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InvisibleDMTme

Registered: 03/22/15
Posts: 80
Could long term use of DMT result in a reduction of endogenous serotonin?
    #21586110 - 04/23/15 02:12 PM (9 years, 27 days ago)

DMT is an analogue of serotonin.
In cocaine / crack additiction the body mistakes the chemicals as dopamine and shuts
off the endogenous supply (causing the addiction).

If the body is mistaking DMT as serotonin it would seem (at least in theory) that
it could do the same with endogenous serotonin.

Anyone have information on this?
I'm having difficulty finding concrete answers (and there seems to be conflicting
information online).

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OfflineHardTrippin
The Ambivalent
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Registered: 11/05/09
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Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: DMTme]
    #21586134 - 04/23/15 02:18 PM (9 years, 27 days ago)

This is a terrible answer to your question because it involves no science, but I honestly just don't feel like I have any deficiency in serotonin after I smoke DMT. I just feel awesome if anything.

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InvisibleDMTme

Registered: 03/22/15
Posts: 80
Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: HardTrippin]
    #21586372 - 04/23/15 03:18 PM (9 years, 27 days ago)

Quote:

HardTrippin said:
This is a terrible answer to your question because it involves no science, but I honestly just don't feel like I have any deficiency in serotonin after I smoke DMT. I just feel awesome if anything.



Feeling would be valid but how long / often have you been smoking it?

Edited by DMTme (04/23/15 03:19 PM)

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InvisibleGottaloveacid
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Registered: 10/20/14
Posts: 3,421
Loc: Colorado, USA
Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: DMTme]
    #21586407 - 04/23/15 03:26 PM (9 years, 27 days ago)

If you did it multiple times a day, then yes, most definitely. There are probably no studies done on this, however since DMT replaces serotonin in vivo, and since DMT has residual effects lasting up to an hour, I bet if you smoked it every hour every day that over time your brain would stop producing as much serotonin. It just won't need to, it sees DMT as being just as useful as 5-HT, so if DMT was always taking serotonin's place, it will just think your brain has enough serotonin.

However, if you abused DMT like that there is a VERY good chance of falling into a deep psychosis. Permenately changing one of the most important endogenous neurotransmitters out for a drug with effects like DMT, you would develop serious side effects that involve mainly the 5-HT2a receptor. Just like with crack or meth, your appetite would go away. You would have troubles sleeping, psychosis, depersonalization, the list goes on and on.

Just research what 5-HT does to the 5-HT2a receptor, then replace the 5-HT with the DMT. You would fuck your brain, hard.


--------------------
   
:mushroom2::mushroom2: The greatest story ever told is the story that never ends!:mushroom2::mushroom2:

wubba lubba dub dubstep :gimmebass:

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Offlinehelenkeller
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Registered: 04/22/15
Posts: 10
Last seen: 8 years, 11 months
Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: DMTme]
    #21586433 - 04/23/15 03:31 PM (9 years, 27 days ago)

I don't think so.  My reason is the duration is much too short to cause neuro receptor damage. I certainly believe it could affect your natural endogenous dmt production though. Just a guess

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Offlinehelenkeller
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Registered: 04/22/15
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Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: helenkeller]
    #21586447 - 04/23/15 03:33 PM (9 years, 27 days ago)

Back when I used to manufacture dmt I smoked level 5 trips multiple times a day for a month or so. No noticeable effect. Absolutely no psychosis.  Psychosis is getting trapped in a particular emotional state.  Dmt helps you realize you're holding on to these states.

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InvisibleGottaloveacid
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Registered: 10/20/14
Posts: 3,421
Loc: Colorado, USA
Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: helenkeller]
    #21586484 - 04/23/15 03:41 PM (9 years, 27 days ago)

I had a friend who also smoked DMT 1-2x daily, he was fine, but keep in mind that is different than being under the influence of DMT ALL the time :smile:

Definition of psychosis - a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.

If you were always under the influence of DMT, or any psychedelic, you would be by definition in a permanent psychosis. You will also frequently see psychologists refer to a psychedelic experience as a short term, temporary psychosis, because that is literally what it is :smile:


--------------------
   
:mushroom2::mushroom2: The greatest story ever told is the story that never ends!:mushroom2::mushroom2:

wubba lubba dub dubstep :gimmebass:

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InvisibleDMTme

Registered: 03/22/15
Posts: 80
Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: Gottaloveacid]
    #21586514 - 04/23/15 03:47 PM (9 years, 27 days ago)

Quote:

Gottaloveacid said:
If you did it multiple times a day, then yes, most definitely. There are probably no studies done on this, however since DMT replaces serotonin in vivo, and since DMT has residual effects lasting up to an hour, I bet if you smoked it every hour every day that over time your brain would stop producing as much serotonin. It just won't need to, it sees DMT as being just as useful as 5-HT, so if DMT was always taking serotonin's place, it will just think your brain has enough serotonin.

However, if you abused DMT like that there is a VERY good chance of falling into a deep psychosis. Permenately changing one of the most important endogenous neurotransmitters out for a drug with effects like DMT, you would develop serious side effects that involve mainly the 5-HT2a receptor. Just like with crack or meth, your appetite would go away. You would have troubles sleeping, psychosis, depersonalization, the list goes on and on.

Just research what 5-HT does to the 5-HT2a receptor, then replace the 5-HT with the DMT. You would fuck your brain, hard.



