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OfflineEgo Trip
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Registered: 10/23/14
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Insanity and DMT
    #21673734 - 05/13/15 08:08 AM (8 years, 8 months ago)

As you all know, humans have DMT in their pineal gland. What if, people who are 'insane' is a result of more DMT in the brain than humans should actually have. I'm talking, insane that they wont be even able to function. Which will result into them tripping into hyperpace and act like what we call insane.

What if...the entities we communicate with are actual insane humans in mental institutions, which are currently in hyperspace right now. They know about everything but they can't tell us.

I actually believe we go to hyperspace when we die. Entities are dead souls.


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Marijuana, LSD, Psilocybin, Salvia, Kratom, DMT, Alprazolam, MDMA:heart:, 2C-B, Ketamine, Methylone, Methylphenidate, Amphetamine, Codeine, Etizolam, MXE, Oxycodone, GHB, Diazepam, 4-aco-dmt, 5-MeO-MiPT, Clonazolam, MDA, PCP, DXM, Ayahuasca


Edited by Ego Trip (05/13/15 08:20 AM)


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OfflinePr0m3theus
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Re: Insanity and DMT [Re: Ego Trip]
    #21673807 - 05/13/15 08:36 AM (8 years, 8 months ago)

DMT has NEVER been proven to exist within the pineal gland; however, the precursors for its biosynthesis have been analyzed within its contents. (N-methyltransferase, tryptophan, etc.)


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InvisibleMescalitoe
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Registered: 05/14/14
Posts: 584
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Re: Insanity and DMT [Re: Ego Trip]
    #21673810 - 05/13/15 08:38 AM (8 years, 8 months ago)

Quote:

Ego Trip said:
As you all know, humans have DMT in their pineal gland. What if, people who are 'insane' is a result of more DMT in the brain than humans should actually have. I'm talking, insane that they wont be even able to function. Which will result into them tripping into hyperpace and act like what we call insane.

What if...the entities we communicate with are actual insane humans in mental institutions, which are currently in hyperspace right now. They know about everything but they can't tell us.

I actually believe we go to hyperspace when we die. Entities are dead souls.




I have always thought something similair to this. What if schizophrenics brains are just pumping out massive doses of DMT causing them to continually hallucinate. That would be something else...


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Offlinethebitterbuffalo26
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Registered: 04/18/15
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Re: Insanity and DMT [Re: Mescalitoe]
    #21673855 - 05/13/15 08:55 AM (8 years, 8 months ago)

Yeah because crazy really is just a chemical imbalance


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InvisibleJean-guy Masta
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Registered: 09/23/14
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Re: Insanity and DMT [Re: Mescalitoe]
    #21673870 - 05/13/15 09:01 AM (8 years, 8 months ago)

Well Maybe not skizofrenia , since it doesn't sound like a hyper space experience from what I heard from friends that have skizofrenia and psychotic episode but I certainly believe that there is people with weird/rare mental illness that live constantly in a psychedelic state . And probably some people do live in the dmt hyperspace .

Must be a fuckin nightmare or eternal pure bliss . Depends on the perspective I guess :lol: but yea OP overall your theory does makes sense to me :thumbup:


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OfflineCoincidentiaoppositorum
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Re: Insanity and DMT [Re: Mescalitoe]
    #21673872 - 05/13/15 09:01 AM (8 years, 8 months ago)

Quote:

Mescalitoe said:
Quote:

Ego Trip said:
As you all know, humans have DMT in their pineal gland. What if, people who are 'insane' is a result of more DMT in the brain than humans should actually have. I'm talking, insane that they wont be even able to function. Which will result into them tripping into hyperpace and act like what we call insane.

What if...the entities we communicate with are actual insane humans in mental institutions, which are currently in hyperspace right now. They know about everything but they can't tell us.

I actually believe we go to hyperspace when we die. Entities are dead souls.




I have always thought something similair to this. What if schizophrenics brains are just pumping out massive doses of DMT causing them to continually hallucinate. That would be something else...





They are finding that scizophrenia may be caused by an over-active serotonin-2a receptor, which is one of DMTs key targets.


