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OfflineStraya
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Prozac and shrooms, what's the big deal?
    #21693537 - 05/18/15 06:42 AM (8 years, 8 months ago)

Hey guys, so i've just searched the forums about what people have to say about prozac and shrooms and i must admit i'm quite surprised.

I've been on prozac for about 10 years and I trip fairly regularly for the last couple of years and have never had a problem. I'm just wondering where all these people saying SSRI's and shrooms are a bad combo? Has anyone got any links or scientific journals to prove this? I know everyone is different but it sounds like a load of shit to me. They are using shrooms to treat people with PTSD from the Australian military at Sydney university who are already on SSRI's so i'm tending to think that they wouldn't do this if it was so fucking dangerous.

Can anyone shed some light on this for me? I've done shrooms a hundred times and yeah i've had one or two trips that weren't super enjoyable at the end but was due to such a high dose and being in a fairly shitty place when i took them.

Cheers


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OfflineAldebaran
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Re: Prozac and shrooms, what's the big deal? [Re: Straya]
    #21693588 - 05/18/15 07:11 AM (8 years, 8 months ago)

As far as I know, there isn't a risk with mixing SSRIs and shrooms, it's simply that they reduce the effects of the trip. For example, if someone says "I took 2 grams of shrooms but I didn't trip" they might get asked what medication they are on.

MAOI type anti-depressants are a different kettle of fish, there is a potentially risky drug interaction and the general advice is not to mix them with shrooms ... I've forgotten the exact details to be honest.


--------------------
I wrote that, but I meant something else


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OfflineStraya
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Re: Prozac and shrooms, what's the big deal? [Re: Aldebaran]
    #21693658 - 05/18/15 08:11 AM (8 years, 8 months ago)

Ahh that's right. I remember reading something about that before, MAOI's are what you should avoid.

Yeah I had 3 grams of cubes the other day and it didn't do heaps, but then i had 2.5 grams of subs and I was having a good time. Guess it just depends on the person


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Offline5-HT2A-Agonist
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Re: Prozac and shrooms, what's the big deal? [Re: Straya]
    #21693671 - 05/18/15 08:18 AM (8 years, 8 months ago)

from erowid:
https://www.erowid.org/chemicals/maois/maois_info8.shtml

seems pretty forward and clear:
"Generally reduce the effects of the psychedelic a bit."

and here:
https://www.erowid.org/chemicals/maois/maois_info4.shtml
even more detailed:
"*Fluoxetine* (Prozac) -- even at doses of this antidepressant ranging from 2 mg/day to 40 mg/day, there was an overall decrease in most effects from LSD (no matter how much acid people took), as well as a decrease in response to ketamine. There was no change in response to psilocybin. There does seem to be a decrease in the response to MDMA."


--------------------
using: psilocybe cubensis, cannabis, kratom, peganum harmala, alcohol experience: mushroom tryptamines usually 3.5g (somtimes with MAOI) every 2nd or 3rd month, since 2014, so far 28 times, 12 times >3g, highest dose so far 5.5g with MAOI, two micro dosing experiment for 17 days, 0.3g each day, and 0.6g every 3rd/4th day for 6 weeks cannabinoids twice a week doses to get high not stoned, since 2011, kratomjust starting but 3g seems a good dose, planned once a weekβ-carbolines only as MAOI in combination with tryptamines, extracted from peganum harmala (syrian rue), alcohol low doses on empty stomach twice a month, mostly in combination with cannabis


Edited by 5-HT2A-Agonist (05/18/15 08:23 AM)


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InvisibleSirShroomsAlott
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Re: Prozac and shrooms, what's the big deal? [Re: 5-HT2A-Agonist]
    #21693988 - 05/18/15 10:36 AM (8 years, 8 months ago)

serotonin syndrome


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Offline5-HT2A-Agonist
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Re: Prozac and shrooms, what's the big deal? [Re: SirShroomsAlott]
    #21693995 - 05/18/15 10:39 AM (8 years, 8 months ago)

where did you get that from? source?

from erowid mixing MAOIs and SSRIs might lead to that, but not SSRIs and psilocin/psilocybin.


