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Coincidentiaoppositorum
deep psychedelic


Registered: 10/27/14
Posts: 1,965
Last seen: 8 years, 4 months
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Re: Insanity and DMT [Re: circastes]
#21682371 - 05/15/15 09:55 AM (8 years, 8 months ago) |
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I was speaking about the 5HT2c receptor not the 5HT2a receptor.
And setonergic circuitry obviously plays a role in scizophrena because these serotonergic receptors are the link between the thalamus (which recieves all the signals going into the body except smell) and the cortex regions, which determine your emotional interpretation of this information.
Nobody knows what causes schizophrenia for a fact, I'm of the oppinion that its a number of different things, but serotonin pathways are obviously involved.
The study you provided just shows that 5HT2a likley is not the sole cause of scizophrenia.
How do.you explain the symptoms of scizophrenia vastly improving when a 5HT2C receptor antagonist is provided? http://link.springer.com/chapter/10.1007%252F978-3-642-25758-2_6
I know its a long paper but http://www.acnp.org/g4/GN401000117/CH115.html covers all of these things you have brought to my attention. Plus you were not even talking about the same receptor subtype that I was.
Again, nobody knows the exact cause, but the serotonergic circuitry is obviously involved.
-E. Borodin
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Bill_Oreilly
ANIMALS (the RAINBOW SERPENT)


Registered: 11/12/11
Posts: 26,370
Loc: Boston
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Quote:
Nature Boy said:
Quote:
Coincidentiaoppositorum said: Endogenous DMT is likely there as the endogenous ligand to the sigma-1 receptor, and probably plays no role in mental illness....though it may be signifigant in understanding the mechanisms of mental illness, I doubt it has any role in mediating or causing it...
-E. Borodin

I agree because when I went insane, it was from BHO and weed concentrates...not DMT-related chemicals.
-------------------- Something there is mysteriously formed, Existing before Heaven and Earth, Silent, still, standing alone, unchanging, All-pervading, unfailing, I do not know its name; I call it tao. If forced to give it a name, I call it Great (ta). Being great, it flows out; Flowing out means far-reaching; Being far-reaching, it is said to return. It's just a shot away..
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JeNousAime
Stranger

Registered: 10/18/08
Posts: 86
Last seen: 6 months, 11 days
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I'm sure I've heard Terence McKenna mention a study which did not find elevated DMT levels in schizophrenics (I'm not 100 percent sure if it was schizophrenics but a study like that would try to correlate elevated DMT levels with something along those lines).
It is interesting to see study's purportedly showing a correlation between elevated endogenous DMT and mental disease, I shall have to check this out at some point (science study's can be a bitch to read and judge hehe)
Edited by JeNousAime (05/15/15 02:56 PM)
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Coincidentiaoppositorum
deep psychedelic


Registered: 10/27/14
Posts: 1,965
Last seen: 8 years, 4 months
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Scizophrenia is difficult, I have a scizophrenic family friend, sometimes he does seem like a person on psilocin, others he seems like a person suffering from amphetamine psychosis, there are different subtypes of scizophrenia, and none of them seem very psychedelic or pleasent, though my friend has told me things that I swear mimic the DMT experiance, it seems like there is A LOT more going on.....again, I'm of the oppinion that its a number of different things that cause scizophrenia, but nobody has figured it out for sure.
studies are great, but can conflict one another, its best to just realize that we don't know yet, and reserve are decisions on its cause until more information becomes available.
-E. Borodin
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