There is a difference between "insanity" and "unsanity", scixophrenia is insanity, while DMT experiances are "unsanity"


-E. Borodin


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OfflineCoincidentiaoppositorum
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Re: Insanity and DMT [Re: Coincidentiaoppositorum]
    #21673880 - 05/13/15 09:04 AM (8 years, 8 months ago)

http://www.acnp.org/g4/GN401000117/CH115.html

For more information on serotonin and serotonergic circuitry s role in schizophrenia visit the link above

-E. Borodin


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OfflineCoincidentiaoppositorum
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Re: Insanity and DMT [Re: Coincidentiaoppositorum]
    #21673888 - 05/13/15 09:08 AM (8 years, 8 months ago)

Endogenous DMT is likely there as the endogenous ligand to the sigma-1 receptor, and probably plays no role in mental illness....though it may be signifigant in understanding the mechanisms of mental illness, I doubt it has any role in mediating or causing it...

-E. Borodin


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InvisibleMescalitoe
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Re: Insanity and DMT [Re: thebitterbuffalo26]
    #21673952 - 05/13/15 09:30 AM (8 years, 8 months ago)

Quote:

thebitterbuffalo26 said:
Yeah because crazy really is just a chemical imbalance



Who's to say it is or isn't.


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Invisiblemoonzo
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Re: Insanity and DMT [Re: Ego Trip]
    #21674467 - 05/13/15 12:24 PM (8 years, 8 months ago)

Quote:

Ego Trip said:
As you all know, humans have DMT in their pineal gland. What if, people who are 'insane' is a result of more DMT in the brain than humans should actually have. I'm talking, insane that they wont be even able to function. Which will result into them tripping into hyperpace and act like what we call insane.

What if...the entities we communicate with are actual insane humans in mental institutions, which are currently in hyperspace right now. They know about everything but they can't tell us.

I actually believe we go to hyperspace when we die. Entities are dead souls.




There is definitely a relation between mental illness and the psychedelic state.


--------------------
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Offlinepineapple3

Registered: 03/29/15
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Re: Insanity and DMT [Re: moonzo]
    #21675159 - 05/13/15 03:37 PM (8 years, 8 months ago)

Elevated urine levels of bufotenine in patients with autistic spectrum disorders and schizophrenia.x
http://www.ncbi.nlm.nih.gov/pubmed/20150873


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OfflineCoincidentiaoppositorum
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Re: Insanity and DMT [Re: pineapple3]
    #21675852 - 05/13/15 06:27 PM (8 years, 8 months ago)

Quote:

pineapple3 said:
Elevated urine levels of bufotenine in patients with autistic spectrum disorders and schizophrenia.x
http://www.ncbi.nlm.nih.gov/pubmed/20150873




It never states if the bufotenine levels are in high enough concentration to have psychological effect....which is what I was interested in here....

Maybe scizophrenics and ADS patients biochemistry causes elevated production of these compounds for others reasons, that don't play role in the psychological aspects of their condition....

Bufotenines activity as a psychedelics is debateable, even as a psychoactive is activity is uncertian, though it does produce physiological effects.
Regardless very I interesting stuff, thank you for sharing.

-E. Borodin


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InvisibleGottaloveacid
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Registered: 10/20/14
Posts: 3,421
Loc: Colorado, USA
Re: Insanity and DMT [Re: Ego Trip]
    #21676317 - 05/13/15 08:08 PM (8 years, 8 months ago)

Quote:

Ego Trip said:
As you all know, humans have DMT in their pineal gland. What if, people who are 'insane' is a result of more DMT in the brain than humans should actually have. I'm talking, insane that they wont be even able to function. Which will result into them tripping into hyperpace and act like what we call insane.

What if...the entities we communicate with are actual insane humans in mental institutions, which are currently in hyperspace right now. They know about everything but they can't tell us.

I actually believe we go to hyperspace when we die. Entities are dead souls.




This is actually true :lol:

Sorry if someone already posted this, don't have the ability to really read a lot of posts right now :laugh:rool:

http://www.ncbi.nlm.nih.gov/pubmed/1070024

Schizophrenics have more DMT in their urine than other people, by a substantial amount.


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Offlinecircastes
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Re: Insanity and DMT [Re: Gottaloveacid]
    #21677460 - 05/14/15 02:08 AM (8 years, 8 months ago)

I thought the 5HT2A receptor was ruled out as being responsible for schizophrenia, or there were mixed results.


