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OfflineDragonChaser
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Trazodone and MDMA interaction
    #21100842 - 01/11/15 10:04 AM (9 years, 4 months ago)

Anyone know if there is an interaction?

I see trazodone is classified as a tetracyclic antidepressant, not an SSRI, so I wasn't sure if it would kill the effects of MDMA like an SSRI would.

Also, once when I was being prescribed Tussionex, the doctor warned me not to take Trazodone with it as it could cause serotonin syndrome.  I didn't see how that was true, and this was the same doctor that said "on the upside, your tonsils look good" while checking my throat out.  I said "they've been removed", and she just shrugged.  It was a total Dr. Zoidberg moment.


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OfflineDragonChaser
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Re: Trazodone and MDMA interaction [Re: DragonChaser]
    #21104584 - 01/11/15 10:04 PM (9 years, 4 months ago)

Bump


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Offlinespixce
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Re: Trazodone and MDMA interaction [Re: DragonChaser] * 1
    #21105115 - 01/11/15 11:57 PM (9 years, 4 months ago)

I don't know much but it could cause serotonin syndrome or make MDMA entirely not work its not worth the risk don't take trazodone unless to sleep or other prescribed uses its not recreational and most people hate it.


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Invisiblesetb
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Re: Trazodone and MDMA interaction [Re: DragonChaser]
    #21105995 - 01/12/15 06:07 AM (9 years, 4 months ago)

It does bind to SERT, so I would imagine that it causes similar interactions.

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OfflineDragonChaser
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Re: Trazodone and MDMA interaction [Re: spixce]
    #21107147 - 01/12/15 11:02 AM (9 years, 4 months ago)

Yeah, I have a script, I've taken it on and off for years for sleep.

I don't hate it but I am going to wean down because thanks to the governmental regulations on health care, not only did my health insurance go from $130/mo to $240/mo in a year, and I went from no deductible to a $3350/year deductible.

Thanks Obama.  Can't afford my scripts now, can barely afford my health insurance.


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OfflineShroomslip
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Re: Trazodone and MDMA interaction [Re: DragonChaser]
    #21107157 - 01/12/15 11:04 AM (9 years, 4 months ago)

He's doing you a favor if it's getting you off that shit.. Trazadone is horrible.


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Re: Trazodone and MDMA interaction [Re: Shroomslip]
    #21107590 - 01/12/15 12:56 PM (9 years, 4 months ago)

What is up with them using mental health drugs as sleep aids like trazodone and seroquel that's really scraping the bottom of the barrel what's next Thorazine and Prozac for insomnia, fuck if its that hard to get Z drugs then you might as well just take some OTC anti-histamines or some clonidine.


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OfflineDragonChaser
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Re: Trazodone and MDMA interaction [Re: spixce]
    #21107647 - 01/12/15 01:07 PM (9 years, 4 months ago)

Yeah, they had me on seroquel like 8 years ago when I was 21 for anxiety/insomnia.


It's a pretty ridiculously strong drug with some serious side effects to give someone for insomnia.  I had the craziest nightmares the entire time I was on it, and it didn't really help me sleep- it put me into a coma for 10-12 hours at a time.

I took it for a few months and said fuck that.


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Invisibleluvdemboomers
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Re: Trazodone and MDMA interaction [Re: Shroomslip]
    #21107709 - 01/12/15 01:21 PM (9 years, 4 months ago)

Quote:

Shroomslip said:
He's doing you a favor if it's getting you off that shit.. Trazadone is horrible.




How so?
'
I started taking it a couple months ago. No way I'd take something like seroquel but I thought trazadone wasn't that bad.

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Re: Trazodone and MDMA interaction [Re: luvdemboomers]
    #21107729 - 01/12/15 01:27 PM (9 years, 4 months ago)

Seroquel is a chemical lobotomy.


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Invisiblemoonrockmushy
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Re: Trazodone and MDMA interaction [Re: DragonChaser]
    #21107795 - 01/12/15 01:40 PM (9 years, 4 months ago)

I can attest to the fact that it negates the effects of cocaine for me.  I don't know about MDMA.

