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OfflinePatlal
You ask too many questions
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Registered: 10/09/10
Posts: 44,849
Loc: Ottawa Flag
Last seen: 9 hours, 44 minutes
New weight loss pill that might actually work!
    #21076190 - 01/06/15 09:55 AM (9 years, 4 months ago)

Dieting might become easier, as scientists at the Salk Institute for Biological Studies have developed a pill that tricks the body into thinking it has consumed a large meal, igniting the fat burning process and cutting the appetite.

The research team is soon to embark on human clinical trials of the compound, called Fexaramine, for it effectively stopped weight gain, lowered cholesterol, controlled blood sugar and minimized inflammation in mice.

Most diet pills on the market -- including appetite suppressants or caffeine-based diet drugs -- dissolve into the blood, whereas Fexaramine remains in the intestines where it causes fewer side effects.

"This pill is like an imaginary meal," said Ronald Evans, director of Salk's Gene Expression Laboratory and senior author of the new paper, published January 5 in the journal Nature Medicine. "It sends out the same signals that normally happen when you eat a lot of food, so the body starts clearing out space to store it. But there are no calories and no change in appetite."

It's been two decades in the making, and the study has centered on the farnesoid X receptor (FXR), a protein that controls much of the digestion process, triggering the release of bile acids, say the researchers.
FXR also plays a role in the storing of fats and sugars, as it controls the blood sugar level and instigates fat burning before meals.

While none of this is news to the scientific community, and pharmaceutical companies have already worked with FXR in the hopes of treating metabolic conditions, Evans's team appears to have made a breakthrough by localizing the effects in the intestines.

"When you eat, you have to quickly activate a series of responses all throughout the body," says Evans. "And the reality is that the very first responder for all this is the intestine."
Fexaramine is also predicted to be safer in humans than other FXR-targeting drugs because it doesn't reach the bloodstream.

After five weeks of Fexaramine treatment, obese mice were not only in better shape, but experienced a rise in body temperature, signaling an increase in metabolism, also indicated by the conversion of white fat deposits to energy-burning beige fat.

The research team is at work organizing human clinical trials and says the drug would work in conjunction with diet and lifestyle changes.

To see a video about how Fexaramine works:



Read more: http://www.ctvnews.ca/health/new-weight-loss-pill-like-an-imaginary-meal-1.2174836#ixzz3O3r5bEij


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InvisibleSoupSandwich
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Folding@home Statistics
Registered: 12/08/14
Posts: 4,440
Loc: Lost
Re: New weight loss pill that might actually work! [Re: Patlal]
    #21076531 - 01/06/15 11:01 AM (9 years, 4 months ago)

Sounds interesting.

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Offlineberdinwall
<3 whooooshhh


Registered: 06/10/12
Posts: 4,276
Loc: West Virginia
Last seen: 2 years, 6 months
Re: New weight loss pill that might actually work! [Re: SoupSandwich]
    #21076584 - 01/06/15 11:05 AM (9 years, 4 months ago)

yeah interesting...interesting.


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InvisibleSoupSandwich
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Registered: 12/08/14
Posts: 4,440
Loc: Lost
Re: New weight loss pill that might actually work! [Re: berdinwall]
    #21076639 - 01/06/15 11:18 AM (9 years, 4 months ago)

I wonder if there's some RC that mimics this, as I could stand to lose about
10 pounds, but would never be prescribed this med. Not currently at least...

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OfflinePatlal
You ask too many questions
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Registered: 10/09/10
Posts: 44,849
Loc: Ottawa Flag
Last seen: 9 hours, 44 minutes
Re: New weight loss pill that might actually work! [Re: SoupSandwich]
    #21076655 - 01/06/15 11:21 AM (9 years, 4 months ago)

Quote:

SoupSandwich said:
I wonder if there's some RC that mimics this, as I could stand to lose about
10 pounds, but would never be prescribed this med. Not currently at least...




The only way you're gonna lose weight while hallucinating is if you're stuck on a desert island for weeks and be constantly dehydrated...


