

Beanhead said:
Quote:

LittleDaddy said:
I don't think you can make LSD from anything natural. the final step of converting the carboxylic acid on LSA to the diethylamide requires thionyl chloride or similarly reactive chemicals and there aren't any enzymes that cause that transformation in nature.




They already did with yeast.




Show me then. That article posted above shows they can make LSA.

Why would they get funding for producing a drug with no supposed benefits? They pitch that they can make LSA Because it's a scaffold for drugs we use.


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The hotter the battle, the sweeter Jah victory.
Put the heathen's back upon the wall.


Edited by LittleDaddy (05/19/15 03:51 AM)


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OfflineBeanhead
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: LittleDaddy] * 1
    #21697098 - 05/19/15 04:00 AM (8 years, 8 months ago)

"Google" "yeast" "LSD"

I've nothing to prove :drugnerd:



Edited by Beanhead (05/19/15 04:03 AM)


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OfflineLittleDaddy
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Beanhead] * 1
    #21698313 - 05/19/15 12:56 PM (8 years, 8 months ago)

There's no article that shows that. The titles may say it, but all the text within the articles only say LSA.


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The hotter the battle, the sweeter Jah victory.
Put the heathen's back upon the wall.


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Invisibleellomello
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: muistrue]
    #21698683 - 05/19/15 02:44 PM (8 years, 8 months ago)

Quote:

muistrue said:
It takes 80 gallons of yeast to produce a single 30mg dose of morphine. I think most people will continue to take the easier route and just grow some poppies.




SO do you have a source for that, Or just blatantly spreading misinformation?
i haven't seen anywhere stating amounts that would be produced by the yeast.

Anyway, yeah poppies are the way to go... i don't think this yeast will escape,
and even if it did i imagine would be more complicated than just brewing some.

IMO, the best chance of this ever reaching the public is if someone makes some
from outside of the high security labs, and then distributes that to everybody.

This sounds far fetched to you and me, but someone with bio engineering degree!
Using the published DNA sequences, and companies that create stretches of DNA.



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Invisiblemuistrue
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: ellomello]
    #21698764 - 05/19/15 03:11 PM (8 years, 8 months ago)

Quote:

ellomello said:
Quote:

muistrue said:
It takes 80 gallons of yeast to produce a single 30mg dose of morphine. I think most people will continue to take the easier route and just grow some poppies.




SO do you have a source for that, Or just blatantly spreading misinformation?
i haven't seen anywhere stating amounts that would be produced by the yeast.




Read the actual study before accusing someone of spreading misinformation. :facepalm:

William C DeLoache, Zachary N Russ, Lauren Narcross, Andrew M Gonzales, Vincent J J Martin & John E Dueber. An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose. Nature Chemical Biology, May 2015 DOI: 10.1038/nchembio.1816

http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.1816.html


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Edited by muistrue (05/19/15 03:24 PM)


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OfflineNotTheDevil
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: muistrue]
    #21698839 - 05/19/15 03:31 PM (8 years, 8 months ago)

I hope the yeast never manages to be able to compete with wild yeasts, as the ecological effects would be devastating.


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InvisibleCognitive_Shift
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: NotTheDevil]
    #21698852 - 05/19/15 03:34 PM (8 years, 8 months ago)

Don't worry jesus loves you.


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L'enfer est plein de bonnes volontés et désirs


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Invisibleellomello
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Cognitive_Shift]
    #21698912 - 05/19/15 03:52 PM (8 years, 8 months ago)

Well, admittedly i was thinking 80 55-gallon drums for some reason, instead of 80 gallons.
Sounds real now, (can't access paper) but i read the abstract and no reference to amounts.


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PAY NO ATTENTION TO THE MAN BEHIND THE CURTAIN get back to the garden

some came singing, some come to play, some come for keeping the dark away


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OfflineLaughingcowwa
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: motaman]
    #21700414 - 05/19/15 10:39 PM (8 years, 8 months ago)

WOW, now where can I procure some this yeast?


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OfflineCLIT
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: motaman]
    #21700775 - 05/20/15 12:40 AM (8 years, 8 months ago)

who read the latest news about a heroin bust in NYC, 150 pounds of heroin worth 50 million? Is that price about right or just estimate?