I'm about to go to bed but will look into your response a little more when I wake.
I think you are probably wrong at least partially though. It should actually help sleep as it's also an analogue for melatonin.
I have been dependent on a medication for years and last night I got a very good sleep (on a very low dose of the medication).
I have 2 questions for you:
1) What is your personal use experience?
2) What are you thoughts on the response which I'm quoting below:


Quote:

helenkeller said:
Back when I used to manufacture dmt I smoked level 5 trips multiple times a day for a month or so. No noticeable effect. Absolutely no psychosis.  Psychosis is getting trapped in a particular emotional state.  Dmt helps you realize you're holding on to these states.




Loved your answer btw helenkeller. It mirrors other accounts I have read online.

Edited by DMTme (04/23/15 03:48 PM)

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InvisibleDMTme

Registered: 03/22/15
Posts: 80
Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: helenkeller]
    #21586535 - 04/23/15 03:50 PM (9 years, 27 days ago)

Quote:

helenkeller said:
I don't think so.  My reason is the duration is much too short to cause neuro receptor damage. I certainly believe it could affect your natural endogenous dmt production though. Just a guess



That would likely manifest in lack of dreams. How was your dreaming after the intense (daily) period you mentioned above?

EDIT:
Also curious to know what caused you to stop the intense use period..

Edited by DMTme (04/23/15 03:56 PM)

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InvisibleGottaloveacid
Weedbass
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Registered: 10/20/14
Posts: 3,421
Loc: Colorado, USA
Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: DMTme]
    #21586582 - 04/23/15 03:57 PM (9 years, 27 days ago)

If the thing about melatonin was true, all tryptamines would fall under that category then, and I am pretty sure drugs like alpha-methyltryptamine (aMT) are extremely stimulating and do not promote sleep :smile: There are several other tryptamines (DiPT for example) that are very stimulating.  Also it could be argued LSD is somewhat a tryptamine as well, and is also very stimulating. Also keep in mind that melatonin is just a hormone. When you take melatonin supplements, you are basically telling your brain to make a hormone, as melatonin in supplement form is non-psychoactive, as it does not cross the blood brain barrier.


To answer your first question, I have done DMT a total of maybe 15-20 times, my first time was rather recently, too. Every time I took it I felt pretty baseline after 45-60 minutes, but if I did it maybe 2-3 times in a row, I would feel pretty scrambled and uncomfortable. I attest that to being the DMT's powerfulness though.

I answered your second question 3 posts up ^


--------------------
   
:mushroom2::mushroom2: The greatest story ever told is the story that never ends!:mushroom2::mushroom2:

wubba lubba dub dubstep :gimmebass:

Edited by Gottaloveacid (04/23/15 04:02 PM)

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OfflineSupachopped719
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Registered: 10/16/13
Posts: 3,311
Last seen: 4 years, 1 month
Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: DMTme]
    #21586661 - 04/23/15 04:07 PM (9 years, 27 days ago)

Quote:

DMTme said:
Quote:

helenkeller said:
I don't think so.  My reason is the duration is much too short to cause neuro receptor damage. I certainly believe it could affect your natural endogenous dmt production though. Just a guess



That would likely manifest in lack of dreams. How was your dreaming after the intense (daily) period you mentioned above?

EDIT:
Also curious to know what caused you to stop the intense use period..




I've also taken dmt multiple times a day for weeks on end, with no side effects, other than a bed sheet that reeks of dmt. 

I stopped because I realized I wanted quality over quantity. When I first started extracting I had so many vial filled with crystal, and still so much bark left over. So I tried to smoke all the time. I couldn't get soo high in my setting, so now I save the blast offs for a special place.

Also my dreams were uneffected by my dmt use, I dream every night and I smoke a ton of weed too.


--------------------
Real Eyes Realize Real Lies.

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Offlinehelenkeller
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Registered: 04/22/15
Posts: 10
Last seen: 8 years, 11 months
Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: DMTme] * 1
    #21588437 - 04/23/15 11:06 PM (9 years, 26 days ago)

Eventually I felt as though I learned everything it had to teach me. 
blasting off helps me to remember and reintegrate the lessons, but so does meditation.

You have to put in the work somehow.  Either meditate, that's work.  Make your own dmt, that's work. Or just work to get money to buy dmt.  Any way it's work Lol.


One of the things I like to say most after I blast people off is this:


Was the trip real?  Did you actually go someplace, or was it all just in your head?  Was. It. Real?

Well, what makes something real?  If you take whatever lessons you are taught, and integrate them into your life, your habits and personality, then it makes an ovservable change and that's as real as it gets. But, if you fail to integrate the lessons learned and you don't make aNY changes, then it was just a fantasy you had in your head, like any daydream that has absolutely no grounds in reality. So integrating the lessons and 'becoming a better person' makes it real.

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InvisibleDMTme

Registered: 03/22/15
Posts: 80
Re: Could long term use of DMT result in a reduction of endogenous serotonin? [Re: helenkeller]
    #21588663 - 04/24/15 12:25 AM (9 years, 26 days ago)

Quote:

helenkeller said:
Eventually I felt as though I learned everything it had to teach me. 
blasting off helps me to remember and reintegrate the lessons, but so does meditation.

You have to put in the work somehow.  Either meditate, that's work.  Make your own dmt, that's work. Or just work to get money to buy dmt.  Any way it's work Lol.

One of the things I like to say most after I blast people off is this:


Was the trip real?  Did you actually go someplace, or was it all just in your head?  Was. It. Real?

Well, what makes something real?  If you take whatever lessons you are taught, and integrate them into your life, your habits and personality, then it makes an ovservable change and that's as real as it gets. But, if you fail to integrate the lessons learned and you don't make aNY changes, then it was just a fantasy you had in your head, like any daydream that has absolutely no grounds in reality. So integrating the lessons and 'becoming a better person' makes it real.



Both poetic and rational. :smile:

Edited by DMTme (04/24/15 12:26 AM)

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