--------------------
using: psilocybe cubensis, cannabis, kratom, peganum harmala, alcohol experience: mushroom tryptamines usually 3.5g (somtimes with MAOI) every 2nd or 3rd month, since 2014, so far 28 times, 12 times >3g, highest dose so far 5.5g with MAOI, two micro dosing experiment for 17 days, 0.3g each day, and 0.6g every 3rd/4th day for 6 weeks cannabinoids twice a week doses to get high not stoned, since 2011, kratomjust starting but 3g seems a good dose, planned once a weekβ-carbolines only as MAOI in combination with tryptamines, extracted from peganum harmala (syrian rue), alcohol low doses on empty stomach twice a month, mostly in combination with cannabis


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InvisibleSirShroomsAlott
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Registered: 05/15/14
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Re: Prozac and shrooms, what's the big deal? [Re: 5-HT2A-Agonist]
    #21694015 - 05/18/15 10:45 AM (8 years, 8 months ago)

http://www.dancesafe.org/OldEbooth/ubbthreads.php?ubb=showflat&Number=118727

http://www.jehovahs-witness.com/topic/180138/scientist-john-hopkins-say-magic-mushrooms-good-you?page=3

http://www.shroomery.org/forums/showflat.php/Number/15565176

http://www.collective-evolution.com/2013/04/18/psychedelic-mushrooms-for-depression/

seems unlikely, but definitely possible. psilocybin and psilocin (if I remember correctly, haven't checked this in a while) act on the same receptors as SSRI's and apart from that are very chemically similar to serotonin, seems less likely with mushrooms then any other drug, but seems possible.


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Offline5-HT2A-Agonist
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Re: Prozac and shrooms, what's the big deal? [Re: SirShroomsAlott]
    #21694289 - 05/18/15 12:02 PM (8 years, 8 months ago)

read it and i could not find any definite source for that combination op is asking for.
all kind of speculation. or can you cite where they reference to?

in the first link they are talking about lexapro (in wikipedia found: escitalopram). seems to be of the class ssri but is not mentioned at all in erowid. so not a reference to prozac and mushrooms.
another poster later refers to a bad outcome using "Paxil or Celexa", so Paroxetine or Citalopram, with mushrooms. erowid shows only about:
"*Paroxetine* (Paxil) -- decrease in response to LSD." so nothing on psilocin/psilocybin.
nothing about Citalopram in the list.
in the end the poster declares:
"The medications I was taking were I think the following.
Paxil or Celexa, Zypreza, Ambien, Xanax, OxyContin, OxyIR, and Remeron."
so i guess i would not refer to that as any reliable source.

second link, the first poster writes a very general warning: "... increased chance of getting "Serotonin Syndrome" which can be deadly if you mix meds ..." not mentioning mushrooms at that point at all.
the next poster answers that its dangerous with maois, but not with mushrooms ... so kind of what i referred to from erowid.

link three:
"... but all went to hell once the mood stabilizer and antidepressants were introduced ..."
mentioning: Lithium Carbonate, Bupropion
erowid:
"LITHIUM: (*alone* or *in combination with a tricyclic antidepressant*) -- increase in response to LSD or psilocybin."
Bupropion, not mentioned in the erowid list, but if you read the article on wikipedia about interactions, its mesing with more than one system there ...
obviously there are enough differences about drugs in the ssris class, so its wise to look up the one you are taking ... so again not a reference to prozac.

link four:
mentioning serotonin syndrom from ssri in general. not talking about combination of mushrooms and ssris at all. i read the whole article.

may i ask how you obtained those links? did you put mushrooms, ssri and serotonin syndrom into the google search? i am serious, not mocking or anything ...

so sure, to be safe just don't do it at all. but that advise is alsways good and true here as everyone on this board takes drugs that messes with your neurochemistry. in the end there is nothing safe when it comes to that. but i guess that will not help the op. my personal advice in the end would be too avoiding mushrooms when you are on any other medication. but easy said for me as i seem mentally fine (so far :smile:)

good luck op!