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Offlineunderfliptown
I suck and you should kill me


Registered: 03/07/11
Posts: 14,344
Last seen: 8 years, 9 months
Re: New weight loss pill that might actually work! [Re: Patlal] * 2
    #21076659 - 01/06/15 11:22 AM (9 years, 4 months ago)

You know the best diet pill? Diet and exercise. Shocking isn't it? :woah:

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Invisiblememes
Blessed


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Registered: 01/11/05
Posts: 27,785
Loc: In a Tree
Re: New weight loss pill that might actually work! [Re: underfliptown] * 1
    #21076663 - 01/06/15 11:22 AM (9 years, 4 months ago)

i'll stick to the whole "drink a full glass of water before you eat" thing.  and then eating healthy and exercising

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InvisibleSalomon
ಠ︵ಠ balance ಠ_ಠ weaver ಠ‿ಠ
Male

Registered: 01/17/09
Posts: 25,128
Loc: America, FUCK YEAH Flag
Re: New weight loss pill that might actually work! [Re: memes]
    #21076672 - 01/06/15 11:27 AM (9 years, 4 months ago)

smoke meth hail satan


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EVERYTHING EVENTUALLY BECOMES A DESERT


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Invisiblelarry.fisherman
shoulda died already
I'm a teapot


Registered: 11/03/12
Posts: 36,312
Re: New weight loss pill that might actually work! [Re: Salomon]
    #21076682 - 01/06/15 11:30 AM (9 years, 4 months ago)

Retard dosing MDMA definitely helps you shred the pounds. I lost ~10lbs once. All water weight. I looked like a crack head. Ribs and everything. 160lbs of sexy.

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OfflineBassfreak
ManBearPig
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Registered: 08/24/10
Posts: 18,014
Last seen: 8 years, 8 months
Re: New weight loss pill that might actually work! [Re: Salomon]
    #21076686 - 01/06/15 11:30 AM (9 years, 4 months ago)

meth and coke is the best way to lose weight


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Tom Brady is a God

Free Tom Brady

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OfflinePatlal
You ask too many questions
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Registered: 10/09/10
Posts: 44,849
Loc: Ottawa Flag
Last seen: 9 hours, 44 minutes
Re: New weight loss pill that might actually work! [Re: Bassfreak]
    #21076695 - 01/06/15 11:33 AM (9 years, 4 months ago)




Meth... Not even once...


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InvisibleVivaLaMushie
RIP LS :(
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Registered: 07/23/12
Posts: 15,711
Loc: Switzerland Flag
Re: New weight loss pill that might actually work! [Re: underfliptown]
    #21076701 - 01/06/15 11:34 AM (9 years, 4 months ago)

Quote:

underfliptown said:
You know the best diet pill? Healthy eating and exercise. Shocking isn't it? :woah:



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Offlinefapjack
Title
 User Gallery


Registered: 07/26/07
Posts: 16,574
Loc: Central New Jersey
Last seen: 4 years, 2 months
Re: New weight loss pill that might actually work! [Re: VivaLaMushie]
    #21077749 - 01/06/15 03:40 PM (9 years, 4 months ago)

Stem fast ftw


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OfflineKingKnowledge
Around
Male


Registered: 03/30/13
Posts: 2,876
Loc: East Coast
Last seen: 4 years, 9 months
Re: New weight loss pill that might actually work! [Re: fapjack] * 1
    #21077825 - 01/06/15 03:54 PM (9 years, 4 months ago)

If you're serious about losing weight, buy ketone strips and go on a strict no-carb diet. http://en.wikipedia.org/wiki/Ketogenic_diet

…or as everyone else says…diet and exercise. Eat a larger quantity of smaller portion meals, be sure to drink a lot of water, and start your metabolism right when you wake up. A bit of cardio, a bit of weight lifting….done.

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InvisibletheRAPeutic
Hueman
Male

Registered: 07/22/13
Posts: 8,702
Re: New weight loss pill that might actually work! [Re: Patlal]
    #21077860 - 01/06/15 04:02 PM (9 years, 4 months ago)

Quote:

underfliptown said:
You know the best diet pill? Diet and exercise. Shocking isn't it? :woah:



Quote:

underfliptown said:
You know the best diet pill? Diet and exercise. Shocking isn't it? :woah:



Quote:

underfliptown said:
You know the best diet pill? Diet and exercise. Shocking isn't it? :woah:



Quote:

underfliptown said:
You know the best diet pill? Diet and exercise. Shocking isn't it? :woah:







/thread

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InvisibleSoupSandwich
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Folding@home Statistics
Registered: 12/08/14
Posts: 4,440
Loc: Lost
Re: New weight loss pill that might actually work! [Re: theRAPeutic]
    #21077935 - 01/06/15 04:19 PM (9 years, 4 months ago)

Some people are just simple minded I guess.
Everything is simply black and white for them...:rolleyes:

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