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jillian
Stranger
Registered: 10/22/03
Posts: 16
Last seen: 18 years, 6 months
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salvia....
#2150891 - 12/01/03 10:24 PM (20 years, 2 months ago) |
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can some1 OD on this???....
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trippinlizard
gridwalker

Registered: 12/29/02
Posts: 219
Loc: in the shade of the mushr...
Last seen: 17 years, 10 months
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Re: salvia.... [Re: jillian]
#2150905 - 12/01/03 10:29 PM (20 years, 2 months ago) |
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die? no. at least not directly from chemical poisoning.
-------------------- fine. do what you want, but i'm drinking the water.
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jillian
Stranger
Registered: 10/22/03
Posts: 16
Last seen: 18 years, 6 months
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ok...i just got done reading some info on it...
thanks..
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Seuss
Error: divide byzero


Registered: 04/27/01
Posts: 23,480
Loc: Caribbean
Last seen: 8 days, 16 hours
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Re: salvia.... [Re: jillian]
#2151150 - 12/02/03 06:19 AM (20 years, 2 months ago) |
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>> can some1 OD on this???....
> die? no. > at least not directly from chemical poisoning.
Any references showing LD50 studies in animals? If not, then you shouldn't be answering this question with such conviction. If so, then I apologize and please post the ref so that I can use it in the future. 
-------------------- Just another spore in the wind.
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cybrbeast
Up, then down, then...



Registered: 01/06/03
Posts: 4,777
Loc: event horizon
Last seen: 7 years, 8 months
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Re: salvia.... [Re: Seuss]
#2151467 - 12/02/03 09:46 AM (20 years, 2 months ago) |
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Not exactly LD-50, but Salvia seems safe enough: http://www.sagewisdom.org/mowryetal.html Abstract BACKGROUND: Salvinorin A is a unique hallucinogen that is seeing increased use in humans. It is not currently a controlled substance and is used as a legal alternative to controlled substances. Usually smoked or buccally absorbed by chewing, doses of approximately 200mcg can produce profound hallucinogenic effects of short duration. The mechanism of action of salvinorin A is at the k-opioid recpetor. Little data is available on the medical effects of this substance so animal studies were undertaken to explore the acute toxic effects of this substance in rats and the chronic effects in mice. METHODS: Rats were anesthetized and administered salvinorin A at 1600mcg/kg or vehicle. Recordings were made of galvanic skin response, EKG, temperature, and pulse pressure for 100 minutes. Mice were chronically exposed to vehicle or 400, 800, 1600, 3200, or 6400 mcg/kg of salvinorin A for two weeks. After exposure the animals were sacrificed and brain, heart, kidney, bone marrow, blood and spleen were removed, fixed, sectioned, stained and examined by light microscopy. Results. No effects were seen on cardiac conduction, temperature, or galvanic skin response. A non-significant rise was seen in pulse pressure. Histologic studies of spleen, blood, brain, liver, kidney, and bone marrow did not find any significant histologic changes at any of the doses examined. CONCLUSIONS: These data suggests that the toxicity of salvinorin A is relatively low, even at doses many times that of what humans are exposed to. However, further studies should be done on blood pressure effects. The psychological impact of this potent hallucinogen should also be investigated.
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futuretribe.space
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trippinlizard
gridwalker

Registered: 12/29/02
Posts: 219
Loc: in the shade of the mushr...
Last seen: 17 years, 10 months
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Re: salvia.... [Re: Seuss]
#2152067 - 12/02/03 02:19 PM (20 years, 2 months ago) |
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No prob. i'll be more thorough next time. 
In toxicity studies mice were dosed at 1 g/kg of salvinorin A (the limits of being able to make a serviceable preparation) and observed them for a week. All animals survived and appeared unharmed, but they were not autopsied (Vald?s et al. 1987).
http://www.sagewisdom.org/valdes94.html
about halfway down, under EXAMINATION OF THE EFFECTS OF SALVINORIN A AND SALVIA DIVINORUM
peace
-------------------- fine. do what you want, but i'm drinking the water.
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cybrbeast
Up, then down, then...



Registered: 01/06/03
Posts: 4,777
Loc: event horizon
Last seen: 7 years, 8 months
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Hehe, that's a better example than mine. 1g/kg, wow. How do rats respond to that, how can they even eat. Or are they tube fed or something.
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futuretribe.space
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recalcitrant
My Own God

Registered: 04/20/02
Posts: 2,927
Loc: Canada West
Last seen: 7 years, 9 months
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plz remember that ppl are not mice.
I am not worried about the ld50 of salvia. I leave this place far sooner than it would kill me.
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We have to answer our own prayers
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