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OnlineLearyfanS
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Today in psychedelic history (04/30) * 1
    #14375188 - 04/29/11 10:43 PM (12 years, 10 months ago)

  • 1963:  Timothy Leary is fired from Harvard




Quote:

According to Andrew Weil, Leary was fired for not showing up to his lecture classes, while Alpert was fired for allegedly giving psilocybin to an undergraduate in an off-campus apartment.  This version is supported by the words of Harvard President Nathan M. Pusey, who, regarding Leary's termination, released the following statement on May 27, 1963:

    On May 6, 1963, the Harvard Corporation voted, because Timothy F. Leary, lecturer on clinical psychology, has failed to keep his classroom appointments and has absented himself from Cambridge without permission, to relieve him from further teaching duty and to terminate his salary as of April 30, 1963.


(https://en.wikipedia.org)









  • 1969:  The movie The Big Cube is released




Quote:

The Big Cube is a 1969 Warner Bros. thriller directed by Tito Davison and starring Lana Turner, Karin Mossberg (in her first and only role), George Chakiris, Dan O'Herlihy and Richard Egan; it was one of Lana Turner's last movies. It is notable for its aggressive portrayal of LSD use and the 1960s youth counterculture as vicious evils.

Plot

Lana Turner plays Adriana Roman, a successful stage actress who retires to marry Charles Winthrop (O'Herlihy), a wealthy tycoon. Winthrop's daughter, Lisa (Mossberg), is instantly distrustful of Adriana. When Charles is killed in a boating accident, Lisa's new boyfriend Johnny (Chakiris) capitalizes on that distrust to lead Lisa to believe that her father's death was murder – a charge exacerbated by Adriana's threat, as per her late husband's instructions, to disinherit Lisa if she marries Johnny.

Johnny and Lisa conspire secretly to dose Adriana's sleeping pills with enough LSD to drive her insane. Though they accomplish their goal – and Adriana is committed to a mental hospital – a playwright friend of Adriana's (Egan) suspects foul play. He writes a play detailing Adriana's traumatic experiences and casts her in the lead role, hoping that replaying her experience on stage will cure her.

Directed by Tito Davison
Produced by Francisco Diaz Barroso
Lindsley Parsons
Written by Edmundo Báez (story)
Tito Davison (story)
William Douglas Lansford (writer)
Starring Lana Turner
Karin Mossberg
George Chakiris
Dan O'Herlihy
Richard Egan
Music by Val Johns
Cinematography Gabriel Figueroa
Distributed by Warner Bros.
Release date(s) April 30, 1969 (US)
Running time 98 mins.
Country United States
Language English


(https://en.wikipedia.org)









  • 1971:  Science Magazine publishes an article titled "LSD And Genetic Damage"




Quote:

Science 30 April 1971:
Vol. 172 no. 3982 pp. 431-440
DOI: 10.1126/science.172.3982.431
LSD and Genetic Damage

  Of nine studies in vitro, six have indicated some degree of induced chromosomal breakage after exposure to LSD; three failed to confirm these results. The damage, when found, was generally of the chromatid type, arising during or after DNA synthesis. This damage, with one exception, was the result of concentrations of drug and durations of exposure which could not be achieved in humans with reasonable dosages. There did not appear to be a dose-response relation. The magnitude of damage, when found, was in the range encompassing the effects of many commonly used substances. The absence in vitro of excretory and detoxifying systems present in vivo, as well as several negative reports, cast doubt on the relevance of in vitro results.

In 21 chromosomal studies in vivo, 310 subjects were examined. Of these, 126 were treated with pure LSD; the other 184 were exposed to illicit, "alleged" LSD. A maximum of only 18 of 126 (14.29 percent) of the subjects in the group exposed to pure LSD showed higher frequency of chromosome aberration than the controls. In contrast, a maximum of 90 of 184 (48.91 percent) of the subjects taking illicit LSD showed an increase in frequency of aberrations. Of all the subjects reported to have chromosome damage, only 18 of the 108 (16.67 percent) were exposed to pure LSD. The frequency of individuals with chromosomal damage reported among illicit drug users was more than triple that associated with the use of pharmacologically pure LSD. We conclude that chromosome damage, when found, was related to the effects of drug abuse in general and not, as initially reported, to LSD alone. We believe that pure LSD ingested in moderate dosages does not produce chromosome damage detectable by available methods.

No significant work on carcinogenic potential of LSD has been reported so far. No cause-and-effect relation and no increase in the incidence of neoplasia among LSD users have been demonstrated. Case reports (three in 4.0 years) of leukemia and other neoplasia in this population are rare.

