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Moonshoe
Blue Mantis


Registered: 05/28/04
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Loc: Iceland
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Would it be safe to take turmeric with mucuna pruriens?
#20764354 - 10/28/14 03:27 PM (9 years, 3 months ago) |
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Mucuna Pruriens increases dopamine levels in the brain and increases testosterone production and human growth hormone production as well as being an aphrodisiac, increasing sperm health, and inducing lucid dreams.
It is advised not to use it was an MAOI,
Turmeric has amazing anti-inflammatory effects, anti-cancer effects, and myriad health benefits, and is considered a reversable MAOI with anti-depressant properties.
Black pepper contains piperizine which apparently massively potentiates turmeric, as well as other things.
Some people have said they use turmeric to potentiate mucuna.
Can anyone speculate if taking a combination of turmeric and mucuna pruriens would be safe and maybe beneficial?
Or would it be dangerous?
How about turmeric, mucuna and black pepper together?
Anyone take turmeric and black pepper ? If you read up on it I think you will start taking it, its of miraculous benefit.
I am quite high on Mucuna Pruriens and coffee and tea and kratom right now and have a huge jar of turmeric.
Turmeric has incredible qualities too numerous to name.
Turmeric and kratom go well together.
Just wondering how far you can push the combinations of beneficial herbs before they become not beneficial.
Any insight appreciated.
They say not to use mucuna every single day but others say it takes several days of consecutive use for full benefits and many body builders do take it daily.
There is no evidence of harm from long term use of mucuna pruriens even though it has been used for thousands of years in vedic medicine.
I think the warning not to use MAOs with mucuna mostly applies to irreversible pharmaceutical MAOI drugs, whereas turmeric is a reversible natural MAO.
So TL,DR: Do you think I can take turmeric and mucuna pruriens at the same time, or should I alternate them day by day?
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Everything I post is fiction.
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teamkiller
ghetto drama whore


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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: Moonshoe] 1
#20764830 - 10/28/14 05:26 PM (9 years, 3 months ago) |
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Quote:
Big Mac A double layer of sear-sizzled 100% pure beef mingled with special sauce on a sesame seed bun and topped with melty American cheese, crisp lettuce, minced onions and tangy pickles.

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s240779

Registered: 12/07/10
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: Moonshoe]
#20765509 - 10/28/14 08:04 PM (9 years, 3 months ago) |
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You need to verify that the MAOI in turmeric is actually bioavailable and that it is present in appreciable quantities. In fact, you need to verify that it even contains an MAOI; you didn't even mention the name of the MAOI chemical in your post! In regard to the first issue, as an example, the naturally-occurring catechin & epicatechin were found to be MAOIs when tested in vitro,[1] but they seem to have a very poor bioavailability.[2] The problem with in vitro testing is that it involves e.g. doing work in a petri dish, while in actuality the substance being tested might not effectively pass through the digestive system or the blood-brain barrier. Check out the following discussion on naturally-occurring MAOIs and bioavailability: link
1. Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla. Wen-Chi Hou, Rong-Dih Lin, Cheng-Tang Chen, Mei-Hsien Lee. Aug. 2005, Journal of Ethnopharmacology, vol. 100, 216-220. DOWNLOAD
2. Bioavailability of Tea Components. Yashin A., Nemzer B., Yashin Y. 28 Apr. 2012, Journal of Food Research, vol. 1, issue 2. DOWNLOAD
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s240779

Registered: 12/07/10
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: s240779]
#20765540 - 10/28/14 08:16 PM (9 years, 3 months ago) |
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Came across something that totally backs up what you spelled out in your first post. This is particularly interesting as I have an interest in MAOIs. Thanks for turning me onto this.
Download for below study here. Downloaded on http://libgen.org.
Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes
Mohit Kumar Bhutani, Mahendra Bishnoi, Shrinivas K. Kulkarni
Journal: Pharmacology Biochemistry and Behavior - PHARMACOL BIOCHEM BEHAV , vol. 92, no. 1, pp. 39-43, 2009 DOI: 10.1016/j.pbb.2008.10.007
Curcumin, a yellow pigment extracted from rhizomes of the plant Curcuma longa (turmeric), has been widely used as food additive and also as a herbal medicine throughout Asia. The present study was designed to study the pharmacological, biochemical and neurochemical effects of daily administration of curcumin to rats subjected to chronic unpredictable stress. Curcumin treatment (20 and 40 mg/kg, i.p., 21 days) significantly reversed the chronic unpredictable stress-induced behavioral (increase immobility period), biochemical (increase monoamine oxidase activity) and neurochemical (depletion of brain monoamine levels) alterations. The combination of piperine (2.5 mg/kg, i.p., 21 days), a bioavailability enhancer, with curcumin (20 and 40 mg/kg, i.p., 21 days) showed significant potentiation of its anti-immobility, neurotransmitter enhancing (serotonin and dopamine) and monoamine oxidase inhibitory (MAO-A) effects as compared to curcumin effect per se. This study provided a scientific rationale for the use of curcumin and its co-administration with piperine in the treatment of depressive disorders
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Moonshoe
Blue Mantis


Registered: 05/28/04
Posts: 27,202
Loc: Iceland
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: s240779]
#20765612 - 10/28/14 08:36 PM (9 years, 3 months ago) |
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Yes I am interested in taking curcumin with piperine but am currently taking mucuna pruriens as well and wasnt sure if it was safe. But I ate a meal with a huge amount of black pepper and turmeric for dinner with no obvious ill effects.
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Everything I post is fiction.
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s240779