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Offlinespixce
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Re: Trazodone and MDMA interaction [Re: moonrockmushy]
    #21107863 - 01/12/15 01:51 PM (9 years, 4 months ago)

Yeah because Seroquel is a dopamine antagonist so it feels like a comedown but worse because you're all delirious it feels similar to about 200mg DPH with more dypsphoria.  For use in psychotic patients this drug can help but its no sleeping pill its a very dangerous drug that should not be used outside of a doctor's supervision.


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Re: Trazodone and MDMA interaction [Re: DragonChaser]
    #21108134 - 01/12/15 02:48 PM (9 years, 4 months ago)

Quote:

DragonChaser said:
Yeah, they had me on seroquel like 8 years ago when I was 21 for anxiety/insomnia.


It's a pretty ridiculously strong drug with some serious side effects to give someone for insomnia.  I had the craziest nightmares the entire time I was on it, and it didn't really help me sleep- it put me into a coma for 10-12 hours at a time.

I took it for a few months and said fuck that.



I've taken trazodone as a sleep-aid and it worked well for me with no side-effects. Seroquel, on the other hand, was awful. It made me feel like a fucking zombie. Side-effects may include irreversible Parkinsonian symptoms... yeah, fuck that. I told my doctor I was done "trying other alternatives" at that point. "We could start you on an SSRI--" Let me just stop your RIGHT THERE. :lol:

Ambien works great but it didn't help me stay asleep, and it inevitably stops working after a while.


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Invisiblemantis
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Re: Trazodone and MDMA interaction [Re: DragonChaser]
    #21108142 - 01/12/15 02:51 PM (9 years, 4 months ago)

Re: Your original question

I think trazodone and MDMA is a dangerous mix. It will probably have 2 possible effects:

1. Serotonin syndrome from too much 5-HT activation
2. ...or it could block the effects of MDMA completely and leave you with only MDMA side-effects, which is the best case scenario (seeing as how it is an antagonist at several 5-HT receptors).


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Offlinespixce
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Re: Trazodone and MDMA interaction [Re: mantis]
    #21108146 - 01/12/15 02:53 PM (9 years, 4 months ago)

Quote:

mantis said:
Quote:

DragonChaser said:
Yeah, they had me on seroquel like 8 years ago when I was 21 for anxiety/insomnia.


It's a pretty ridiculously strong drug with some serious side effects to give someone for insomnia.  I had the craziest nightmares the entire time I was on it, and it didn't really help me sleep- it put me into a coma for 10-12 hours at a time.

I took it for a few months and said fuck that.



I've taken trazodone as a sleep-aid and it worked well for me with no side-effects. Seroquel, on the other hand, was awful. It made me feel like a fucking zombie. Side-effects may include irreversible Parkinsonian symptoms... yeah, fuck that. I told my doctor I was done "trying other alternatives" at that point. "We could start you on an SSRI--" Let me just stop your RIGHT THERE. :lol:

Ambien works great but it didn't help me stay asleep, and it inevitably stops working after a while.



Is it true that ambien is a deliriant?


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Invisiblemantis
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Re: Trazodone and MDMA interaction [Re: spixce]
    #21108154 - 01/12/15 02:55 PM (9 years, 4 months ago)

It's not classified as a deliriant but rapid withdrawal may cause delirium. It's a short-acting hypnotic.


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Invisiblemoonrockmushy
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Re: Trazodone and MDMA interaction [Re: spixce]
    #21109295 - 01/12/15 06:30 PM (9 years, 4 months ago)

Quote:

spixce said:
Yeah because Seroquel is a dopamine antagonist so it feels like a comedown but worse because you're all delirious it feels similar to about 200mg DPH with more dypsphoria.  For use in psychotic patients this drug can help but its no sleeping pill its a very dangerous drug that should not be used outside of a doctor's supervision.




I was talking about trazadone not seroquel.  I have heard similar things about seroquel but have only taken that a handful of times.

I found that trazadone was pretty effective helping with cocaine comedown, but once I took it there was no more getting high that night.  If I took more coke I would feel next to no effects.

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