The results of early chromosome studies suggested that true genetic damage might be a consequence of LSD exposure. The comprehensive evidence from studies on drosophila indicates no mutagenic effect from 0.28 to 500 µg of LSD per milliliter and a definite mutagenic effect from 2,000 to 10,000 µg/ml; this is consistent with a threshold response or a sigmoid dose-effect relation. We believe that LSD is, in fact, a weak mutagen, effective only in extremely high doses; it is unlikely to be mutagenic in any concentration used by human subjects.

Circular dichroism experiments suggested that the specific mechanism of action of LSD on DNA may be a direct interaction resulting in conformational changes in the DNA helix. These changes are unlikely to result in a decrease of internal stability sufficient to cause breakage of chromosomes, but they may be the physical basis of the weak mutagenicity.

Early chromosomal studies implicated LSD as a potential cause of congenital malformations, fetal wastage, and germinal chromosome damage. First reports of a teratogenic effect in hamsters and rats have not been confirmed. A review of 15 rodent studies indicated a wide range of individual, strain, and species susceptibility to the effects of LSD. The applicability of such investigations to man is doubtful. In a study of human pregnancies, those exposed to illicit LSD had an elevated rate of spontaneous abortions. There is no reported instance of a malformed child born to a woman who ingested pure LSD; there are six cases of malformation associated with exposure to illicit LSD, four of which have similar limb defects. Given, however, the high frequency of unexplained "spontaneous" birth defects, the rare occurrence of malformed infants born to women who used illicit LSD may be coincidental. While there is no evidence that pure LSD is teratogenic in man, the use of any drug during pregnancy requires that its potential benefits significantly outweigh its potential hazards.

From our own work and from a review of the literature, we believe that pure LSD ingested in moderate doses does not damage chromosomes in vivo, does not cause detectable genetic damage, and is not a teratogen or a carcinogen in man. Within these bounds, therefore, we suggest that, other than during pregnancy, there is no present contraindication to the continued controlled experimental use of pure LSD.

Note added in proof: A brief review has been brought to our attention. Although based on a sample of only 15 studies the author reached conclusions similar to our own (92).


(http://www.sciencemag.org)















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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


Edited by Learyfan (04/25/21 10:11 AM)

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Offlinebholzer
quasi-scientist

Folding@home Statistics
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Re: Today in psychedelic history (04/30) [Re: Learyfan] * 2
    #14375421 - 04/29/11 11:36 PM (12 years, 10 months ago)

Great posts, love reading these all the time!


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Use these substances wisely, they have the ability to cause life altering realizations.

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Offlinek00laid
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Re: Today in psychedelic history (04/30) [Re: bholzer] * 1
    #14375977 - 04/30/11 03:15 AM (12 years, 10 months ago)

i like reading these too <3


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AMU - AMU Q & A - MyVideo Teks!

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OnlineLearyfanS
It's the psychedelic movement!
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Registered: 04/20/01
Posts: 34,142
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Re: Today in psychedelic history (04/30) [Re: k00laid]
    #16158774 - 04/30/12 04:42 AM (11 years, 9 months ago)

:heart:

















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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


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OfflineLucyfer
Psychonautic Voyager


Registered: 03/06/12
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Re: Today in psychedelic history (04/30) [Re: Learyfan] * 2
    #16159159 - 04/30/12 08:00 AM (11 years, 9 months ago)

LEARY :heart:


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ANYTHING AND EVERYTHING I post on here is used for fictional purposes only. I do not use drugs, sell drugs, or condone drug use.

"You are only as young as the last time you changed your mind." -Timothy Leary

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OfflineSoreSpore
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Re: Today in psychedelic history (04/30) [Re: Lucyfer] * 2
    #16159251 - 04/30/12 08:28 AM (11 years, 9 months ago)

Cool post.
:whathesaid:

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OnlineLearyfanS
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Registered: 04/20/01
Posts: 34,142
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Re: Today in psychedelic history (04/30) [Re: SoreSpore]
    #18190795 - 04/30/13 05:45 AM (10 years, 9 months ago)

50th anniversary of Leary's firing today.















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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


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OnlineLearyfanS
It's the psychedelic movement!
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Registered: 04/20/01
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Re: Today in psychedelic history (04/30) [Re: Learyfan]
    #19920417 - 04/30/14 05:42 AM (9 years, 9 months ago)

45th anniversary of one of the earlier movies to feature LSD, The Big Cube.  Here's the trailer. 



