--------------------
using: psilocybe cubensis, cannabis, kratom, peganum harmala, alcohol experience: mushroom tryptamines usually 3.5g (somtimes with MAOI) every 2nd or 3rd month, since 2014, so far 28 times, 12 times >3g, highest dose so far 5.5g with MAOI, two micro dosing experiment for 17 days, 0.3g each day, and 0.6g every 3rd/4th day for 6 weeks cannabinoids twice a week doses to get high not stoned, since 2011, kratomjust starting but 3g seems a good dose, planned once a weekβ-carbolines only as MAOI in combination with tryptamines, extracted from peganum harmala (syrian rue), alcohol low doses on empty stomach twice a month, mostly in combination with cannabis


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OfflineTrippieHunter
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Re: Prozac and shrooms, what's the big deal? [Re: 5-HT2A-Agonist]
    #21694386 - 05/18/15 12:33 PM (8 years, 8 months ago)

IME, I take 20mg of paxil now, was at 80mg 4 months ago. The paxil greatly reduces the trip. I have done a little research now and this is the only

effect of taking an SSRI while taking a psychedelic that I can really see or have experienced. I'm not going to quote or site anything as it has been done.


--------------------
Just remember keep the camera rolling and
FILM THE POLICE!!! CLICK ME

WHO'S SIDE ARE YOU ON? CLICK ME TOO!

Let it go and you will trip into wonderland!


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InvisibleSirShroomsAlott
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Registered: 05/15/14
Posts: 6,945
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Re: Prozac and shrooms, what's the big deal? [Re: 5-HT2A-Agonist]
    #21694409 - 05/18/15 12:39 PM (8 years, 8 months ago)

Quote:

5-HT2A-Agonist said:
read it and i could not find any definite source for that combination op is asking for.
all kind of speculation. or can you cite where they reference to?

in the first link they are talking about lexapro (in wikipedia found: escitalopram). seems to be of the class ssri but is not mentioned at all in erowid. so not a reference to prozac and mushrooms.
another poster later refers to a bad outcome using "Paxil or Celexa", so Paroxetine or Citalopram, with mushrooms. erowid shows only about:
"*Paroxetine* (Paxil) -- decrease in response to LSD." so nothing on psilocin/psilocybin.
nothing about Citalopram in the list.
in the end the poster declares:
"The medications I was taking were I think the following.
Paxil or Celexa, Zypreza, Ambien, Xanax, OxyContin, OxyIR, and Remeron."
so i guess i would not refer to that as any reliable source.

second link, the first poster writes a very general warning: "... increased chance of getting "Serotonin Syndrome" which can be deadly if you mix meds ..." not mentioning mushrooms at that point at all.
the next poster answers that its dangerous with maois, but not with mushrooms ... so kind of what i referred to from erowid.

link three:
"... but all went to hell once the mood stabilizer and antidepressants were introduced ..."
mentioning: Lithium Carbonate, Bupropion
erowid:
"LITHIUM: (*alone* or *in combination with a tricyclic antidepressant*) -- increase in response to LSD or psilocybin."
Bupropion, not mentioned in the erowid list, but if you read the article on wikipedia about interactions, its mesing with more than one system there ...
obviously there are enough differences about drugs in the ssris class, so its wise to look up the one you are taking ... so again not a reference to prozac.

link four:
mentioning serotonin syndrom from ssri in general. not talking about combination of mushrooms and ssris at all. i read the whole article.

may i ask how you obtained those links? did you put mushrooms, ssri and serotonin syndrom into the google search? i am serious, not mocking or anything ...

so sure, to be safe just don't do it at all. but that advise is alsways good and true here as everyone on this board takes drugs that messes with your neurochemistry. in the end there is nothing safe when it comes to that. but i guess that will not help the op. my personal advice in the end would be too avoiding mushrooms when you are on any other medication. but easy said for me as i seem mentally fine (so far :smile:)

good luck op!




yes....lol....that is exactly how i found them hahahahahahahaha


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OfflineStraya
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Re: Prozac and shrooms, what's the big deal? [Re: SirShroomsAlott]
    #21694466 - 05/18/15 12:54 PM (8 years, 8 months ago)

