Home | Community | Message Board

MRCA Tyroler Gluckspilze
Please support our sponsors.

Feedback and Administration >> Shroomery News Service

Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Jump to first unread post. Pages: 1
Up, then down, then...
Male User Gallery

Folding@home Statistics
Registered: 01/06/03
Posts: 4,777
Loc: event horizon
Last seen: 5 months, 8 days
Puffer Fish Poison Painkiller
    #2150015 - 12/01/03 06:56 PM (12 years, 10 months ago)


TORONTO -- A tiny Canadian company wants to use poison from a fish -- a substance more toxic than cyanide -- to help cancer patients suppress pain or to wean heroin addicts off their habit.

International Wex Technologies, a Vancouver-based company listed on the small-cap Canadian Venture Exchange, says early trials show positive results from tetrodotoxin, although bigger and more extensive tests will be needed before the product reaches the marketing stage.

It says the new drug could be on the market within three years, if all the tests work out.

The new drug is derived from blowfish poison -- a substance so dangerous that a mere trace can paralyze a person within minutes.

The blowfish is known to gourmets as the source of the sometimes deadly Japanese fugu delicacy, a dish that can be prepared only by trained and licensed chefs, because the slip of a knife can poison the food, causing the diner to drop to the ground convulsing and gasping for air.

It has been described as the culinary version of Russian roulette.

But the drug derived from the poison, tetrodotoxin, has already passed two phases of clinical tests, and doctors conducting early surveys say it eased pain in terminally ill cancer patients, where no other pain medication had worked.

"It quickly became apparent that some patients were having a dramatic response. You would not have expected these results in existing treatments," said Dr Edward Sellers, a professor of pharmacology at the University of Toronto who helped Wex conduct its Phase II trials, a study of 22 patients.

Sellers said one patient in his mid-50s was in such agony that he couldn't even wear his clothes without sharp surges of pain.

But with shots of Tectin, Wex's patented name for tetrodotoxin, his pain subsided for more than week.

Researchers injected patients with several micrograms of Tectin -- a quantity so small it can't be seen with the naked eye -- twice a day for four days, and found that nearly 70 percent experienced a reduction in pain.

Pain relief began around the third day of treatment, and often lasted after the final injection. In some cases, the relief extended beyond 15 days, the study showed.

Tectin, a sodium channel blocker, stops nerves from sending pain signals to the brain.

The company says Tectin differs from other painkillers in that it doesn't have the same side effects as morphine and its derivatives, doesn't interact with other medicines and is not addictive. It is up to 3,200 times stronger than morphine.

The success of the early Tectin tests is a small coup for a company that has set its sights on the $38 billion North American painkiller market, some 10 percent of which comes from managing cancer pain.

Wex says that each puffer fish can provide about 600 doses of the drug from within its liver, kidneys and reproductive organs, so there is no shortage of the toxin.

It wasn't always about pain for Wex.

Wex's founder, Hay Kong Shum, a medical technician who was educated in Russia and China, originally hoped Tectin would help ease withdrawal symptoms.

But preliminary studies found the poison had painkilling properties and the company, facing limited resources, decided to take a shortcut to profitability. It put the heroin therapy on the back burner and turned to the painkiller industry.

"It was the easiest way for us to get to market," said Donna Shum, Hay Kong's daughter and Wex's chief operating officer.

Wex's interim test results have caused some murmurings among health-care workers who wonder about the potential of this painkiller.

But researchers and analysts are not yet touting Tectin as a drug to rival morphine. Wex still has to take its drug through crucial phase III trials, where it ramps up its test numbers to at least 400 patients.

The drug also faces an image problem.

"Because it's associated with death, it got a bad rap," said Sellers.

And although the scientific community may acknowledge the properties and benefits of the compound, it is less accepting of a drug derived from nature.

"There is a resistance from the medical community to accept treatments from the natural world," said Rob Peets, an analyst with Golden Capital Securities. "If this was a chemical product it would have been snapped up a long time ago."

Wex's stock has jumped about 150 percent since August.

I wonder if it also has the pleasurable effects of drugs like morphine. Especially since it is not addictive.


Post Extras: Print Post  Remind Me! Notify Moderator
Trip'n Time

Registered: 11/17/02
Posts: 2,207
Loc: Florida
Last seen: 10 years, 8 months
Re: Puffer Fish Poison Painkiller [Re: cybrbeast]
    #2150422 - 12/01/03 09:08 PM (12 years, 10 months ago)

Wow thats great :smile:
Theres so much suffering other there...

Post Extras: Print Post  Remind Me! Notify Moderator
Jump to top. Pages: 1

Feedback and Administration >> Shroomery News Service

Similar ThreadsPosterViewsRepliesLast post
* From Haitian Zombie Poison to Inuit Knives Made of Feces veggie 1,329 5 04/03/08 08:21 AM
by Seuss
* Men hallucinate after eating fish
( 1 2 3 4 all )
veggie 5,671 60 04/27/06 03:17 PM
by EquilibriuM
* Prescription painkillers causing more fatal overdoses [WA] veggie 1,589 4 02/07/07 09:34 AM
by white_noise
* Family poisoned by mushrooms first to receive experimental treatment [CA] veggie 2,670 6 01/14/07 11:51 PM
by fastfred
* Could Afghan Poppies Be Painkillers for the Poor? veggie 1,161 2 10/14/07 03:03 PM
by a_guy_named_ai
* The frog poison seeped into my blood. I would gain clairvoyant powers veggie 1,074 3 09/09/05 08:27 PM
by MikeOLogical
* Scientists explore abuse-resistant painkillers veggie 1,963 4 03/12/07 08:07 PM
by 2FiNiTe
* FDA reversal OKs morphine painkiller for dying vinsue 1,084 4 04/13/09 04:35 PM
by Seuss

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: motaman, karode13, Alan Rockefeller, naum, Mostly_Harmless
840 topic views. 1 members, 10 guests and 5 web crawlers are browsing this forum.
[ Toggle Favorite | Print Topic | Stats ]
Search this thread:
Please support our sponsors.

Copyright 1997-2016 Mind Media. Some rights reserved.

Generated in 0.044 seconds spending 0.004 seconds on 14 queries.