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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


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InvisibleThayendanegea
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Re: Today in psychedelic history (04/30) [Re: Learyfan] * 2
    #19920677 - 04/30/14 08:22 AM (9 years, 9 months ago)

Very cool...thanks Learyfan:sunny:


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Look Deep Into Nature,and Then You Will Understand Everything Better.

Albert Einstein

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OnlineLearyfanS
It's the psychedelic movement!
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Registered: 04/20/01
Posts: 34,142
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Re: Today in psychedelic history (04/30) [Re: Thayendanegea]
    #21616415 - 04/30/15 06:09 AM (8 years, 9 months ago)

No problem!

:cool:

















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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


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OnlineLearyfanS
It's the psychedelic movement!
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Registered: 04/20/01
Posts: 34,142
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Re: Today in psychedelic history (04/30) [Re: Learyfan]
    #23171937 - 04/30/16 07:43 AM (7 years, 9 months ago)

No problem at all.














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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


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OnlineLearyfanS
It's the psychedelic movement!
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Registered: 04/20/01
Posts: 34,142
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Last seen: 6 minutes, 56 seconds
Re: Today in psychedelic history (04/30) [Re: Learyfan] * 1
    #24283113 - 04/30/17 02:52 AM (6 years, 9 months ago)

The pleasure is all mine dude. 

:cool:














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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


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OfflineTheHunt
Known To Disturb An Ego
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Re: Today in psychedelic history (04/30) [Re: Learyfan] * 1
    #24283120 - 04/30/17 03:07 AM (6 years, 9 months ago)

haha man you like,welcomed me,before i thanked you for always bumping these things.


What would we do with out you, the site needs to auto bump your history posts.
They really make the shroomery that more complete.


--------------------
This is not a game. We are not players. We do not play.
Gymnopilus aeruginosus Gymnopilus luteofolius Panaeolopsis sp. Panaeolus bispora Panaeolus cinctulus Panaeolus olivaceus Pluteus salicinus Psilocybe allenii Psilocybe azurescens Psilocybe cyanescens Psilocybe ovoideocystidiata Psilocybe pelliculosa Psilocybe semilanceata Psilocybe stuntzii

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OnlineLearyfanS
It's the psychedelic movement!
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Registered: 04/20/01
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Re: Today in psychedelic history (04/30) [Re: TheHunt]
    #25174944 - 04/30/18 06:30 AM (5 years, 9 months ago)

55th anniversary of Leary being fired from / quitting Harvard.










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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


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OnlineLearyfanS
It's the psychedelic movement!
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Registered: 04/20/01
Posts: 34,142
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Last seen: 6 minutes, 56 seconds
Re: Today in psychedelic history (04/30) [Re: Learyfan]
    #25963872 - 04/30/19 05:46 AM (4 years, 9 months ago)

50th anniversary of The Big Cube today.











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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


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OnlineLearyfanS
It's the psychedelic movement!
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Registered: 04/20/01
Posts: 34,142
Loc: High pride!
Last seen: 6 minutes, 56 seconds
Re: Today in psychedelic history (04/30) [Re: Learyfan]
    #26638798 - 04/30/20 11:21 AM (3 years, 9 months ago)

Annual bump.










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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


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Offlinek00laid
NEMO
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Re: Today in psychedelic history (04/30) [Re: Learyfan] * 1
    #26639231 - 04/30/20 02:50 PM (3 years, 9 months ago)

Quote:

Learyfan said:
Annual bump.














love it. love you.


--------------------
AMU - AMU Q & A - MyVideo Teks!

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OnlineLearyfanS
It's the psychedelic movement!
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Registered: 04/20/01
Posts: 34,142
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Last seen: 6 minutes, 56 seconds
Re: Today in psychedelic history (04/30) [Re: k00laid]
    #27287450 - 04/30/21 04:12 AM (2 years, 9 months ago)

Love you too, kOOlaid! I hope that one day you will celebrate your 50th anniversary at The Shroomery! Speaking of which, today is the 50th anniversary of that "LSD and Genetic Damage" article from Science Magazine.









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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


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OfflineSpidereffect26
Stranger
Registered: 04/29/21
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Re: Today in psychedelic history (04/30) [Re: Learyfan]
    #27287731 - 04/30/21 10:57 AM (2 years, 9 months ago)

Wow

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OnlineLearyfanS
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Re: Today in psychedelic history (04/30) [Re: Learyfan] * 1
    #27757361 - 04/30/22 09:09 AM (1 year, 9 months ago)

Annual bump.









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Mp3 of the month:  The Fe-Fi-Four Plus 2 - I Wanna Come Back (From the World of LSD)


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