Oh well i've donated my mind to the cause and i've had no negative side effectsm put me down as a statistic :rockon:


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InvisibleSirShroomsAlott
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Registered: 05/15/14
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Re: Prozac and shrooms, what's the big deal? [Re: Straya]
    #21695084 - 05/18/15 04:20 PM (8 years, 8 months ago)

there you go lol, don't quote me on this, but I would think just doing it one time wouldn't be enough for the worst side effects (unless maybe you're a schizo) so as long as you aren't noticing anything negative, then keep doing you

:rockthefuckout:

I think people just say that shit because SSRI's can have negative effects when mixed with other psychedelics, like serotonin syndrome(even though it doesn't seem to be likely/possible with shrooms), or because it just diminishes the trip (maybe, I know it does for other psychs, not positive about shroomies)


Edited by SirShroomsAlott (05/18/15 04:25 PM)


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Offlinecircastes
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Re: Prozac and shrooms, what's the big deal? [Re: SirShroomsAlott]
    #21695637 - 05/18/15 07:19 PM (8 years, 8 months ago)

I think people on heavy pharms usually have some form of brain damage from their illness, even major depression shrinks the brain a bit, or else schizophrenia IS a form of brain damage, and this damage is why they don't trip. Only a healthy, alive brain/person can trip in the classic sense. They may get something but it'll be nothing like most of shroomery are used to. The more healthy your brain, the more you trip, is another way to put it. Some mentally ill people have blank minds at the climax of episodes, how could you even know you were tripping?

The brain has to be properly and naturally wired as a whole interlocking set of systems, any brain damage turns consciousness 'off' at least partially. Moderate and severe TBI patients have a symptom called 'no self'. 'They' are just 'there' in some vague, somewhat impossible sense. If consciousness is 'turned down' or 'off' there's no way all the flooded or emptied dopamine and serotonin pathways are going to divert the brain into a trip. It's just how the brain works.

I speak from experience.

I have gone from a very sick brain to a very healthy one due to unknown causes, but it all started on mushrooms one day.


--------------------
My solitude...
My shield...
My armour...

TESTED
WITH
FULL
FORCE


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InvisibleGottaloveacid
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Re: Prozac and shrooms, what's the big deal? [Re: Aldebaran]
    #21696806 - 05/19/15 12:12 AM (8 years, 8 months ago)

Quote:

SirShroomsAlott said:
serotonin syndrome




No

Quote:

Straya said:
MAOI's are what you should avoid.




No


Quote:

Aldebaran said:
As far as I know, there isn't a risk with mixing SSRIs and shrooms, it's simply that they reduce the effects of the trip. For example, if someone says "I took 2 grams of shrooms but I didn't trip" they might get asked what medication they are on.




Yes


SSRI's basically block your serotonin receptors from reuptaking anything within the axon, and if you were on shrooms, that means the SSRI will be blocking your 5-HT2a receptor from reuptaking psilocybin. That is why you don't trip as hard.

It isn't harmful at all (unless you account the harmfulness of srri's themselves)

MAOIs are also totally safe with clasical tryptamines and lysergamides. They will make the trip MUCH stronger though, so cut your dose in half at the very least. MAOIs inhibit an enzyme that normally destroys serotonin outside of the axon.... that enzyme is called MAO. MAO also breaks down psychedelics. When MAO is inhibited (mao-Inhibitor), there is nothing to break down the psychedelic. That means it stays in your brain for much longer and has a stronger effect.


--------------------
   
:mushroom2::mushroom2: The greatest story ever told is the story that never ends!:mushroom2::mushroom2:

wubba lubba dub dubstep :gimmebass:


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Offline5-HT2A-Agonist
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Re: Prozac and shrooms, what's the big deal? [Re: Gottaloveacid]
    #21696825 - 05/19/15 12:25 AM (8 years, 8 months ago)

Quote:


Quote:

Straya said:
MAOI's are what you should avoid.