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InvisibleCognitive_Shift
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: CLIT]
    #21700780 - 05/20/15 12:42 AM (8 years, 8 months ago)

Quote:

CLIT said:
150 pounds of heroin worth 50 million? Is that price about right or just estimate?



What would jesus do?


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OfflineCLIT
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Cognitive_Shift]
    #21700992 - 05/20/15 02:36 AM (8 years, 8 months ago)

he would do you in the butt!

Quote:

Cognitive_Shift said:
Quote:

CLIT said:
150 pounds of heroin worth 50 million? Is that price about right or just estimate?



What would jesus do?




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InvisibleDistorted Vision
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: CLIT]
    #21701534 - 05/20/15 08:18 AM (8 years, 8 months ago)

Quote:

CLIT said:
who read the latest news about a heroin bust in NYC, 150 pounds of heroin worth 50 million? Is that price about right or just estimate?




If people buy grams for $740, then yes. It's worth more like 6.5  mil - 7 mil if he sold grams for a price that he would never get rid of it all in his life time.

More like 2 mil. worth for the big guy.


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"Yo yo just here to spread my clit and show ya'll what a wonderful and free being we are all inside lets take the acid and turn inside into the outside come on over baby lets smell the roses ohh ohh come on we're about to get lit show my undies to your baby I'll hug it down three times go around frown come on we aint a nice clown kiss me upside down down down come on sorry if you cant handle my wokeness come on lets take her panties off write shroomery on my asshole and taste it lick it make if feel like we was 1978 come on baby lets do the locamotion"-Twig dude


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OfflineCoincidentiaoppositorum
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Distorted Vision]
    #21701599 - 05/20/15 08:42 AM (8 years, 8 months ago)

Poppies do not produce herion (diacetyl-morphine) which is semi-senthetic and does not occor in nature....

Poppies produce opioid alkaloids like morphine and codeine, but herion is not naturally produced by any plants....

-E. Borodin


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OfflineCLIT
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Coincidentiaoppositorum]
    #21704959 - 05/21/15 12:50 AM (8 years, 8 months ago)

people do not get high off morphine or codeine like that? I would assume it's a safer and more natural fix?

Would cocaine then be "natural" but what's up with the chemical precursors to turn it into powder form? Shouldn't there be a natural extraction method of it from coca leaves into smokeable form (atleast) and not necessarily HCL for snorting?

Quote:

Coincidentiaoppositorum said:
Poppies do not produce herion (diacetyl-morphine) which is semi-senthetic and does not occor in nature....

Poppies produce opioid alkaloids like morphine and codeine, but herion is not naturally produced by any plants....

-E. Borodin




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OfflineCoincidentiaoppositorum
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: CLIT]
    #21705583 - 05/21/15 08:38 AM (8 years, 8 months ago)

Quote:

CLIT said:
people do not get high off morphine or codeine like that? I would assume it's a safer and more natural fix?

Would cocaine then be "natural" but what's up with the chemical precursors to turn it into powder form? Shouldn't there be a natural extraction method of it from coca leaves into smokeable form (atleast) and not necessarily HCL for snorting?

Quote:

Coincidentiaoppositorum said:
Poppies do not produce herion (diacetyl-morphine) which is semi-senthetic and does not occor in nature....

Poppies produce opioid alkaloids like morphine and codeine, but herion is not naturally produced by any plants....

-E. Borodin








To obtain natural alkaloids an extraction must be performed, with cocaine they use kerosine as a solvent, every extraction will require a chemical solvent that the alkaloid is soluble in, but as the solvent is evaporated or removed under vacuum, the natural plant alkaloid is left in a fairly pure form, with the chemicals from the extraction process all being removed and not left in the final product. So even though man extracted these compounds, it was the plant that naturally produced them.

Morphine is natural, the poppies latex is collected (this is raw opium) and then the morphine is extracted from it, this is where the natural part ends...then:
The morphine then has 2 acetyl groups added on to the structure of the molecule via a man-made chemical process, this is why "diacetyl-morphine" or "heroin" is not natural, its made by man not the plant, the plant only gives us the precursor "morphine"

I was simply making the point that poppies don't produce heroin (diacetyl-motphine).

Poppies do produce codeine, morphine, and several other natural opioids, but diacetyl-morphine isn't one of them....