Registered: 12/07/10
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: Moonshoe]
#20765673 - 10/28/14 08:50 PM (9 years, 3 months ago) |
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L-dopa, which is found in Mucuna pruriens, is indeed contraindicated with MAOIs. You're correct in that MAOIs are classed as either reversible and irreversible and it is known that tyramine isn't contraindicated with reversible MAOIs (tyramine is the byproduct found in most MAOI-restricted foods such as cheese and wine). L-dopa may be safe as well, however by taking it you may be compromising the effectiveness of the curcumin because the body may reverse the action of the curcumin in order to safely metabolize the l-dopa. This is just speculation on my part. Also note that your idea of alternating between remedies every other day may not work out because the monoamine oxidase in your brain may be inhibited by the curcumin for an extended period of time. Irreversible MAOIs are known for inducing extended inhibition, however reversibles may produce the effect for greater than 24 hours.
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Moonshoe
Blue Mantis


Registered: 05/28/04
Posts: 27,202
Loc: Iceland
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: s240779]
#20765750 - 10/28/14 09:04 PM (9 years, 3 months ago) |
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Ok well I will not take curcumin again I guess, at least not for a while as i take mucuna. But maybe since I had turmeric for dinner I cant take mucuna for breakfast?
I dont know.
I guess its either or. I dont want to wait a full day before taking it again...
Shit.
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Everything I post is fiction.
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s240779

Registered: 12/07/10
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: Moonshoe]
#20765759 - 10/28/14 09:08 PM (9 years, 3 months ago) |
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The effects of MAOIs sound much more promising than the effects of l-dopa, though. Do you have any evidence that l-dopa produces impressive results? MAOIs have a significant histroy behind them. This psychiatrist argues that they're much more effective than modern antidepressants: http://www.psychotropical.com/index.php/anti-depressants/anti-depressants-maois
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Moonshoe
Blue Mantis


Registered: 05/28/04
Posts: 27,202
Loc: Iceland
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: s240779]
#20765805 - 10/28/14 09:23 PM (9 years, 3 months ago) |
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So you would recommend taking turmeric with black pepper instead of mucuna pruriens?
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Everything I post is fiction.
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s240779

Registered: 12/07/10
Posts: 12,880
Last seen: 2 months, 27 days
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: Moonshoe]
#20765832 - 10/28/14 09:26 PM (9 years, 3 months ago) |
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Well, I just reccommend going by substantial information. We have reason to believe that curcumin can produce significant mood-boosting effects (based on the study I posted). Is there any promising research on l-dopa? You have to decide what is worth your commitment.
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Moonshoe
Blue Mantis


Registered: 05/28/04
Posts: 27,202
Loc: Iceland
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: s240779]
#20765850 - 10/28/14 09:30 PM (9 years, 3 months ago) |
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Well there is evidence that mucuna pruriens increases testosterone and human growth hormone (which enhance my weight gain and muscle building goals) and there are strong reasons to believe higher levels of dopamine in the brain correspond with a better mood (many pleasurable drugs act by increasing dopamine in the brain, eg. adderall, marijuana, mxe, ritalin etc) and Mucuna pruriens does seems to induce a high of sorts. And it induces lucid dreams, and is an aphrodisiac...
But turmeric is extremely healthy for you and enhances mood also. Ideally one could take both but if contraindicated perhaps not.
Today I took mucuna pruriens and then a few hours later took turmeric and black pepper and didnt have any obvious problems...
I think I will continue to take mucuna for a while and maybe switch to turmeric and black pepper later...
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Everything I post is fiction.
Edited by Moonshoe (10/28/14 09:31 PM)
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s240779

Registered: 12/07/10
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: Moonshoe]
#20765918 - 10/28/14 09:50 PM (9 years, 3 months ago) |
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aZombie
Yugen



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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: s240779]
#20765943 - 10/28/14 09:58 PM (9 years, 3 months ago) |
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Posting so I remember to check out this thread later when I have time available.
Interesting topic guys!
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Moonshoe
Blue Mantis


Registered: 05/28/04
Posts: 27,202
Loc: Iceland
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: aZombie]
#20766102 - 10/28/14 10:36 PM (9 years, 3 months ago) |
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It seems that the only interactions listed for turmeric anywhere are for blood thinners.
So I dont see anywhere that turmeric interacts with L dopa or mucuna pruriens negatively.
I will not take turmeric anymore but will be buying some green tea extract to take with my mucuna which potentiates it greatly.
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Everything I post is fiction.
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spore baby



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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: Moonshoe]
#20766117 - 10/28/14 10:41 PM (9 years, 3 months ago) |
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.
Edited by spore baby (12/13/14 02:27 PM)
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s240779

Registered: 12/07/10
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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: s240779]
#20766293 - 10/29/14 12:02 AM (9 years, 3 months ago) |
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Tripsurfer
Bring Back Asante!



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Re: Would it be safe to take turmeric with mucuna pruriens? [Re: s240779]
#20766425 - 10/29/14 01:10 AM (9 years, 3 months ago) |
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I use turmeric and black pepper all the time. Pretty basic ingredients of curry no?
-------------------- Ach en wee ben ik de klos, met mijn boog schoot ik een albatros... A philosopher is a person who knows less and less about more and more, until he knows nothing about everything.

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