No





please watch out, op is taking SSRIs (prozak) and that you should not mix with MAOIs as it might lead to serotonin syndrom.
so YES, op should avoid MAOIs!

nobody warned about MAOIs with psychedelics. i do that and find it to be a great combination. but when it comes to MAOIs warnings are always a good idea, referring to food restrictions and potentiating effects.


--------------------
using: psilocybe cubensis, cannabis, kratom, peganum harmala, alcohol experience: mushroom tryptamines usually 3.5g (somtimes with MAOI) every 2nd or 3rd month, since 2014, so far 28 times, 12 times >3g, highest dose so far 5.5g with MAOI, two micro dosing experiment for 17 days, 0.3g each day, and 0.6g every 3rd/4th day for 6 weeks cannabinoids twice a week doses to get high not stoned, since 2011, kratomjust starting but 3g seems a good dose, planned once a weekβ-carbolines only as MAOI in combination with tryptamines, extracted from peganum harmala (syrian rue), alcohol low doses on empty stomach twice a month, mostly in combination with cannabis


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OfflineStraya
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Re: Prozac and shrooms, what's the big deal? [Re: Gottaloveacid]
    #21697287 - 05/19/15 06:28 AM (8 years, 8 months ago)

Quote:

5-HT2A-Agonist said:
Quote:


Quote:

Straya said:
MAOI's are what you should avoid.




No





please watch out, op is taking SSRIs (prozak) and that you should not mix with MAOIs as it might lead to serotonin syndrom.
so YES, op should avoid MAOIs!

nobody warned about MAOIs with psychedelics. i do that and find it to be a great combination. but when it comes to MAOIs warnings are always a good idea, referring to food restrictions and potentiating effects.




Thank you my point exactly!


Quote:

Gottaloveacid said:

That is why you don't trip as hard.




Also i trip as hard as all my non-medicated mates, we take the same amount and all reach a very similar level. Obviously what you're saying doesn't apply to everyone... Maybe in your case that was how it went but not everyone.


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InvisibleGottaloveacid
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Re: Prozac and shrooms, what's the big deal? [Re: Straya]
    #21697682 - 05/19/15 09:40 AM (8 years, 8 months ago)

Definitely avoid ssri if you are taking maois! But if your aren't, or is safe to take an maoi with a psychedelic.

How do you know that you are tripping as hard as your friends who aren't on an ssri? The SSRI isn't working of you tripped normally. Have you talked to your doctor about upping the dose?


--------------------
   
:mushroom2::mushroom2: The greatest story ever told is the story that never ends!:mushroom2::mushroom2:

wubba lubba dub dubstep :gimmebass:


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OfflineStraya
Wot?!


Registered: 03/04/12
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Re: Prozac and shrooms, what's the big deal? [Re: Gottaloveacid]
    #21697859 - 05/19/15 10:24 AM (8 years, 8 months ago)

I'm at the maximum dose at the moment.

I know because we will sit there and talk about the amount of visuals, laughter, capacity to complete simple tasks like unlock a phone and roll a cigarette. Not saying it's identical but isn't far off and sometimes will go over the level 1-5 trip guide with them to see where we were at.

Trust me my meds work... Extremely well... 2 days without and it's unpleasant to say the least


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Invisible4HO-DMT
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Re: Prozac and shrooms, what's the big deal? [Re: Straya]
    #21698159 - 05/19/15 12:00 PM (8 years, 8 months ago)

I took prozac for years every day and also dosed mushrooms, LSD, mescaline, MDMA and MDA. I had no interaction what-so-ever. I still tripped as good as before I took these meds.  I also found that after coming down from a trip, Mirtazapine, was a great way to give you trippy dreams. I have heard that others have diminished trips when on SSRI's, but this has not been my experience.


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Invisible4HO-DMT
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Re: Prozac and shrooms, what's the big deal? [Re: 4HO-DMT]
    #21698166 - 05/19/15 12:02 PM (8 years, 8 months ago)

I recently was switched to a mood stabilizer, latuda. I am curious to know if I can trip while on this. Sadly, I don't think that I can. :nonono:


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