-E. Borodin


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OfflineCoincidentiaoppositorum
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Distorted Vision]
    #21705617 - 05/21/15 08:54 AM (8 years, 8 months ago)

Quote:

Distorted Vision said:
Quote:

CLIT said:
who read the latest news about a heroin bust in NYC, 150 pounds of heroin worth 50 million? Is that price about right or just estimate?




If people buy grams for $740, then yes. It's worth more like 6.5  mil - 7 mil if he sold grams for a price that he would never get rid of it all in his life time.

More like 2 mil. worth for the big guy.




Herion is the cheapest drug on the market, .25g costs $20, grams go for $60-80....

Drug agencies are full of shit when the make up these outrageous price estimates....

-E. Borodin


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OfflineCLIT
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Coincidentiaoppositorum]
    #21709091 - 05/22/15 03:39 AM (8 years, 8 months ago)

Why isn't morphine a preferred drug by most who uses heroin considering it would be as natural as weed or shrooms and even cocaine? Perhaps a simpler and safer process as well? Then again "china white" is really fentanyl so some people who may think they are using heroin are really using fentanyl.

this is how I view this; in cocaine extraction for example: put the coca leaves in a flask add extractor/solvent, let sit for awhile, using a filter, pour the mixture into another flask, then that liquid is where the cocaine is? No longer in the leaves, right? The leaves can be dumped. So how does one crystalize the liquid to turn into cocaine crystrals? Evaporation? I'm not quite sure how using a hydrochloric and sulfuric acid crystalizes something liquid.

Quote:

Coincidentiaoppositorum said:
Quote:

CLIT said:
people do not get high off morphine or codeine like that? I would assume it's a safer and more natural fix?

Would cocaine then be "natural" but what's up with the chemical precursors to turn it into powder form? Shouldn't there be a natural extraction method of it from coca leaves into smokeable form (atleast) and not necessarily HCL for snorting?

Quote:

Coincidentiaoppositorum said:
Poppies do not produce herion (diacetyl-morphine) which is semi-senthetic and does not occor in nature....

Poppies produce opioid alkaloids like morphine and codeine, but herion is not naturally produced by any plants....

-E. Borodin








To obtain natural alkaloids an extraction must be performed, with cocaine they use kerosine as a solvent, every extraction will require a chemical solvent that the alkaloid is soluble in, but as the solvent is evaporated or removed under vacuum, the natural plant alkaloid is left in a fairly pure form, with the chemicals from the extraction process all being removed and not left in the final product. So even though man extracted these compounds, it was the plant that naturally produced them.

Morphine is natural, the poppies latex is collected (this is raw opium) and then the morphine is extracted from it, this is where the natural part ends...then:
The morphine then has 2 acetyl groups added on to the structure of the molecule via a man-made chemical process, this is why "diacetyl-morphine" or "heroin" is not natural, its made by man not the plant, the plant only gives us the precursor "morphine"

I was simply making the point that poppies don't produce heroin (diacetyl-motphine).

Poppies do produce codeine, morphine, and several other natural opioids, but diacetyl-morphine isn't one of them....

-E. Borodin




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OfflineCoincidentiaoppositorum
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: CLIT]
    #21709284 - 05/22/15 06:34 AM (8 years, 8 months ago)

Morphine is not prefered because its actually fairly weak, diacetylmorphine is much much more active in the opioid receptors and has a higher binding affinity at the mu opioid receptors.

Though people do chop down home-grown opioid poppies ad brew a tea from them that contains multiple opioids and can be quite strong.... https://www.erowid.org/plants/poppy/poppy_info2.shtml

Here's cocaine extract basics:

Step 1

The coca leaves are put into an above ground container or in a plastic lined pit. An alkaline material (sodium carbonate) and water are added to the leaves. Here the alkaline material enables the cocaine alkaloid present in the leaf to be extracted into the kerosene.

Step 2

A water immiscible solvent (kerosene) is added to water, solution and leaves. The mixture is then agitated. Usually this is accomplished by having several people stomp on the leaves. The solvent acts to extract water insoluble cocaine alkaloids from the alkaline solution.

Step 3

Cocaine alkaloids and kerosene separate from the water and leaves. The water and leaves are then drained off.