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Offlinecircastes
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Re: Insanity and DMT [Re: circastes]
    #21677462 - 05/14/15 02:09 AM (8 years, 8 months ago)

Your study was published 15 years ago.


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OfflineNature Boy
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Re: Insanity and DMT [Re: Coincidentiaoppositorum]
    #21677659 - 05/14/15 05:00 AM (8 years, 8 months ago)

Quote:

Coincidentiaoppositorum said:
Endogenous DMT is likely there as the endogenous ligand to the sigma-1 receptor, and probably plays no role in mental illness....though it may be signifigant in understanding the mechanisms of mental illness, I doubt it has any role in mediating or causing it...

-E. Borodin




:whathesaid:


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OfflineCoincidentiaoppositorum
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Re: Insanity and DMT [Re: circastes]
    #21677857 - 05/14/15 06:50 AM (8 years, 8 months ago)

Quote:

circastes said:
I thought the 5HT2A receptor was ruled out as being responsible for schizophrenia, or there were mixed results.




In the early days, schizophrenia was thought to be a dopeamine involved condition, in recent times we understand serotonin circuitry may play a bigger role, every signal entering the brain is sent to the thalamus (except smells), where its filter then sent to the cortex regions where you interpret it on an emotional level, this lower informational brain, the thalamus, is linked to the higher brain, cortex regions, by this sertonergic circuitry, meaning your serotonin receptor system.

http://www.acnp.org/g4/GN401000117/CH115.html

This paper explains possible serotergenic roles in scizophrenia.....though it doesn't matter who you ask because nobody knows, its best to select the best possible option until something better comes along.

-E. Borodin


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OfflineCoincidentiaoppositorum
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Re: Insanity and DMT [Re: Coincidentiaoppositorum]
    #21677863 - 05/14/15 06:52 AM (8 years, 8 months ago)

CRITICAL TESTS OF THE 5-HT HYPOTHESIS OF SCHIZOPHRENIA

The original DA hypothesis of schizophrenia has been supported by three types of findings: first, that all neuroleptics were effective D2 receptor antagonistss; second, that functional alteration in brain dopaminergic function were present in schizophrenia; and third, that drugs were increase brain dopaminergic activity can either induce psychosis in normal individuals or exacerbate symptoms in schizophrenes (see Brain Imaging in Mood Disorders ,this volume). The extent to which comparable data is available with regard to 5-HT and schizophrenia will now be reviewed.

Fundamental to testing the 5-HT hypothesis of schizophrenia is the determination of whether serotonergic drugs can affect the psychopathology and cognitive dysfunction of schizophrenia (either to exacerbate or to ameliorate these components of the illness) as do the drugs which act on the dopaminergic system (e.g., amphetamine and neuroleptics). However, drug effects per se cannot provide the basis for concluding that 5-HT is involved in the etiology of schizophrenia. Alterations in serotonergic neurotransmission must also be demonstrable (e.g., receptor changes not due to drug to drug treatment). A large number of potential antipsychotic agents which are 5-HT2Areceptor antagonistss have been evaluated in patients with schizophrenia, providing evidence for the importance of this receptor for antipsychotic drug action (52,74). Additionally, a number of direct and indirect 5-HT agonists (fenfluramine, 5-hydroxytryptophan [ 5-HTP], mCPP, and tryptophan) sometimes exacerbate symptoms of schizophrenia (50,63,67,69). Finally, many studies of schizophrenia have demonstrated alterations in: 1) serotonergic neurotransmission as measured by the concentration of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the density of 5-HT1A or 5-HT2A receptors in post-mortem brain specimens; 2) hormonal and behavioral responses to serotonergic drugs; and 3) abnormalities of 5-HT and its metabolites in blood or CSF.

