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Amazon Shop for: Salvia

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Offlinejillian
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Registered: 10/22/03
Posts: 16
Last seen: 11 years, 3 months
salvia....
    #2150891 - 12/02/03 12:24 AM (13 years, 10 days ago)

can some1 OD on this???....


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Offlinetrippinlizard
gridwalker

Registered: 12/29/02
Posts: 219
Loc: in the shade of the mushr...
Last seen: 10 years, 8 months
Re: salvia.... [Re: jillian]
    #2150905 - 12/02/03 12:29 AM (13 years, 10 days ago)

die? no.
at least not directly from chemical poisoning.


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fine. do what you want, but i'm drinking the water.


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Offlinejillian
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Registered: 10/22/03
Posts: 16
Last seen: 11 years, 3 months
Re: salvia.... [Re: trippinlizard]
    #2150977 - 12/02/03 12:46 AM (13 years, 10 days ago)

ok...i just got done reading some info on it...

thanks..


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OfflineSeussA
Error: divide byzero

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Registered: 04/27/01
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Re: salvia.... [Re: jillian]
    #2151150 - 12/02/03 08:19 AM (13 years, 9 days ago)

>> can some1 OD on this???....

> die? no.
> at least not directly from chemical poisoning.

Any references showing LD50 studies in animals?  If not, then you shouldn't be answering this question with such conviction.  If so, then I apologize and please post the ref so that I can use it in the future.  :smile:




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Just another spore in the wind.


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Offlinecybrbeast
Up, then down, then...
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Re: salvia.... [Re: Seuss]
    #2151467 - 12/02/03 11:46 AM (13 years, 9 days ago)

Not exactly LD-50, but Salvia seems safe enough:
http://www.sagewisdom.org/mowryetal.html
Abstract
BACKGROUND: Salvinorin A is a unique hallucinogen that is seeing increased use in humans. It is not currently a controlled substance and is used as a legal alternative to controlled substances. Usually smoked or buccally absorbed by chewing, doses of approximately 200mcg can produce profound hallucinogenic effects of short duration. The mechanism of action of salvinorin A is at the k-opioid recpetor. Little data is available on the medical effects of this substance so animal studies were undertaken to explore the acute toxic effects of this substance in rats and the chronic effects in mice.

METHODS: Rats were anesthetized and administered salvinorin A at 1600mcg/kg or vehicle. Recordings were made of galvanic skin response, EKG, temperature, and pulse pressure for 100 minutes. Mice were chronically exposed to vehicle or 400, 800, 1600, 3200, or 6400 mcg/kg of salvinorin A for two weeks. After exposure the animals were sacrificed and brain, heart, kidney, bone marrow, blood and spleen were removed, fixed, sectioned, stained and examined by light microscopy. Results. No effects were seen on cardiac conduction, temperature, or galvanic skin response. A non-significant rise was seen in pulse pressure. Histologic studies of spleen, blood, brain, liver, kidney, and bone marrow did not find any significant histologic changes at any of the doses examined.

CONCLUSIONS: These data suggests that the toxicity of salvinorin A is relatively low, even at doses many times that of what humans are exposed to. However, further studies should be done on blood pressure effects. The psychological impact of this potent hallucinogen should also be investigated.


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futuretribe.space


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Offlinetrippinlizard
gridwalker

Registered: 12/29/02
Posts: 219
Loc: in the shade of the mushr...
Last seen: 10 years, 8 months
Re: salvia.... [Re: Seuss]
    #2152067 - 12/02/03 04:19 PM (13 years, 9 days ago)

No prob. i'll be more thorough next time. :smile:

In toxicity studies mice were dosed at 1 g/kg of salvinorin A (the limits of being able to make a serviceable preparation) and observed them for a week. All animals survived and appeared unharmed, but they were not autopsied (Vald?s et al. 1987).

http://www.sagewisdom.org/valdes94.html

about halfway down, under EXAMINATION OF THE EFFECTS OF SALVINORIN A AND SALVIA DIVINORUM

peace 


--------------------
fine. do what you want, but i'm drinking the water.


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Offlinecybrbeast
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Re: salvia.... [Re: trippinlizard]
    #2153029 - 12/02/03 10:18 PM (13 years, 9 days ago)

Hehe, that's a better example than mine. 1g/kg, wow. How do rats respond to that, how can they even eat. Or are they tube fed or something.


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futuretribe.space


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Offlinerecalcitrant
My Own God

Registered: 04/20/02
Posts: 2,927
Loc: Canada West
Last seen: 6 months, 27 days
Re: salvia.... [Re: cybrbeast]
    #2153781 - 12/03/03 02:22 AM (13 years, 9 days ago)

plz remember that ppl are not mice.

I am not worried about the ld50 of salvia. I leave this place far sooner than it would kill me.


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We have to answer our own prayers


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Amazon Shop for: Salvia

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