Step 4

Cocaine alkaloids are extracted from the kerosene into a dilute acid solution (H2SO4). Alkaline material (sodium carbonate) is added to the remaining solution which causes a precipitate to form. The acid and the water are drained off and the precipitate is filtered and dried to produce coca paste, a chunky off-white to light brown, putty-like substance. As a guide to relative quantities of coca leaf and the resultant amount of coca paste, 250 pounds of dried coca leaf should provide approx. 2.2 pounds of coca paste. This is assuming the leaf is "worked" for a couple of days. The paste will contain approx. 30 percent cocaine alkaloid and 10 percent ecgonine depending on the variety and quality of the coca leaf.


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OfflineCoincidentiaoppositorum
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Coincidentiaoppositorum]
    #21709291 - 05/22/15 06:36 AM (8 years, 8 months ago)

Above was cocaine leaf to cocaine paste, here is cocaine paste to freebase:

Step 1

The coca paste is added to sulfuric acid or hydrochloric acid and water. The paste is dissolved into the acid solution.

Step 2

Potassium permanganate is combined with water. This mixture is added to the coca paste and acid solution. Potassium permanganate is used in this step to extract other alkaloids and material that are undesired in the final product. In particular, potassium permanganate is used to break down the alkaloid ciscinnamoylcocaine which is found in large concentrations in E. Novogranatense varieties. If the coca paste has a high concentration of this alkaloid and potassium permanganate is not used then crystallisation of cocaine HCl will be very difficult to achieve.

Step 3

This mixture is allowed to stand for about six hours.

Step 4

The solution is filtered and the precipitate is discarded. Ammonia water (ammonium hydroxide) is added to the filtered solution and another precipitate is formed.

Step 5

The liquid is drained from the solution and the remaining precipitate is usually dried with heating lamps. The resulting powder is cocaine base with a roughly one to one conversion ratio from paste to base. ie. 2.2 pounds of paste results in roughly the same weight in base. It is common in Colombia to skip the base stage of cocaine processing by going from coca paste right to cocaine HCl. This can be accomplished by eliminating the last part of step four in coca paste processing and skipping to step two of the cocaine base phase where the coca paste is added to the potassium permanganate solution.


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OfflineCoincidentiaoppositorum
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Coincidentiaoppositorum]
    #21709297 - 05/22/15 06:38 AM (8 years, 8 months ago)

Here is cocaine freebase to cocaine HCL

Step 1

Acetone or ether is added to dissolve the cocaine base and the solution is filtered to remove undesirable material.

Step 2

Hydrochloric acid diluted in acetone or ether is added to the cocaine solution. The addition of the hydrochloric acid causes the cocaine to precipitate (crystallise) out of the solution as cocaine hydrochloride. The HCl is then filtered out for drying.

Step 3

The remaining acetone/ether solvent can be discarded or reused.

Step 4

Cocaine HCl is dried under heat lamps, laid out to dry with the aid of fans, or dried in microwave ovens. The yield from 1 kg of base will vary widely, depending on quality of coca base and efficiency of processing, but should be approx. 1 pound.


https://www.erowid.org/archive/rhodium/chemistry/coca2cocaine.html

The link above goes in depth and should further answer your questions



















E. Borodin


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OfflineCLIT
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: Coincidentiaoppositorum]
    #21712928 - 05/23/15 03:11 AM (8 years, 8 months ago)

So pretty much it's as easy as drying shrooms as well? I dried mines laying on paper towels for a day in front of electric fan aka air drying.


Edited by CLIT (05/23/15 03:12 AM)


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OfflineCoincidentiaoppositorum
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Re: Home-brewed heroin? Scientists create yeast that can make sugar into opiates [Re: CLIT]
    #21713240 - 05/23/15 07:04 AM (8 years, 8 months ago)

...more or less, while extracting THC in butane you are left with a BHO/THC liquid, you have it in a glass pot, then you put the bottom of said glass pot into boiling water, and within a minute all the butane evaporates and your left with golden THC...so there are quicker ways than blowing a fan over the solvents surface, some ways require putting the solvent under vacuum for quick evaporation....

You can throw your fresh mushrooms into a toaster-oven (NOT a toaster) for speedy, mold free, drying....

-E. Borodin


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