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OfflineEyeLoveMusic
Psychedelic Psycho

Registered: 05/03/11
Posts: 64
Last seen: 7 years, 2 months
Two questions regarding medication and two specific hallucinogens
    #21397152 - 03/12/15 11:27 AM (9 years, 2 months ago)

I'm unsure if this is the right board to ask these questions so I'm sorry if it isn't but:

1. I'm aware that many medications can either exacerbate or block the effects of most serotonergic Psychedelics, but are any of them known to significantly reduce the mental effects of DXM?

and

2. Would Depakote cancel out the effects of 25i-NBOMe?

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OfflineEyeLoveMusic
Psychedelic Psycho

Registered: 05/03/11
Posts: 64
Last seen: 7 years, 2 months
Re: Two questions regarding medication and two specific hallucinogens [Re: EyeLoveMusic]
    #21398467 - 03/12/15 04:10 PM (9 years, 2 months ago)

pl0x?

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OfflineEyeLoveMusic
Psychedelic Psycho

Registered: 05/03/11
Posts: 64
Last seen: 7 years, 2 months
Re: Two questions regarding medication and two specific hallucinogens [Re: EyeLoveMusic]
    #21400928 - 03/13/15 05:19 AM (9 years, 2 months ago)

ummmm do you guys not know or are you just choosing to not help me

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OfflineUrist
The Dwarf
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Registered: 02/11/15
Posts: 372
Loc: A Dwarf Fortress
Last seen: 9 months, 2 days
Re: Two questions regarding medication and two specific hallucinogens [Re: EyeLoveMusic]
    #21401043 - 03/13/15 06:27 AM (9 years, 2 months ago)

I just have no clue tbh...


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Edited by Urist (03/13/15 06:28 AM)

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OfflineEyeLoveMusic
Psychedelic Psycho

Registered: 05/03/11
Posts: 64
Last seen: 7 years, 2 months
Re: Two questions regarding medication and two specific hallucinogens [Re: Urist]
    #21401068 - 03/13/15 06:38 AM (9 years, 2 months ago)

I appreciate you for trying to help, positive vibrations have been sent in your direction.

But Depakote is a mood stabilizer/antipsychotic, not an SSRI, so I was wondering if anybody had any firsthand experience or more extensive knowledge of that drug in particular.

I'm probably not as well-versed in the pharmacological arts as many users here, so I'm not clear that Depakote would have the same effects on a psychedelic as its compadre Seroquel would, or if 25i may be in some way unique to other serotonergic psychs. I believe Lithium is well-known to strongly potentiate certain psychedelics, in spite of it generally being prescribed to treat Bipolar disorder (as is Depakote), so I'm unsure of the technical specifics here.

As for DXM (or rather dissociatives in general), it's mostly a moderately high tolerance that's keeping me from feeling full effects (currently about 2 months into a 6 month T-break), but I feel like some medications may reduce (though certainly not eradicate, in my case at least) the effects of Dex and and it's sister substances. I know risperdal COMPLETELY kept me from feeling the effects of MXE, on more than one occasion.

Can anyone offer any insight?

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OfflineUrist
The Dwarf
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Registered: 02/11/15
Posts: 372
Loc: A Dwarf Fortress
Last seen: 9 months, 2 days
Re: Two questions regarding medication and two specific hallucinogens [Re: EyeLoveMusic]
    #21401101 - 03/13/15 06:55 AM (9 years, 2 months ago)

From what I've read there are no adverse effects, other than the reduction in trip intensity or trip blockage. But I dont know for sure...I know that MAOI antipsychotics increase psychedelic effects but Depakote inhibits a different liver enzyme. It stimulates GABA production and inhibits it's inhibitors ...so it may cause increased anxiety....probably not good to trip on it.


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OfflinePine93
Stranger

Registered: 08/05/13
Posts: 22
Last seen: 9 years, 1 month
Re: Two questions regarding medication and two specific hallucinogens [Re: Urist]
    #21402497 - 03/13/15 02:39 PM (9 years, 2 months ago)

DXM and maoi = serotonin syndrome. I know Depakote is not an MAOI, but just keep in mind that DXM has contraindications that many 5-ht psychedelics do not.

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