The study of the role of 5-HT in schizophrenia has been advanced by the cloning of multiple 5-HT receptors. To date, 14 distinct 5-HT receptors have been identified via molecular biology and pharmacologic techniques (41; see Molecular Biology of Seotonin Rerceptors: A Basis for Understanding and Addressing Brain Function,Serotonin Receptor Subtypes and Ligands and Sertonin Receptors: Signal Transduction Pathways in this volume). Clozapine, the prototype of an atypical antipsychotic drug, was more effective than chlorpromazine or haloperidol in treatment-resistant schizophrenia (51) and has a very high affinity (,10nM) for the 5-HT2A,5-HT2C, 5-HT6, and 5-HT7 receptors (79,98,99,104).Clozapine is also a moderately potent partial agonist at the 5-HT1A receptor and a 5-HT3 antagonists (see ref. 74 for review). The classical definition of an atypical antipsychotic drug is one that shows a marked dissociation between doses that block amphetamine-induced stereotype and those that cause catalepsy. There may also be a dissociation between the antipsychotic effect and extrapyramidal symptoms (EPS). A number of other atypical antipsychotic agents have also been found to have greater affinity for 5-HT2A than D2 receptors in vitro. The ratio of 5-HT2A / D2 affinities distinguishes between typical and atypical antipsychotics better than any other known pharmacologic feature (79,104). Risperidone and olanzapine, both of which have high 5-HT2A receptor blocking activity relative to their D2 affinity (78,104), have greater efficacy for treating negative symptoms of schizophrenia and produce fewer EPS than haloperidol (8,14). These observations are consistent with the hypothesis that 5-HT2A receptor antagonism is of value in an antipsychotic drug, since these agents do not share other properties that might produce this profile.

The fact that many atypical antipsychotic agents are potent 5-HT2A antagonistss is interesting in light of the evidence that stimulation of 5-HT2A or possibly 5-HT2C receptors is the basis for the hallucinogenic action of indoleamines such as LSD or psilocybin (30). Clozapine is a potent antagonistss at both of these receptor types. Clozapine and other potent 5-HT2A antagonistss such as olanzapine and mianserin ameliorate the psychosis due to L-DOPA or direct-acting DA agonists such as bromocriptine and pergolide in patients with Parkinson’s disease. The dose and plasma levels of clozapine that are effective in treating DA-induced psychosis in these patients is in a range in which 5-HT2A receptor blockade is likely to be the basis for its efficacy (75), rather than D4 receptors blockade, as suggested by Seeman et al. (106).This conclusion is supported by the evidence that two potent D4 antagonistss were ineffective antipsychotic agents in controlled clinical trails of schizophrenics. A comparison of the effect of the D2/D3 antagonists raclopride, the D1 blocker SCH 23390, the 5-HT1A agonist, 8-OH-DPAT, and the 5-HT2A / 2C antagonists ritanserin on catalepsy and conditioned avoidance (CAR) behavior also suggested actions on 5-HT1A as well as 5-HT2A receptors, but not the D receptor, might be the basis for at least some of clozapine’s advantages, since the two 5-HT agents inhibited raclopride-induced catalepsy and potentiated the effect of raclopride on the CAR (125). Many but not all atypical antipsychotic drugs are also potent antagonistss at 5-HT6 or 5-HT7 receptors; some typical neuroleptics are also potent 5-HT6 or 5-HT7 antagonistsi (99). 5-HT6 and 5-HT7 receptors are present in striatal and cortico-limbic areas, respectively (41,83). Blockade of these receptors could also contribute to some of the effects of atypical antipsychotic drugs, but consideration of the group of atypicals indicates that potent 5-HT6 or 5-HT7 receptor antagonism of high 5-HT6 / D2 or 5-HT7 / D2 ratios are not essential features of typical antipsychotic drugs (99). These receptors may play a modulatory role, however. Not until specific 5-HT6 or 5-HT7 agonists are available and have been adequately tested in the clinic will it be possible to determine the importance of these receptors in schizophrenia


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OfflineCoincidentiaoppositorum
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Re: Insanity and DMT [Re: circastes]
    #21677872 - 05/14/15 06:54 AM (8 years, 8 months ago)

Quote:

circastes said:
Your study was published 15 years ago.




The information is still relevant, it was published over a 25 year period....

-E. Borodin


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Offlinecircastes
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Re: Insanity and DMT [Re: Coincidentiaoppositorum]
    #21679866 - 05/14/15 05:29 PM (8 years, 8 months ago)

Hm okay.

http://www.szgene.org/geneoverview.asp?geneid=293

Here is a table of all research done on attempts to link 5HT2A to schizophrenia.

I researched this a while back because I'm supposed to have had a drug induced psychosis and there is chronic schizophrenia in my family, and I wanted/still want to take psychedelics.


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My solitude...
My shield...
My armour...

TESTED
WITH
FULL
FORCE


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